CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: withanolide
Accession: CHEBI:74716
browse the term
Definition: Any steroid lactone that is a C28 steroid with a modified side chain forming a lactone ring and its substituted derivatives.
Synonyms: related_synonym: withanolides
xref: LIPID_MAPS_instance:LMST01160000; Wikipedia:Withanolide
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]
CTD
PMID:20438634
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA]
CTD
PMID:34995708
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Adam17
ADAM metallopeptidase domain 17
multiple interactions
ISO
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
CTD
PMID:24632454
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]
CTD
PMID:35734936
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alox15
arachidonate 15-lipoxygenase
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein]
CTD
PMID:35734936
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Atf4
activating transcription factor 4
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]
CTD
PMID:21266191
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Bad
BCL2-associated agonist of cell death
multiple interactions
ISO
withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein
CTD
PMID:20438634
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]
CTD
PMID:35734936
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
withaferin A results in decreased expression of BCL2 protein withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]
CTD
PMID:20438634 PMID:21256832 PMID:21964475 PMID:35734936
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2a1
BCL2-related protein A1
multiple interactions
ISO
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]
CTD
PMID:20438634
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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Bcl2l11
Bcl2-like 11
decreases expression multiple interactions
ISO EXP
withaferin A results in decreased expression of BCL2L11 protein withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]
CTD
PMID:20438634 PMID:35734936
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Casp3
caspase 3
multiple interactions
EXP ISO
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein] withaferin A inhibits the reaction [Elements, Radioactive results in increased activity of CASP3 protein]
CTD
PMID:35734936 PMID:36716864
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]
CTD
PMID:35734936
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions increases expression
EXP ISO
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein] withaferin A results in increased expression of CAT protein
CTD
PMID:35734936 PMID:36716864
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]
CTD
PMID:20438634
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
multiple interactions
ISO
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]
CTD
PMID:20438634
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
affects binding increases expression multiple interactions
ISO
withaferin A binds to CDKN1A protein withaferin A results in increased expression of CDKN1A mRNA withaferin A results in increased expression of and affects the localization of CDKN1A protein
CTD
PMID:22973447
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2aip
CDKN2A interacting protein
decreases expression
ISO
withaferin A results in decreased expression of CDKN2AIP protein
CTD
PMID:22973447
NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033
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Cldn1
claudin 1
decreases response to substance decreases expression
ISO
CLDN1 protein results in decreased susceptibility to withaferin A withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein
CTD
PMID:33665778
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Cp
ceruloplasmin
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein]
CTD
PMID:35734936
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cpt1c
carnitine palmitoyltransferase 1c
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA]
CTD
PMID:34995708
NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
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Crp
C-reactive protein
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein]
CTD
PMID:35734936
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Ddit3
DNA-damage inducible transcript 3
affects response to substance increases expression multiple interactions
ISO
DDIT3 mRNA affects the susceptibility to withaferin A withaferin A results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]
CTD
