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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-obesity agent
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Accession:CHEBI:74518 term browser browse the term
Definition:Any substance which is used to reduce or control weight.
Synonyms:related_synonym: anti-obesity agents;   anti-obestic agent;   anti-obestic agents
 xref: Wikipedia:Anti-obesity



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duvoglustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:25445511 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G App amyloid beta precursor protein decreases response to substance ISO 1-Deoxynojirimycin results in decreased susceptibility to APP protein CTD PMID:19028522 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; 1-Deoxynojirimycin inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein] CTD PMID:19028522 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of CD36 mRNA] CTD PMID:25445511 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:25445511 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 1-Deoxynojirimycin inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein] CTD PMID:19028522 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:25445511 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbp2 fructose-bisphosphatase 2 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FBP2 protein] CTD PMID:25446853 NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein] CTD PMID:25446853 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gck glucokinase multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein] CTD PMID:25446853 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 1-Deoxynojirimycin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:25445511 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Insr insulin receptor multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein] CTD PMID:25446853 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA] CTD PMID:25446853 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PCX protein] CTD PMID:25446853 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PCK1 protein] CTD PMID:25446853 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] results in increased expression of PDHA1 mRNA CTD PMID:25446853 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PDK1 mRNA] CTD PMID:25446853 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pfkp phosphofructokinase, platelet multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein] CTD PMID:25446853 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PKLR protein] CTD PMID:25446853 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions ISO [1-Deoxynojirimycin co-treated with Dietary Fats] results in increased expression of PPARGC1B mRNA CTD PMID:25445511 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
ginsenoside Rb1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein] CTD PMID:19781563 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of BMP2 mRNA]
ginsenoside Rb1 results in increased expression of BMP2 mRNA
CTD PMID:27470910 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] CTD PMID:19781563 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:22386813 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
CTD PMID:19781563 PMID:25422538 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]
ginsenoside Rb1 results in increased expression of IGF1 mRNA
CTD PMID:27470910 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il6 interleukin 6 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:17655881 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:17655881 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein] CTD PMID:17655881 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 increases expression ISO ginsenoside Rb1 results in increased expression of KCNE1 CTD PMID:24615935 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ginsenoside Rb1 affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rb1 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:22386813 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; [ginsenoside Rb1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; ginsenoside Rb1 results in increased activity of and results in increased localization of NFE2L2 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
ginsenoside Rb1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
ginsenoside Rb1 results in increased expression of NFE2L2 mRNA
CTD PMID:19781563 PMID:22780686 PMID:25422538 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rb1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein] CTD PMID:22386813 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
EXP ginsenoside Rb1 results in increased expression of RUNX2 mRNA
ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of RUNX2 mRNA]
CTD PMID:27470910 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein CTD PMID:25297453 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of TGFB1 mRNA]
ginsenoside Rb1 results in increased expression of TGFB1 mRNA
CTD PMID:27470910 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA] CTD PMID:22386813 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]
ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein
CTD PMID:22386813 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
indirubin-3'-monoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta affects expression ISO indirubin-3'-monoxime affects the expression of ACTB protein CTD PMID:18958680 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
ISO AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]
indirubin-3'-monoxime binds to and results in increased activity of AHR protein
indirubin-3'-monoxime binds to AHR protein
CTD PMID:15001395 PMID:21948866 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression
ISO Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of ALDH1A1 protein] CTD PMID:21948866 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO indirubin-3'-monoxime results in decreased expression of ALDH1A2 protein CTD PMID:21948866 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Ar androgen receptor increases activity ISO indirubin-3'-monoxime analog results in increased activity of AR protein; indirubin-3'-monoxime results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO indirubin-3'-monoxime results in decreased expression of BAX mRNA CTD PMID:18958680 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BCL2L1 mRNA CTD PMID:18958680 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA CTD PMID:18958680 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CAT mRNA CTD PMID:18958680 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA CTD PMID:18958680 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cd40 CD40 molecule multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD40 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
indirubin-3'-monoxime results in decreased expression of CD40 protein
CTD PMID:21948866 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of CD80 protein
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased expression of CD80 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]
