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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acivicin
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Accession:CHEBI:74545 term browser browse the term
Definition:An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
Synonyms:exact_synonym: (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
 related_synonym: (alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid;   (alphaS,5S)-alpha-amino-3-chloro-2-isoxazoline-5-acetic acid;   AT-125;   Antibiotic AT 125;   Formula=C5H7ClN2O3;   InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1;   InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N;   NSC-163501;   SMILES=[H][C@]1(CC(Cl)=NO1)[C@H](N)C(O)=O;   U 42126;   U-42,126;   acivicine;   acivicino;   acivicinum
 xref: CAS:42228-92-2;   KEGG:D02755
 xref_mesh: MESH:C006303
 xref: MetaCyc:CPD0-1036;   PDBeChem:AVN;   PMID:11478776;   PMID:14586123;   PMID:2383250;   PMID:2894949;   PMID:3112985;   PMID:3165971;   PMID:3710919;   PMID:3915184;   PMID:6102405;   PMID:7026076;   PMID:7150366;   PMID:8060335;   PMID:9829740;   Reaxys:1074649;   Wikipedia:Acivicin



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acivicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA] CTD PMID:14766015 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
decreases activity
ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:15629191 PMID:19419996 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        antimicrobial agent 18193
          acivicin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        amino acid 15954
                                          alpha-amino acid 13872
                                            L-alpha-amino acid 12862
                                              non-proteinogenic L-alpha-amino acid 2917
                                                acivicin 2
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