PMID:21266191
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddit4
DNA-damage-inducible transcript 4
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]
CTD
PMID:21266191
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Dnmt1
DNA methyltransferase 1
decreases expression
ISO
withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein
CTD
PMID:23593078
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dnmt3a
DNA methyltransferase 3 alpha
decreases expression
ISO
withaferin A results in decreased expression of DNMT3A mRNA
CTD
PMID:23593078
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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Dnmt3b
DNA methyltransferase 3 beta
decreases expression
ISO
withaferin A results in decreased expression of DNMT3B mRNA
CTD
PMID:23593078
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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Edil3
EGF like repeats and discoidin domains 3
decreases expression
ISO
withaferin A results in decreased expression of EDIL3 mRNA
CTD
PMID:33665778
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
multiple interactions
ISO
withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA]
CTD
PMID:34995708
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Eif2a
eukaryotic translation initiation factor 2A
increases phosphorylation
ISO
withaferin A results in increased phosphorylation of EIF2A protein
CTD
PMID:21266191
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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Ezr
ezrin
multiple interactions
ISO
[withanone co-treated with withaferin A] results in decreased expression of EZR protein
CTD
PMID:25236891
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Fas
Fas cell surface death receptor
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]
CTD
PMID:35734936
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fasn
fatty acid synthase
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA]
CTD
PMID:34995708
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
withaferin A results in increased expression of FOSL1 mRNA
CTD
PMID:33665778
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
withaferin A results in decreased expression of G6PC1 protein
CTD
PMID:37467946
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA]
CTD
PMID:34995708
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein]
CTD
PMID:34995708
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gsr
glutathione-disulfide reductase
multiple interactions
ISO
withaferin A binds to and affects the localization of GSR protein
CTD
PMID:37467946
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hdac1
histone deacetylase 1
decreases expression
ISO
withaferin A results in decreased expression of HDAC1 protein
CTD
PMID:23593078
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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Hmox1
heme oxygenase 1
increases expression
ISO
withaferin A results in increased expression of HMOX1 protein
CTD
PMID:36716864
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hnrnpk
heterogeneous nuclear ribonucleoprotein K
multiple interactions
ISO
[withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein
CTD
PMID:25236891
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
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Hsf1
heat shock transcription factor 1
increases activity
ISO
withaferin A results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Hspa9
heat shock protein family A (Hsp70) member 9
affects binding multiple interactions
ISO
withaferin A binds to HSPA9 protein [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD
PMID:22973447 PMID:25236891
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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Il1b
interleukin 1 beta
multiple interactions
ISO
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:24632454 PMID:37467946
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO EXP
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]
CTD
PMID:20438634 PMID:35734936
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Krt13
keratin 13
decreases expression
ISO
withaferin A results in decreased expression of KRT13 mRNA
CTD
PMID:33665778
NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084
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Mapk1
mitogen activated protein kinase 1
multiple interactions increases phosphorylation
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD
PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD
PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