CTD PMID:21948866 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] CTD PMID:21948866 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO indirubin-3'-monoxime results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CDKN1A mRNA CTD PMID:18958680 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 protein
indirubin-3'-monoxime results in increased expression of CYP1A1 mRNA
indirubin-3'-monoxime results in increased expression of CYP1A1 protein
CTD PMID:15001395 PMID:18958680 PMID:21948866 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO indirubin-3'-monoxime results in decreased expression of EPHX2 mRNA CTD PMID:18958680 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO indirubin-3'-monoxime results in decreased expression of GPX1 mRNA CTD PMID:18958680 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO indirubin-3'-monoxime results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO indirubin-3'-monoxime results in increased expression of GSR mRNA CTD PMID:18958680 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HMOX1 mRNA CTD PMID:18958680 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA2 mRNA CTD PMID:18958680 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions
increases expression
ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA9 mRNA
indirubin-3'-monoxime results in increased expression of HSPA9 mRNA
CTD PMID:18958680 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of ICAM1 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
indirubin-3'-monoxime results in decreased expression of ICAM1 protein
CTD PMID:21948866 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of IDO1 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO1 protein]
CTD PMID:21948866 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of IDO2 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO2 protein]
CTD PMID:21948866 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
JBrowse link
G Ifng interferon gamma decreases secretion ISO indirubin-3'-monoxime results in decreased secretion of IFNG protein CTD PMID:21948866 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases secretion
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased secretion of IL10 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
indirubin-3'-monoxime results in decreased secretion of IL10 protein
CTD PMID:21948866 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL1B protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:21948866 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases secretion ISO indirubin-3'-monoxime results in increased secretion of IL2 protein CTD PMID:21948866 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il27 interleukin 27 decreases expression
multiple interactions
ISO indirubin-3'-monoxime results in decreased expression of IL27 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein]
CTD PMID:21948866 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of IL6 protein; [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL6 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21948866 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgax integrin subunit alpha X multiple interactions
decreases expression
ISO AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein] CTD PMID:21948866 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO indirubin-3'-monoxime results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA6 mRNA CTD PMID:18958680 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA CTD PMID:18958680 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of NFKBIA mRNA CTD PMID:18958680 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein CTD PMID:18958680 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO indirubin-3'-monoxime results in decreased expression of RAD23A mRNA CTD PMID:18958680 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased activity of RELA protein
indirubin-3'-monoxime results in decreased activity of RELA protein
CTD PMID:21948866 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA CTD PMID:18958680 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases activity ISO indirubin-3'-monoxime results in decreased activity of SGK1 protein CTD PMID:12534346 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOD2 mRNA CTD PMID:18958680 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of TGFB2 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB2 protein]
CTD PMID:21948866 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression
multiple interactions
ISO indirubin-3'-monoxime results in increased expression of TGFB3 protein
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB3 protein]
CTD PMID:21948866 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of TNF protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21948866 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ung uracil-DNA glycosylase increases expression ISO indirubin-3'-monoxime results in increased expression of UNG mRNA CTD PMID:18958680 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
lorcaserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO UGT2B17 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO UGT2B7 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
miglustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO miglustat inhibits the reaction [ST8SIA1 protein results in increased expression of BCL2 protein] CTD PMID:11574545 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Canx calnexin multiple interactions ISO miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form] CTD PMID:18230692 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat results in increased activity of CFTR protein mutant form]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]; miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO miglustat inhibits the reaction [[ST8SIA1 protein affects the abundance of Gangliosides] which results in decreased expression of PAWR protein] CTD PMID:11574545 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 multiple interactions ISO miglustat inhibits the reaction [[ST8SIA1 protein affects the abundance of Gangliosides] which results in decreased expression of PAWR protein]; miglustat inhibits the reaction [ST8SIA1 protein results in increased expression of BCL2 protein] CTD PMID:11574545 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase multiple interactions ISO [miglustat results in decreased activity of UGCG protein] which results in decreased abundance of Gangliosides; [miglustat results in decreased activity of UGCG protein] which results in decreased abundance of Glucosylceramides CTD PMID:10037475 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase decreases activity ISO orlistat results in decreased activity of ABHD12 protein CTD PMID:18657971 NCBI chr 3:139,659,315...139,719,529
Ensembl chr 3:139,659,317...139,719,564
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase decreases activity ISO orlistat results in decreased activity of ABHD16A protein CTD PMID:18657971 NCBI chr20:3,719,089...3,733,952
Ensembl chr20:3,719,091...3,733,927
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression
ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]
Orlistat results in decreased expression of ACACA mRNA
CTD PMID:32347045 PMID:33476690 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Orlistat results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acot8 acyl-CoA thioesterase 8 decreases expression ISO Orlistat results in decreased expression of ACOT8 protein CTD PMID:30667213 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP
