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Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-obesity agent
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Accession:CHEBI:74518 term browser browse the term
Definition:Any substance which is used to reduce or control weight.
Synonyms:related_synonym: anti-obesity agents;   anti-obestic agent;   anti-obestic agents
 xref: Wikipedia:Anti-obesity



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3-iodothyronamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhcg Rh family, C glycoprotein affects uptake ISO RHCG mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:142,941,046...142,965,242
Ensembl chr 1:142,941,048...142,965,376
JBrowse link
G Slc16a7 solute carrier family 16 member 7 affects uptake ISO SLC16A7 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:62,936,567...63,040,386
JBrowse link
G Slc17a5 solute carrier family 17 member 5 affects uptake ISO SLC17A5 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 8:88,274,497...88,309,734
Ensembl chr 8:88,274,721...88,309,664
JBrowse link
G Slc26a11 solute carrier family 26 member 11 affects uptake ISO SLC26A11 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr10:105,112,020...105,134,393
Ensembl chr10:105,112,080...105,134,784
JBrowse link
G Slc27a1 solute carrier family 27 member 1 affects uptake ISO SLC27A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,313,015...18,330,045
JBrowse link
G Slc28a3 solute carrier family 28 member 3 affects uptake ISO SLC28A3 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr17:6,068,034...6,120,421
Ensembl chr17:6,068,060...6,120,417
JBrowse link
G Slc29a2 solute carrier family 29 member 2 affects uptake ISO SLC29A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:211,756,588...211,764,561
Ensembl chr 1:211,757,000...211,764,560
JBrowse link
G Slc30a10 solute carrier family 30, member 10 affects uptake ISO SLC30A10 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr13:99,529,664...99,584,442
Ensembl chr13:99,529,790...99,544,213
JBrowse link
G Slc30a8 solute carrier family 30 member 8 affects uptake ISO SLC30A8 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 7:85,481,864...85,517,255
Ensembl chr 7:85,481,864...85,517,177
JBrowse link
G Slc31a1 solute carrier family 31 member 1 affects uptake ISO SLC31A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809
JBrowse link
G Slc35c2 solute carrier family 35 member C2 affects uptake ISO SLC35H1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:174,431,688...174,442,852
Ensembl chr 3:174,431,718...174,442,792
JBrowse link
G Slc35d2 solute carrier family 35 member D2 affects uptake ISO SLC35D2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr17:992,153...1,025,476
Ensembl chr17:993,646...1,025,475
JBrowse link
G Slc37a1 solute carrier family 37 member 1 affects uptake ISO SLC37A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr20:9,361,733...9,435,227
Ensembl chr20:9,379,664...9,435,229
JBrowse link
G Slc43a3 solute carrier family 43, member 3 affects uptake ISO SLC43A3 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:90,415,977...90,436,976
JBrowse link
G Slc45a2 solute carrier family 45, member 2 affects uptake ISO SLC45A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 2:61,690,828...61,723,437
Ensembl chr 2:61,690,828...61,723,437
JBrowse link
G Slc45a4 solute carrier family 45, member 4 affects uptake ISO SLC45A4 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 7:107,370,826...107,459,163
Ensembl chr 7:107,371,273...107,398,284
JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects uptake ISO SLC46A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869
JBrowse link
G Slc6a18 solute carrier family 6 member 18 affects uptake ISO SLC6A18 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:31,436,577...31,450,478
Ensembl chr 1:31,436,630...31,450,478
JBrowse link
G Slc7a1 solute carrier family 7 member 1 affects uptake ISO SLC7A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030
JBrowse link
G Slc7a14 solute carrier family 7, member 14 affects uptake ISO SLC7A14 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 2:113,993,781...114,099,810
Ensembl chr 2:113,993,785...114,099,804
JBrowse link
G Slc7a2 solute carrier family 7 member 2 affects uptake ISO SLC7A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr16:58,115,991...58,174,256
Ensembl chr16:58,120,968...58,174,256
JBrowse link
G Slc9a4 solute carrier family 9 member A4 affects uptake ISO SLC9A4 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 9:50,320,948...50,375,336
Ensembl chr 9:50,320,586...50,375,335
JBrowse link
G Slc9a5 solute carrier family 9 member A5 affects uptake ISO SLC9A5 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr19:50,135,973...50,156,833
Ensembl chr19:50,136,740...50,156,827
JBrowse link
G Slc9a6 solute carrier family 9 member A6 affects uptake ISO SLC9A6 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr  X:139,468,045...139,524,111
Ensembl chr  X:139,458,127...139,524,109
JBrowse link
G Slc9a7 solute carrier family 9 member A7 affects uptake ISO SLC9A7 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr  X:4,767,578...4,948,602
Ensembl chr  X:4,767,915...4,948,602
JBrowse link
G Slc9a8 solute carrier family 9 member A8 affects uptake ISO SLC9A8 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:176,559,658...176,617,510
Ensembl chr 3:176,567,124...176,617,511
JBrowse link
G Slc9a9 solute carrier family 9 member A9 affects uptake ISO SLC9A9 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 8:104,112,279...104,675,944
Ensembl chr 8:104,112,559...104,676,891
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake ISO SLCO1A2 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 affects uptake ISO SLCO3A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 1:137,516,037...137,797,836
Ensembl chr 1:137,505,158...137,797,836
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 affects uptake ISO SLCO4A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:187,936,820...187,955,871
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 affects uptake ISO SLCO4C1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 9:104,624,802...104,676,462
Ensembl chr 9:104,624,802...104,676,462
JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 affects uptake ISO SLCO5A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 5:11,012,001...11,141,180
Ensembl chr 5:11,012,075...11,141,177
JBrowse link
G Slco6b1 solute carrier organic anion transporter family member 6B1 affects uptake ISO SLCO6A1 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 NCBI chr 9:104,713,945...104,794,649
Ensembl chr 9:104,718,624...104,794,649
JBrowse link
AM6545 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO AM6545 inhibits the reaction [Ethanol results in increased expression of AGER mRNA] CTD PMID:39251147 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO [Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; AM6545 inhibits the reaction [Streptozocin results in increased expression of AGTR1A mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein] CTD PMID:30184259 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO AM6545 results in increased phosphorylation of AKT1 protein CTD PMID:39216835 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alb albumin multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in increased expression of ALB protein] CTD PMID:30184259 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Arg1 arginase 1 multiple interactions ISO AM6545 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone affects the expression of ARG1 mRNA]; AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]; Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]] CTD PMID:30184259 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] CTD PMID:30184259 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]] CTD PMID:30184259 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA] CTD PMID:30184259 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059
JBrowse link
G Cd163 CD163 molecule multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]] CTD PMID:30184259 NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]] CTD PMID:30184259 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO AM6545 affects the reaction [Ethanol affects the expression of CNR1 protein]
[Ethanol co-treated with AM6545] results in increased expression of CNR1 protein
CTD PMID:39251147 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO AM6545 affects the reaction [Ethanol affects the expression of CNR2 protein]
[Ethanol co-treated with AM6545] results in increased expression of CNR2 protein
CTD PMID:39251147 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:30184259 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO AM6545 inhibits the reaction [Ethanol results in increased expression of HMGB1 mRNA] CTD PMID:39251147 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]] CTD PMID:30184259 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO AM6545 inhibits the reaction [Ethanol results in increased expression of IL1B mRNA] CTD PMID:39251147 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO AM6545 results in increased phosphorylation of MAPK1 protein CTD PMID:39216835 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO AM6545 results in increased phosphorylation of MAPK3 protein CTD PMID:39216835 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]] CTD PMID:30184259 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO AM6545 results in increased phosphorylation of MTOR protein CTD PMID:39216835 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]] CTD PMID:30184259 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]] CTD PMID:30184259 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]; AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]] CTD PMID:30184259 NCBI chr13:70,993,622...71,011,585
Ensembl chr13:70,999,186...71,011,572
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha decreases phosphorylation ISO AM6545 results in decreased phosphorylation of PRKAR2A protein CTD PMID:39216835 NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO AM6545 inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]] CTD PMID:30184259 PMID:39251147 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
danuglipron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glp1r glucagon-like peptide 1 receptor increases activity
multiple interactions
ISO danuglipron results in increased activity of GLP1R protein
[danuglipron results in increased activity of GLP1R protein] which results in increased abundance of Cyclic AMP
CTD PMID:39395609 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases activity ISO danuglipron results in increased activity of KCNH2 protein CTD PMID:39395609 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
duvoglustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:25445511 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G App amyloid beta precursor protein decreases response to substance ISO 1-Deoxynojirimycin results in decreased susceptibility to APP protein CTD PMID:19028522 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; 1-Deoxynojirimycin inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein] CTD PMID:19028522 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of CD36 mRNA] CTD PMID:25445511 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:25445511 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 1-Deoxynojirimycin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein] CTD PMID:19028522 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:25445511 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fbp2 fructose-bisphosphatase 2 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FBP2 protein] CTD PMID:25446853 NCBI chr17:2,241,767...2,259,371
Ensembl chr17:2,241,975...2,259,366
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC1 protein] CTD PMID:25446853 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033
JBrowse link
G Gck glucokinase multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein] CTD PMID:25446853 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:25445511 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein] CTD PMID:25446853 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Insr insulin receptor multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein] CTD PMID:25446853 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA] CTD PMID:25446853 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PCX protein] CTD PMID:25446853 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PCK1 protein] CTD PMID:25446853 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] results in increased expression of PDHA1 mRNA CTD PMID:25446853 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:38,509,084...38,522,536
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PDK1 mRNA] CTD PMID:25446853 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
JBrowse link
G Pfkp phosphofructokinase, platelet multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein] CTD PMID:25446853 NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PKLR protein] CTD PMID:25446853 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions ISO [1-Deoxynojirimycin co-treated with Dietary Fats] results in increased expression of PPARGC1B mRNA CTD PMID:25445511 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466
JBrowse link
ginsenoside Rb1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein] CTD PMID:19781563 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1A mRNA] CTD PMID:34812491 NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1B2 mRNA] CTD PMID:34812491 NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of BMP2 mRNA]
ginsenoside Rb1 results in increased expression of BMP2 mRNA
CTD PMID:27470910 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760
JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein] CTD PMID:38373586 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] CTD PMID:19781563 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CLCN7 mRNA] CTD PMID:34812491 NCBI chr10:14,656,261...14,681,632
Ensembl chr10:14,656,245...14,681,631
JBrowse link
G Ctsb cathepsin B multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSB mRNA] CTD PMID:34812491 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
JBrowse link
G Ctsd cathepsin D multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSD mRNA] CTD PMID:34812491 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:22386813 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gsdmd gasdermin D multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein] CTD PMID:38373586 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