increases phosphorylation
ISO
withaferin A results in increased phosphorylation of MAPK8 protein
CTD
PMID:21964475
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
multiple interactions increases expression
ISO
MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] withaferin A results in increased expression of MCL1 protein
CTD
PMID:24019090
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mecp2
methyl CpG binding protein 2
decreases expression
ISO
withaferin A results in decreased expression of MECP2 protein
CTD
PMID:23593078
NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
[withanone co-treated with withaferin A] results in decreased expression of MMP2 protein
CTD
PMID:25236891
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mpo
myeloperoxidase
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein]
CTD
PMID:35734936
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfe2l2
NFE2 like bZIP transcription factor 2
affects binding increases phosphorylation
ISO
withaferin A binds to NFE2L2 protein withaferin A results in increased phosphorylation of NFE2L2 protein
CTD
PMID:22973447 PMID:36716864
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
CTD
PMID:20438634
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]
CTD
PMID:35734936
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA]
CTD
PMID:34995708
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nt5e
5' nucleotidase, ecto
increases expression
ISO
withaferin A results in increased expression of NT5E mRNA
CTD
PMID:33665778
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage
ISO
Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
CTD
PMID:20438634 PMID:24019090
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Prdx2
peroxiredoxin 2
increases expression
ISO
withaferin A results in increased expression of PRDX2 protein
CTD
PMID:36716864
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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Procr
protein C receptor
multiple interactions
ISO
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
CTD
PMID:24632454
NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD
PMID:21396905
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD
PMID:20438634
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Serpina6
serpin family A member 6
decreases expression
ISO
withaferin A results in decreased expression of SERPINA6 protein
CTD
PMID:37467946
NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349
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Slco4a1
solute carrier organic anion transporter family, member 4a1
increases expression
ISO
withaferin A results in increased expression of SLCO4A1 mRNA
CTD
PMID:33665778
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
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Sod2
superoxide dismutase 2
multiple interactions increases expression
ISO
SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] withaferin A results in increased expression of SOD2 protein
CTD
PMID:24019090 PMID:36716864
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]
CTD
PMID:34995708
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA]
CTD
PMID:34995708
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
G
Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein]
CTD
PMID:21396905
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein]
CTD
PMID:21396905
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tat
tyrosine aminotransferase
decreases expression
ISO
withaferin A results in decreased expression of TAT protein
CTD
PMID:37467946
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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Tmt1a
thiol methyltransferase 1A
decreases expression
ISO
withaferin A results in decreased expression of TMT1A mRNA
CTD
PMID:33665778
NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
G
Tnf
tumor necrosis factor
multiple interactions decreases activity
ISO EXP
withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] withaferin A results in decreased activity of TNF protein withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]
CTD
PMID:20438634 PMID:24632454 PMID:35734936 PMID:37467946
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip3
TNF alpha induced protein 3
multiple interactions
ISO
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]
CTD
PMID:20438634
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
G
Tp53
tumor protein p53
increases expression multiple interactions affects binding
ISO
withaferin A results in increased expression of TP53 mRNA [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein] withaferin A binds to TP53 protein