ISO
orlistat inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]
CTD PMID:25087745 PMID:33476690 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion of Arachidonic Acid] CTD PMID:28721267 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO orlistat results in increased expression of ATF4 mRNA CTD PMID:17283163 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of BAX mRNA] CTD PMID:32450208 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] CTD PMID:32450208 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO
EXP
orlistat results in increased activity of CASP3 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]
orlistat results in increased cleavage of CASP3 protein
CTD PMID:17283163 PMID:20805790 PMID:21723078 PMID:32450208 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP
orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein; orlistat results in increased cleavage of and results in increased activity of CASP8 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA]
CTD PMID:18796435 PMID:20577697 PMID:32450208 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
orlistat results in increased activity of CASP9 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP9 mRNA]
CTD PMID:20805790 PMID:32450208 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP
ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT protein]
Orlistat results in decreased expression of CAT protein
CTD PMID:25087745 PMID:30667213 PMID:32450208 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin multiple interactions
decreases secretion
ISO [[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]
orlistat results in decreased secretion of CCK protein
CTD PMID:11408251 PMID:18303078 PMID:18647814 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Orlistat results in decreased expression of CCNA2 protein CTD PMID:30667213 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO Orlistat results in increased expression of CCND1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]
CTD PMID:30667213 PMID:32045588 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Orlistat results in increased expression of CCNE1 protein CTD PMID:30667213 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein] CTD PMID:32045588 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Orlistat results in decreased expression of CDK1 protein CTD PMID:30667213 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Orlistat results in decreased expression of CDK2 protein CTD PMID:30667213 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Orlistat results in decreased expression of CDK4 protein CTD PMID:30667213 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Orlistat results in increased expression of CDKN1A protein CTD PMID:30667213 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO orlistat results in increased expression of CDKN1B protein CTD PMID:15138278 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cel carboxyl ester lipase decreases activity ISO orlistat results in decreased activity of CEL protein CTD PMID:11592731 PMID:12381337 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Clps colipase multiple interactions ISO orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil] CTD PMID:15158758 NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO orlistat results in decreased expression of CPB2 protein CTD PMID:16959692 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Orlistat results in decreased expression of CPT1A protein CTD PMID:30667213 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Orlistat results in decreased expression of CPT2 protein CTD PMID:30667213 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Orlistat results in increased expression of CYP3A4 mRNA; Orlistat results in increased expression of CYP3A4 protein CTD PMID:20599501 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dagla diacylglycerol lipase, alpha decreases activity ISO orlistat results in decreased activity of DAGLA protein CTD PMID:16466961 NCBI chr 1:206,890,635...206,947,332
Ensembl chr 1:206,890,638...206,947,232
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO orlistat results in increased expression of DDIT3 mRNA CTD PMID:17283163 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO orlistat results in increased expression of DDIT4 mRNA CTD PMID:18796435 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
ISO orlistat results in increased phosphorylation of EIF2A protein
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
Cycloheximide inhibits the reaction [orlistat results in increased phosphorylation of EIF2A protein]
orlistat analog results in increased phosphorylation of EIF2A protein; orlistat results in increased phosphorylation of EIF2A protein
CTD PMID:17283163 PMID:20577697 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases response to substance
multiple interactions
ISO EIF2AK3 gene mutant form results in increased susceptibility to orlistat
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
CTD PMID:17283163 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation ISO orlistat results in increased phosphorylation of EIF4E protein CTD PMID:18796435 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance
affects localization
decreases expression
ISO ERBB2 protein affects the susceptibility to orlistat
orlistat affects the localization of ERBB2 protein
orlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 protein
CTD PMID:15870086 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Etv4 ETS variant transcription factor 4 increases expression ISO orlistat results in increased expression of ETV4 protein CTD PMID:15870086 NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Orlistat results in decreased expression of FABP1 protein CTD PMID:30667213 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Orlistat results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase affects binding
decreases expression
decreases activity
multiple interactions
affects response to substance
ISO orlistat analog binds to FASN protein
Orlistat results in decreased expression of FASN protein
orlistat results in decreased activity of FASN protein
[orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterified; orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]
orlistat analog results in decreased activity of FASN protein; orlistat results in decreased activity of FASN protein
[Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [Orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein; Orlistat binds to and results in decreased activity of FASN protein; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
FASN protein affects the susceptibility to orlistat
CTD PMID:15026345 PMID:15138278 PMID:15870086 PMID:17012255 PMID:17618296 More... NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gcg glucagon multiple interactions
decreases secretion
decreases expression
ISO orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]
orlistat results in decreased secretion of GCG protein
orlistat results in decreased expression of GCG protein
