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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chromogenic compound
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Accession:CHEBI:75050 term browser browse the term
Definition:Colourless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into coloured compounds. They are used in biochemical assays and in diagnosis as indicators, particularly in the form of enzyme substrates.
Synonyms:related_synonym: chromogen;   chromogenic compounds;   chromogens



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2-hydroxy-5-nitrophenyl hydrogen sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sts steroid sulfatase decreases activity ISO 4-nitrocatechol sulfate results in decreased activity of STS protein CTD PMID:6874424 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO [UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide CTD PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Car9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa alpha glucosidase multiple interactions
increases metabolic processing
ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
JBrowse link
4-nitrophenyl beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO 4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] CTD PMID:11856762 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
4-nitrophenyl beta-D-xyloside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP 4-nitrophenyl beta-D-xyloside inhibits the reaction [FSHB protein results in increased activity of PDE4A protein] CTD PMID:17261351 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Pde4a phosphodiesterase 4A multiple interactions EXP 4-nitrophenyl beta-D-xyloside inhibits the reaction [FSHB protein results in increased activity of PDE4A protein] CTD PMID:17261351 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
diacetylmonoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO diacetylmonoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein] CTD PMID:22960624 PMID:22975155 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
affects localization
EXP
ISO
diacetylmonoxime results in decreased expression of ACTA2
diacetylmonoxime affects the localization of ACTA2 protein
CTD PMID:11591817 PMID:11868461 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein] CTD PMID:1276991 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Casp3 caspase 3 multiple interactions ISO diacetylmonoxime inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] CTD PMID:12530016 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO diacetylmonoxime results in decreased expression of CDKN1A protein CTD PMID:15252113 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO diacetylmonoxime results in increased expression of CDKN1B protein CTD PMID:15252113 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO diacetylmonoxime results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myog myogenin decreases expression ISO diacetylmonoxime results in decreased expression of MYOG protein CTD PMID:15252113 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Tf transferrin decreases uptake ISO diacetylmonoxime results in decreased uptake of TF protein CTD PMID:16563724 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
glycyl-L-phenylalanine 2-naphthylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nox1 NADPH oxidase 1 multiple interactions ISO 1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]; NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
keto-phenylpyruvic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO phenylpyruvic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] CTD PMID:22981274 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        indicator 8706
          visual indicator 4338
            colour indicator 4338
              one-colour indicator 25
                chromogenic compound 25
                  1-naphthyl N-acetyl-beta-D-glucosaminide 0
                  2-hydroxy-5-nitrophenyl hydrogen sulfate 1
                  2-naphthol AS BI-beta-D-glucuronide 0
                  2-naphthyl alpha-D-glucoside 0
                  2-naphthyl alpha-L-fucoside 0
                  2-naphthyl beta-D-galactoside 0
                  2-naphthyl beta-D-glucoside 0
                  2-naphthyl beta-L-fucoside 0
                  2-naphthyl butyrate 0
                  2-naphthyl dihydrogen phosphate 0
                  2-naphthyl octanoate 0
                  2-naphthyl tetradecanoate 0
                  2-nitrophenyl N-acetyl-alpha-D-glucosaminide 0
                  2-nitrophenyl N-acetyl-beta-D-glucosaminide 0
                  2-nitrophenyl beta-D-galactoside 0
                  2-nitrophenyl beta-D-glucoside 6-phosphate 0
                  3-(p-nitrophenyl)propanoic acid 0
                  4-(dimethylamino)benzaldehyde 0