CTD PMID:19781563 PMID:25422538 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]
ginsenoside Rb1 results in increased expression of IGF1 mRNA
CTD PMID:27470910 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Il18 interleukin 18 multiple interactions EXP
ISO
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL18 protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL18 protein]
CTD PMID:38373586 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL1B protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL1B protein]
CTD PMID:38373586 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:17655881 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:17655881 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein] CTD PMID:17655881 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 increases expression ISO ginsenoside Rb1 results in increased expression of KCNE1 CTD PMID:24615935 NCBI chr11:45,066,875...45,080,024
Ensembl chr11:45,064,162...45,081,247
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ginsenoside Rb1 affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of LAMP1 mRNA] CTD PMID:34812491 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Chloroquine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein] CTD PMID:38373586 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]]; ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein] CTD PMID:38373586 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rb1 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:22386813 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; [ginsenoside Rb1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; ginsenoside Rb1 results in increased activity of and results in increased localization of NFE2L2 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
ginsenoside Rb1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
ginsenoside Rb1 results in increased expression of NFE2L2 mRNA
CTD PMID:19781563 PMID:22780686 PMID:25422538 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein] CTD PMID:38373586 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094
JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rb1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]] CTD PMID:38373586 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]] CTD PMID:38373586 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein] CTD PMID:22386813 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
EXP ginsenoside Rb1 results in increased expression of RUNX2 mRNA
ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of RUNX2 mRNA]
CTD PMID:27470910 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein CTD PMID:25297453 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO
EXP
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]
ginsenoside Rb1 results in decreased expression of SQSTM1 protein
CTD PMID:34812491 PMID:38373586 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO
EXP
[ginsenoside Rb1 co-treated with alpha-Chlorohydrin] affects the localization of TFEB protein; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of TFEB mRNA]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of and affects the localization of TFEB protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of and affects the localization of TFEB protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]
CTD PMID:34812491 PMID:38373586 NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of TGFB1 mRNA]
ginsenoside Rb1 results in increased expression of TGFB1 mRNA
CTD PMID:27470910 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA] CTD PMID:22386813 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]
ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein
CTD PMID:22386813 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
JBrowse link
indirubin-3'-monoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta affects expression ISO indirubin-3'-monoxime affects the expression of ACTB protein CTD PMID:18958680 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
ISO AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]
indirubin-3'-monoxime binds to and results in increased activity of AHR protein
indirubin-3'-monoxime binds to AHR protein
CTD PMID:15001395 PMID:21948866 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression
ISO Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of ALDH1A1 protein] CTD PMID:21948866 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO indirubin-3'-monoxime results in decreased expression of ALDH1A2 protein CTD PMID:21948866 NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240
JBrowse link
G Ar androgen receptor increases activity ISO indirubin-3'-monoxime analog results in increased activity of AR protein; indirubin-3'-monoxime results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO indirubin-3'-monoxime results in decreased expression of BAX mRNA CTD PMID:18958680 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BCL2L1 mRNA CTD PMID:18958680 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA CTD PMID:18958680 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Cat catalase multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CAT mRNA CTD PMID:18958680 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA CTD PMID:18958680 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
JBrowse link
G Cd40 CD40 molecule multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD40 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
indirubin-3'-monoxime results in decreased expression of CD40 protein
CTD PMID:21948866 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847
JBrowse link
G Cd80 Cd80 molecule increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of CD80 protein
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased expression of CD80 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]
CTD PMID:21948866 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540
JBrowse link
G Cd86 CD86 molecule multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] CTD PMID:21948866 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO indirubin-3'-monoxime results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CDKN1A mRNA CTD PMID:18958680 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 protein
indirubin-3'-monoxime results in increased expression of CYP1A1 mRNA
indirubin-3'-monoxime results in increased expression of CYP1A1 protein
CTD PMID:15001395 PMID:18958680 PMID:21948866 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO indirubin-3'-monoxime results in decreased expression of EPHX2 mRNA CTD PMID:18958680 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO indirubin-3'-monoxime results in decreased expression of GPX1 mRNA CTD PMID:18958680 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO indirubin-3'-monoxime results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO indirubin-3'-monoxime results in increased expression of GSR mRNA CTD PMID:18958680 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HMOX1 mRNA CTD PMID:18958680 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA2 mRNA CTD PMID:18958680 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133
JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA6 mRNA CTD PMID:18958680 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions
increases expression
ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA9 mRNA
indirubin-3'-monoxime results in increased expression of HSPA9 mRNA
CTD PMID:18958680 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of ICAM1 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
indirubin-3'-monoxime results in decreased expression of ICAM1 protein
CTD PMID:21948866 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of IDO1 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO1 protein]
CTD PMID:21948866 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of IDO2 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO2 protein]
CTD PMID:21948866 NCBI chr16:74,161,761...74,200,651
Ensembl chr16:74,161,774...74,200,650
JBrowse link
G Ifng interferon gamma decreases secretion ISO indirubin-3'-monoxime results in decreased secretion of IFNG protein CTD PMID:21948866 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases secretion
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased secretion of IL10 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
indirubin-3'-monoxime results in decreased secretion of IL10 protein
CTD PMID:21948866 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL1B protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:21948866 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il2 interleukin 2 increases secretion ISO indirubin-3'-monoxime results in increased secretion of IL2 protein CTD PMID:21948866 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il27 interleukin 27 decreases expression
multiple interactions
ISO indirubin-3'-monoxime results in decreased expression of IL27 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein]
CTD PMID:21948866 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of IL6 protein; [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL6 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21948866 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Itgax integrin subunit alpha X multiple interactions
decreases expression
ISO AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein] CTD PMID:21948866 NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression ISO indirubin-3'-monoxime analog results in increased expression of KLK3 mRNA; indirubin-3'-monoxime results in increased expression of KLK3 mRNA CTD PMID:21111724 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO indirubin-3'-monoxime results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA CTD PMID:18958680 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of NFKBIA mRNA CTD PMID:18958680 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein CTD PMID:18958680 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO indirubin-3'-monoxime results in decreased expression of RAD23A mRNA CTD PMID:18958680 NCBI chr19:40,219,235...40,225,543
Ensembl chr19:40,219,636...40,225,543
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased activity of RELA protein
indirubin-3'-monoxime results in decreased activity of RELA protein
CTD PMID:21948866 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA CTD PMID:18958680 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases activity ISO indirubin-3'-monoxime results in decreased activity of SGK1 protein CTD PMID:12534346 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOD2 mRNA CTD PMID:18958680 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of TGFB2 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB2 protein]
CTD PMID:21948866 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of TGFB3 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB3 protein]
CTD PMID:21948866 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of TNF protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21948866 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Ung uracil-DNA glycosylase increases expression ISO indirubin-3'-monoxime results in increased expression of UNG mRNA CTD PMID:18958680 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257
JBrowse link
lorcaserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO lorcaserin results in decreased expression of CCL2 mRNA CTD PMID:36687627 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ffar4 free fatty acid receptor 4 increases expression ISO lorcaserin results in increased expression of FFAR4 mRNA CTD PMID:36687627 NCBI chr 1:245,286,009...245,304,029
Ensembl chr 1:245,285,883...245,304,031
JBrowse link
G Il13 interleukin 13 increases expression ISO lorcaserin results in increased expression of IL13 mRNA CTD PMID:36687627 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO lorcaserin results in decreased expression of IL1B mRNA CTD PMID:36687627 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 decreases expression ISO lorcaserin results in decreased expression of IL6 mRNA CTD PMID:36687627 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases mutagenesis EXP lorcaserin results in increased mutagenesis of PIK3CA gene CTD PMID:38851877 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO lorcaserin results in decreased expression of TNF mRNA CTD PMID:36687627 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO UGT2B17 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO UGT2B7 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
JBrowse link
miglustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO miglustat inhibits the reaction [ST8SIA1 protein results in increased expression of BCL2 protein] CTD PMID:11574545 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Canx calnexin multiple interactions ISO miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form] CTD PMID:18230692 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat results in increased activity of CFTR protein mutant form]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]; miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO miglustat inhibits the reaction [[ST8SIA1 protein affects the abundance of Gangliosides] which results in decreased expression of PAWR protein] CTD PMID:11574545 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 multiple interactions ISO miglustat inhibits the reaction [[ST8SIA1 protein affects the abundance of Gangliosides] which results in decreased expression of PAWR protein]; miglustat inhibits the reaction [ST8SIA1 protein results in increased expression of BCL2 protein] CTD PMID:11574545 NCBI chr 4:177,513,966...177,651,553
Ensembl chr 4:177,520,926...177,651,553
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase multiple interactions ISO [miglustat results in decreased activity of UGCG protein] which results in decreased abundance of Gangliosides; [miglustat results in decreased activity of UGCG protein] which results in decreased abundance of Glucosylceramides CTD PMID:10037475 NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417
JBrowse link
nomilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx2 epoxide hydrolase 2 multiple interactions ISO nomilin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase decreases activity ISO orlistat results in decreased activity of ABHD12 protein CTD PMID:18657971 NCBI chr 3:160,119,724...160,179,959
Ensembl chr 3:160,119,724...160,179,969
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase decreases activity ISO orlistat results in decreased activity of ABHD16A protein CTD PMID:18657971 NCBI chr20:3,723,756...3,738,617
