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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naltrexone
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Accession:CHEBI:7465 term browser browse the term
Definition:An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.
Synonyms:exact_synonym: 3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one
 related_synonym: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one;   17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one;   Formula=C20H23NO4;   InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1;   InChIKey=DQCKKXVULJGBQN-XFWGSAIBSA-N;   N-Cyclopropylmethyl-14-hydroxydihydromorphinone;   N-Cyclopropylmethylnoroxymorphone;   SMILES=Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC1CC1
 xref: Beilstein:3596648;   CAS:16590-41-3;   DrugBank:DB00704;   Drug_Central:1765;   HMDB:HMDB0014842;   KEGG:C07253;   KEGG:D05113;   LINCS:LSM-3962
 xref_mesh: MESH:D009271
 xref: PMID:17023477;   PMID:24107112;   PMID:24659754;   PMID:27690505;   PMID:27700187;   PMID:27787292;   PMID:27813192;   PMID:27875802;   PMID:27922226;   PMID:27936293;   PMID:27987236;   PMID:28011389;   PMID:28029718;   PMID:28044452;   PMID:28061017;   PMID:28068780;   PMID:28106937;   PMID:28118565;   PMID:28130024;   PMID:28144772;   PMID:28153651;   PMID:28161142;   PMID:28168894;   PMID:28184294;   Patent:US3332950;   Reaxys:3596648;   Wikipedia:Naltrexone
 cyclic_relationship: is_conjugate_base_of CHEBI:134688


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naltrexone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein] CTD PMID:27323860 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein]; Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]
Naltrexone results in increased secretion of CRH protein
CTD PMID:3031743 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein] CTD PMID:27323860 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance ISO DRD2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO Naltrexone promotes the reaction [Ethanol results in increased expression of EGR1 mRNA]
Naltrexone results in increased expression of EGR1 mRNA
CTD PMID:18427989 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27323860 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein] CTD PMID:27323860 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases secretion
increases expression
ISO Naltrexone results in increased secretion of FSHB protein
Naltrexone results in increased expression of FSHB protein
CTD PMID:6323369 PMID:7745028 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 affects response to substance ISO GABRA6 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA] CTD PMID:27323860 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
increases secretion
ISO Naltrexone results in increased expression of LHB protein
Naltrexone results in increased secretion of LHB protein
CTD PMID:6323369 PMID:7745028 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity ISO Naltrexone results in decreased activity of NOS2 protein CTD PMID:15694688 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ogfr opioid growth factor receptor increases expression ISO Naltrexone results in increased expression of OGFR CTD PMID:21685240 NCBI chr 3:176,093,662...176,099,949
Ensembl chr 3:175,930,505...176,099,987
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naltrexone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naltrexone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
affects response to substance
ISO
EXP
[[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP
Naltrexone binds to OPRM1 protein
OPRM1 affects the susceptibility to Naltrexone
CTD PMID:7562497 PMID:11413242 PMID:18250251 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects response to substance
ISO Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]
SLC6A3 gene polymorphism affects the susceptibility to Naltrexone
CTD PMID:9765353 PMID:18552399 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Naltrexone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15917999 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        xenobiotic 18391
          naltrexone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  organic heteropolycyclic compound 18035
                                    organic heteropentacyclic compound 13367
                                      naltrexone 19
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