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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ancitabine
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Accession:CHEBI:74838 term browser browse the term
Definition:An organic heterotricyclic compound resulting from the formal condensation of the oxo group of cytidine to the 2' position with loss of water to give the corresponding cyclic ether. A prodrug, it is metabolised to the antineoplastic agent cytarabine, so is used to maintain a more constant antineoplastic action.
Synonyms:exact_synonym: (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
 related_synonym: 2,2'-O-cyclocytidine;   2,2'-anhydro-1-(beta-D-arabinofuranosyl)cytosine;   2,2'-anhydro-AraC;   2,2'-anhydroarabinosylcytosine;   2,2'-anhydrocytidine;   2,2'-cyclocytidine;   Formula=C9H11N3O4;   InChI=1S/C9H11N3O4/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8/h1-2,4,6-8,10,13-14H,3H2/t4-,6-,7+,8-/m1/s1;   InChIKey=BBDAGFIXKZCXAH-CCXZUQQUSA-N;   SMILES=OC[C@H]1O[C@@H]2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O;   [2R-(2alpha,3beta,3abeta,9abeta)]-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-6H-furo[2',3':4,5]pxazolo[3,2-a]pyrimidine-2-methanol;   ancitabina;   ancitabinum;   anhydrocytidine;   cyclocytidine
 xref: CAS:31698-14-3;   Drug_Central:212
 xref_mesh: MESH:D003504
 xref: PMID:6204036;   PMID:6206222;   PMID:77191;   Patent:US3463850;   Reaxys:669322
 cyclic_relationship: is_conjugate_base_of CHEBI:74842


show annotations for term's descendants           Sort by:
ancitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyss cystatin S increases expression EXP Ancitabine results in increased expression of CYSS protein CTD PMID:7686006 NCBI chr 3:157,892,660...157,897,265
Ensembl chr 3:137,432,049...137,436,610 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance ISO TIMP3 protein affects the susceptibility to Ancitabine CTD PMID:18202788 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          antimetabolite 10331
            ancitabine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic heterocyclic compound 18895
                                  organic heteropolycyclic compound 18318
                                    organic heterotricyclic compound 15880
                                      ancitabine 3
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