Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monomethyl succinate
go back to main search page
Accession:CHEBI:75146 term browser browse the term
Definition:A dicarboxylic acid monoester that is succinic acid in which one of the carboxy groups has been converted to its methyl ester.
Synonyms:exact_synonym: 4-methoxy-4-oxobutanoic acid
 related_synonym: 3-carbomethoxypropanoic acid;   Formula=C5H8O4;   InChI=1S/C5H8O4/c1-9-5(8)3-2-4(6)7/h2-3H2,1H3,(H,6,7);   InChIKey=JDRMYOQETPMYQX-UHFFFAOYSA-N;   SMILES=COC(=O)CCC(O)=O;   butanedioic acid 1-methyl ester;   butanedioic acid monomethyl ester;   methyl hydrogen succinate;   succinic acid 4-methyl ester;   succinic acid monomethyl ester
 xref: CAS:3878-55-5
 xref_mesh: MESH:C041105
 xref: PMID:12145163;   PMID:12369722;   PMID:1322278;   PMID:3047128;   PMID:6712257;   PMID:7710767;   PMID:7712680;   PMID:7733255;   PMID:7857680;   PMID:7979832;   PMID:8293819;   PMID:9697158;   Patent:CN101823961;   Reaxys:1722669

show annotations for term's descendants           Sort by:
monomethyl succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein] CTD PMID:21548882 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            anti-ulcer drug 777
              succinic acid 220
                succinate ester 111
                  hemisuccinate 107
                    monomethyl succinate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      dicarboxylic acids and O-substituted derivatives 10300
                                        dicarboxylic acid 10292
                                          alpha,omega-dicarboxylic acid 2784
                                            succinic acid 220
                                              succinate ester 111
                                                hemisuccinate 107
                                                  monomethyl succinate 2
paths to the root