Ensembl chr20:3,723,757...3,738,736
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression
ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]
Orlistat results in decreased expression of ACACA mRNA
CTD PMID:32347045 PMID:33476690 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Orlistat results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Acot8 acyl-CoA thioesterase 8 decreases expression ISO Orlistat results in decreased expression of ACOT8 protein CTD PMID:30667213 NCBI chr 3:173,950,530...173,962,188
Ensembl chr 3:173,950,531...173,962,570
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP
ISO
orlistat inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]
CTD PMID:25087745 PMID:33476690 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion of Arachidonic Acid] CTD PMID:28721267 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO orlistat results in increased expression of ATF4 mRNA CTD PMID:17283163 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of BAX mRNA] CTD PMID:32450208 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] CTD PMID:32450208 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO
EXP
orlistat results in increased activity of CASP3 protein
orlistat results in increased cleavage of CASP3 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]
CTD PMID:17283163 PMID:20805790 PMID:21723078 PMID:32450208 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP
orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein; orlistat results in increased cleavage of and results in increased activity of CASP8 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA]
CTD PMID:18796435 PMID:20577697 PMID:32450208 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
orlistat results in increased activity of CASP9 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP9 mRNA]
CTD PMID:20805790 PMID:32450208 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP
ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT protein]
Orlistat results in decreased expression of CAT protein
CTD PMID:25087745 PMID:30667213 PMID:32450208 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cck cholecystokinin multiple interactions
decreases secretion
ISO [[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]
orlistat results in decreased secretion of CCK protein
CTD PMID:11408251 PMID:18303078 PMID:18647814 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Orlistat results in decreased expression of CCNA2 protein CTD PMID:30667213 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO Orlistat results in increased expression of CCND1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]
CTD PMID:30667213 PMID:32045588 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Orlistat results in increased expression of CCNE1 protein CTD PMID:30667213 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein] CTD PMID:32045588 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Orlistat results in decreased expression of CDK1 protein CTD PMID:30667213 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Orlistat results in decreased expression of CDK2 protein CTD PMID:30667213 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Orlistat results in decreased expression of CDK4 protein CTD PMID:30667213 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Orlistat results in increased expression of CDKN1A protein CTD PMID:30667213 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO orlistat results in increased expression of CDKN1B protein CTD PMID:15138278 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cel carboxyl ester lipase decreases activity ISO orlistat results in decreased activity of CEL protein CTD PMID:11592731 PMID:12381337 NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019
JBrowse link
G Clps colipase multiple interactions ISO orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil] CTD PMID:15158758 NCBI chr20:6,622,234...6,624,414
Ensembl chr20:6,622,231...6,624,505
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO orlistat results in decreased expression of CPB2 protein CTD PMID:16959692 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:56,966,839...57,015,962
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Orlistat results in decreased expression of CPT1A protein CTD PMID:30667213 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Orlistat results in decreased expression of CPT2 protein CTD PMID:30667213 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Orlistat results in increased expression of CYP3A4 mRNA; Orlistat results in increased expression of CYP3A4 protein CTD PMID:20599501 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Dagla diacylglycerol lipase, alpha decreases activity ISO orlistat results in decreased activity of DAGLA protein CTD PMID:16466961 NCBI chr 1:216,315,515...216,372,219
Ensembl chr 1:216,315,516...216,372,111
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO orlistat results in increased expression of DDIT3 mRNA CTD PMID:17283163 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO orlistat results in increased expression of DDIT4 mRNA CTD PMID:18796435 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
ISO orlistat results in increased phosphorylation of EIF2A protein
orlistat analog results in increased phosphorylation of EIF2A protein; orlistat results in increased phosphorylation of EIF2A protein
Cycloheximide inhibits the reaction [orlistat results in increased phosphorylation of EIF2A protein]
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
CTD PMID:17283163 PMID:20577697 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases response to substance
multiple interactions
ISO EIF2AK3 gene mutant form results in increased susceptibility to orlistat
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
CTD PMID:17283163 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation ISO orlistat results in increased phosphorylation of EIF4E protein CTD PMID:18796435 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance
decreases expression
affects localization
ISO ERBB2 protein affects the susceptibility to orlistat
orlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 protein
orlistat affects the localization of ERBB2 protein
CTD PMID:15870086 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G Etv4 ETS variant transcription factor 4 increases expression ISO orlistat results in increased expression of ETV4 protein CTD PMID:15870086 NCBI chr10:87,206,977...87,222,202
Ensembl chr10:87,206,977...87,222,318
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Orlistat results in decreased expression of FABP1 protein CTD PMID:30667213 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Orlistat results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Fasn fatty acid synthase affects binding
affects response to substance
multiple interactions
decreases activity
decreases expression
ISO orlistat analog binds to FASN protein
FASN protein affects the susceptibility to orlistat
[Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [Orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein; Orlistat binds to and results in decreased activity of FASN protein; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
orlistat analog results in decreased activity of FASN protein; orlistat results in decreased activity of FASN protein
[orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterified; orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]
Orlistat results in decreased expression of FASN protein
CTD PMID:15026345 PMID:15138278 PMID:15870086 PMID:17012255 PMID:17618296 More... NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Gcg glucagon multiple interactions
decreases expression
decreases secretion
ISO orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]
orlistat results in decreased expression of GCG protein
orlistat results in decreased secretion of GCG protein
CTD PMID:12915676 PMID:18647814 PMID:19837920 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO orlistat inhibits the reaction [Olive Oil results in decreased expression of GHRL protein]; orlistat inhibits the reaction [Triglycerides results in decreased secretion of GHRL protein] CTD PMID:15998659 PMID:17138722 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969
JBrowse link
G Gip gastric inhibitory polypeptide decreases expression ISO orlistat results in decreased expression of GIP protein CTD PMID:12915676 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA] CTD PMID:32450208 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gpx8 glutathione peroxidase 8 increases expression ISO orlistat results in increased expression of GPX8 mRNA CTD PMID:18796435 NCBI chr 2:46,409,646...46,413,401
Ensembl chr 2:46,409,139...46,413,406
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GSR protein] CTD PMID:32450208 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression ISO orlistat results in decreased expression of HBA1 protein modified form CTD PMID:19207292 PMID:19461584 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO orlistat results in increased expression of HSPA5 mRNA CTD PMID:17283163 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Il10 interleukin 10 increases expression EXP Orlistat results in increased expression of IL10 mRNA CTD PMID:32450208 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA] CTD PMID:32450208 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]
CTD PMID:21088047 PMID:32045588 PMID:32735172 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] CTD PMID:25087745 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Ins2 insulin 2 decreases expression
increases expression
affects expression
multiple interactions
ISO orlistat results in decreased expression of INS protein
orlistat results in increased expression of INS protein
orlistat affects the expression of INS protein
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]
CTD PMID:10095983 PMID:11274935 PMID:12915676 PMID:33476690 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression ISO orlistat results in increased expression of KDELR3 mRNA CTD PMID:18796435 NCBI chr 7:112,959,632...112,969,858
Ensembl chr 7:112,959,718...112,969,858
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO orlistat results in decreased expression of KDR protein CTD PMID:17012255 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Krt81 keratin 81 increases expression ISO orlistat results in increased expression of KRT81 mRNA CTD PMID:18796435 NCBI chr 7:134,455,840...134,460,971
Ensembl chr 7:134,455,842...134,460,967
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein] CTD PMID:25087745 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081
JBrowse link
G Lep leptin multiple interactions ISO
EXP
orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 PMID:25087745 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lipf lipase F, gastric type decreases activity ISO orlistat results in decreased activity of LIPF protein CTD PMID:11408251 PMID:12381337 NCBI chr 1:240,906,706...240,925,053
Ensembl chr 1:240,906,706...240,925,053
JBrowse link
G Lpl lipoprotein lipase decreases activity
multiple interactions
ISO
EXP
orlistat results in decreased activity of LPL protein
orlistat inhibits the reaction [Dietary Fats results in decreased expression of LPL protein]
orlistat inhibits the reaction [[LPL protein results in increased hydrolysis of Triglycerides] which results in increased uptake of Triglycerides]; orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]
[orlistat results in decreased activity of LPL protein] which affects the uptake of Triglycerides
CTD PMID:12388125 PMID:12573449 PMID:15910848 PMID:15994321 PMID:18698144 More... NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein] CTD PMID:32045588 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein] CTD PMID:32045588 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D decreases activity EXP orlistat results in decreased activity of NAPEPLD protein CTD PMID:16466961 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA
CTD PMID:32450208 PMID:33476690 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein] CTD PMID:32450208 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Npy neuropeptide Y increases expression ISO orlistat results in increased expression of NPY protein CTD PMID:15962606 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO orlistat results in increased activity of NR1I2 protein CTD PMID:20599501 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Orlistat binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Nts neurotensin multiple interactions ISO Orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]; Orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein
orlistat results in increased cleavage of PARP1 protein
CTD PMID:15870086 PMID:17283163 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein] CTD PMID:32045588 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
JBrowse link
G Pla2g7 phospholipase A2 group VII decreases activity
multiple interactions
ISO orlistat results in decreased activity of PLA2G7 protein
[orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein; [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein
CTD PMID:16911813 PMID:18513463 PMID:18657971 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747
JBrowse link
G Pnlip pancreatic lipase decreases secretion
decreases activity
multiple interactions
affects folding
ISO
EXP
orlistat results in decreased secretion of PNLIP protein
orlistat results in decreased activity of PNLIP protein
orlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]
orlistat affects the folding of PNLIP protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]
CTD PMID:11408251 PMID:11668201 PMID:12381337 PMID:15158758 PMID:19346257 NCBI chr 1:267,760,073...267,797,797
Ensembl chr 1:267,784,724...267,797,795
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases activity ISO
EXP
orlistat results in decreased activity of PNLIPRP2 protein
Orlistat results in decreased activity of PNLIPRP2 protein
CTD PMID:9822688 PMID:17401110 NCBI chr 1:267,883,906...267,902,572
Ensembl chr 1:267,883,906...267,902,572
JBrowse link
G Pon1 paraoxonase 1 increases activity ISO orlistat results in increased activity of PON1 protein CTD PMID:11820148 PMID:17134960 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA] CTD PMID:33476690 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Orlistat results in increased expression of PPARG mRNA CTD PMID:32347045 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO Orlistat results in decreased expression of PPT1 protein CTD PMID:30667213 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200
