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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:74838 term browser browse the term
Definition:An organic heterotricyclic compound resulting from the formal condensation of the oxo group of cytidine to the 2' position with loss of water to give the corresponding cyclic ether. A prodrug, it is metabolised to the antineoplastic agent cytarabine, so is used to maintain a more constant antineoplastic action.
Synonyms:exact_synonym: (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
 related_synonym: 2,2'-O-cyclocytidine;   2,2'-anhydro-1-(beta-D-arabinofuranosyl)cytosine;   2,2'-anhydro-AraC;   2,2'-anhydroarabinosylcytosine;   2,2'-anhydrocytidine;   2,2'-cyclocytidine;   Formula=C9H11N3O4;   InChI=1S/C9H11N3O4/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8/h1-2,4,6-8,10,13-14H,3H2/t4-,6-,7+,8-/m1/s1;   InChIKey=BBDAGFIXKZCXAH-CCXZUQQUSA-N;   SMILES=OC[C@H]1O[C@@H]2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O;   [2R-(2alpha,3beta,3abeta,9abeta)]-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-6H-furo[2',3':4,5]pxazolo[3,2-a]pyrimidine-2-methanol;   ancitabina;   ancitabinum;   anhydrocytidine;   cyclocytidine
 xref: CAS:31698-14-3;   Drug_Central:212
 xref_mesh: MESH:D003504
 xref: PMID:6204036;   PMID:6206222;   PMID:77191;   Patent:US3463850;   Reaxys:669322
 cyclic_relationship: is_conjugate_base_of CHEBI:74842

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ancitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance ISO TIMP3 protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          antimetabolite 8506
            ancitabine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      ancitabine 2
paths to the root