Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-aminoacridine
go back to main search page
Accession:CHEBI:74789 term browser browse the term
Definition:An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.
Synonyms:exact_synonym: acridin-9-amine
 related_synonym: 10-amino-5-azaanthracene;   5-aminoacridine;   9-acridinamine;   9AA;   Formula=C13H10N2;   InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15);   InChIKey=XJGFWWJLMVZSIG-UHFFFAOYSA-N;   SMILES=Nc1c2ccccc2nc2ccccc12;   aminacrin;   aminacrine;   aminoacridina;   aminoacridine;   aminoacridinum
 xref: CAS:90-45-9;   Drug_Central:160;   LINCS:LSM-15516
 xref_mesh: MESH:D000585
 xref: PMID:22477060;   PMID:23257326;   PMID:24341665;   Reaxys:141171;   Wikipedia:9-Aminoacridine
 cyclic_relationship: is_conjugate_base_of CHEBI:74835



show annotations for term's descendants           Sort by:
 
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
decreases activity
ISO Aminacrine binds to ACHE protein
Aminacrine results in decreased activity of ACHE protein
CTD PMID:31176713 PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions
ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        MALDI matrix material 952
          9-aminoacridine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organic heteropolycyclic compound 18067
                                    organic heterotricyclic compound 14649
                                      dibenzopyridine 154
                                        acridines 121
                                          aminoacridines 17
                                            9-aminoacridine 8
paths to the root