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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-aminoacridine
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Accession:CHEBI:74789 term browser browse the term
Definition:An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.
Synonyms:exact_synonym: acridin-9-amine
 related_synonym: 10-amino-5-azaanthracene;   5-aminoacridine;   9-acridinamine;   9AA;   Formula=C13H10N2;   InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15);   InChIKey=XJGFWWJLMVZSIG-UHFFFAOYSA-N;   SMILES=Nc1c2ccccc2nc2ccccc12;   aminacrin;   aminacrine;   aminoacridina;   aminoacridine;   aminoacridinum
 xref: CAS:90-45-9;   Drug_Central:160;   LINCS:LSM-15516
 xref_mesh: MESH:D000585
 xref: PMID:22477060;   PMID:23257326;   PMID:24341665;   Reaxys:141171;   Wikipedia:9-Aminoacridine
 cyclic_relationship: is_conjugate_base_of CHEBI:74835


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9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding ISO Aminacrine binds to ACHE protein CTD PMID:31176713 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions
ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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  CHEBI ontology 19841
    role 19792
      application 19465
        MALDI matrix material 935
          9-aminoacridine 8
Path 2
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteropolycyclic compound 17874
                                    organic heterotricyclic compound 14593
                                      dibenzopyridine 155
                                        acridines 122
                                          aminoacridines 17
                                            9-aminoacridine 8
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