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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monomethyl succinate
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Accession:CHEBI:75146 term browser browse the term
Definition:A dicarboxylic acid monoester that is succinic acid in which one of the carboxy groups has been converted to its methyl ester.
Synonyms:exact_synonym: 4-methoxy-4-oxobutanoic acid
 related_synonym: 3-carbomethoxypropanoic acid;   Formula=C5H8O4;   InChI=1S/C5H8O4/c1-9-5(8)3-2-4(6)7/h2-3H2,1H3,(H,6,7);   InChIKey=JDRMYOQETPMYQX-UHFFFAOYSA-N;   SMILES=COC(=O)CCC(O)=O;   butanedioic acid 1-methyl ester;   butanedioic acid monomethyl ester;   methyl hydrogen succinate;   succinic acid 4-methyl ester;   succinic acid monomethyl ester
 xref: CAS:3878-55-5
 xref_mesh: MESH:C041105
 xref: PMID:12145163;   PMID:12369722;   PMID:1322278;   PMID:3047128;   PMID:6712257;   PMID:7710767;   PMID:7712680;   PMID:7733255;   PMID:7857680;   PMID:7979832;   PMID:8293819;   PMID:9697158;   Patent:CN101823961;   Reaxys:1722669

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monomethyl succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G Tp53 tumor protein p53 multiple interactions ISO monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein] CTD PMID:21548882 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      application 19477
        pharmaceutical 19350
          drug 19350
            anti-ulcer drug 778
              succinic acid 220
                succinate ester 111
                  hemisuccinate 107
                    monomethyl succinate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic group 18550
                              organic divalent group 18541
                                organodiyl group 18541
                                  carbonyl group 18447
                                    carbonyl compound 18447
                                      dicarboxylic acids and O-substituted derivatives 10292
                                        dicarboxylic acid 10283
                                          alpha,omega-dicarboxylic acid 2781
                                            succinic acid 220
                                              succinate ester 111
                                                hemisuccinate 107
                                                  monomethyl succinate 2
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