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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dabrafenib
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Accession:CHEBI:75045 term browser browse the term
Definition:An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Synonyms:exact_synonym: N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
 related_synonym: Formula=C23H20F3N5O2S2;   InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29);   InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N;   SMILES=CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1
 xref: CAS:1195765-45-7;   Drug_Central:4801;   KEGG:D10064;   LINCS:LSM-6303
 xref_mesh: MESH:C561627
 xref: PMID:22981500;   PMID:23237741;   PMID:23249624;   PMID:23276366;   PMID:23290787;   PMID:23317446;   PMID:23403819;   PMID:23463215;   PMID:23470635;   PMID:23515890;   PMID:23537694;   PMID:23552670;   PMID:23608920;   PMID:23617957;   PMID:23621583;   PMID:23656699;   PMID:23709751;   PMID:23714462;   PMID:23795808;   PMID:23807941;   PMID:23833299;   PMID:23844038;   PMID:23846776;   PMID:23870055;   PMID:23881668;   Patent:WO2011047238;   Reaxys:19689971;   Wikipedia:Dabrafenib


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dabrafenib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions
affects response to substance
decreases activity
increases response to substance
ISO [BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 protein; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]; CCND1 protein inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; fatostatin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; MAPK1 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]
dabrafenib results in decreased activity of BRAF protein; dabrafenib results in decreased activity of BRAF protein mutant form
CTD PMID:20823850 PMID:23237741 PMID:26978007 PMID:29950559 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO CCND1 protein inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib] CTD PMID:26978007 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of GPT protein] CTD PMID:27458080 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of ICAM1 mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of ICAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein] CTD PMID:27458080 PMID:29042256 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased secretion of IL6 protein] CTD PMID:27458080 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]] CTD PMID:29042256 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb5 integrin subunit beta 5 multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]] CTD PMID:29042256 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance
multiple interactions
ISO KRAS protein affects the susceptibility to dabrafenib
[KRAS protein affects the susceptibility to dabrafenib] which affects the expression of TNFRSF10B protein; [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK1 protein; [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein
CTD PMID:27222248 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK1 protein; dabrafenib inhibits the reaction [GSK690693 results in increased phosphorylation of MAPK1 protein]; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK1 protein]; MAPK1 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK1 protein] CTD PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein; dabrafenib inhibits the reaction [GSK690693 results in increased phosphorylation of MAPK3 protein]; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK3 protein]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK3 protein] CTD PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased activity of RELA protein] CTD PMID:27458080 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sele selectin E multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein] CTD PMID:27458080 PMID:29042256 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions
ISO dabrafenib results in decreased cleavage of SREBF1 protein
[BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 protein
CTD PMID:29950559 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with dabrafenib] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:104,611,026...104,640,033
Ensembl chr 6:104,611,026...104,615,302
JBrowse link
G Tgfbi transforming growth factor, beta induced multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]; dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein] CTD PMID:29042256 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of TNF protein] CTD PMID:27458080 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of VCAM1 mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of VCAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein] CTD PMID:27458080 PMID:29042256 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        antimicrobial agent 17373
          antiviral agent 10273
            anticoronaviral agent 8973
              dabrafenib 17
                dabrafenib mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      s-block molecular entity 19423
                        hydrogen molecular entity 19416
                          hydrides 18755
                            inorganic hydride 17460
                              pnictogen hydride 17435
                                nitrogen hydride 17281
                                  azane 17017
                                    ammonia 17016
                                      organic amino compound 17015
                                        aromatic amine 13682
                                          aminopyrimidine 1296
                                            dabrafenib 17
                                              dabrafenib mesylate 0
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