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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:74838 term browser browse the term
Definition:An organic heterotricyclic compound resulting from the formal condensation of the oxo group of cytidine to the 2' position with loss of water to give the corresponding cyclic ether. A prodrug, it is metabolised to the antineoplastic agent cytarabine, so is used to maintain a more constant antineoplastic action.
Synonyms:exact_synonym: (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
 related_synonym: 2,2'-O-cyclocytidine;   2,2'-anhydro-1-(beta-D-arabinofuranosyl)cytosine;   2,2'-anhydro-AraC;   2,2'-anhydroarabinosylcytosine;   2,2'-anhydrocytidine;   2,2'-cyclocytidine;   Formula=C9H11N3O4;   InChI=1S/C9H11N3O4/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8/h1-2,4,6-8,10,13-14H,3H2/t4-,6-,7+,8-/m1/s1;   InChIKey=BBDAGFIXKZCXAH-CCXZUQQUSA-N;   SMILES=OC[C@H]1O[C@@H]2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O;   [2R-(2alpha,3beta,3abeta,9abeta)]-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-6H-furo[2',3':4,5]pxazolo[3,2-a]pyrimidine-2-methanol;   ancitabina;   ancitabinum;   anhydrocytidine;   cyclocytidine
 xref: CAS:31698-14-3;   Drug_Central:212
 xref_mesh: MESH:D003504
 xref: PMID:6204036;   PMID:6206222;   PMID:77191;   Patent:US3463850;   Reaxys:669322
 cyclic_relationship: is_conjugate_base_of CHEBI:74842

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ancitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance ISO TIMP3 protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        biochemical role 19514
          antimetabolite 10288
            ancitabine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    p-block element atom 19780
                      carbon group element atom 19728
                        carbon atom 19725
                          organic molecular entity 19725
                            organic molecule 19678
                              organic cyclic compound 19491
                                organic heterocyclic compound 18855
                                  organic heteropolycyclic compound 18262
                                    organic heterotricyclic compound 15618
                                      ancitabine 2
paths to the root