Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolylfluanid
go back to main search page
Accession:CHEBI:75182 term browser browse the term
Definition:A member of the class of sulfamides that is dichlofluanid in which the hydrogen at the para position of the phenyl group is replaced by a methyl group. A fungicide first marketed in 1971 and used in the cultivation of fruit and vegetables, as well as in wood preservatives, it is no longer approved for use in the European Union.
Synonyms:exact_synonym: N-{[dichloro(fluoro)methyl]sulfanyl}-N',N'-dimethyl-N-(4-methylphenyl)sulfuric diamide
 related_synonym: 1,1-Dichloro-N-((dimethylamino)sulfonyl)-1-fluoro-N-(4-methylphenyl)methanesulfenamide;   Dichloro-N-((dimethylamino)sulphonyl)fluoro-N-(p-tolyl)methanesulphenamide;   Euparen Multi;   Formula=C10H13Cl2FN2O2S2;   InChI=1S/C10H13Cl2FN2O2S2/c1-8-4-6-9(7-5-8)15(18-10(11,12)13)19(16,17)14(2)3/h4-7H,1-3H3;   InChIKey=HYVWIQDYBVKITD-UHFFFAOYSA-N;   SMILES=CN(C)S(=O)(=O)N(SC(F)(Cl)Cl)c1ccc(C)cc1;   Tolylfluanide
 xref: CAS:731-27-1;   KEGG:C18899
 xref_mesh: MESH:C070021
 xref: PMID:15941588;   PMID:17390776;   PMID:1854993;   PMID:19927138;   PMID:20803363;   PMID:20824571;   PMID:20930027;   PMID:21112833;   PMID:21154844;   PMID:21229388;   PMID:21637552;   PMID:22022782;   PMID:22213400;   PMID:22387882;   PMID:22562348;   PMID:22743627;   PMID:22853990;   PMID:23058941;   PMID:23340252;   PMID:23846394;   PPDB:645;   Patent:EP1527683;   Patent:US2011195946;   Pesticides:tolylfluanid;   Reaxys:2949607


show annotations for term's descendants           Sort by:
 
tolylfluanid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Ins2 insulin 2 multiple interactions ISO N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding
multiple interactions
ISO N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide binds to NR3C1 protein
N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]
CTD PMID:15755314 PMID:26647222 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA] CTD PMID:26647222 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:26647222 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        aetiopathogenetic role 19035
          genotoxin 17473
            tolylfluanid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              oxoacid 18488
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11099
                                    sulfuric acid 8011
                                      sulfuric acid derivative 8011
                                        sulfuric amide 22
                                          sulfamides 22
                                            sulfamide 8
                                              tolylfluanid 8
paths to the root