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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nerolidol
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Accession:CHEBI:7524 term browser browse the term
Definition:A farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent.
Synonyms:exact_synonym: 3,7,11-trimethyldodeca-1,6,10-trien-3-ol
 related_synonym: 3,7,11-trimethyl-1,6,10-dodecatrien-3-ol;   3-hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene;   FEMA 2772;   Formula=C15H26O;   InChI=1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3;   InChIKey=FQTLCLSUCSAZDY-UHFFFAOYSA-N;   SMILES=[H]C(CCC(C)(O)C=C)=C(C)CCC=C(C)C;   Stirrup
 xref: AGR:IND607344987;   CAS:7212-44-4;   Chemspider:8549;   FooDB:FDB014378;   HMDB:HMDB0035662;   KNApSAcK:C00003166
 xref_mesh: MESH:C037055
 xref: PMID:25880240;   PMID:27136520;   PMID:31715307;   PMID:31827712;   PMID:32048763;   PMID:32825411;   PMID:32941795;   PMID:33212213;   PMID:33611212;   PMID:33613971;   PMID:33999335;   Reaxys:1724135;   Wikipedia:Nerolidol


show annotations for term's descendants           Sort by:
nerolidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP [nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein; nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein]; nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33212213 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] CTD PMID:33212213 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO nerolidol results in increased expression of BAX mRNA CTD PMID:35357761 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nerolidol results in decreased expression of BCL2 mRNA CTD PMID:35357761 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression ISO nerolidol results in increased expression of CASP3 mRNA CTD PMID:35357761 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein] CTD PMID:33212213 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO nerolidol results in decreased expression of CCND1 mRNA CTD PMID:35357761 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP [nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein CTD PMID:33212213 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein] CTD PMID:33212213 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:33212213 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33212213 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO nerolidol results in increased expression of and results in increased phosphorylation of MAPK8 mRNA CTD PMID:35357761 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein] CTD PMID:33212213 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein] CTD PMID:33212213 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein] CTD PMID:33212213 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:33212213 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein] CTD PMID:33212213 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein] CTD PMID:33212213 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] CTD PMID:33212213 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein] CTD PMID:33212213 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein] CTD PMID:33212213 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      chemical role 19497
        antioxidant 16054
          nerolidol 21
            (6E)-nerolidol + 0
            (6Z)-nerolidol + 0
            nerolidol glycoside 0
            nerolidyl diphosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    main group molecular entity 19845
                      s-block molecular entity 19678
                        hydrogen molecular entity 19667
                          hydrides 19146
                            organic hydride 18704
                              organic fundamental parent 18704
                                hydrocarbon 18428
                                  terpene 13842
                                    terpenoid 13536
                                      sesquiterpenoid 3266
                                        farnesane sesquiterpenoid 132
                                          nerolidol 21
                                            (6E)-nerolidol + 0
                                            (6Z)-nerolidol + 0
                                            nerolidol glycoside 0
                                            nerolidyl diphosphate 0
paths to the root