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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:picropodophyllotoxin
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Accession:CHEBI:75251 term browser browse the term
Definition:An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
Synonyms:exact_synonym: (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
 related_synonym: Formula=C22H22O8;   InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1;   InChIKey=YJGVMLPVUAXIQN-HAEOHBJNSA-N;   Picropodophyllin;   SMILES=[H][C@]12COC(=O)[C@@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1[C@@H]2O
 alt_id: CHEBI:8204;   MESH:C415032
 xref: CAS:477-47-4;   HMDB:HMDB0031452;   KEGG:C10871;   KNApSAcK:C00002619
 xref_mesh: MESH:C415032
 xref: PMID:19070483;   PMID:19115065;   PMID:20150364;   PMID:21251888;   PMID:21330319;   PMID:21423728;   PMID:21968616;   PMID:22159423;   PMID:22215905;   PMID:22392915;   PMID:22495823;   PMID:23515289;   PMID:23624780;   PMID:23665331;   PMID:23699657;   PMID:23710710;   PMID:23797814;   PMID:24182354;   PMID:24406046;   PMID:25163779;   PMID:26021470;   PMID:26323364;   Patent:WO2012047172;   Reaxys:99161


show annotations for term's descendants           Sort by:
picropodophyllotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein] CTD PMID:25118938 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO picropodophyllin results in decreased expression of BIRC5 protein CTD PMID:16166596 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases activity ISO picropodophyllin results in decreased activity of CDK1 protein CTD PMID:16166596 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [picropodophyllin co-treated with IGF1 protein] results in increased expression of TNF mRNA; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA]; picropodophyllin inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; picropodophyllin inhibits the reaction [IGF1 protein results in increased expression of IL1B mRNA]; picropodophyllin promotes the reaction [IGF1 protein results in increased expression of IL6 mRNA] CTD PMID:21371294 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases activity
multiple interactions		 ISO picropodophyllin results in decreased activity of IGF1R protein
[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]
picropodophyllin binds to and results in decreased activity of IGF1R protein		 CTD PMID:16166596 PMID:21371294 PMID:23673518 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; picropodophyllin inhibits the reaction [IGF1 protein results in increased expression of IL1B mRNA] CTD PMID:21371294 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA; picropodophyllin promotes the reaction [IGF1 protein results in increased expression of IL6 mRNA]
picropodophyllin results in increased expression of IL6 mRNA		 CTD PMID:21371294 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO picropodophyllin results in decreased phosphorylation of MAPK1 protein CTD PMID:16166596 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO picropodophyllin results in decreased phosphorylation of MAPK3 protein CTD PMID:16166596 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO picropodophyllin results in decreased expression of MCL1 protein CTD PMID:16166596 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO picropodophyllin inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased activity of MMP2 protein] CTD PMID:33571556 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO picropodophyllin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; picropodophyllin inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA] CTD PMID:21371294 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [picropodophyllin co-treated with IGF1 protein] results in increased expression of TNF mRNA; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA] CTD PMID:21371294 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      application 19710
        pharmaceutical 19536
          drug 19536
            antineoplastic agent 17692
              picropodophyllotoxin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic molecule 19744
                              organic cyclic compound 19549
                                organic heterocyclic compound 18888
                                  organic heteropolycyclic compound 18315
                                    organic heterotetracyclic compound 9215
                                      furonaphthodioxole 689
                                        picropodophyllotoxin 16
paths to the root