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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aclacinomycin A
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Accession:CHEBI:74619 term browser browse the term
Definition:An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity.
Synonyms:exact_synonym: methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl}-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
 related_synonym: Formula=C42H53NO15;   InChI=1S/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+/m0/s1;   InChIKey=USZYSDMBJDPRIF-SVEJIMAYSA-N;   MA 144-A1;   SMILES=CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)N(C)C)c2c(O)c3C(=O)c4c(O)cccc4C(=O)c3cc2[C@H]1C(=O)OC;   aclarubicin;   aclarubicina;   aclarubicine;   aclarubicinum
 xref: CAS:57576-44-0;   Drug_Central:80;   KEGG:C18638;   KEGG:D02756;   KEGG:G09914
 xref_mesh: MESH:D015250
 xref: MetaCyc:CPD-12960;   PMID:19626543;   PMID:19744710;   PMID:20047095;   PMID:20399885;   PMID:20855424;   PMID:21130493;   PMID:21939347;   PMID:22077238;   PMID:22082134;   PMID:22374527;   PMID:22493369;   PMID:23418619;   PMID:23432721;   PMID:23533247;   PMID:23537708;   PMID:23595277;   PMID:23602475;   PMID:23613979;   PMID:23616245;   PMID:23664707;   Reaxys:4901152;   Wikipedia:Aclarubicin
 cyclic_relationship: is_conjugate_base_of CHEBI:74353;   is_tautomer_of CHEBI:77980


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aclacinomycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Aclarubicin CTD PMID:9491796 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Aclarubicin results in increased activity of CASP3 protein
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Aclarubicin results in increased activity of CASP3 protein]
CTD PMID:16215684 PMID:20399885 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Aclarubicin results in increased activity of CASP8 protein CTD PMID:20399885 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO Aclarubicin results in increased degradation of DFFA protein CTD PMID:12370496 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Gata1 GATA binding protein 1 multiple interactions
increases expression
increases activity
ISO Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]
Aclarubicin results in increased activity of GATA1 protein
CTD PMID:10656287 PMID:14623254 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO Aclarubicin results in increased expression of GSTP1 mRNA; Aclarubicin results in increased expression of GSTP1 protein
Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]
CTD PMID:14623254 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmbs hydroxymethylbilane synthase increases expression
multiple interactions
ISO Aclarubicin results in increased expression of HMBS mRNA
Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]
CTD PMID:10656287 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Nfe2 nuclear factor, erythroid 2 increases expression
multiple interactions
ISO Aclarubicin results in increased expression of NFE2 mRNA
Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]
CTD PMID:10656287 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects activity ISO Aclarubicin affects the activity of PARP1 protein CTD PMID:20399885 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aclarubicin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity ISO Aclarubicin results in decreased activity of SOD1 protein CTD PMID:10656287 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases response to substance ISO XIAP protein results in increased susceptibility to Aclarubicin CTD PMID:10815900 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          aclacinomycin A 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          quinone 8379
                                            acenoquinone 7512
                                              tetracenequinones 7390
                                                aklavinone 12
                                                  aclacinomycin A 12
paths to the root