CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: iodoacetic acid
Accession: CHEBI:74571
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Definition: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
Synonyms: related_synonym: 2-iodoacetic acid; CH2ICO2H; CH2ICOOH; Formula=C2H3IO2; ICH2CO2H; ICH2COOH; InChI=1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5); InChIKey=JDNTWHVOXJZDSN-UHFFFAOYSA-N; SMILES=OC(=O)CI; iodoethanoic acid; monoiodoacetic acid
xref: CAS:64-69-7; LINCS:LSM-5944; LIPID_MAPS_instance:LMFA01090135
xref_mesh: MESH:D019807
xref: PMID:21740901; PMID:22206935; PMID:22251455; PMID:22562395; PMID:23613747; PMID:23641915; PMID:23657794; Reaxys:1739079; Wikipedia:Iodoacetic_acid
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
Iodoacetic Acid results in increased expression of AIFM1 mRNA
CTD
PMID:31693920
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Iodoacetic Acid results in increased expression of BAX mRNA
CTD
PMID:31693920
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Iodoacetic Acid results in decreased expression of BCL2 mRNA
CTD
PMID:31693920
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bcl2l10
BCL2 like 10
decreases expression
ISO
Iodoacetic Acid results in decreased expression of BCL2L10 mRNA
CTD
PMID:31693920
NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CCL2 mRNA
CTD
PMID:23397585
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccna2
cyclin A2
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CCNA2 mRNA
CTD
PMID:31693920
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Ccnb1
cyclin B1
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CCNB1 mRNA
CTD
PMID:31693920
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Ccnd2
cyclin D2
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CCND2 mRNA
CTD
PMID:31693920
NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
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Ccne1
cyclin E1
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CCNE1 mRNA
CTD
PMID:31693920
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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Cdk4
cyclin-dependent kinase 4
increases expression
ISO
Iodoacetic Acid results in increased expression of CDK4 mRNA
CTD
PMID:31693920
NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Iodoacetic Acid results in increased expression of CDKN1A mRNA
CTD
PMID:31693920
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
ISO
Iodoacetic Acid results in increased expression of CYP11A1 mRNA
CTD
PMID:31693920
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CYP17A1 mRNA
CTD
PMID:31693920
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression
ISO
Iodoacetic Acid results in decreased expression of CYP19A1 mRNA
CTD
PMID:31693920
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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Esr1
estrogen receptor 1
decreases expression
ISO
Iodoacetic Acid results in decreased expression of ESR1 mRNA
CTD
PMID:31693920
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Grk1
G protein-coupled receptor kinase 1
multiple interactions
ISO
[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA; Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]
CTD
PMID:18624922
NCBI chr16:81,153,489...81,165,442
Ensembl chr16:81,153,489...81,165,442
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Hras
HRas proto-oncogene, GTPase
increases response to substance
ISO
HRAS protein modified form results in increased susceptibility to Iodoacetic Acid
CTD
PMID:19923925
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
decreases expression
ISO
Iodoacetic Acid results in decreased expression of HSD17B1 mRNA
CTD
PMID:31693920
NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
increases expression
ISO
Iodoacetic Acid results in increased expression of HSD3B1 mRNA
CTD
PMID:31693920
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Id2
inhibitor of DNA binding 2
decreases expression
ISO
Iodoacetic Acid results in decreased expression of ID2 mRNA
CTD
PMID:23397585
NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
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Id3
inhibitor of DNA binding 3, HLH protein
decreases expression
ISO
Iodoacetic Acid results in decreased expression of ID3 mRNA
CTD
PMID:23397585
NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
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Klf9
Kruppel-like factor 9
decreases expression
ISO
Iodoacetic Acid results in decreased expression of KLF9 mRNA
CTD
PMID:23397585
NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Iodoacetic Acid results in decreased expression of MKI67 mRNA
CTD
PMID:31693920
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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Parp1
poly (ADP-ribose) polymerase 1
increases expression
ISO
Iodoacetic Acid results in increased expression of PARP1 protein modified form
CTD
PMID:25944804
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Rgs1
regulator of G-protein signaling 1
multiple interactions
ISO
[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]
CTD
PMID:18624922
NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
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Sstr1
somatostatin receptor 1
multiple interactions
ISO
Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]
CTD
PMID:18624922
NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611
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Star
steroidogenic acute regulatory protein
increases expression
ISO
Iodoacetic Acid results in increased expression of STAR mRNA
CTD
PMID:31693920
NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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