CTD PMID:12915676 PMID:18647814 PMID:19837920 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO orlistat inhibits the reaction [Olive Oil results in decreased expression of GHRL protein]; orlistat inhibits the reaction [Triglycerides results in decreased secretion of GHRL protein] CTD PMID:15998659 PMID:17138722 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Gip gastric inhibitory polypeptide decreases expression ISO orlistat results in decreased expression of GIP protein CTD PMID:12915676 NCBI chr10:80,968,410...80,976,506
Ensembl chr10:80,968,352...80,976,503
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA] CTD PMID:32450208 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx8 glutathione peroxidase 8 increases expression ISO orlistat results in increased expression of GPX8 mRNA CTD PMID:18796435 NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GSR protein] CTD PMID:32450208 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression ISO orlistat results in decreased expression of HBA1 protein modified form CTD PMID:19207292 PMID:19461584 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO orlistat results in increased expression of HSPA5 mRNA CTD PMID:17283163 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il10 interleukin 10 increases expression EXP Orlistat results in increased expression of IL10 mRNA CTD PMID:32450208 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA] CTD PMID:32450208 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 PMID:32045588 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 decreases expression
multiple interactions
affects expression
increases expression
ISO orlistat results in decreased expression of INS protein
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]
orlistat affects the expression of INS protein
orlistat results in increased expression of INS protein
CTD PMID:10095983 PMID:11274935 PMID:12915676 PMID:33476690 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression ISO orlistat results in increased expression of KDELR3 mRNA CTD PMID:18796435 NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO orlistat results in decreased expression of KDR protein CTD PMID:17012255 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Krt81 keratin 81 increases expression ISO orlistat results in increased expression of KRT81 mRNA CTD PMID:18796435 NCBI chr 7:132,577,112...132,582,238
Ensembl chr 7:132,576,492...132,582,170
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein] CTD PMID:25087745 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lep leptin multiple interactions ISO
EXP
orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 PMID:25087745 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lipf lipase F, gastric type decreases activity ISO orlistat results in decreased activity of LIPF protein CTD PMID:11408251 PMID:12381337 NCBI chr 1:231,493,498...231,511,845
Ensembl chr 1:231,493,498...231,511,845
JBrowse link
G Lpl lipoprotein lipase decreases activity
multiple interactions
ISO
EXP
orlistat results in decreased activity of LPL protein
[orlistat results in decreased activity of LPL protein] which affects the uptake of Triglycerides
orlistat inhibits the reaction [[LPL protein results in increased hydrolysis of Triglycerides] which results in increased uptake of Triglycerides]; orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]
orlistat inhibits the reaction [Dietary Fats results in decreased expression of LPL protein]
CTD PMID:12388125 PMID:12573449 PMID:15910848 PMID:15994321 PMID:18698144 More... NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein] CTD PMID:32045588 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein] CTD PMID:32045588 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D decreases activity EXP orlistat results in decreased activity of NAPEPLD protein CTD PMID:16466961 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA
CTD PMID:32450208 PMID:33476690 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein] CTD PMID:32450208 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y increases expression ISO orlistat results in increased expression of NPY protein CTD PMID:15962606 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO orlistat results in increased activity of NR1I2 protein CTD PMID:20599501 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Orlistat binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nts neurotensin multiple interactions ISO Orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]; Orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein
orlistat results in increased cleavage of PARP1 protein
CTD PMID:15870086 PMID:17283163 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein] CTD PMID:32045588 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pla2g7 phospholipase A2 group VII decreases activity
multiple interactions
ISO orlistat results in decreased activity of PLA2G7 protein
[orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein; [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein
CTD PMID:16911813 PMID:18513463 PMID:18657971 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Pnlip pancreatic lipase decreases secretion
multiple interactions
affects folding
decreases activity
ISO
EXP
orlistat results in decreased secretion of PNLIP protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]
orlistat affects the folding of PNLIP protein
orlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]
orlistat results in decreased activity of PNLIP protein
CTD PMID:11408251 PMID:11668201 PMID:12381337 PMID:15158758 PMID:19346257 NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases activity ISO
EXP
orlistat results in decreased activity of PNLIPRP2 protein
Orlistat results in decreased activity of PNLIPRP2 protein
CTD PMID:9822688 PMID:17401110 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434
JBrowse link
G Pon1 paraoxonase 1 increases activity ISO orlistat results in increased activity of PON1 protein CTD PMID:11820148 PMID:17134960 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA] CTD PMID:33476690 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Orlistat results in increased expression of PPARG mRNA CTD PMID:32347045 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO Orlistat results in decreased expression of PPT1 protein CTD PMID:30667213 NCBI chr 5:135,121,176...135,141,076
Ensembl chr 5:135,121,163...135,142,048
JBrowse link
G Ppy pancreatic polypeptide multiple interactions ISO orlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein] CTD PMID:15998659 NCBI chr10:87,054,747...87,056,044
Ensembl chr10:87,054,756...87,055,455
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP
ISO
orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]
orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
CTD PMID:18390901 PMID:19167487 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO Orlistat results in increased expression of PTEN protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]
CTD PMID:32045588 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein] CTD PMID:32045588 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pyy peptide YY decreases secretion
multiple interactions
ISO orlistat results in decreased secretion of PYY protein
orlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]; orlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]
