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Accession:CHEBI:75179 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.
Synonyms:exact_synonym: 2'-deoxy-5-(trifluoromethyl)uridine
 related_synonym: 5-(Trifluoromethyl)deoxyuridine;   5-Trifluoromethyl-2-deoxyuridine;   Formula=C10H11F3N2O5;   InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1;   InChIKey=VSQQQLOSPVPRAZ-RRKCRQDMSA-N;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(c(=O)[nH]c1=O)C(F)(F)F;   Trifluoromethyldeoxyuridine;   Trifluorothymidine;   Viroptic;   trifluorothymine deoxyriboside;   trifluridina;   trifluridinum
 alt_id: CHEBI:9713
 xref: CAS:70-00-8 "ChemIDplus";   CAS:70-00-8 "KEGG DRUG";   DrugBank:DB00432;   Drug_Central:2743 "DrugCentral";   HMDB:HMDB0014576;   KEGG:D00391;   LINCS:LSM-5217
 xref_mesh: MESH:D014271
 xref: PMID:19816940 "Europe PMC";   PMID:19886911 "Europe PMC";   PMID:20861476 "Europe PMC";   PMID:21278209 "Europe PMC";   PMID:21491084 "Europe PMC";   PMID:22076553 "Europe PMC";   PMID:22607463 "Europe PMC";   PMID:22662200 "Europe PMC";   PMID:22735906 "Europe PMC";   PMID:22977515 "Europe PMC";   PMID:23343513 "Europe PMC";   PMID:23386782 "Europe PMC";   PMID:23521072 "Europe PMC";   PMID:23919755 "Europe PMC";   Reaxys:568095 "Reaxys";   Wikipedia:Trifluridine

show annotations for term's descendants       view all columns           Sort by:
trifluridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          antimetabolite 8472
            trifluridine 6
              Lonsurf 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            heteroorganic entity 18998
                              organochalcogen compound 18715
                                organooxygen compound 18625
                                  carbohydrates and carbohydrate derivatives 11731
                                    carbohydrate 11731
                                      carbohydrate derivative 11345
                                        glycosyl compound 10297
                                          N-glycosyl compound 4207
                                            nucleoside 4030
                                              deoxyribonucleoside 982
                                                2'-deoxyribonucleoside 310
                                                  pyrimidine 2'-deoxyribonucleoside 295
                                                    trifluridine 6
                                                      Lonsurf 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.