JBrowse link
G Ppy pancreatic polypeptide multiple interactions ISO orlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein] CTD PMID:15998659 NCBI chr10:87,554,941...87,556,236
Ensembl chr10:87,554,950...87,556,719
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP
ISO
orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]
orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
CTD PMID:18390901 PMID:19167487 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO Orlistat results in increased expression of PTEN protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]
CTD PMID:32045588 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein] CTD PMID:32045588 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Pyy peptide YY decreases secretion
multiple interactions
ISO orlistat results in decreased secretion of PYY protein
orlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]; orlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]
CTD PMID:15998659 PMID:17138722 PMID:18647814 NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO orlistat results in decreased phosphorylation of RB1 protein CTD PMID:15138278 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA] CTD PMID:32450208 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases expression ISO orlistat results in increased expression of SEC24D mRNA CTD PMID:18796435 NCBI chr 2:214,103,138...214,211,155
Ensembl chr 2:214,103,190...214,211,144
JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions
decreases expression
ISO [orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein
orlistat results in decreased expression of SKP2 protein
CTD PMID:15138278 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO orlistat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]
Orlistat results in decreased expression of SREBF1 protein
CTD PMID:32045588 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Tf transferrin multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA CTD PMID:33476690 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of TLR4 protein] CTD PMID:32735172 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF protein]
CTD PMID:15994321 PMID:32045588 PMID:32450208 PMID:32735172 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO orlistat results in increased susceptibility to TNFSF10 protein CTD PMID:18796435 PMID:21406729 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of TP53 mRNA] CTD PMID:32450208 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link
resolvin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21724996 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Ifng interferon gamma multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:21724996 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21724996 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; resolvin D2 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21724996 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
rimonabant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha affects expression ISO Rimonabant affects the expression of ACACA mRNA CTD PMID:20110567 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Acacb acetyl-CoA carboxylase beta increases expression ISO Rimonabant results in increased expression of ACACB mRNA CTD PMID:20110567 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain affects expression
multiple interactions
ISO Rimonabant affects the expression of ACADM mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ACADM mRNA]
CTD PMID:19030233 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ACBD5 mRNA] CTD PMID:19030233 NCBI chr17:90,114,250...90,156,286
Ensembl chr17:90,114,375...90,156,286
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Rimonabant results in decreased expression of ACTA2 mRNA CTD PMID:21863215 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Actr2 actin related protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ACTR2 mRNA] CTD PMID:19030233 NCBI chr14:98,500,119...98,535,092
Ensembl chr14:98,500,138...98,541,998
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ADAMTS1 mRNA] CTD PMID:19030233 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Rimonabant results in decreased expression of ADGRE1 mRNA CTD PMID:30365523 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Rimonabant results in increased expression of ADIPOQ mRNA; Rimonabant results in increased expression of ADIPOQ protein CTD PMID:16282221 PMID:20110567 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 multiple interactions
increases expression
ISO Rimonabant inhibits the reaction [MIR762 mRNA results in decreased expression of AGAP2 mRNA]; Rimonabant promotes the reaction [Dietary Fats results in increased expression of AGAP2 mRNA]
Rimonabant results in increased expression of AGAP2 mRNA
CTD PMID:30910812 NCBI chr 7:64,782,618...64,799,624
Ensembl chr 7:64,782,612...64,799,640
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
Rimonabant inhibits the reaction [Dronabinol results in decreased phosphorylation of AKT1 protein]
Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; Rimonabant inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]
CTD PMID:12834810 PMID:31917333 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alkbh1 alkB homolog 1, histone H2A dioxygenase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of ALKBH1 mRNA] CTD PMID:19030233 NCBI chr 6:112,799,234...112,819,708
Ensembl chr 6:112,799,234...112,819,708
JBrowse link
G Anxa1 annexin A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ANXA1 mRNA] CTD PMID:19030233 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831
JBrowse link
G Anxa2 annexin A2 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ANXA2 mRNA]
Rimonabant affects the expression of ANXA2 mRNA
CTD PMID:19030233 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631
JBrowse link
G Apob apolipoprotein B increases secretion ISO Rimonabant results in increased secretion of APOB protein CTD PMID:20110567 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814
JBrowse link
G App amyloid beta precursor protein affects expression
multiple interactions
ISO Rimonabant affects the expression of APP mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of APP mRNA]
CTD PMID:19030233 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Arg1 arginase 1 multiple interactions ISO Rimonabant promotes the reaction [Dietary Fats results in increased expression of ARG1] CTD PMID:30910812 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 affects expression
multiple interactions
ISO Rimonabant affects the expression of ARHGEF12 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ARHGEF12 mRNA]
CTD PMID:19030233 NCBI chr 8:52,247,047...52,373,158
Ensembl chr 8:52,247,047...52,372,376
JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ARPP19 mRNA] CTD PMID:19030233 NCBI chr 8:84,660,166...84,683,012
Ensembl chr 8:119,691,942...119,692,385
Ensembl chr 8:119,691,942...119,692,385
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR1 protein]]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR2 protein]] CTD PMID:27779402 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of ATF4 mRNA] CTD PMID:31054322 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of ATF6 mRNA] CTD PMID:31054322 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
JBrowse link
G Atp5me ATP synthase membrane subunit e multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of ATP5ME mRNA] CTD PMID:19030233 NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,464,800...1,465,988
JBrowse link
G Atrnl1 attractin like 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ATRNL1 mRNA] CTD PMID:19030233 NCBI chr 1:266,676,051...267,216,847
Ensembl chr 1:266,675,852...267,216,842
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Rimonabant results in decreased expression of AURKB protein CTD PMID:19479993 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]]
Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of BAX protein]
CTD PMID:27932991 PMID:30769029 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of BCL2 protein] CTD PMID:26967640 PMID:30769029 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA] CTD PMID:20929960 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of BRAF mRNA] CTD PMID:19030233 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of BZW1 mRNA] CTD PMID:19030233 NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684
JBrowse link
G C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of C1GALT1 mRNA] CTD PMID:19030233 NCBI chr 4:36,894,440...36,932,434
Ensembl chr 4:36,894,488...36,932,441
JBrowse link
G Cab39l calcium binding protein 39-like multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAB39L mRNA] CTD PMID:19030233 NCBI chr15:37,782,778...37,885,191
Ensembl chr15:37,782,870...37,919,742
JBrowse link
G Calm1 calmodulin 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CALM1 mRNA]
Rimonabant affects the expression of CALM1 mRNA
CTD PMID:19030233 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381
JBrowse link
G Canx calnexin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CANX mRNA] CTD PMID:19030233 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857
JBrowse link
G Capn7 calpain 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAPN7 mRNA] CTD PMID:19030233 NCBI chr16:6,552,048...6,588,317
Ensembl chr16:6,552,049...6,588,316
JBrowse link
G Cartpt CART prepropeptide multiple interactions
increases response to substance
affects expression
ISO FAAH affects the reaction [Rimonabant affects the expression of CARTPT protein]
CARTPT results in increased susceptibility to Rimonabant
CTD PMID:16131814 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of CASP1 protein] CTD PMID:27932991 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CASP12 mRNA] CTD PMID:19030233 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Rimonabant inhibits the reaction [XLR-11 results in increased activity of CASP3 protein]
Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased cleavage of CASP3 protein]]; Rimonabant inhibits the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased cleavage of and results in increased activity of CASP3 protein]]
CTD PMID:26209559 PMID:29410032 PMID:30769029 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cav1 caveolin 1 affects expression
multiple interactions
ISO Rimonabant affects the expression of CAV1 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAV1 mRNA]
CTD PMID:19030233 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
JBrowse link
G Cav2 caveolin 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAV2 mRNA] CTD PMID:19030233 NCBI chr 4:46,582,681...46,590,058
Ensembl chr 4:46,582,096...46,591,425
JBrowse link
G Cavin1 caveolae associated protein 1 affects expression ISO Rimonabant affects the expression of CAVIN1 mRNA CTD PMID:19030233 NCBI chr10:86,384,401...86,398,240
Ensembl chr10:86,384,401...86,396,383
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CCAR1 mRNA] CTD PMID:19030233 NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2]
Rimonabant results in decreased expression of CCL2 mRNA
CTD PMID:30365523 PMID:32832534 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL3] CTD PMID:32832534 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Rimonabant results in increased expression of CCNB1 protein CTD PMID:19479993 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Rimonabant results in decreased expression of CCND1 protein CTD PMID:16822929 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of CCND2 protein] CTD PMID:26967640 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CCNG1 mRNA] CTD PMID:19030233 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766
JBrowse link
G Ccpg1 cell cycle progression 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CCPG1 mRNA] CTD PMID:19030233 NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:82,600,536...82,660,246
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Rimonabant co-treated with MIR762 mRNA] affects the expression of CCR7 mRNA CTD PMID:30910812 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501
JBrowse link
G Cd36 CD36 molecule affects expression
multiple interactions
ISO Rimonabant affects the expression of CD36 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CD36 mRNA]
CTD PMID:19030233 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cdc73 cell division cycle 73 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CDC73 mRNA] CTD PMID:19030233 NCBI chr13:57,897,924...58,000,031
Ensembl chr13:57,883,983...57,999,978
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions ISO Rimonabant inhibits the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein]; Rimonabant inhibits the reaction [Ethanol results in increased activity of CDK5 protein] CTD PMID:30143782 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO Rimonabant inhibits the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein] CTD PMID:30143782 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272
JBrowse link
G Cdkl2 cyclin dependent kinase like 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CDKL2 mRNA] CTD PMID:19030233 NCBI chr14:16,312,154...16,347,524
Ensembl chr14:16,312,932...16,347,523
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Rimonabant results in increased expression of CDKN1B protein CTD PMID:16822929 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Rimonabant inhibits the reaction [butylparaben results in increased expression of CEBPA mRNA] CTD PMID:27659731 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of CEBPD mRNA] CTD PMID:19030233 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CHD9 mRNA] CTD PMID:19030233 NCBI chr19:32,114,379...32,337,488
Ensembl chr19:32,115,920...32,319,042
JBrowse link
G Chek1 checkpoint kinase 1 decreases phosphorylation ISO Rimonabant results in decreased phosphorylation of CHEK1 protein CTD PMID:19479993 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359
JBrowse link
G Clic4 chloride intracellular channel 4 affects expression
multiple interactions
ISO Rimonabant affects the expression of CLIC4 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CLIC4 mRNA]
CTD PMID:19030233 NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118
JBrowse link
G Cltc clathrin heavy chain multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CLTC mRNA] CTD PMID:19030233 NCBI chr10:72,014,984...72,073,308
Ensembl chr10:72,014,986...72,070,691
JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CNOT1 mRNA] CTD PMID:19030233 NCBI chr19:9,261,290...9,352,636
Ensembl chr19:9,261,294...9,352,636
