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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor
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Accession:CHEBI:74570 term browser browse the term
Definition:An EC 2.3.2.* (aminoacyltransferase) inhibitor that interferes with the action of gamma-glutamyltransferase (EC 2.3.2.2).
Synonyms:related_synonym: (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitor;   (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitors;   EC 2.3.2.2 inhibitor;   EC 2.3.2.2 inhibitors;   GGT inhibitor;   GGT inhibitors;   L-gamma-glutamyl transpeptidase inhibitor;   L-gamma-glutamyl transpeptidase inhibitors;   L-gamma-glutamyltransferase inhibitor;   L-gamma-glutamyltransferase inhibitors;   L-glutamyltransferase inhibitor;   L-glutamyltransferase inhibitors;   alpha-glutamyl transpeptidase inhibitor;   alpha-glutamyl transpeptidase inhibitors;   gamma-GPT inhibitor;   gamma-GPT inhibitors;   gamma-GT inhibitor;   gamma-GT inhibitors;   gamma-GTP inhibitor;   gamma-GTP inhibitors;   gamma-glutamyl peptidyltransferase inhibitor;   gamma-glutamyl peptidyltransferase inhibitors;   gamma-glutamyl transpeptidase inhibitor;   gamma-glutamyl transpeptidase inhibitors;   gamma-glutamyltransferase (EC 2.3.2.2) inhibitors;   gamma-glutamyltransferase inhibitor;   gamma-glutamyltransferase inhibitors;   gamma-glutamyltranspeptidase inhibitor;   gamma-glutamyltranspeptidase inhibitors;   glutamyl transpeptidase inhibitor;   glutamyl transpeptidase inhibitors
 xref: Wikipedia:Gamma-glutamyl_transpeptidase


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acivicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA] CTD PMID:14766015 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G Ggt1 gamma-glutamyltransferase 1 multiple interactions
decreases activity
ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:15629191 PMID:19419996 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          enzyme inhibitor 18227
            EC 2.* (transferase) inhibitor 13872
              EC 2.3.* (acyltransferase) inhibitor 560
                EC 2.3.2.* (aminoacyltransferase) inhibitor 30
                  EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor 2
                    acivicin 2
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