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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nandrolone
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Accession:CHEBI:7466 term browser browse the term
Definition:A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.
Synonyms:related_synonym: (17beta)-17-hydroxyestr-4-en-3-one;   17beta-hydroxy-19-nor-4-androsten-3-one;   17beta-hydroxy-4-estren-3-one;   17beta-hydroxyestr-4-en-3-one;   19-Norandrostenolone;   19-Nortestosterone;   4-estren-17beta-ol-3-one;   Formula=C18H26O2;   InChI=1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-17,20H,2-9H2,1H3/t13-,14+,15+,16-,17-,18-/m0/s1;   InChIKey=NPAGDVCDWIYMMC-IZPLOLCNSA-N;   SMILES=[H][C@]12CCC(=O)C=C1CC[C@]1([H])[C@]2([H])CC[C@]2(C)[C@@H](O)CC[C@@]12[H]
 xref: Beilstein:2055849;   Beilstein:4690380;   CAS:434-22-0;   DrugBank:DB00984;   Drug_Central:1879;   Gmelin:1228044;   HMDB:HMDB0002725;   KEGG:C07254;   KEGG:D08250
 xref_mesh: MESH:D009277
 xref: PMID:11888015;   PMID:19055689;   PMID:20020363;   PMID:24405322;   Reaxys:2055849;   VSDB:1861;   Wikipedia:Nandrolone



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nandrolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule multiple interactions ISO Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein] CTD PMID:28412309 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] CTD PMID:12628686 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nandrolone binds to and results in increased activity of ESR1 protein CTD PMID:29162470 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP 19-nortestosterone binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression
multiple interactions
ISO Nandrolone results in increased expression of RACK1 mRNA; Nandrolone results in increased expression of RACK1 protein
Flutamide inhibits the reaction [Nandrolone results in increased expression of RACK1 mRNA]
CTD PMID:28412309 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nandrolone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein] CTD PMID:28412309 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
nandrolone phenpropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
affects localization
ISO nandrolone phenpropionate binds to and results in increased activity of AR protein
nandrolone phenpropionate affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    chemical entity 20049
      group 19976
        organic group 18937
          3-oxo-Delta(4)-steroid group 9130
            3-oxo-Delta(4) steroid 9130
              nandrolone 8
                nandrolone phenpropionate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        oxo steroid 10295
                                          3-oxo steroid 9895
                                            3-oxo-Delta(4) steroid 9130
                                              nandrolone 8
                                                nandrolone phenpropionate 1
paths to the root