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of CNP protein] CTD PMID:32956517 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity
affects localization
affects binding
decreases expression
ISO
EXP
1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea analog inhibits the reaction [Rimonabant binds to CNR1 protein]; 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea inhibits the reaction [Rimonabant binds to CNR1 protein]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Rimonabant binds to CNR1 protein]; 5F-CUMYL-PICA inhibits the reaction [Rimonabant binds to CNR1 protein]; AM 6527 inhibits the reaction [Rimonabant binds to CNR1 protein]; arachidonyl dopamine inhibits the reaction [Rimonabant binds to CNR1 protein]; Dronabinol inhibits the reaction [Rimonabant binds to CNR1 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate analog inhibits the reaction [Rimonabant binds to CNR1 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate inhibits the reaction [Rimonabant binds to CNR1 protein]; N'-((3Z)-1-(1-hexyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide affects the reaction [Rimonabant binds to CNR1 protein]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [Rimonabant binds to CNR1 protein]; Rimonabant binds to and results in decreased activity of CNR1 protein; Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased activity of CNR1]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR1 protein]]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole results in increased activity of CNR1 protein]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP]; Rimonabant inhibits the reaction [anandamide results in increased activity of CNR1]; Rimonabant inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]; Rimonabant inhibits the reaction [HU 211 results in increased activity of CNR1]
Rimonabant results in decreased activity of CNR1 protein
Rimonabant affects the localization of CNR1 protein
Rimonabant results in decreased expression of CNR1 mRNA
[Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; [Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog; Cannabidiol inhibits the reaction [Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]]; Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]; Rimonabant binds to and results in decreased activity of CNR1 protein; Rimonabant inhibits the reaction [1-(5-fluoropentyl)-3-(1-naphthoyl)indole analog binds to CNR1 protein]; Rimonabant inhibits the reaction [1-(5-fluoropentyl)-3-(1-naphthoyl)indole binds to CNR1 protein]; Rimonabant inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of CNR1 protein]
6-methyl-3-(2-nitro-1-(thiophen-2-yl)propyl)-2-phenyl-1H-indole inhibits the reaction [Rimonabant binds to CNR1 protein]; [Rimonabant binds to and results in decreased activity of CNR1 protein] which affects the expression of FOS protein; [Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine; Rimonabant binds to and results in decreased activity of CNR1 protein; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CNR1 mRNA]; Rimonabant inhibits the reaction [5F-ADB cannabinoid binds to and results in increased activity of CNR1 protein]; Rimonabant inhibits the reaction [5F-ADB cannabinoid metabolite binds to and results in increased activity of CNR1 protein]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; Rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; Rimonabant inhibits the reaction [HU 211 binds to and results in increased activity of CNR1 protein]
CTD PMID:10027878 PMID:10422789 PMID:10871313 PMID:11517236 PMID:11558437 More... NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR2 protein]]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole results in increased activity of CNR2 protein] CTD PMID:27779402 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Rimonabant results in decreased expression of COL1A1 mRNA CTD PMID:21863215 PMID:30365523 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Copg2 COPI coat complex subunit gamma 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of COPG2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of COPG2 mRNA]
CTD PMID:19030233 NCBI chr 4:60,333,455...60,468,953
Ensembl chr 4:60,333,455...60,469,145
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Rimonabant results in increased expression of CPT1A mRNA CTD PMID:30365523 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of CREB1 protein]
Rimonabant inhibits the reaction [Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein]
CTD PMID:15913574 PMID:19912468 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CREB3L2 mRNA] CTD PMID:19030233 NCBI chr 4:66,874,623...66,990,962
Ensembl chr 4:66,387,126...66,990,832
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Rimonabant results in decreased expression of CRH mRNA
Dronabinol affects the reaction [Rimonabant results in decreased expression of CRH mRNA]; Rimonabant inhibits the reaction [HU 211 results in decreased expression of CRH mRNA]
CTD PMID:12968131 PMID:15099659 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Csde1 cold shock domain containing E1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CSDE1 mRNA] CTD PMID:19030233 NCBI chr 2:193,234,546...193,271,301
Ensembl chr 2:193,243,526...193,271,301
JBrowse link
G Cul1 cullin 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CUL1 mRNA] CTD PMID:19030233 NCBI chr 4:77,551,781...77,634,210
Ensembl chr 4:77,551,787...77,621,760
JBrowse link
G Cul3 cullin 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CUL3 mRNA] CTD PMID:19030233 NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CXADR mRNA] CTD PMID:19030233 NCBI chr11:30,469,778...30,516,990
Ensembl chr11:30,469,526...30,516,988
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CXCL10] CTD PMID:32832534 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CXCL1] CTD PMID:32832534 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CYP4V3 mRNA] CTD PMID:19030233 NCBI chr16:53,650,978...53,675,916
Ensembl chr16:53,650,569...53,676,746
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of DDIT3 mRNA] CTD PMID:31054322 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Ddx27 DEAD-box helicase 27 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of DDX27 mRNA] CTD PMID:19030233 NCBI chr 3:176,163,220...176,182,418
Ensembl chr 3:176,163,203...176,182,410
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DDX3X mRNA] CTD PMID:19030233 NCBI chr  X:12,152,346...12,165,983
Ensembl chr  X:12,152,346...12,165,983
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DNAJC10 mRNA] CTD PMID:19030233 NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DPP4 mRNA] CTD PMID:19030233 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422
JBrowse link
G Dr1 down-regulator of transcription 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DR1 mRNA] CTD PMID:19030233 NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,603,204...1,614,556
JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DYNC1I2 mRNA] CTD PMID:19030233 NCBI chr 3:76,441,621...76,492,782
Ensembl chr 3:76,424,469...76,492,782
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EDEM1 mRNA] CTD PMID:19030233 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060
JBrowse link
G Efna5 ephrin A5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EFNA5 mRNA] CTD PMID:19030233 NCBI chr 9:109,763,786...110,042,396
Ensembl chr 9:109,767,252...110,042,348
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 multiple interactions ISO Rimonabant inhibits the reaction [Ethanol promotes the reaction [EHMT2 protein binds to RAC1 promoter]] CTD PMID:30143782 NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,924,263...3,941,384
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EIF4G2 mRNA] CTD PMID:19030233 NCBI chr 1:174,616,102...174,628,252
Ensembl chr 1:174,616,103...174,628,252
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EIF5 mRNA] CTD PMID:19030233 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ELL2 mRNA] CTD PMID:19030233 NCBI chr 2:6,910,446...6,990,654
Ensembl chr 2:6,921,771...7,016,199
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EPS15 mRNA] CTD PMID:19030233 NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:129,274,502...129,374,856
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ERMP1 mRNA] CTD PMID:19030233 NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:236,801,466...236,839,197
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions EXP
ISO
[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Rimonabant] affects the expression of FAAH mRNA
FAAH affects the reaction [Rimonabant affects the expression of CARTPT protein]; Rimonabant inhibits the reaction [FAAH gene mutant form results in increased susceptibility to anandamide]
CTD PMID:16131814 PMID:27385208 PMID:32833042 NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396
JBrowse link
G Fam199x family with sequence similarity 199, X-linked multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FAM199X mRNA] CTD PMID:19030233 NCBI chr  X:105,176,504...105,212,207
Ensembl chr  X:105,176,504...105,212,207
JBrowse link
G Far1 fatty acyl CoA reductase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FAR1 mRNA] CTD PMID:19030233 NCBI chr 1:177,078,973...177,140,363
Ensembl chr 1:177,079,150...177,161,696
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of FASN mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of FASN mRNA]
CTD PMID:19030233 PMID:20110567 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fbxl5 F-box and leucine-rich repeat protein 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FBXL5 mRNA] CTD PMID:19030233 NCBI chr14:71,517,452...71,559,850
Ensembl chr14:71,480,270...71,560,652
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of FBXW7 mRNA] CTD PMID:19030233 NCBI chr 2:172,447,738...172,609,591
Ensembl chr 2:172,447,738...172,609,591
JBrowse link
G Fem1a fem-1 homolog A multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of FEM1A mRNA] CTD PMID:19030233 NCBI chr 9:1,178,857...1,181,063
Ensembl chr 9:1,177,543...1,188,006
JBrowse link
G Fermt2 FERM domain containing kindlin 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FERMT2 mRNA] CTD PMID:19030233 NCBI chr15:21,162,603...21,257,995
Ensembl chr15:21,162,605...21,258,115
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]
Rimonabant affects the expression of FGF1 mRNA
CTD PMID:19030233 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FMR1 mRNA] CTD PMID:19030233 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:152,284,841...152,322,675
JBrowse link
G Fndc3b fibronectin type III domain containing 3B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FNDC3B mRNA] CTD PMID:19030233 NCBI chr 2:112,240,108...112,546,113
Ensembl chr 2:112,243,202...112,546,306
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOS protein]
[Rimonabant binds to and results in decreased activity of CNR1 protein] which affects the expression of FOS protein; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
CTD PMID:9751146 PMID:12560108 PMID:15280883 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSB protein] CTD PMID:9751146 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSL1 protein] CTD PMID:9751146 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSL2 protein] CTD PMID:9751146 NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406
JBrowse link
G Frmd4b FERM domain containing 4B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FRMD4B mRNA] CTD PMID:19030233 NCBI chr 4:131,452,361...131,778,734
Ensembl chr 4:131,452,365...131,640,287
JBrowse link
G G6pc3 glucose 6 phosphatase catalytic subunit 3 increases expression ISO Rimonabant results in increased expression of G6PC3 mRNA CTD PMID:20110567 NCBI chr10:87,647,149...87,651,385
Ensembl chr10:87,647,062...87,653,453
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Rimonabant results in increased expression of GAPDH mRNA CTD PMID:16282221 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of GFAP protein
Rimonabant inhibits the reaction [Dronabinol results in increased expression of GFAP mRNA]
CTD PMID:21373835 PMID:36529297 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GGPS1 mRNA] CTD PMID:19030233 NCBI chr17:55,958,750...55,982,762
Ensembl chr17:55,958,755...55,971,709
JBrowse link
G Gls glutaminase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GLS mRNA] CTD PMID:19030233 NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GMFB mRNA] CTD PMID:19030233 NCBI chr15:22,549,705...22,560,125
Ensembl chr15:22,547,034...22,560,308
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 decreases expression ISO Rimonabant results in decreased expression of GPLD1 mRNA CTD PMID:20110567 NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975
JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions ISO Rimonabant binds to and results in increased activity of GPR55 protein CTD PMID:17876302 NCBI chr 9:94,037,748...94,081,426
Ensembl chr 9:94,036,162...94,088,707
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases expression EXP
ISO
Rimonabant results in decreased expression of GPT protein CTD PMID:28705172 PMID:30365523 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression
multiple interactions
ISO Rimonabant affects the expression of GRB14 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GRB14 mRNA]
CTD PMID:19030233 NCBI chr 3:69,976,331...70,091,921
Ensembl chr 3:69,976,339...70,091,921
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIA1]
Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIA1 mRNA]
CTD PMID:19912468 PMID:29230395 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2A] CTD PMID:19912468 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2B] CTD PMID:19912468 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP Rimonabant results in increased expression of GSTA1 mRNA CTD PMID:30365523 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
JBrowse link
G Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 affects expression ISO Rimonabant affects the expression of HDHD2 mRNA CTD PMID:19030233 NCBI chr18:72,763,313...72,801,679
Ensembl chr18:72,749,976...72,801,679
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HIF1A mRNA] CTD PMID:19030233 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HIPK3 mRNA] CTD PMID:19030233 NCBI chr 3:111,251,863...111,322,815
Ensembl chr 3:111,251,863...111,322,772