CTD
PMID:22973447
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tuba1a
tubulin, alpha 1A
decreases expression
ISO
withaferin A results in decreased expression of TUBA1A mRNA
CTD
PMID:24297176
NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
G
Tubb5
tubulin, beta 5 class I
decreases expression
ISO
withaferin A results in decreased expression of TUBB mRNA
CTD
PMID:24297176
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
G
Vegfa
vascular endothelial growth factor A
multiple interactions decreases expression
ISO
[withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] withaferin A results in decreased expression of VEGFA protein
CTD
PMID:20438634 PMID:25236891
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Xbp1
X-box binding protein 1
increases expression increases splicing
ISO
withaferin A results in increased expression of XBP1 protein withaferin A results in increased splicing of XBP1 mRNA
CTD
PMID:21266191
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19811
role
19818
biological role
19785
biochemical role
19496
metabolite
19484
eukaryotic metabolite
19303
plant metabolite
17945
withanolide
79
(+)-(5alpha,23R,24Z)-lanosta-8,24-dien-3,7-dioxo-23,26-gamma-lactone
0
(14alpha,17beta,20S,22R)-14,20-Epoxy-17-hydroxy-1-oxowitha-3,5,24-trienolide
0
(17S,23S)-17,23-epoxy-3beta,15alpha-dihydroxy-11-oxo-5alpha-lanosta-8-en-26,23-olide
0
(17S,23S)-17,23-epoxy-3beta,15alpha-dihydroxy-7,11-dioxo-5alpha-lanosta-8-en-26,23-olide
0
(17S,23S)-17,23-epoxy-3beta,7beta-dihydroxy-11,15-dioxo-5alpha-lanosta-8-en-26,23-olide
0
(17S,23S)-17,23-epoxy-3beta-hydroxy-7,11,15-trioxo-5alpha-lanosta-8-en-26,23-olide
0
(1alpha,3beta,20S,22R,24S,25S)-Pubescenin
0
(3b,20R,22R)-3,20,27-Trihydroxy-1-oxowitha-5,24-dienolide 3-glucoside
0
(5alpha,6beta,14alpha,20R,22R)-5,6,14,20,27-Pentahydroxy-1-oxowith-24-enolide
0
1-Acetyl-3,14,20-trihydroxywitha-5,24-dienolide 3-glucoside
0
1-Acetyl-3,27-dihydroxywitha-5,24-dienolide 3-glucoside
0
12-deoxywithastramonolide
0
14alpha-Hydroxyixocarpanolide
0
15beta-Hydroxynicandrin B
0
17alpha-hydroxywithaferin A
0
17alpha-hydroxywithanolide D
0
2,3-Dihydrowithanolide E
0
2,3-dihydro-3beta-O-sulfate withaferin A
0
2,3-dihydro-3beta-methoxy withaferin A
0
2,3-dihydrowithaferin A
0
2-[1-[1-hydroxy-10,13-dimethyl-3-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-4,5-dimethyl-2,3-dihydropyran-6-one
0
2-[1-[1-hydroxy-10,13-dimethyl-3-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-4-(hydroxymethyl)-5-methyl-2,3-dihydropyran-6-one
0
20-hydroxytubocapsanolide A
0
23-Hydroxyphysalolactone
0
23-hydroxytubocapsanolide A
0
24-methyl-lanost-8,24-dien-23S,26-lactone
0
27-hydroxywithanone
0
28-Hydroxywithanolide E
0
3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide
0
4beta-Hydroxywithanolide E
0
Antrolactone A
0
Antrolactone B
0
Applanlactone A
0
Artabotryol A
0
Astraeusin Q
0
Astrakurkurone
0
Coagulin R 3-glucoside
0
Colobetaolactone B
0
Colobetaolactone I
0
Colobetaolactone II
0
Colobetaolactone III
0
Dinoxin B
0
Dtxsid40950237
0
Fomefficinin
0
Fomefficinol A
0
Fomefficinol B
0
Fomitopsin B
0
Fomitopsin C
0
Fomitopsin E
0
Fomitopsin F
0
Fomlactone A
0
Fomlactone B
0
Fomlactone C
0
Ganodermalactone E
0
Ganodermalactone Q
0
Ganodermalactone R
0
Ganodermalactone S
0
Ganodermalactone W
0
Ganodermalactone X
0
Ganosporelactone A
0
Ganotropic acid
0
Gibbosicolid A
0
Gibbosicolid B
0
Gibbosicolid C
0
Gibbosicolid D
0
Hexagonin A
0
Hexagonin B
0
Hexagonin C
0
Hexagonin D
0
Hexatenuin A
0
Hexatenuin B
0
Irpexolide A
0
Ixocarpalactone A
0
Ixocarpalactone B
0
Ixocarpanolide
0
LSM-5073
0
LSM-6432
0
LSM-6721
0
Lepiotaprocerin C
0
Lepiotaprocerin E
0
Lepiotaprocerin F
0
Lepiotaprocerin G
0
Lepiotaprocerin K
0
Lepiotaprocerin L
0
Minabeolide-3
0
Officimalonic acid B
0
Officimalonic acid C
0
Palustrisolide A
0
Palustrisolide B
0
Palustrisolide C
0
Palustrisolide D
0
Palustrisolide E
0
Palustrisolide F
0
Palustrisolide G
0
Penijanthoid A
0
Penijanthoid B
0
Physagulin A
0
Physagulin B
0
Physagulin C
0
Physagulin D
0
Physagulin E
0
Physagulin F
0
Physagulin G
0
Physalolactone B
0
Physalolactone B 3-glucoside
0
Physalolactone C
0
Physangulide
0
Physapruin B
0
Physapubenolide
0
Pubesenolide
0
Spiroganocalitone A
0
Spiroganocalitone B
0
Spiroganocalitone C
0
Spiroganocalitone D
0
Taccalonolide A
0
Vamonolide
0
Withangulatin A
0
Withanolide A
0
Withanolide B
0
Withaperuvin B
0
Withaperuvin C
0
Withaperuvin D
0
Withaperuvin E
0
Withaperuvin F
0
Withaperuvin G
0
Withaperuvin H
0
Withaphysacarpin
0
minabeolide 1
0
minabeolide 2
0
minabeolide 4
0
