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ONTOLOGY REPORT - ANNOTATIONS


Term:GCB
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Accession:CHEBI:74858 term browser browse the term
Definition:An organic disulfide that is L-685,458 in which the C-terminal amide group is coupled to a biotin moiety via a long linker containing the disulfide group.
Synonyms:exact_synonym: N-{(2R,4R,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-N-{15,25,41,49-tetraoxo-53-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,17,20,23,30,33,36-nonaoxa-44,45-dithia-14,26,40,48-tetraazatripentacont-1-yl}-L-phenylalaninamide
 related_synonym: Formula=C82H130N10O20S3;   InChI=1S/C82H130N10O20S3/c1-61(2)53-67(88-77(98)65(54-62-21-9-6-10-22-62)57-70(93)66(55-63-23-11-7-12-24-63)91-81(102)112-82(3,4)5)79(100)89-68(56-64-25-13-8-14-26-64)78(99)87-33-20-38-106-42-46-108-45-41-105-37-19-32-85-75(97)59-111-50-48-109-47-49-110-58-74(96)84-31-18-36-104-40-44-107-43-39-103-35-17-30-83-73(95)29-51-114-115-52-34-86-72(94)28-16-15-27-71-76-69(60-113-71)90-80(101)92-76/h6-14,21-26,61,65-71,76,93H,15-20,27-60H2,1-5H3,(H,83,95)(H,84,96)(H,85,97)(H,86,94)(H,87,99)(H,88,98)(H,89,100)(H,91,102)(H2,90,92,101)/t65-,66+,67+,68+,69+,70-,71+,76+/m1/s1;   InChIKey=IMMOTHDSNAXMDK-NLYMJQDSSA-N;   SMILES=[H][C@]12CS[C@@H](CCCCC(=O)NCCSSCCC(=O)NCCCOCCOCCOCCCNC(=O)COCCOCCOCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)Cc3ccccc3)[C@@]1([H])NC(=O)N2
 xref: PMID:19754663 "Europe PMC";   PMID:22771797 "SUBMITTER"


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Path 1
Term Annotations click to browse term
  CHEBI ontology 20761
    role 20739
      biological role 20738
        biochemical role 19827
          cofactor 15967
            biotin 14
              GCB 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20761
    subatomic particle 20754
      composite particle 20754
        hadron 20754
          baryon 20754
            nucleon 20754
              atomic nucleus 20754
                atom 20754
                  main group element atom 20674
                    p-block element atom 20674
                      carbon group element atom 20410
                        carbon atom 20386
                          organic molecular entity 20386
                            organic group 19051
                              organic divalent group 19040
                                organodiyl group 19040
                                  carbonyl group 19012
                                    carbonyl compound 19012
                                      carboxylic acid 18684
                                        carboacyl group 17286
                                          univalent carboacyl group 17286
                                            carbamoyl group 16937
                                              carboxamide 16937
                                                monocarboxylic acid amide 13433
                                                  urea 5097
                                                    ureas 5096
                                                      biotins 14
                                                        biotin 14
                                                          GCB 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.