CTD PMID:15998659 PMID:17138722 PMID:18647814 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO orlistat results in decreased phosphorylation of RB1 protein CTD PMID:15138278 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA] CTD PMID:32450208 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases expression ISO orlistat results in increased expression of SEC24D mRNA CTD PMID:18796435 NCBI chr 2:211,418,557...211,526,588
Ensembl chr 2:211,418,623...211,526,587
JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions
decreases expression
ISO [orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein
orlistat results in decreased expression of SKP2 protein
CTD PMID:15138278 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO orlistat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]
Orlistat results in decreased expression of SREBF1 protein
CTD PMID:32045588 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tf transferrin multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA CTD PMID:33476690 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
CTD PMID:15994321 PMID:32045588 PMID:32450208 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO orlistat results in increased susceptibility to TNFSF10 protein CTD PMID:18796435 PMID:21406729 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of TP53 mRNA] CTD PMID:32450208 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
resolvin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21724996 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL2 protein] CTD PMID:21724996 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 protein] CTD PMID:21724996 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:21724996 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:21724996 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:21724996 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:21724996 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ITGAL mRNA] CTD PMID:21724996 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; resolvin D2 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21724996 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of NFKBIA mRNA] CTD PMID:21724996 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21724996 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of RELA protein] CTD PMID:21724996 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; resolvin D2 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21724996 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:21724996 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
rimonabant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha affects expression ISO Rimonabant affects the expression of ACACA mRNA CTD PMID:20110567 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta increases expression ISO Rimonabant results in increased expression of ACACB mRNA CTD PMID:20110567 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain affects expression
multiple interactions
ISO Rimonabant affects the expression of ACADM mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ACADM mRNA]
CTD PMID:19030233 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ACBD5 mRNA] CTD PMID:19030233 NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Rimonabant results in decreased expression of ACTA2 mRNA CTD PMID:21863215 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actr2 actin related protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ACTR2 mRNA] CTD PMID:19030233 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ADAMTS1 mRNA] CTD PMID:19030233 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Rimonabant results in decreased expression of ADGRE1 mRNA CTD PMID:30365523 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Rimonabant results in increased expression of ADIPOQ mRNA; Rimonabant results in increased expression of ADIPOQ protein CTD PMID:16282221 PMID:20110567 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 multiple interactions
increases expression
ISO Rimonabant inhibits the reaction [MIR762 mRNA results in decreased expression of AGAP2 mRNA]; Rimonabant promotes the reaction [Dietary Fats results in increased expression of AGAP2 mRNA]
Rimonabant results in increased expression of AGAP2 mRNA
CTD PMID:30910812 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295
JBrowse link
G Akap2 A-kinase anchoring protein 2 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PAKAP mRNA]
Rimonabant affects the expression of PAKAP mRNA
CTD PMID:19030233 NCBI chr 5:72,536,986...72,648,524
Ensembl chr 5:72,181,718...72,648,524
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
Rimonabant inhibits the reaction [Dronabinol results in decreased phosphorylation of AKT1 protein]
Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; Rimonabant inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]
CTD PMID:12834810 PMID:31917333 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Anxa1 annexin A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ANXA1 mRNA] CTD PMID:19030233 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa2 annexin A2 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ANXA2 mRNA]
Rimonabant affects the expression of ANXA2 mRNA
CTD PMID:19030233 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Apob apolipoprotein B increases secretion ISO Rimonabant results in increased secretion of APOB protein CTD PMID:20110567 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G App amyloid beta precursor protein affects expression
multiple interactions
ISO Rimonabant affects the expression of APP mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of APP mRNA]
CTD PMID:19030233 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arg1 arginase 1 multiple interactions ISO Rimonabant promotes the reaction [Dietary Fats results in increased expression of ARG1] CTD PMID:30910812 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 affects expression
multiple interactions
ISO Rimonabant affects the expression of ARHGEF12 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ARHGEF12 mRNA]
CTD PMID:19030233 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ARPP19 mRNA] CTD PMID:19030233 NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR1 protein]]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR2 protein]] CTD PMID:27779402 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of ATF4 mRNA] CTD PMID:31054322 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of ATF6 mRNA] CTD PMID:31054322 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atp5me ATP synthase membrane subunit e multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of ATP5K mRNA] CTD PMID:19030233 NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
JBrowse link
G Atrnl1 attractin like 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ATRNL1 mRNA] CTD PMID:19030233 NCBI chr 1:256,670,976...257,219,291
Ensembl chr 1:256,670,627...257,213,197
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Rimonabant results in decreased expression of AURKB protein CTD PMID:19479993 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]]
Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of BAX protein]
CTD PMID:27932991 PMID:30769029 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of BCL2 protein] CTD PMID:26967640 PMID:30769029 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA] CTD PMID:20929960 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of BRAF mRNA] CTD PMID:19030233 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of BZW1 mRNA] CTD PMID:19030233 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
