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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:formestane
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Accession:CHEBI:75172 term browser browse the term
Definition:A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
Synonyms:exact_synonym: 4-hydroxyandrost-4-ene-3,17-dione
 related_synonym: 4-OH-A;   4-OHAD;   4-hydroxy-4-androstene-3,17-dione;   4-hydroxy-Delta(4)-androstenedione;   4-hydroxyandrostenedione;   CGP 32349;   Formula=C19H26O3;   InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1;   InChIKey=OSVMTWJCGUFAOD-KZQROQTASA-N;   Lentaron;   SMILES=[H][C@@]12CCC3=C(O)C(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H];   formestano;   formestanum
 xref: CAS:566-48-3;   DrugBank:DB08905;   Drug_Central:1238;   KEGG:D07260
 xref_mesh: MESH:C014594
 xref: PMID:1419285;   PMID:1637664;   PMID:17207827;   PMID:22354842;   PMID:23339113;   PMID:6665821;   Reaxys:4198373;   Wikipedia:Formestane


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formestane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor increases expression
multiple interactions		 EXP formestane analog results in increased expression of AR mRNA; formestane metabolite results in increased expression of AR mRNA; formestane results in increased expression of AR mRNA
formestane metabolite inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]		 CTD PMID:29702199 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA] CTD PMID:21273442 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions
decreases activity		 EXP
ISO		 formestane inhibits the reaction [Atrazine results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [propazine results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [Simazine results in increased activity of CYP19A1 protein]
formestane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein]; formestane promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP19A1 mRNA]
formestane results in decreased activity of CYP19A1 protein		 CTD PMID:10746939 PMID:10806373 PMID:15242824 PMID:15319488 PMID:16177243 More... NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G ESR1 estrogen receptor 1 increases expression EXP formestane metabolite results in increased expression of ESR1 mRNA CTD PMID:29702199 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO formestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein] CTD PMID:22120136 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 decreases activity EXP formestane results in decreased activity of HSD17B1 protein CTD PMID:15876411 NCBI chr17:42,552,923...42,555,214
Ensembl chr17:42,552,922...42,555,214 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            antineoplastic agent 20859
              formestane 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbonyl compound 23563
                                    ketone 19347
                                      oxo steroid 11043
                                        3-oxo steroid 10440
                                          3-oxo-Delta(4) steroid 9651
                                            formestane 6
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