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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nandrolone
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Accession:CHEBI:7466 term browser browse the term
Definition:A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.
Synonyms:related_synonym: (17beta)-17-hydroxyestr-4-en-3-one;   17beta-hydroxy-19-nor-4-androsten-3-one;   17beta-hydroxy-4-estren-3-one;   17beta-hydroxyestr-4-en-3-one;   19-Norandrostenolone;   19-Nortestosterone;   4-estren-17beta-ol-3-one;   Formula=C18H26O2;   InChI=1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-17,20H,2-9H2,1H3/t13-,14+,15+,16-,17-,18-/m0/s1;   InChIKey=NPAGDVCDWIYMMC-IZPLOLCNSA-N;   SMILES=[H][C@]12CCC(=O)C=C1CC[C@]1([H])[C@]2([H])CC[C@]2(C)[C@@H](O)CC[C@@]12[H]
 xref: Beilstein:2055849;   Beilstein:4690380;   CAS:434-22-0;   DrugBank:DB00984;   Drug_Central:1879;   Gmelin:1228044;   HMDB:HMDB0002725;   KEGG:C07254;   KEGG:D08250
 xref_mesh: MESH:D009277
 xref: PMID:11888015;   PMID:19055689;   PMID:20020363;   PMID:24405322;   Reaxys:2055849;   VSDB:1861;   Wikipedia:Nandrolone

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nandrolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule multiple interactions ISO Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein] CTD PMID:28412309 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] CTD PMID:12628686 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nandrolone binds to and results in increased activity of ESR1 protein CTD PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression
multiple interactions		 ISO Nandrolone results in increased expression of RACK1 mRNA; Nandrolone results in increased expression of RACK1 protein
Flutamide inhibits the reaction [Nandrolone results in increased expression of RACK1 mRNA]		 CTD PMID:28412309 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nandrolone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein] CTD PMID:28412309 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
nandrolone phenpropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
affects localization		 ISO nandrolone phenpropionate binds to and results in increased activity of AR protein
nandrolone phenpropionate affects the localization of AR protein		 CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      group 19767
        organic group 18550
          3-oxo-Delta(4)-steroid group 7947
            3-oxo-Delta(4) steroid 7947
              nandrolone 7
                nandrolone phenpropionate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic group 18550
                              organic divalent group 18541
                                organodiyl group 18541
                                  carbonyl group 18447
                                    carbonyl compound 18447
                                      ketone 16192
                                        oxo steroid 9293
                                          3-oxo steroid 8819
                                            3-oxo-Delta(4) steroid 7947
                                              nandrolone 7
                                                nandrolone phenpropionate 1
paths to the root