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Rimonabant results in increased expression of HMOX1 mRNA; Rimonabant results in increased expression of HMOX1 protein CTD PMID:30365523 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases activity ISO Rimonabant results in decreased activity of HNF4A protein CTD PMID:31981244 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HSP90AA1 mRNA] CTD PMID:19030233 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of HSPA5 mRNA] CTD PMID:31054322 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Hycc2 hyccin PI4KA lipid kinase complex subunit 2 affects expression ISO Rimonabant affects the expression of HYCC2 mRNA CTD PMID:19030233 NCBI chr 9:67,551,064...67,623,353
Ensembl chr 9:67,551,064...67,587,186
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of ICAM1 protein
Rimonabant inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
CTD PMID:21373835 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Ifng interferon gamma multiple interactions EXP Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in decreased expression of NOS2 mRNA]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:11520904 PMID:11727767 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IGF1 mRNA] CTD PMID:19030233 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 affects expression
multiple interactions
ISO Rimonabant affects the expression of IGFBP5 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IGFBP5 mRNA]
CTD PMID:19030233 NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]] CTD PMID:32385136 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of IL12RB2 mRNA] CTD PMID:14741435 PMID:18792785 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of IL18 protein] CTD PMID:27932991 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [OMDM-1 cpd inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL1B]; Rimonabant inhibits the reaction [OMDM-1 cpd inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Rimonabant promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15748152 PMID:32832534 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL6] CTD PMID:32832534 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions
decreases expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of INS1 protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of INS1 protein]
Rimonabant results in decreased expression of INS1 protein
CTD PMID:19030233 PMID:26563389 PMID:26967640 PMID:30910812 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Ins2 insulin 2 decreases expression ISO Rimonabant results in decreased expression of INS protein CTD PMID:20110567 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IQGAP1 mRNA]
Rimonabant affects the expression of IQGAP1 mRNA
CTD PMID:19030233 NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:144,088,793...144,179,043
JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IRF5] CTD PMID:32832534 NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552
JBrowse link
G Itgam integrin subunit alpha M decreases expression EXP Rimonabant results in decreased expression of ITGAM mRNA CTD PMID:30365523 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITGAV mRNA] CTD PMID:19030233 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITGB1 mRNA] CTD PMID:19030233 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITPR2 mRNA] CTD PMID:19030233 NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:180,760,442...181,164,763
JBrowse link
G Ivns1abp influenza virus NS1A binding protein multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IVNS1ABP mRNA] CTD PMID:19030233 NCBI chr13:65,977,069...65,996,685
Ensembl chr13:65,977,045...65,997,547
JBrowse link
G Kif5b kinesin family member 5B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KIF5B mRNA] CTD PMID:19030233 NCBI chr17:56,185,386...56,222,990
Ensembl chr17:56,185,380...56,223,008
JBrowse link
G Klf4 KLF transcription factor 4 increases expression
multiple interactions
ISO Rimonabant results in increased expression of KLF4 mRNA
MIR466J mRNA affects the reaction [Rimonabant results in increased expression of KLF4 mRNA]; Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of KLF4 mRNA]
CTD PMID:30910812 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592
JBrowse link
G Klf6 KLF transcription factor 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KLF6 mRNA] CTD PMID:19030233 NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601
JBrowse link
G Klhl9 kelch-like family member 9 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KLHL9 mRNA] CTD PMID:19030233 NCBI chr 5:108,449,492...108,453,676
Ensembl chr 5:108,437,583...108,454,140
JBrowse link
G Kpna3 karyopherin subunit alpha 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KPNA3 mRNA] CTD PMID:19030233 NCBI chr15:39,712,375...39,786,127
Ensembl chr15:39,712,381...39,786,319
JBrowse link
G Kpnb1 karyopherin subunit beta 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KPNB1 mRNA] CTD PMID:19030233 NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,642,082...82,670,856
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LAMP2 mRNA] CTD PMID:19030233 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LARGE1 mRNA]
Rimonabant affects the expression of LARGE1 mRNA
CTD PMID:19030233 NCBI chr19:11,609,004...12,057,174
Ensembl chr19:11,609,004...12,054,707
JBrowse link
G Lep leptin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of BCL2 protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of CCND2 protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of INS1 protein] CTD PMID:19030233 PMID:26967640 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in decreased expression of LHB protein] CTD PMID:9825732 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lipc lipase C, hepatic type increases expression ISO Rimonabant results in increased expression of LIPC mRNA CTD PMID:20110567 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285
JBrowse link
G Lipe lipase E, hormone sensitive type affects expression ISO Rimonabant affects the expression of LIPE mRNA CTD PMID:20110567 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117
JBrowse link
G Lmo1 LIM domain only 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LMO1 mRNA] CTD PMID:19030233 NCBI chr 1:172,567,156...172,603,282
Ensembl chr 1:172,567,156...172,603,157
JBrowse link
G Lpgat1 lysophosphatidylglycerol acyltransferase 1 affects expression ISO Rimonabant affects the expression of LPGAT1 mRNA CTD PMID:19030233 NCBI chr13:105,825,630...105,896,366
Ensembl chr13:105,820,468...105,896,364
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LRRFIP1 mRNA] CTD PMID:19030233 NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:99,039,614...99,167,779
JBrowse link
G Mag myelin-associated glycoprotein multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of MAG protein] CTD PMID:32956517 NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:95,275,635...95,291,060
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Rimonabant results in increased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:31570772 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects localization
decreases activity
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]
Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in decreased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in decreased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Rimonabant affects the localization of MAPK1 protein
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]
Rimonabant results in decreased activity of MAPK1 protein
CTD PMID:8526880 PMID:11553284 PMID:12657697 PMID:12834810 PMID:16282221 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
affects localization
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]
Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in decreased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in decreased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Rimonabant results in decreased activity of MAPK3 protein
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]
Rimonabant affects the localization of MAPK3 protein
CTD PMID:8526880 PMID:11553284 PMID:12657697 PMID:12834810 PMID:16282221 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein] CTD PMID:18950629 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MARCHF6 mRNA] CTD PMID:19030233 NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MBNL1 mRNA] CTD PMID:19030233 NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MBNL2 mRNA] CTD PMID:19030233 NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827
JBrowse link
G Mbp myelin basic protein multiple interactions EXP Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased expression of MBP protein] CTD PMID:17880390 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of MEF2C mRNA] CTD PMID:36529297 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640
JBrowse link
G Mest mesoderm specific transcript affects expression
multiple interactions
ISO Rimonabant affects the expression of MEST mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
CTD PMID:19030233 NCBI chr 4:60,321,814...60,332,288
Ensembl chr 4:60,316,102...60,333,509
JBrowse link
G Mgll monoglyceride lipase affects response to substance ISO MGLL protein affects the susceptibility to Rimonabant CTD PMID:21911610 NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440
JBrowse link
G Mir16-2 microRNA 16-2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of MIR16-2 mRNA] CTD PMID:19030233 NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO Rimonabant inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein] CTD PMID:31220554 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression EXP Rimonabant results in decreased expression of MMP13 mRNA CTD PMID:21863215 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
JBrowse link
G Mog myelin oligodendrocyte glycoprotein multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of MOG protein] CTD PMID:32956517 NCBI chr20:1,514,110...1,528,716 JBrowse link
G Mospd1 motile sperm domain containing 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MOSPD1 mRNA] CTD PMID:19030233 NCBI chr  X:138,019,719...138,047,475
Ensembl chr14:86,500,797...86,503,187
Ensembl chr  X:86,500,797...86,503,187
JBrowse link
G Mycbp2 MYC binding protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MYCBP2 mRNA] CTD PMID:19030233 NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NAP1L1 mRNA] CTD PMID:19030233 NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:48,819,477...48,844,104
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions EXP [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Rimonabant] affects the expression of NAPEPLD mRNA CTD PMID:32833042 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014
JBrowse link
G Ncl nucleolin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NCL mRNA] CTD PMID:19030233 NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083
JBrowse link
G Ndc1 NDC1 transmembrane nucleoporin affects expression ISO Rimonabant affects the expression of NDC1 mRNA CTD PMID:19030233 NCBI chr 5:127,384,172...127,431,093
Ensembl chr 5:127,384,665...127,431,090
JBrowse link
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFB11 mRNA] CTD PMID:19030233 NCBI chr  X:4,126,317...4,128,575
Ensembl chr  X:4,126,245...4,128,566
JBrowse link
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFB9 mRNA]
Rimonabant affects the expression of NDUFB9 mRNA
CTD PMID:19030233 NCBI chr 7:92,370,423...92,376,841
Ensembl chr 7:92,370,467...92,379,955
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFS8 mRNA] CTD PMID:19030233 NCBI chr 1:210,569,823...210,573,707
Ensembl chr 1:210,569,824...210,572,971
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NEDD4 mRNA] CTD PMID:19030233 NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633
JBrowse link
G Nek7 NIMA-related kinase 7 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NEK7 mRNA]
Rimonabant affects the expression of NEK7 mRNA
CTD PMID:19030233 NCBI chr13:52,573,730...52,700,869
Ensembl chr13:52,573,730...52,700,823
JBrowse link
G Nes nestin multiple interactions ISO [Rimonabant co-treated with Dronabinol] results in increased expression of NES mRNA CTD PMID:36529297 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NFATC3 mRNA] CTD PMID:19030233 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Rimonabant results in increased expression of NFE2L2 mRNA CTD PMID:30365523 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nid1 nidogen 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NID1 mRNA]
Rimonabant affects the expression of NID1 mRNA
CTD PMID:19030233 NCBI chr17:93,069,013...93,142,416
Ensembl chr17:93,069,278...93,142,386
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of NLRP3]
Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of NLRP3 protein]
CTD PMID:27932991 PMID:32832534 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[Rimonabant co-treated with SR 144528] inhibits the reaction [OMDM-1 cpd inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NOS2]; Rimonabant promotes the reaction [PF 3845 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Rimonabant inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in decreased expression of NOS2 mRNA]
CTD PMID:11520904 PMID:15748152 PMID:30910812 PMID:31121907 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Npr3 natriuretic peptide receptor 3 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NPR3 mRNA]
Rimonabant affects the expression of NPR3 mRNA
CTD PMID:19030233 NCBI chr 2:62,592,557...62,660,497
Ensembl chr 2:62,597,668...62,660,066
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Rimonabant results in increased expression of NQO1 mRNA; Rimonabant results in increased expression of NQO1 protein CTD PMID:30365523 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NR3C1 mRNA] CTD PMID:19030233 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Ntn1 netrin 1 multiple interactions
decreases expression
ISO Rimonabant affects the reaction [Dietary Fats affects the expression of NTN1 protein]; Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NTN1 mRNA]; Rimonabant inhibits the reaction [MIR762 mRNA results in increased expression of NTN1 mRNA]
Rimonabant results in decreased expression of NTN1 mRNA
CTD PMID:30910812 NCBI chr10:53,398,852...53,597,595
Ensembl chr10:53,398,852...53,584,060
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of OPA1 mRNA] CTD PMID:19030233 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 affects expression
multiple interactions
ISO Rimonabant affects the expression of OSBPL8 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of OSBPL8 mRNA]
CTD PMID:19030233 NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151
JBrowse link
G Pakap paralemmin A kinase anchor protein multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PAKAP mRNA]
Rimonabant affects the expression of PAKAP mRNA
