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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ancitabine
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Accession:CHEBI:74838 term browser browse the term
Definition:An organic heterotricyclic compound resulting from the formal condensation of the oxo group of cytidine to the 2' position with loss of water to give the corresponding cyclic ether. A prodrug, it is metabolised to the antineoplastic agent cytarabine, so is used to maintain a more constant antineoplastic action.
Synonyms:exact_synonym: (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
 related_synonym: 2,2'-O-cyclocytidine;   2,2'-anhydro-1-(beta-D-arabinofuranosyl)cytosine;   2,2'-anhydro-AraC;   2,2'-anhydroarabinosylcytosine;   2,2'-anhydrocytidine;   2,2'-cyclocytidine;   Formula=C9H11N3O4;   InChI=1S/C9H11N3O4/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8/h1-2,4,6-8,10,13-14H,3H2/t4-,6-,7+,8-/m1/s1;   InChIKey=BBDAGFIXKZCXAH-CCXZUQQUSA-N;   SMILES=OC[C@H]1O[C@@H]2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O;   [2R-(2alpha,3beta,3abeta,9abeta)]-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-6H-furo[2',3':4,5]pxazolo[3,2-a]pyrimidine-2-methanol;   ancitabina;   ancitabinum;   anhydrocytidine;   cyclocytidine
 xref: CAS:31698-14-3;   Drug_Central:212
 xref_mesh: MESH:D003504
 xref: PMID:6204036;   PMID:6206222;   PMID:77191;   Patent:US3463850;   Reaxys:669322
 cyclic_relationship: is_conjugate_base_of CHEBI:74842


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ancitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance ISO TIMP3 protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          antimetabolite 8575
            ancitabine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  organic heteropolycyclic compound 18297
                                    organic heterotricyclic compound 15634
                                      ancitabine 2
paths to the root