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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iodoacetic acid
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Accession:CHEBI:74571 term browser browse the term
Definition:A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
Synonyms:related_synonym: 2-iodoacetic acid;   CH2ICO2H;   CH2ICOOH;   Formula=C2H3IO2;   ICH2CO2H;   ICH2COOH;   InChI=1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5);   InChIKey=JDNTWHVOXJZDSN-UHFFFAOYSA-N;   SMILES=OC(=O)CI;   iodoethanoic acid;   monoiodoacetic acid
 xref: CAS:64-69-7;   LINCS:LSM-5944;   LIPID_MAPS_instance:LMFA01090135
 xref_mesh: MESH:D019807
 xref: PMID:21740901;   PMID:22206935;   PMID:22251455;   PMID:22562395;   PMID:23613747;   PMID:23641915;   PMID:23657794;   Reaxys:1739079;   Wikipedia:Iodoacetic_acid

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iodoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Iodoacetic Acid results in increased expression of AIFM1 mRNA CTD PMID:31693920 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Iodoacetic Acid results in increased expression of BAX mRNA CTD PMID:31693920 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Iodoacetic Acid results in decreased expression of BCL2 mRNA CTD PMID:31693920 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression ISO Iodoacetic Acid results in decreased expression of BCL2L10 mRNA CTD PMID:31693920 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Iodoacetic Acid results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Iodoacetic Acid results in decreased expression of CCNA2 mRNA CTD PMID:31693920 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Iodoacetic Acid results in decreased expression of CCNB1 mRNA CTD PMID:31693920 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Iodoacetic Acid results in decreased expression of CCND2 mRNA CTD PMID:31693920 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Iodoacetic Acid results in decreased expression of CCNE1 mRNA CTD PMID:31693920 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Iodoacetic Acid results in increased expression of CDK4 mRNA CTD PMID:31693920 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Iodoacetic Acid results in increased expression of CDKN1A mRNA CTD PMID:31693920 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Iodoacetic Acid results in increased expression of CYP11A1 mRNA CTD PMID:31693920 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Iodoacetic Acid results in decreased expression of CYP17A1 mRNA CTD PMID:31693920 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Iodoacetic Acid results in decreased expression of CYP19A1 mRNA CTD PMID:31693920 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Iodoacetic Acid results in decreased expression of ESR1 mRNA CTD PMID:31693920 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Grk1 G protein-coupled receptor kinase 1 multiple interactions ISO [Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA; Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA] CTD PMID:18624922 NCBI chr16:81,153,489...81,165,442
Ensembl chr16:81,153,489...81,165,442 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance ISO HRAS protein modified form results in increased susceptibility to Iodoacetic Acid CTD PMID:19923925 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO Iodoacetic Acid results in decreased expression of HSD17B1 mRNA CTD PMID:31693920 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO Iodoacetic Acid results in increased expression of HSD3B1 mRNA CTD PMID:31693920
G Id2 inhibitor of DNA binding 2 decreases expression ISO Iodoacetic Acid results in decreased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Iodoacetic Acid results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223 		JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Iodoacetic Acid results in decreased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Iodoacetic Acid results in decreased expression of MKI67 mRNA CTD PMID:31693920 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Iodoacetic Acid results in increased expression of PARP1 protein modified form CTD PMID:25944804 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 multiple interactions ISO [Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] CTD PMID:18624922 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599 		JBrowse link
G Sstr1 somatostatin receptor 1 multiple interactions ISO Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] CTD PMID:18624922 NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Iodoacetic Acid results in increased expression of STAR mRNA CTD PMID:31693920 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19790
      application 19464
        food additive 14732
          food acidity regulator 11684
            acetic acid 10817
              haloacetic acid 53
                iodoacetic acid 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        monocarboxylic acid 17487
                                          acetic acid 10817
                                            haloacetic acid 53
                                              iodoacetic acid 27
paths to the root