JBrowse link
G C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of C1GALT1 mRNA] CTD PMID:19030233 NCBI chr 4:35,930,743...35,966,102
Ensembl chr 4:35,928,104...35,961,831
JBrowse link
G Cab39l calcium binding protein 39-like multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAB39L mRNA] CTD PMID:19030233 NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545
JBrowse link
G Calm1 calmodulin 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CALM1 mRNA]
Rimonabant affects the expression of CALM1 mRNA
CTD PMID:19030233 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Canx calnexin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CANX mRNA] CTD PMID:19030233 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Capn7 calpain 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAPN7 mRNA] CTD PMID:19030233 NCBI chr16:6,545,630...6,581,908
Ensembl chr16:6,545,731...6,581,905
JBrowse link
G Cartpt CART prepropeptide multiple interactions
increases response to substance
affects expression
ISO FAAH affects the reaction [Rimonabant affects the expression of CARTPT protein]
CARTPT results in increased susceptibility to Rimonabant
CTD PMID:16131814 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of CASP1 protein] CTD PMID:27932991 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CASP12 mRNA] CTD PMID:19030233 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Rimonabant inhibits the reaction [XLR-11 results in increased activity of CASP3 protein]
Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased cleavage of CASP3 protein]]; Rimonabant inhibits the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased cleavage of and results in increased activity of CASP3 protein]]
CTD PMID:26209559 PMID:29410032 PMID:30769029 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cav1 caveolin 1 affects expression
multiple interactions
ISO Rimonabant affects the expression of CAV1 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAV1 mRNA]
CTD PMID:19030233 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cav2 caveolin 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CAV2 mRNA] CTD PMID:19030233 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Cavin1 caveolae associated protein 1 affects expression ISO Rimonabant affects the expression of CAVIN1 mRNA CTD PMID:19030233 NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CCAR1 mRNA] CTD PMID:19030233 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL2]
Rimonabant results in decreased expression of CCL2 mRNA
CTD PMID:30365523 PMID:32832534 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CCL3] CTD PMID:32832534 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Rimonabant results in increased expression of CCNB1 protein CTD PMID:19479993 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Rimonabant results in decreased expression of CCND1 protein CTD PMID:16822929 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of CCND2 protein] CTD PMID:26967640 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CCNG1 mRNA] CTD PMID:19030233 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccpg1 cell cycle progression 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CCPG1 mRNA] CTD PMID:19030233 NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Rimonabant co-treated with MIR762 mRNA] affects the expression of CCR7 mRNA CTD PMID:30910812 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd36 CD36 molecule affects expression
multiple interactions
ISO Rimonabant affects the expression of CD36 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CD36 mRNA]
CTD PMID:19030233 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdc73 cell division cycle 73 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CDC73 mRNA] CTD PMID:19030233 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions ISO Rimonabant inhibits the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein]; Rimonabant inhibits the reaction [Ethanol results in increased activity of CDK5 protein] CTD PMID:30143782 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO Rimonabant inhibits the reaction [[Ethanol results in increased activity of CDK5 protein] which results in increased degradation of CDK5R1 protein] CTD PMID:30143782 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdkl2 cyclin dependent kinase like 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CDKL2 mRNA] CTD PMID:19030233 NCBI chr14:16,027,381...16,063,257
Ensembl chr14:16,028,363...16,063,252
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Rimonabant results in increased expression of CDKN1B protein CTD PMID:16822929 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Rimonabant inhibits the reaction [butylparaben results in increased expression of CEBPA mRNA] CTD PMID:27659731 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of CEBPD mRNA] CTD PMID:19030233 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CHD9 mRNA] CTD PMID:19030233 NCBI chr19:15,941,535...16,146,220
Ensembl chr19:15,942,687...16,164,556
JBrowse link
G Chek1 checkpoint kinase 1 decreases phosphorylation ISO Rimonabant results in decreased phosphorylation of CHEK1 protein CTD PMID:19479993 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Clic4 chloride intracellular channel 4 affects expression
multiple interactions
ISO Rimonabant affects the expression of CLIC4 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CLIC4 mRNA]
CTD PMID:19030233 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Cltc clathrin heavy chain multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CLTC mRNA] CTD PMID:19030233 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CNOT1 mRNA] CTD PMID:19030233 NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of CNP protein] CTD PMID:32956517 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity
affects localization
affects binding
decreases expression
ISO
EXP
1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea analog inhibits the reaction [Rimonabant binds to CNR1 protein]; 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea inhibits the reaction [Rimonabant binds to CNR1 protein]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Rimonabant binds to CNR1 protein]; 5F-CUMYL-PICA inhibits the reaction [Rimonabant binds to CNR1 protein]; AM 6527 inhibits the reaction [Rimonabant binds to CNR1 protein]; arachidonyl dopamine inhibits the reaction [Rimonabant binds to CNR1 protein]; Dronabinol inhibits the reaction [Rimonabant binds to CNR1 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate analog inhibits the reaction [Rimonabant binds to CNR1 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate inhibits the reaction [Rimonabant binds to CNR1 protein]; N'-((3Z)-1-(1-hexyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide affects the reaction [Rimonabant binds to CNR1 protein]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [Rimonabant binds to CNR1 protein]; Rimonabant binds to and results in decreased activity of CNR1 protein; Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased activity of CNR1]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR1 protein]]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole results in increased activity of CNR1 protein]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP]; Rimonabant inhibits the reaction [anandamide results in increased activity of CNR1]; Rimonabant inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]; Rimonabant inhibits the reaction [HU 211 results in increased activity of CNR1]