minabeolide 5
0
minabeolide 8
0
paraminabeolide A
0
paraminabeolide B
0
paraminabeolide C
0
paraminabeolide D
0
paraminabeolide E
0
paraminabeolide F
0
physalolactone
0
tubocapsanolide A +
0
tubocapsanolide F
0
viscosalactone B
0
withaferin A +
79
withalongolide A
0
withalongolide B
0
withalongolide C
0
withalongolide D
0
withalongolide E
0
withalongolide G
0
withanolide D +
0
Path 2
CHEBI ontology
19811
subatomic particle
19809
composite particle
19809
hadron
19840
baryon
19809
nucleon
19809
atomic nucleus
19809
atom
19809
main group element atom
19759
p-block element atom
19759
carbon group element atom
19708
carbon atom
19734
organic molecular entity
19705
heteroorganic entity
19459
organochalcogen compound
19222
organooxygen compound
19137
ester
17247
carboxylic ester
16563
lactone
12512
steroid lactone
465
withanolide
79
(+)-(5alpha,23R,24Z)-lanosta-8,24-dien-3,7-dioxo-23,26-gamma-lactone
0
(14alpha,17beta,20S,22R)-14,20-Epoxy-17-hydroxy-1-oxowitha-3,5,24-trienolide
0
(17S,23S)-17,23-epoxy-3beta,15alpha-dihydroxy-11-oxo-5alpha-lanosta-8-en-26,23-olide
0
(17S,23S)-17,23-epoxy-3beta,15alpha-dihydroxy-7,11-dioxo-5alpha-lanosta-8-en-26,23-olide
0
(17S,23S)-17,23-epoxy-3beta,7beta-dihydroxy-11,15-dioxo-5alpha-lanosta-8-en-26,23-olide
0
(17S,23S)-17,23-epoxy-3beta-hydroxy-7,11,15-trioxo-5alpha-lanosta-8-en-26,23-olide
0
(1alpha,3beta,20S,22R,24S,25S)-Pubescenin
0
(3b,20R,22R)-3,20,27-Trihydroxy-1-oxowitha-5,24-dienolide 3-glucoside
0
(5alpha,6beta,14alpha,20R,22R)-5,6,14,20,27-Pentahydroxy-1-oxowith-24-enolide
0
1-Acetyl-3,14,20-trihydroxywitha-5,24-dienolide 3-glucoside
0
1-Acetyl-3,27-dihydroxywitha-5,24-dienolide 3-glucoside
0
12-deoxywithastramonolide
0
14alpha-Hydroxyixocarpanolide
0
15beta-Hydroxynicandrin B
0
17alpha-hydroxywithaferin A
0
17alpha-hydroxywithanolide D
0
2,3-Dihydrowithanolide E
0
2,3-dihydro-3beta-O-sulfate withaferin A
0
2,3-dihydro-3beta-methoxy withaferin A
0
2,3-dihydrowithaferin A
0
2-[1-[1-hydroxy-10,13-dimethyl-3-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-4,5-dimethyl-2,3-dihydropyran-6-one
0
2-[1-[1-hydroxy-10,13-dimethyl-3-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-4-(hydroxymethyl)-5-methyl-2,3-dihydropyran-6-one
0
20-hydroxytubocapsanolide A
0
23-Hydroxyphysalolactone
0
23-hydroxytubocapsanolide A
0
24-methyl-lanost-8,24-dien-23S,26-lactone
0
27-hydroxywithanone
0
28-Hydroxywithanolide E
0
3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide
0
4beta-Hydroxywithanolide E
0
Antrolactone A
0
Antrolactone B
0
Applanlactone A
0
Artabotryol A
0
Astraeusin Q
0
Astrakurkurone
0
Coagulin R 3-glucoside
0
Colobetaolactone B
0
Colobetaolactone I
0
Colobetaolactone II
0
Colobetaolactone III
0
Dinoxin B
0
Dtxsid40950237
0
Fomefficinin
0
Fomefficinol A
0
Fomefficinol B
0
Fomitopsin B
0
Fomitopsin C
0
Fomitopsin E
0
Fomitopsin F
0
Fomlactone A
0
Fomlactone B
0
Fomlactone C
0
Ganodermalactone E
0
Ganodermalactone Q
0
Ganodermalactone R
0
Ganodermalactone S
0
Ganodermalactone W
0
Ganodermalactone X
0
Ganosporelactone A
0
Ganotropic acid
0
Gibbosicolid A
0
Gibbosicolid B
0
Gibbosicolid C
0
Gibbosicolid D
0
Hexagonin A
0
Hexagonin B
0
Hexagonin C
0
Hexagonin D
0
Hexatenuin A
0
Hexatenuin B
0
Irpexolide A
0
Ixocarpalactone A
0
Ixocarpalactone B
0
Ixocarpanolide
0
LSM-5073
0
LSM-6432
0
LSM-6721
0
Lepiotaprocerin C
0
Lepiotaprocerin E
0
Lepiotaprocerin F
0
Lepiotaprocerin G
0
Lepiotaprocerin K
0
Lepiotaprocerin L
0
Minabeolide-3
0
Officimalonic acid B
0
Officimalonic acid C
0
Palustrisolide A
0
Palustrisolide B
0
Palustrisolide C
0
Palustrisolide D
0
Palustrisolide E
0
Palustrisolide F
0
Palustrisolide G
0
Penijanthoid A
0
Penijanthoid B
0
Physagulin A
0
Physagulin B
0
Physagulin C
0
Physagulin D
0
Physagulin E
0
Physagulin F
0
Physagulin G
0
Physalolactone B
0
Physalolactone B 3-glucoside
0
Physalolactone C
0
Physangulide
0
Physapruin B
0
Physapubenolide
0
Pubesenolide
0
Spiroganocalitone A
0
Spiroganocalitone B
0
Spiroganocalitone C
0
Spiroganocalitone D
0
Taccalonolide A
0
Vamonolide
0
Withangulatin A
0
Withanolide A
0
Withanolide B
0
Withaperuvin B
0
Withaperuvin C
0
Withaperuvin D
0
Withaperuvin E
0
Withaperuvin F
0
Withaperuvin G
0
Withaperuvin H
0
Withaphysacarpin
0
minabeolide 1
0
minabeolide 2
0
minabeolide 4
0
minabeolide 5
0
minabeolide 8
0
paraminabeolide A
0
paraminabeolide B
0
paraminabeolide C
0
paraminabeolide D
0
paraminabeolide E
0
paraminabeolide F
0
physalolactone
0
tubocapsanolide A +
0
tubocapsanolide F
0
viscosalactone B
0
withaferin A +
79
withalongolide A
0
withalongolide B
0
withalongolide C
0
withalongolide D
0
withalongolide E
0
withalongolide G
0
withanolide D +
0