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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-methylhistamine
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Accession:CHEBI:74759 term browser browse the term
Definition:An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position.
Synonyms:exact_synonym: 1-(1H-imidazol-5-yl)propan-2-amine
 related_synonym: Formula=C6H11N3;   InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9);   InChIKey=XNQIOISZPFVUFG-UHFFFAOYSA-N;   SMILES=CC(N)Cc1cnc[nH]1
 xref: CAS:6986-90-9
 xref_mesh: MESH:C069357
 xref: PMID:20045936;   PMID:9131398;   Reaxys:956816;   Wikipedia:Alpha-Methylhistamine


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alpha-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide decreases expression EXP alpha-methylhistamine results in decreased expression of GAL mRNA CTD PMID:11956952 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gast gastrin multiple interactions EXP alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine] CTD PMID:2470453 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Hdc histidine decarboxylase decreases expression EXP alpha-methylhistamine results in decreased expression of HDC mRNA CTD PMID:11956952 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions
affects binding		 EXP
ISO		 6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]; Endocannabinoids inhibits the reaction [alpha-methylhistamine binds to and results in increased activity of HRH3 protein]; Histamine H3 Antagonists inhibits the reaction [alpha-methylhistamine binds to HRH3 protein]		 CTD PMID:11956952 PMID:21634396 PMID:30102254 PMID:31369746 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Hrh4 histamine receptor H4 multiple interactions ISO [alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; alpha-methylhistamine binds to and results in increased activity of HRH4 protein; HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:11181941 PMID:12235264 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345 		JBrowse link
G Ifng interferon gamma affects expression ISO alpha-methylhistamine affects the expression of IFNG protein CTD PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il16 interleukin 16 increases expression
multiple interactions		 ISO alpha-methylhistamine results in increased expression of IL16 protein
HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein]		 CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL1B protein]] CTD PMID:31369746 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]] CTD PMID:31369746 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]] CTD PMID:31369746 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]] CTD PMID:31369746 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of RELA protein]] CTD PMID:31369746 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of TNF protein]] CTD PMID:31369746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        molecular messenger 18575
          neurotransmitter 11184
            histamine 95
              alpha-methylhistamine 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic molecule 19602
                              organic cyclic compound 19412
                                organic heterocyclic compound 18771
                                  heteroarene 16885
                                    monocyclic heteroarene 14243
                                      azole 13605
                                        diazole 8636
                                          imidazoles 7732
                                            histamine 95
                                              alpha-methylhistamine 13
paths to the root