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ONTOLOGY REPORT - ANNOTATIONS


Term:neostigmine
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Accession:CHEBI:7514 term browser browse the term
Definition:A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium
 related_synonym: (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate;   3-Trimethylammoniumphenyl N,N-dimethylcarbamate;   Eustigmin;   Eustigmine;   Formula=C12H19N2O2;   InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1;   InChIKey=ALWKGYPQUAPLQC-UHFFFAOYSA-N;   Prostigmine;   SMILES=CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C;   Vagostigmine;   m-Trimethylammoniumphenyldimethylcarbamate
 xref: Beilstein:3615946;   CAS:59-99-4;   DrugBank:DB01400;   Drug_Central:1897;   HMDB:HMDB0015472;   KEGG:C07258;   KEGG:D08261;   LINCS:LSM-5360
 xref_mesh: MESH:D009388
 xref: PMID:7200780;   PMID:8584207;   Reaxys:3615946;   Wikipedia:Neostigmine


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neostigmine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Pygl glycogen phosphorylase L JBrowse link 6 92,597,759 92,643,734 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19778
    chemical entity 19777
      molecular entity 19775
        ion 15878
          organic ion 8310
            organic cation 7122
              quaternary ammonium ion 5063
                neostigmine 5
                  neostigmine bromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19778
    subatomic particle 19776
      composite particle 19776
        hadron 19776
          baryon 19776
            nucleon 19776
              atomic nucleus 19776
                atom 19776
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19405
                        hydrogen molecular entity 19395
                          hydrides 18370
                            inorganic hydride 17216
                              pnictogen hydride 17179
                                nitrogen hydride 17015
                                  ammonium 8222
                                    ammonium ion derivative 8217
                                      quaternary ammonium ion 5063
                                        neostigmine 5
                                          neostigmine bromide 0
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