CTD PMID:19030233 NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Rimonabant results in decreased expression of PARP1 protein CTD PMID:19479993 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PCX mRNA] CTD PMID:19030233 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Rimonabant results in increased expression of PCK1 mRNA CTD PMID:20110567 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PCYOX1 mRNA]
Rimonabant affects the expression of PCYOX1 mRNA
CTD PMID:19030233 NCBI chr 4:120,389,545...120,400,382
Ensembl chr 4:120,388,180...120,400,382
JBrowse link
G Phip pleckstrin homology domain interacting protein multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PHIP mRNA] CTD PMID:19030233 NCBI chr 8:92,656,890...92,771,098
Ensembl chr 8:92,656,890...92,771,021
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression
multiple interactions
ISO Rimonabant affects the expression of PIK3CA mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PIK3CA mRNA]
CTD PMID:19030233 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
JBrowse link
G Plac8 placenta associated 8 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PLAC8 mRNA] CTD PMID:19030233 NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PLEKHA1 mRNA] CTD PMID:19030233 NCBI chr 1:194,858,239...194,909,418
Ensembl chr 1:194,851,547...194,909,413
JBrowse link
G Plin2 perilipin 2 decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of PLIN2 protein
Rimonabant inhibits the reaction [Oleic Acid results in increased expression of PLIN2 protein]
CTD PMID:31570772 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878
JBrowse link
G Pmm1 phosphomannomutase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PMM1 mRNA] CTD PMID:19030233 NCBI chr 7:115,346,767...115,357,137
Ensembl chr 7:115,346,771...115,357,024
JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of POLD2 mRNA] CTD PMID:19030233 NCBI chr14:84,962,933...84,969,148
Ensembl chr14:84,962,022...84,967,874
JBrowse link
G Polr2j RNA polymerase II subunit J multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of POLR2J mRNA] CTD PMID:19030233 NCBI chr12:26,179,649...26,185,201
Ensembl chr12:26,179,649...26,185,201
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Rimonabant results in increased expression of PPARA mRNA CTD PMID:30365523 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Rimonabant affects the expression of PPARG mRNA CTD PMID:20110567 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppfibp1 PPFIA binding protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PPFIBP1 mRNA] CTD PMID:19030233 NCBI chr 4:181,538,249...181,682,079
Ensembl chr 4:181,539,450...181,682,076
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PPP1CB mRNA] CTD PMID:19030233 NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PPP3CA mRNA] CTD PMID:19030233 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554
JBrowse link
G Prkd3 protein kinase D3 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRKD3 mRNA]
Rimonabant affects the expression of PRKD3 mRNA
CTD PMID:19030233 NCBI chr 6:21,784,665...21,860,600
Ensembl chr 6:21,784,673...21,860,600
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance
multiple interactions
ISO
EXP
PRKN results in decreased susceptibility to Rimonabant
Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein]
CTD PMID:15882845 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO
EXP
Rimonabant inhibits the reaction [Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]]
Dronabinol affects the reaction [Rimonabant results in increased expression of PRL protein]; Rimonabant inhibits the reaction [Dronabinol results in decreased expression of PRL protein]
CTD PMID:9825732 PMID:15099659 PMID:31154070 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Prpf40a pre-mRNA processing factor 40 homolog A multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRPF40A mRNA] CTD PMID:19030233 NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 affects expression
multiple interactions
ISO Rimonabant affects the expression of PRPS1 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRPS1 mRNA]
CTD PMID:19030233 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:108,920,651...108,942,711
JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PTBP3 mRNA] CTD PMID:19030233 NCBI chr 5:79,108,376...79,194,533
Ensembl chr 5:79,108,376...79,194,508
JBrowse link
G Pten phosphatase and tensin homolog affects expression
multiple interactions
EXP Rimonabant affects the expression of PTEN mRNA
[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Rimonabant] affects the expression of PTEN mRNA
CTD PMID:32833042 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PTGES2 mRNA] CTD PMID:19030233 NCBI chr 3:36,088,246...36,095,430
Ensembl chr 3:36,088,246...36,097,694
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PTGS2 protein]]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; Rimonabant inhibits the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]] CTD PMID:26209559 PMID:30769029 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PTP4A1 mRNA] CTD PMID:19030233 NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176
JBrowse link
G Pyy peptide YY multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PYY mRNA] CTD PMID:19030233 NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Rimonabant inhibits the reaction [Ethanol promotes the reaction [EHMT2 protein binds to RAC1 promoter]]; Rimonabant inhibits the reaction [Ethanol results in decreased expression of RAC1 protein] CTD PMID:30143782 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased localization of RAF1 protein]; Rimonabant inhibits the reaction [methanandamide results in increased localization of RAF1 protein] CTD PMID:12834810 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
JBrowse link
G Ramp2 receptor activity modifying protein 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of RAMP2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RAMP2 mRNA]
CTD PMID:19030233 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,688,703...86,691,231
JBrowse link
G Rbms1 RNA binding motif, single stranded interacting protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RBMS1 mRNA] CTD PMID:19030233 NCBI chr 3:65,604,475...65,829,072
Ensembl chr 3:65,606,358...65,829,013
JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO rimonabant decreases expression of Rbp4 mRNA and protein in adipose tissue, aortic tissue and adipocytes RGD PMID:21585349 RGD:329853312 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RBPJ mRNA] CTD PMID:19030233 NCBI chr14:61,551,366...61,736,220
Ensembl chr14:61,551,366...61,736,307
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO Rimonabant inhibits the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]
Rimonabant results in decreased expression of RELA protein
CTD PMID:21373835 PMID:26209559 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RFNG mRNA]
Rimonabant affects the expression of RFNG mRNA
CTD PMID:19030233 NCBI chr10:106,545,543...106,548,644
Ensembl chr10:106,545,543...106,548,644
JBrowse link
G Rgs11 regulator of G-protein signaling 11 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RGS11 mRNA] CTD PMID:19030233 NCBI chr10:15,727,279...15,735,536
Ensembl chr10:15,727,279...15,735,536
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein] CTD PMID:31220554 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK3 protein] CTD PMID:31220554 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025
JBrowse link
G Rnf141 ring finger protein 141 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF141 mRNA] CTD PMID:19030233 NCBI chr 1:174,365,789...174,391,848 JBrowse link
G Rnf185 ring finger protein 185 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RNF185 mRNA] CTD PMID:19030233 NCBI chr14:82,516,153...82,554,199
Ensembl chr14:82,516,154...82,553,466
JBrowse link
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF19A mRNA] CTD PMID:19030233 NCBI chr 7:69,310,947...69,350,567
Ensembl chr 7:69,310,947...69,350,225
JBrowse link
G Rnf2 ring finger protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF2 mRNA] CTD PMID:19030233 NCBI chr13:66,103,943...66,136,038
Ensembl chr13:66,083,653...66,133,161
JBrowse link
G Rnf6 ring finger protein 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF6 mRNA] CTD PMID:19030233 NCBI chr12:13,929,160...13,940,663
Ensembl chr12:13,931,074...13,940,652
JBrowse link
G Rp9 RP9, pre-mRNA splicing factor multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RP9 mRNA] CTD PMID:19030233 NCBI chr 8:29,218,564...29,281,211
Ensembl chr 8:29,217,346...29,281,150
JBrowse link
G Rpf2 ribosome production factor 2 homolog multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPF2 mRNA] CTD PMID:19030233 NCBI chr20:45,184,511...45,205,983
Ensembl chr20:45,184,512...45,206,001
JBrowse link
G Rpl18 ribosomal protein L18 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPL18 mRNA] CTD PMID:19030233 NCBI chr 1:105,325,269...105,327,911
Ensembl chr 1:105,325,250...105,327,910
JBrowse link
G Rpl28 ribosomal protein L28 affects expression
multiple interactions
ISO Rimonabant affects the expression of RPL28 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPL28 mRNA]
CTD PMID:19030233 NCBI chr 1:78,080,945...78,083,532
Ensembl chr 1:78,080,945...78,083,771
JBrowse link
G Rpl41 ribosomal protein L41 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPL41 mRNA] CTD PMID:19030233 NCBI chr 7:1,562,417...1,563,497 JBrowse link
G Rps10 ribosomal protein S10 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPS10 mRNA] CTD PMID:19030233 NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150
JBrowse link
G Rps15 ribosomal protein S15 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPS15 mRNA] CTD PMID:19030233 NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:10,066,677...10,068,123
JBrowse link
G Rps28 ribosomal protein S28 affects expression ISO Rimonabant affects the expression of RPS28 mRNA CTD PMID:19030233 NCBI chr 7:15,309,964...15,311,333
Ensembl chr16:72,591,164...72,591,373
Ensembl chr 7:72,591,164...72,591,373
Ensembl chr16:72,591,164...72,591,373
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Rimonabant results in decreased phosphorylation of RPS6 protein CTD PMID:30687088 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
JBrowse link
G Rps8 ribosomal protein S8 affects expression
multiple interactions
ISO Rimonabant affects the expression of RPS8 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPS8 mRNA]
CTD PMID:19030233 NCBI chr 5:135,866,941...135,869,511
Ensembl chr 5:135,866,941...135,869,548
JBrowse link
G Rras2 RAS related 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RRAS2 mRNA] CTD PMID:19030233 NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:177,668,144...177,737,551
JBrowse link
G Rxrb retinoid X receptor beta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RXRB mRNA] CTD PMID:19030233 NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359
JBrowse link
G Ryk receptor-like tyrosine kinase affects expression
multiple interactions
ISO Rimonabant affects the expression of RYK mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RYK mRNA]
CTD PMID:19030233 NCBI chr 8:112,298,158...112,370,912
Ensembl chr 8:112,298,369...112,370,908
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Rimonabant results in increased expression of SCARB1 mRNA CTD PMID:20110567 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Rimonabant results in decreased expression of SCD1 mRNA CTD PMID:20110567 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SCD2 mRNA] CTD PMID:19030233 NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874
JBrowse link
G Scoc short coiled-coil protein multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SCOC mRNA] CTD PMID:19030233 NCBI chr19:41,564,166...41,593,932
Ensembl chr19:41,564,112...41,597,912
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEC62 mRNA] CTD PMID:19030233 NCBI chr 2:114,499,317...114,526,705
Ensembl chr 2:114,499,317...114,530,321
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEC63 mRNA] CTD PMID:19030233 NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248
JBrowse link
G Sema3c semaphorin 3C multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEMA3C mRNA] CTD PMID:19030233 NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:18,538,454...18,701,740
JBrowse link
G Sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase affects expression ISO Rimonabant affects the expression of SEPSECS mRNA CTD PMID:19030233 NCBI chr14:62,524,287...62,554,529
Ensembl chr14:62,524,313...62,554,533
JBrowse link
G Septin2 septin 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEPTIN2 mRNA] CTD PMID:19030233 NCBI chr 9:101,465,535...101,498,766
Ensembl chr 9:101,465,650...101,498,759
JBrowse link
G Septin6 septin 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SEPTIN6 mRNA] CTD PMID:19030233 NCBI chr  X:121,018,951...121,157,677
Ensembl chr  X:121,018,944...121,095,792
JBrowse link
G Serpinb6a serpin family B member 6A multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SERPINB6A mRNA]
Rimonabant affects the expression of SERPINB6A mRNA
CTD PMID:19030233 NCBI chr17:31,076,811...31,195,035
Ensembl chr17:31,158,622...31,196,545
JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Rimonabant results in decreased expression of SERPINE1 protein CTD PMID:17882151 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Sestd1 SEC14 and spectrin domain containing 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SESTD1 mRNA]
Rimonabant affects the expression of SESTD1 mRNA
CTD PMID:19030233 NCBI chr 3:82,530,796...82,627,960
Ensembl chr 3:82,537,092...82,588,078
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SGTA mRNA] CTD PMID:19030233 NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:9,304,197...9,321,669
JBrowse link
G Sh3bgrl SH3 domain binding glutamate rich protein like multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SH3BGRL mRNA] CTD PMID:19030233 NCBI chr  X:78,242,704...78,343,633
Ensembl chr  X:78,242,405...78,343,634
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SIPA1L1 mRNA]
Rimonabant affects the expression of SIPA1L1 mRNA
CTD PMID:19030233 NCBI chr 6:107,570,569...107,849,613
Ensembl chr 6:107,737,392...107,848,160
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SLC2A4 mRNA] CTD PMID:19030233 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SLC39A10 mRNA] CTD PMID:19030233 NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:62,370,598...62,454,747
JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SLC39A8 mRNA] CTD PMID:19030233 NCBI chr 2:226,845,686...226,992,668
Ensembl chr 2:226,929,644...226,992,667
JBrowse link
G Smarca2 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SMARCA2 mRNA] CTD PMID:19030233 NCBI chr 1:233,617,277...233,784,908