Rimonabant results in decreased activity of CNR1 protein
Rimonabant affects the localization of CNR1 protein
Rimonabant results in decreased expression of CNR1 mRNA
[Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; [Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog; Cannabidiol inhibits the reaction [Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]]; Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]; Rimonabant binds to and results in decreased activity of CNR1 protein; Rimonabant inhibits the reaction [1-(5-fluoropentyl)-3-(1-naphthoyl)indole analog binds to CNR1 protein]; Rimonabant inhibits the reaction [1-(5-fluoropentyl)-3-(1-naphthoyl)indole binds to CNR1 protein]; Rimonabant inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of CNR1 protein]
6-methyl-3-(2-nitro-1-(thiophen-2-yl)propyl)-2-phenyl-1H-indole inhibits the reaction [Rimonabant binds to CNR1 protein]; [Rimonabant binds to and results in decreased activity of CNR1 protein] which affects the expression of FOS protein; [Rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine; Rimonabant binds to and results in decreased activity of CNR1 protein; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CNR1 mRNA]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; Rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; Rimonabant inhibits the reaction [HU 211 binds to and results in increased activity of CNR1 protein]
CTD PMID:10027878 PMID:10422789 PMID:10871313 PMID:11517236 PMID:11558437 More... NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR2 protein]]; Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole results in increased activity of CNR2 protein] CTD PMID:27779402 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Rimonabant results in decreased expression of COL1A1 mRNA CTD PMID:21863215 PMID:30365523 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Copg2 COPI coat complex subunit gamma 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of COPG2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of COPG2 mRNA]
CTD PMID:19030233 NCBI chr 4:59,366,086...59,501,591
Ensembl chr 4:59,366,086...59,501,618
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Rimonabant results in increased expression of CPT1A mRNA CTD PMID:30365523 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of CREB1 protein]
Rimonabant inhibits the reaction [Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein]
CTD PMID:15913574 PMID:19912468 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CREB3L2 mRNA] CTD PMID:19030233 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Rimonabant results in decreased expression of CRH mRNA
Dronabinol affects the reaction [Rimonabant results in decreased expression of CRH mRNA]; Rimonabant inhibits the reaction [HU 211 results in decreased expression of CRH mRNA]
CTD PMID:12968131 PMID:15099659 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Csde1 cold shock domain containing E1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CSDE1 mRNA] CTD PMID:19030233 NCBI chr 2:190,546,015...190,582,790
Ensembl chr 2:190,554,980...190,582,784
JBrowse link
G Cul1 cullin 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CUL1 mRNA] CTD PMID:19030233 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
JBrowse link
G Cul3 cullin 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CUL3 mRNA] CTD PMID:19030233 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CXADR mRNA] CTD PMID:19030233 NCBI chr11:16,982,752...17,030,078
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CXCL10] CTD PMID:32832534 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of CXCL1] CTD PMID:32832534 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CYP4V3 mRNA] CTD PMID:19030233 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of DDIT3 mRNA] CTD PMID:31054322 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx27 DEAD-box helicase 27 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of DDX27 mRNA] CTD PMID:19030233 NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DDX3X mRNA] CTD PMID:19030233 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DNAJC10 mRNA] CTD PMID:19030233 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DPP4 mRNA] CTD PMID:19030233 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Dr1 down-regulator of transcription 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DR1 mRNA] CTD PMID:19030233 NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of DYNC1I2 mRNA] CTD PMID:19030233 NCBI chr 3:56,033,882...56,085,080
Ensembl chr 3:56,033,917...56,085,080
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EDEM1 mRNA] CTD PMID:19030233 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
JBrowse link
G Efna5 ephrin A5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EFNA5 mRNA] CTD PMID:19030233 NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 multiple interactions ISO Rimonabant inhibits the reaction [Ethanol promotes the reaction [EHMT2 protein binds to RAC1 promoter]] CTD PMID:30143782 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EIF4G2 mRNA] CTD PMID:19030233 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EIF5 mRNA] CTD PMID:19030233 Ensembl chr 6:130,589,143...130,597,656 JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ELL2 mRNA] CTD PMID:19030233 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of EPS15 mRNA] CTD PMID:19030233 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ERMP1 mRNA] CTD PMID:19030233 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions EXP
ISO
[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Rimonabant] affects the expression of FAAH mRNA
FAAH affects the reaction [Rimonabant affects the expression of CARTPT protein]; Rimonabant inhibits the reaction [FAAH gene mutant form results in increased susceptibility to anandamide]
CTD PMID:16131814 PMID:27385208 PMID:32833042 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fam126b family with sequence similarity 126, member B affects expression ISO Rimonabant affects the expression of FAM126B mRNA CTD PMID:19030233 NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007
JBrowse link
G Fam199x family with sequence similarity 199, X-linked multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FAM199X mRNA] CTD PMID:19030233 NCBI chr  X:100,384,502...100,413,150
Ensembl chr  X:100,384,225...100,414,938
JBrowse link
G Far1 fatty acyl CoA reductase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FAR1 mRNA] CTD PMID:19030233 NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of FASN mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of FASN mRNA]
CTD PMID:19030233 PMID:20110567 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbxl5 F-box and leucine-rich repeat protein 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FBXL5 mRNA] CTD PMID:19030233 NCBI chr14:67,305,109...67,347,383
Ensembl chr14:67,267,801...67,347,383
