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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor
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Accession:CHEBI:74520 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44).
Synonyms:related_synonym: 6-phospho-D-gluconate dehydrogenase inhibitor;   6-phospho-D-gluconate dehydrogenase inhibitors;   6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) inhibitor;   6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) inhibitors;   6-phosphogluconate dehydrogenase (decarboxylating) inhibitor;   6-phosphogluconate dehydrogenase (decarboxylating) inhibitors;   6-phosphogluconic carboxylase inhibitor;   6-phosphogluconic carboxylase inhibitors;   6-phosphogluconic dehydrogenase inhibitor;   6-phosphogluconic dehydrogenase inhibitors;   EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitors;   EC 1.1.1.44 inhibitor;   EC 1.1.1.44 inhibitors;   NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitor;   NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitors;   phosphogluconic acid dehydrogenase inhibitor;   phosphogluconic acid dehydrogenase inhibitors
 xref: Wikipedia:Phosphogluconate_dehydrogenase_(decarboxylating)


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6-aminonicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [6-Aminonicotinamide co-treated with spautin-1] results in increased degradation of EIF4A1 protein CTD PMID:30821613 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression		 ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein] CTD PMID:12898533 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein] CTD PMID:25246272 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein] CTD PMID:25246272 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of IL1B protein] CTD PMID:12898533 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT1 protein]; 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT2 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of IL1B protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of NTF3 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TGFB1 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TNF protein]
6-Aminonicotinamide results in increased expression of IL6 protein		 CTD PMID:12898533 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
decreases response to substance		 ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT2 protein]
6-Aminonicotinamide results in increased expression of MT2 protein
MT2 protein results in decreased susceptibility to 6-Aminonicotinamide		 CTD PMID:11835189 PMID:12898533 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO 6-Aminonicotinamide results in increased expression of MT3 protein CTD PMID:10785446 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ntf3 neurotrophin 3 increases expression
multiple interactions		 ISO 6-Aminonicotinamide results in increased expression of NTF3 protein
IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of NTF3 protein]		 CTD PMID:12898533 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] CTD PMID:25246272 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO 6-Aminonicotinamide results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TGFB1 protein] CTD PMID:12898533 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO 6-Aminonicotinamide results in increased expression of TNF protein
IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TNF protein]		 CTD PMID:12898533 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          enzyme inhibitor 18603
            EC 1.* (oxidoreductase) inhibitor 17293
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 5877
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 4174
                  EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor 13
                    6-aminonicotinamide 13
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