Ensembl chr 1:233,617,366...233,784,869
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression EXP Rimonabant results in decreased expression of SOCS1 mRNA CTD PMID:30365523 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression EXP Rimonabant results in decreased expression of SOCS3 mRNA CTD PMID:30365523 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 affects expression ISO Rimonabant affects the expression of SORBS2 mRNA CTD PMID:19030233 NCBI chr16:53,167,795...53,481,300
Ensembl chr16:53,167,827...53,358,986
JBrowse link
G Sparc secreted protein acidic and cysteine rich multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SPARC mRNA]
Rimonabant affects the expression of SPARC mRNA
CTD PMID:19030233 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SPTBN1 mRNA]
Rimonabant affects the expression of SPTBN1 mRNA
CTD PMID:19030233 NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of SRC protein] CTD PMID:16046413 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Srp72 signal recognition particle 72 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SRP72 mRNA] CTD PMID:19030233 NCBI chr14:31,522,424...31,549,978
Ensembl chr14:31,522,963...31,550,151
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ST3GAL6 mRNA] CTD PMID:19030233 NCBI chr11:55,530,120...55,590,950
Ensembl chr11:55,530,248...55,598,720
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of STAT3 protein] CTD PMID:16046413 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO [MIR466J mRNA co-treated with Rimonabant] affects the expression of STAT6 mRNA; Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of STAT6 mRNA] CTD PMID:30910812 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
JBrowse link
G Stim2 stromal interaction molecule 2 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of STIM2 mRNA]
Rimonabant affects the expression of STIM2 mRNA
CTD PMID:19030233 NCBI chr14:61,091,550...61,217,281
Ensembl chr14:61,091,550...61,217,080
JBrowse link
G Strn4 striatin 4 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of STRN4 mRNA] CTD PMID:19030233 NCBI chr 1:86,614,193...86,639,959
Ensembl chr 1:86,610,210...86,639,955
JBrowse link
G Tcea1 transcription elongation factor A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TCEA1 mRNA] CTD PMID:19030233 NCBI chr 5:19,414,351...19,466,629
Ensembl chr15:12,831,339...12,834,156
Ensembl chr 5:12,831,339...12,834,156
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Rimonabant results in decreased expression of TGFB1 mRNA CTD PMID:30365523 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TGIF2 mRNA] CTD PMID:19030233 NCBI chr 3:165,791,101...165,808,669
Ensembl chr 3:165,793,480...165,808,666
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity
EXP Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein]
Rimonabant results in increased activity of TH protein
CTD PMID:9188039 PMID:10700552 PMID:15882845 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions EXP Rimonabant inhibits the reaction [methanandamide affects the expression of THY1 mRNA] CTD PMID:17591864 NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Rimonabant results in decreased expression of TIMP1 mRNA CTD PMID:21863215 PMID:30365523 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Tmed7 transmembrane p24 trafficking protein 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TMED7 mRNA] CTD PMID:19030233 NCBI chr18:41,505,167...41,512,243
Ensembl chr18:41,478,539...41,512,243
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TNF]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of TNF protein]]
Rimonabant results in decreased expression of TNF mRNA
CTD PMID:20110567 PMID:30365523 PMID:30769029 PMID:32832534 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TOMM20 mRNA] CTD PMID:19030233 NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510
JBrowse link
G Tpm4 tropomyosin 4 affects expression
multiple interactions
ISO Rimonabant affects the expression of TPM4 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TPM4 mRNA]
CTD PMID:19030233 NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Rimonabant inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Rimonabant inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; Rimonabant inhibits the reaction [N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of TRPV1 protein] CTD PMID:11278420 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of TSEN2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TSEN2 mRNA]
CTD PMID:19030233 NCBI chr 4:150,275,389...150,310,846
Ensembl chr 4:150,275,501...150,313,013
JBrowse link
G Tspan5 tetraspanin 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TSPAN5 mRNA] CTD PMID:19030233 NCBI chr 2:229,967,521...230,139,012
Ensembl chr 2:229,967,235...230,142,685
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP Rimonabant results in increased expression of TXNRD1 mRNA CTD PMID:30365523 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
JBrowse link
G Unc5b unc-5 netrin receptor B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of UNC5B mRNA] CTD PMID:30910812 NCBI chr20:29,240,639...29,307,270
Ensembl chr20:29,240,650...29,307,270
JBrowse link
G Usp46 ubiquitin specific peptidase 46 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of USP46 mRNA] CTD PMID:19030233 NCBI chr14:34,504,074...34,573,318
Ensembl chr14:34,504,118...34,573,307
JBrowse link
G Usp48 ubiquitin specific peptidase 48 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of USP48 mRNA] CTD PMID:19030233 NCBI chr 5:155,083,520...155,151,208
Ensembl chr 5:155,083,587...155,151,208
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO Rimonabant inhibits the reaction [Glucose results in increased expression of VCAM1 protein]
Rimonabant results in decreased expression of VCAM1 protein
CTD PMID:21373835 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vcl vinculin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of VCL mRNA] CTD PMID:19030233 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of and results in decreased secretion of VEGFA protein] CTD PMID:15313899 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of VIM mRNA]
Rimonabant affects the expression of VIM mRNA
CTD PMID:19030233 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of VLDLR mRNA] CTD PMID:19030233 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154
JBrowse link
G Wdr26 WD repeat domain 26 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WDR26 mRNA] CTD PMID:19030233 NCBI chr13:95,462,017...95,503,826
Ensembl chr13:95,462,020...95,503,738
JBrowse link
G Wdr7 WD repeat domain 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of WDR7 mRNA] CTD PMID:19030233 NCBI chr18:59,435,733...59,718,800
Ensembl chr18:59,435,768...59,718,800
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WSB1 mRNA] CTD PMID:19030233 NCBI chr10:64,700,752...64,717,038
Ensembl chr10:64,700,762...64,716,832
JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WWP1 mRNA] CTD PMID:19030233 NCBI chr 5:37,889,280...37,982,743
Ensembl chr 5:37,895,398...37,982,959
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WWTR1 mRNA] CTD PMID:19030233 NCBI chr 2:143,801,181...143,916,941
Ensembl chr 2:143,801,181...143,991,950
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
ISO Rimonabant results in increased expression of XBP1 mRNA
[Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of XBP1 mRNA alternative form]; Gemcitabine promotes the reaction [Rimonabant results in increased expression of XBP1 mRNA]
CTD PMID:21525939 PMID:31054322 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link
G Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of ZDHHC2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ZDHHC2 mRNA]
CTD PMID:19030233 NCBI chr16:58,511,931...58,581,530
Ensembl chr16:58,511,934...58,581,516
JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of ZDHHC7 mRNA] CTD PMID:19030233 NCBI chr19:65,048,140...65,065,286
Ensembl chr19:65,037,310...65,065,286
JBrowse link
G Zhx1 zinc fingers and homeoboxes 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ZHX1 mRNA] CTD PMID:19030233 NCBI chr 7:91,472,193...91,501,984
Ensembl chr 7:91,473,836...91,501,115
JBrowse link
G Znrf2 zinc and ring finger 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ZNRF2 mRNA] CTD PMID:19030233 NCBI chr 4:85,274,626...85,358,083
Ensembl chr 4:85,280,702...85,358,083
JBrowse link
G Zwilch zwilch kinetochore protein affects expression ISO Rimonabant affects the expression of ZWILCH mRNA CTD PMID:19030233 NCBI chr 8:73,532,968...73,566,214
Ensembl chr 8:73,533,703...73,571,299
JBrowse link
semaglutide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:36075570 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein] CTD PMID:36075570 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP
ISO
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]
CTD PMID:36075570 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:36075570 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:36075570 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:36075570 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:36075570 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
sibutramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sibutramine results in increased expression of BAX protein CTD PMID:27838152 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sibutramine results in decreased expression of BCL2 protein CTD PMID:27838152 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 increases activity ISO sibutramine results in increased activity of CASP3 protein CTD PMID:27838152 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO sibutramine results in decreased activity of CYP2B6 protein
sibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:23777987 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO sibutramine results in decreased activity of CYP2C19 protein CTD PMID:23777987 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects response to substance
affects metabolic processing
ISO CYP3A4 protein affects the susceptibility to sibutramine
CYP3A4 protein affects the metabolism of sibutramine
CTD PMID:27838152 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO sibutramine results in increased expression of DDIT3 mRNA; sibutramine results in increased expression of DDIT3 protein CTD PMID:27838152 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO sibutramine results in decreased expression of and affects the phosphorylation of NOS3 protein CTD PMID:27838152 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression ISO sibutramine results in decreased expression of PSMB5 protein CTD PMID:27838152 NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO sibutramine results in decreased expression of PSMB8 protein CTD PMID:27838152 NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031
JBrowse link
tiratricol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein] CTD PMID:16324150 NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,641,862...83,685,545
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of NR1I2 protein; [3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO 3,3',5-triiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein]
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRA protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]
CTD PMID:16324150 PMID:31566444 PMID:33049310 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
JBrowse link
G Thrb thyroid hormone receptor beta increases activity
affects binding
multiple interactions
ISO 3,3',5-triiodothyroacetic acid results in increased activity of THRB protein
3,3',5-triiodothyroacetic acid binds to THRB protein
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRB protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
CTD PMID:31077750 PMID:31566444 PMID:33049310 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680
JBrowse link
G Tp53 tumor protein p53 affects activity ISO 3,3',5-triiodothyroacetic acid affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
tris(picolinato)chromium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
JBrowse link
G Avp arginine vasopressin multiple interactions EXP chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]; chromium tripicolinate affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; INS1 protein affects the reaction [chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] CTD PMID:9446840 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased expression of BAX protein] CTD PMID:19376147 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO chromium tripicolinate results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased activity of CASP3 protein]
CTD PMID:19376147 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
chromium tripicolinate results in decreased activity of CAT protein
CTD PMID:19693677 PMID:23122718 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of GSR protein] CTD PMID:23122718 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form CTD PMID:17684468 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141
JBrowse link
G Ins1 insulin 1 multiple interactions EXP chromium tripicolinate affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; INS1 protein affects the reaction [chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] CTD PMID:9446840 PMID:16424121 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP chromium tripicolinate results in decreased expression of and results in decreased activity of PTPN1 protein CTD PMID:16424121 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416
JBrowse link

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  CHEBI ontology 20862
    role 20820
      biological role 20818
        pharmacological role 19911
          anti-obesity agent 536
            (S)-nandinine + 0
            3-iodothyronamine 33
            AM6545 25
            AS1842856 0
            BAM15 0
            C75 0
            G-1 0
            GSK126 0
            N-[(S)-lactoyl]-L-phenylalanine 0
            UAB126 0
            ZG-2291 0
            ampkinone 0
            danuglipron 2
            desiccated thyroid extract 0
            duvoglustat + 27
            ginsenoside Rb1 39
            indirubin-3'-monoxime 49
            lorcaserin 11
            nomilin 1
            orlistat 105
            questinol 0
            resolvin D2 14
            rimonabant 328
            semaglutide 7
            sibiskoside 0
            sibutramine 11
            sigmoidin A 0
            tiratricol 10
            tirzepatide 0
            tris(picolinato)chromium 10
            xuezhikang 0
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