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ONTOLOGY REPORT - ANNOTATIONS


Term:rifaximin
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Accession:CHEBI:75246 term browser browse the term
Definition:A semisynthetic member of the class of rifamycins and non-systemic gastrointestinal site-specific broad spectrum antibiotic. Used in the treatment of traveller's diarrhoea, hepatic encephalopathy and irritable bowel syndrome.
Synonyms:exact_synonym: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl acetate
 related_synonym: Formula=C43H51N3O11;   InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1;   InChIKey=NZCRJKRKKOLAOJ-XRCRFVBUSA-N;   Rifamycin L 105;   Rifamycin L 105SV;   Rifaxidin;   SMILES=CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c1c(nc5cc(C)ccn15)c4c3C2=O;   Xifaxsan;   rifaximina;   rifaximine;   rifaximinun
 xref: CAS:80621-81-4 "ChemIDplus";   CAS:80621-81-4 "KEGG DRUG";   DrugBank:DB01220;   Drug_Central:2379 "DrugCentral";   HMDB:HMDB0015351;   KEGG:D02554
 xref_mesh: MESH:C042734
 xref: PMID:23092785 "Europe PMC";   PMID:23095030 "Europe PMC";   PMID:23183443 "Europe PMC";   PMID:23216382 "Europe PMC";   PMID:23273888 "Europe PMC";   PMID:23274384 "Europe PMC";   PMID:23275147 "Europe PMC";   PMID:23303506 "Europe PMC";   PMID:23314671 "Europe PMC";   PMID:23340064 "Europe PMC";   PMID:23389621 "Europe PMC";   PMID:23445237 "Europe PMC";   PMID:23526308 "Europe PMC";   PMID:23556126 "Europe PMC";   PMID:23565181 "Europe PMC";   PMID:23589147 "Europe PMC";   PMID:23640348 "Europe PMC";   PMID:23653636 "Europe PMC";   PMID:23740443 "Europe PMC";   PMID:23798671 "Europe PMC";   PMID:23843564 "Europe PMC";   PMID:23877348 "Europe PMC";   PMID:23922656 "Europe PMC";   PMID:25214516 "Europe PMC";   PMID:25339518 "Europe PMC";   PMID:25565769 "Europe PMC";   PMID:25586470 "Europe PMC";   PMID:25641072 "Europe PMC";   PMID:25835116 "Europe PMC";   PMID:25867912 "Europe PMC";   PMID:25932262 "Europe PMC";   PMID:26028929 "Europe PMC";   PMID:26043290 "Europe PMC";   Reaxys:7790802 "Reaxys";   Wikipedia:Rifaximin


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rifaximin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:6480464
G Cidec cell death-inducing DFFA-like effector c JBrowse link 4 145,377,482 145,390,497 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6480464
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 2 102,701,903 102,871,257 RGD:6480464
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:6480464
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        antimicrobial agent 17158
          rifaximin 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        carboacyl group 16948
                                          univalent carboacyl group 16948
                                            carbamoyl group 16627
                                              carboxamide 16627
                                                lactam 2856
                                                  ansamycin 750
                                                    rifamycins 381
                                                      rifaximin 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.