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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acivicin
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Accession:CHEBI:74545 term browser browse the term
Definition:An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
Synonyms:exact_synonym: (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
 related_synonym: (alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid;   (alphaS,5S)-alpha-amino-3-chloro-2-isoxazoline-5-acetic acid;   AT-125;   Antibiotic AT 125;   Formula=C5H7ClN2O3;   InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1;   InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N;   NSC-163501;   SMILES=[H][C@]1(CC(Cl)=NO1)[C@H](N)C(O)=O;   U 42126;   U-42,126;   acivicine;   acivicino;   acivicinum
 xref: CAS:42228-92-2;   KEGG:D02755
 xref_mesh: MESH:C006303
 xref: MetaCyc:CPD0-1036;   PDBeChem:AVN;   PMID:11478776;   PMID:14586123;   PMID:2383250;   PMID:2894949;   PMID:3112985;   PMID:3165971;   PMID:3710919;   PMID:3915184;   PMID:6102405;   PMID:7026076;   PMID:7150366;   PMID:8060335;   PMID:9829740;   Reaxys:1074649;   Wikipedia:Acivicin


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acivicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA] CTD PMID:14766015 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
decreases activity
ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:15629191 PMID:19419996 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        antimicrobial agent 17372
          acivicin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        amino acid 14108
                                          alpha-amino acid 11594
                                            L-alpha-amino acid 11429
                                              non-proteinogenic L-alpha-amino acid 598
                                                acivicin 2
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