                  4-methylumbelliferone beta-D-glucuronide 6
                  4-methylumbelliferyl alpha-D-galactoside 0
                  4-methylumbelliferyl alpha-L-arabinoside 0
                  4-methylumbelliferyl beta-D-galactoside 2
                  4-methylumbelliferyl beta-D-glucoside 1
                  4-methylumbelliferyl butyate 0
                  4-nitrophenyl 6-O-phosphono-beta-D-galactoside 0
                  4-nitrophenyl N-acetyl-alpha-D-glucosaminide 0
                  4-nitrophenyl N-acetyl-beta-D-glucosaminide 0
                  4-nitrophenyl alpha-D-glucoside 0
                  4-nitrophenyl alpha-D-xyloside 0
                  4-nitrophenyl alpha-L-arabinoside 0
                  4-nitrophenyl alpha-L-fucoside 0
                  4-nitrophenyl beta-D-glucoside 0
                  4-nitrophenyl beta-D-glucuronide 1
                  4-nitrophenyl beta-D-xyloside 2
                  4-nitrophenyl beta-L-fucoside 0
                  4-nitrophenyl beta-lactoside 0
                  5-bromo-3-hydroxyindole 0
                  5-bromo-3-indolyl decanoate 0
                  5-bromo-4-chloro-3-hydroxyindole 0
                  5-bromo-4-chloro-3-indolyl N-acetyl-beta-D-glucosaminide 0
                  5-bromo-4-chloro-3-indolyl acetate 0
                  5-bromo-4-chloro-3-indolyl alpha-D-mannoside 0
                  5-bromo-4-chloro-3-indolyl beta-D-galactoside 0
                  5-bromo-4-chloro-3-indolyl beta-D-glucoside 0
                  5-bromo-4-chloro-3-indolyl beta-D-glucuronide 0
                  5-bromo-4-chloro-3-indolyl phosphate 0
                  5-bromo-4-chloro-3-indolyl thymidine 3'-phosphate 0
                  5-oxo-L-proline 2-naphthylamide 0
                  6-bromo-2-naphthyl alpha-D-galactoside 0
                  6-bromo-2-naphthyl beta-D-galactoside 0
                  6-bromo-2-naphthyl beta-D-glucoside 0
                  6-bromo-2-naphthyl beta-D-mannoside 0
                  DL-methionine 2-naphthylamide 0
                  L-alanine 2-naphthylamide 0
                  L-alanyl-L-alanine 2-naphthylamide 0
                  L-alanyl-L-phenylalanyl-L-proline 2-naphthylamide 0
                  L-arginine 2-naphthylamide 0
                  L-asparagine 2-naphthylamide 0
                  L-cysteine 2-naphthylamide 0
                  L-cystine di-2-naphthylamide 0
                  L-glutamine 2-naphthylamide 0
                  L-glutamyl-L-glutamic acid 2-naphthylamide 0
                  L-glutamylglycine 2-naphthylamide 0
                  L-glutamylglycyl-L-arginine 2-naphthylamide 0
                  L-histidine 2-naphthylamide 0
                  L-hydroxyproline 2-naphthylamide 0
                  L-isoleucine 2-naphthylamide 0
                  L-leucine 2-naphthylamide 0
                  L-leucine 4-methoxy-2-naphthylamide 0
                  L-leucylglycine 2-naphthylamide 0
                  L-lysine 2-naphthylamide 0
                  L-ornithine 2-naphthylamide 0
                  L-phenylalanine 2-naphthylamide 0
                  L-proline 2-naphthylamide 0
                  L-serine 2-naphthylamide 0
                  L-seryl-L-tyrosine 2-naphthylamide 0
                  L-threonine 2-naphthylamide 0
                  L-tryptophan 2-naphthylamide 0
                  L-tyrosine 2-naphthylamide 0
                  L-valine 2-naphthylamide 0
                  N-(alpha-L-aspartyl)-2-naphthylamine 0
                  N-(alpha-L-glutamyl)-2-naphthylamine 0
                  N-(gamma-L-glutamyl)-2-naphthylamine 0
                  N-benzoyl-D-arginine 2-naphthylamide + 0
                  N-benzoyl-D-phenylalanine 2-naphthylamide + 0
                  N-benzoyl-DL-arginine 2-naphthylamide 0
                  N-benzoyl-DL-phenylalanine 2-naphthylamide 0
                  N-benzoyl-L-arginine 2-naphthylamide + 0
                  N-benzoyl-L-leucine 2-naphthylamide 0
                  N-benzoyl-L-phenylalanine 2-naphthylamide + 0
                  N-benzoyl-L-valylglycine 4-methoxy-2-naphthylamide 0
                  N-carbobenzyloxy-glycylglycyl-L-arginine 2-naphthylamide 0
                  N-glutaryl-L-phenylalanine 2-naphthylamide 0
                  beta-alanine 2-naphthylamide 0
                  bis(p-nitrophenyl)phosphocholine 0
                  diacetylmonoxime 9
                  ethyl N-benzoyl-L-tyrosinate 0
                  glycine 2-naphthylamide 0
                  glycyl-L-phenylalanine 2-naphthylamide 1
                  glycyl-L-proline 2-naphthylamide 0
                  glycyl-L-tryptophan 2-naphthylamide 0
                  glycylglycine 2-naphthylamide 0
                  keto-phenylpyruvate 0
                  keto-phenylpyruvic acid + 2
                  p-nitrophenyl phenyl phosphonate 0
                  phenyl hydrogen phosphonate 0
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