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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naloxone
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Accession:CHEBI:7459 term browser browse the term
Definition:A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
Synonyms:exact_synonym: 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
 related_synonym: 1-N-Allyl-14-hydroxynordihydromorphinone;   17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one;   Formula=C19H21NO4;   InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1;   InChIKey=UZHSEJADLWPNLE-GRGSLBFTSA-N;   SMILES=Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C;   naloxona;   naloxonum
 xref: Beilstein:1089071;   CAS:465-65-6;   DrugBank:DB01183;   Drug_Central:1878;   HMDB:HMDB0015314;   KEGG:C07252;   KEGG:D08249;   LINCS:LSM-3504
 xref_mesh: MESH:D009270
 xref: PMID:17023477;   PMID:24868924;   PMID:25468814;   PMID:26469689;   PMID:26604818;   PMID:26634308;   Patent:GB939287;   Patent:US3254088;   Reaxys:1089071;   Wikipedia:Naloxone
 cyclic_relationship: is_conjugate_base_of CHEBI:90756



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naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Naloxone results in increased expression of ABCB1 mRNA
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:17522070 PMID:26554626 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Naloxone results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Naloxone results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Naloxone inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:17989109 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33872574 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form] CTD PMID:20600172 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Naloxone results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Naloxone results in decreased secretion of AVP protein CTD PMID:6850280 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]] CTD PMID:12927789 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Naloxone results in increased expression of BCL2 protein
CTD PMID:12927789 PMID:16004788 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity
multiple interactions
EXP Naloxone affects the activity of CALCA protein
Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]
CTD PMID:7906887 PMID:10075105 PMID:27030709 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form] CTD PMID:20600172 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression EXP Naloxone results in increased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin multiple interactions EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:17084265 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
affects binding
ISO CES1 protein binds to and results in increased metabolism of Naloxone
Naloxone binds to CES1 protein
CTD PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Naloxone results in decreased expression of CRH mRNA
Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]
CTD PMID:12431775 PMID:33872574 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions
increases response to substance
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone
CRHR1 gene mutant form results in increased susceptibility to Naloxone
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 PMID:28434951 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Ctsl cathepsin L increases expression EXP Naloxone results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] CTD PMID:19397953 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] CTD PMID:15542745 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Naloxone results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein] CTD PMID:20564181 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]
CTD PMID:9041360 PMID:15196794 PMID:16935424 PMID:17549049 PMID:22590628 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Naloxone results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form] CTD PMID:20600172 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Naloxone results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] CTD PMID:15497504
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Naloxone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases response to substance ISO Naloxone results in increased susceptibility to IL1B protein CTD PMID:19458216 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases response to substance
ISO Freund's Adjuvant inhibits the reaction [Naloxone results in decreased susceptibility to IL2 protein] CTD PMID:12421473 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:17084265 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf7 Kruppel like factor 7 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] CTD PMID:14644156 NCBI chr 9:65,437,535...65,484,720
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Naloxone results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lgals3 galectin 3 increases expression EXP Naloxone results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
affects expression
multiple interactions
ISO
EXP
Naloxone results in increased expression of LHB protein
Naloxone affects the expression of LHB protein
Naloxone affects the expression of and affects the secretion of LHB protein
CTD PMID:1794335 PMID:2745936 PMID:2880862 PMID:7629406 PMID:15905218 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Naloxone results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G LOC367746 similar to Spindlin-like protein 2 (SPIN-2) decreases expression EXP Naloxone results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,371...17,192,351
Ensembl chr  X:17,180,474...17,192,351
JBrowse link
G Ltf lactotransferrin decreases activity EXP Naloxone results in decreased activity of LTF protein CTD PMID:14563657 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK1 protein
Naloxone results in increased phosphorylation of MAPK1 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK3 protein
Naloxone results in increased phosphorylation of MAPK3 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir16 microRNA 16 increases expression EXP Naloxone results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Naloxone results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Naloxone results in increased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] CTD PMID:20519536 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Naloxone results in decreased expression of NPPA protein CTD PMID:11311734 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naloxone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naloxone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]
Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
Naloxone binds to OPRM1 protein
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine; Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Naloxone binds to and results in decreased activity of OPRM1 protein; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
CTD PMID:1528399 PMID:1654493 PMID:7562497 PMID:8383026 PMID:8987795 More... NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Naloxone results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Naloxone results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone; Naloxone binds to and results in increased activity of POMC protein alternative form
Naloxone results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
Naloxone results in increased expression of POMC protein alternative form
CTD PMID:2255747 PMID:2846107 PMID:3157294 PMID:6089027 PMID:24398105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prl prolactin affects expression
decreases expression
ISO
EXP
Naloxone affects the expression of PRL protein
Naloxone results in decreased expression of PRL protein
CTD PMID:1794335 PMID:7629406 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Naloxone results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ren renin increases activity ISO Naloxone results in increased activity of REN protein CTD PMID:3157294 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Sell selectin L multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Naloxone inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Naloxone inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Naloxone results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein] CTD PMID:11976266 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases phosphorylation
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25308750 PMID:25582704 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Naloxone results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Naloxone results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Naloxone affects the reaction [Methadone binds to TLR4 protein]; Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Naloxone results in decreased expression of TNF protein
CTD PMID:16004788 PMID:17084265 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Naloxone results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Naloxone results in decreased expression of TP53 mRNA
CTD PMID:12927789 PMID:17522070 PMID:19397953 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Naloxone results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 protein affects the metabolism of Naloxone
UGT2B7 protein results in increased glucuronidation of Naloxone
CTD PMID:15286053 PMID:28762043 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            central nervous system drug 16514
              central nervous system depressant 16011
                naloxone 78
                  naloxegol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organonitrogen compound 18544
                                alkaloid 5686
                                  isoquinoline alkaloid 1139
                                    morphinane alkaloid 663
                                      morphinan 638
                                        naloxone 78
                                          naloxegol 0
paths to the root