Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dabrafenib
go back to main search page
Accession:CHEBI:75045 term browser browse the term
Definition:An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Synonyms:exact_synonym: N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
 related_synonym: Formula=C23H20F3N5O2S2;   InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29);   InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N;   SMILES=CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1
 xref: CAS:1195765-45-7;   Drug_Central:4801;   KEGG:D10064;   LINCS:LSM-6303
 xref_mesh: MESH:C561627
 xref: PMID:22981500;   PMID:23237741;   PMID:23249624;   PMID:23276366;   PMID:23290787;   PMID:23317446;   PMID:23403819;   PMID:23463215;   PMID:23470635;   PMID:23515890;   PMID:23537694;   PMID:23552670;   PMID:23608920;   PMID:23617957;   PMID:23621583;   PMID:23656699;   PMID:23709751;   PMID:23714462;   PMID:23795808;   PMID:23807941;   PMID:23833299;   PMID:23844038;   PMID:23846776;   PMID:23870055;   PMID:23881668;   Patent:WO2011047238;   Reaxys:19689971;   Wikipedia:Dabrafenib



show annotations for term's descendants           Sort by:
 
dabrafenib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions
affects response to substance
decreases activity
increases response to substance
ISO [BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 protein; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]; CCND1 protein inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; fatostatin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; MAPK1 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]
dabrafenib results in decreased activity of BRAF protein; dabrafenib results in decreased activity of BRAF protein mutant form
CTD PMID:20823850 PMID:23237741 PMID:26978007 PMID:29950559 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO CCND1 protein inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib] CTD PMID:26978007 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of GPT protein] CTD PMID:27458080 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of ICAM1 mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of ICAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein] CTD PMID:27458080 PMID:29042256 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased secretion of IL6 protein] CTD PMID:27458080 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]] CTD PMID:29042256 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb5 integrin subunit beta 5 multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [ITGAV protein binds to ITGB5 protein]] CTD PMID:29042256 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance
multiple interactions
ISO KRAS protein affects the susceptibility to dabrafenib
[KRAS protein affects the susceptibility to dabrafenib] which affects the expression of TNFRSF10B protein; [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK1 protein; [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein
CTD PMID:27222248 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK1 protein; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK1 protein]; MAPK1 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK1 protein] CTD PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK3 protein]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK3 protein] CTD PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased activity of RELA protein] CTD PMID:27458080 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sele selectin E multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein] CTD PMID:27458080 PMID:29042256 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions
ISO dabrafenib results in decreased cleavage of SREBF1 protein
[BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 protein
CTD PMID:29950559 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with dabrafenib] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Tgfbi transforming growth factor, beta induced multiple interactions ISO dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]; dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein] CTD PMID:29042256 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of TNF protein] CTD PMID:27458080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO dabrafenib inhibits the reaction [Polyphosphates results in increased expression of VCAM1 mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of VCAM1 protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein] CTD PMID:27458080 PMID:29042256 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          antiviral agent 10459
            anticoronaviral agent 9054
              dabrafenib 17
                dabrafenib mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        aromatic amine 13710
                                          aminopyrimidine 1599
                                            dabrafenib 17
                                              dabrafenib mesylate 0
paths to the root