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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acivicin
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Accession:CHEBI:74545 term browser browse the term
Definition:An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
Synonyms:exact_synonym: (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
 related_synonym: (alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid;   (alphaS,5S)-alpha-amino-3-chloro-2-isoxazoline-5-acetic acid;   AT-125;   Antibiotic AT 125;   Formula=C5H7ClN2O3;   InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1;   InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N;   NSC-163501;   SMILES=[H][C@]1(CC(Cl)=NO1)[C@H](N)C(O)=O;   U 42126;   U-42,126;   acivicine;   acivicino;   acivicinum
 xref: CAS:42228-92-2;   KEGG:D02755
 xref_mesh: MESH:C006303
 xref: MetaCyc:CPD0-1036;   PDBeChem:AVN;   PMID:11478776;   PMID:14586123;   PMID:2383250;   PMID:2894949;   PMID:3112985;   PMID:3165971;   PMID:3710919;   PMID:3915184;   PMID:6102405;   PMID:7026076;   PMID:7150366;   PMID:8060335;   PMID:9829740;   Reaxys:1074649;   Wikipedia:Acivicin



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acivicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA] CTD PMID:14766015 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
decreases activity
ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:15629191 PMID:19419996 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          acivicin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        amino acid 14936
                                          alpha-amino acid 12944
                                            L-alpha-amino acid 11603
                                              non-proteinogenic L-alpha-amino acid 790
                                                acivicin 2
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