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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:7514 term browser browse the term
Definition:A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium
 related_synonym: (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate;   3-Trimethylammoniumphenyl N,N-dimethylcarbamate;   Eustigmin;   Eustigmine;   Formula=C12H19N2O2;   InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1;   InChIKey=ALWKGYPQUAPLQC-UHFFFAOYSA-N;   Prostigmine;   SMILES=CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C;   Vagostigmine;   m-Trimethylammoniumphenyldimethylcarbamate
 xref: Beilstein:3615946;   CAS:59-99-4;   DrugBank:DB01400;   Drug_Central:1897;   HMDB:HMDB0015472;   KEGG:C07258;   KEGG:D08261;   LINCS:LSM-5360
 xref_mesh: MESH:D009388
 xref: PMID:7200780;   PMID:8584207;   Reaxys:3615946;   Wikipedia:Neostigmine

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neostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Neostigmine results in decreased activity of ACHE protein CTD PMID:623676 PMID:19105816 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase affects response to substance ISO BCHE affects the susceptibility to Neostigmine CTD PMID:18399847 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Il10 interleukin 10 increases expression EXP Neostigmine results in increased expression of IL10 protein CTD PMID:17872965 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Pygl glycogen phosphorylase L increases activity
multiple interactions
EXP Neostigmine results in increased activity of PYGL protein modified form
Phentolamine inhibits the reaction [Neostigmine results in increased activity of PYGL protein modified form]
CTD PMID:1350317 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Neostigmine results in decreased expression of TNF protein CTD PMID:17872965 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        ion 15935
          organic ion 8447
            organic cation 7303
              quaternary ammonium ion 5090
                neostigmine 5
                  neostigmine bromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  ammonium 8210
                                    ammonium ion derivative 8206
                                      quaternary ammonium ion 5090
                                        neostigmine 5
                                          neostigmine bromide 0
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