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of FBXW7 mRNA] CTD PMID:19030233 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Fem1a fem-1 homolog A multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of FEM1A mRNA] CTD PMID:19030233 NCBI chr 9:1,091,695...1,093,901
Ensembl chr 9:1,090,527...1,100,628
JBrowse link
G Fermt2 FERM domain containing kindlin 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FERMT2 mRNA] CTD PMID:19030233 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]
Rimonabant affects the expression of FGF1 mRNA
CTD PMID:19030233 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FMR1 mRNA] CTD PMID:19030233 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Fndc3b fibronectin type III domain containing 3B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FNDC3B mRNA] CTD PMID:19030233 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOS protein]
[Rimonabant binds to and results in decreased activity of CNR1 protein] which affects the expression of FOS protein; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
CTD PMID:9751146 PMID:12560108 PMID:15280883 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSB protein] CTD PMID:9751146 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSL1 protein] CTD PMID:9751146 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSL2 protein] CTD PMID:9751146 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Frmd4b FERM domain containing 4B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of FRMD4B mRNA] CTD PMID:19030233 NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197
JBrowse link
G G6pc3 glucose 6 phosphatase catalytic subunit 3 increases expression ISO Rimonabant results in increased expression of G6PC3 mRNA CTD PMID:20110567 NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Rimonabant results in increased expression of GAPDH mRNA CTD PMID:16282221 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Rimonabant results in decreased expression of GFAP protein CTD PMID:21373835 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GGPS1 mRNA] CTD PMID:19030233 NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220
JBrowse link
G Gls glutaminase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GLS mRNA] CTD PMID:19030233 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GMFB mRNA] CTD PMID:19030233 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 decreases expression ISO Rimonabant results in decreased expression of GPLD1 mRNA CTD PMID:20110567 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions ISO Rimonabant binds to and results in increased activity of GPR55 protein CTD PMID:17876302 NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases expression EXP
ISO
Rimonabant results in decreased expression of GPT protein CTD PMID:28705172 PMID:30365523 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression
multiple interactions
ISO Rimonabant affects the expression of GRB14 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of GRB14 mRNA]
CTD PMID:19030233 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIA1]
Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIA1 mRNA]
CTD PMID:19912468 PMID:29230395 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2A] CTD PMID:19912468 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2B] CTD PMID:19912468 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP Rimonabant results in increased expression of GSTA1 mRNA CTD PMID:30365523 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 affects expression ISO Rimonabant affects the expression of HDHD2 mRNA CTD PMID:19030233 NCBI chr18:70,475,037...70,526,471
Ensembl chr18:70,474,926...70,526,470
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HIF1A mRNA] CTD PMID:19030233 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HIPK3 mRNA] CTD PMID:19030233 NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Rimonabant results in increased expression of HMOX1 mRNA; Rimonabant results in increased expression of HMOX1 protein CTD PMID:30365523 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases activity ISO Rimonabant results in decreased activity of HNF4A protein CTD PMID:31981244 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HSP90AA1 mRNA] CTD PMID:19030233 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of HSPA5 mRNA] CTD PMID:31054322 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of ICAM1 protein
Rimonabant inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
CTD PMID:21373835 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions EXP Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in decreased expression of NOS2 mRNA]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:11520904 PMID:11727767 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IGF1 mRNA] CTD PMID:19030233 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 affects expression
multiple interactions
ISO Rimonabant affects the expression of IGFBP5 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IGFBP5 mRNA]
CTD PMID:19030233 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]] CTD PMID:32385136 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in decreased expression of IL12RB2 mRNA] CTD PMID:14741435 PMID:18792785 NCBI chr 4:96,424,615...96,515,327
Ensembl chr 4:96,426,842...96,515,289
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of IL18 protein] CTD PMID:27932991 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Rimonabant co-treated with SR 144528] inhibits the reaction [OMDM-1 cpd inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL1B]; Rimonabant inhibits the reaction [OMDM-1 cpd inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Rimonabant promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15748152 PMID:32832534 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IL6] CTD PMID:32832534 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 decreases expression ISO Rimonabant results in decreased expression of INS protein CTD PMID:20110567 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ipo11 importin 11 affects expression
multiple interactions
ISO Rimonabant affects the expression of IPO11 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IPO11 mRNA]
CTD PMID:19030233 NCBI chr 2:38,169,688...38,342,929 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IQGAP1 mRNA]
Rimonabant affects the expression of IQGAP1 mRNA
CTD PMID:19030233 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of IRF5] CTD PMID:32832534 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
JBrowse link
G Itgam integrin subunit alpha M decreases expression EXP Rimonabant results in decreased expression of ITGAM mRNA CTD PMID:30365523 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITGAV mRNA] CTD PMID:19030233 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITGB1 mRNA] CTD PMID:19030233 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ITPR2 mRNA] CTD PMID:19030233 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
JBrowse link
G Ivns1abp influenza virus NS1A binding protein multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of IVNS1ABP mRNA] CTD PMID:19030233 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701
JBrowse link
G Kif5b kinesin family member 5B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KIF5B mRNA] CTD PMID:19030233 NCBI chr17:51,489,873...51,527,508
Ensembl chr17:51,489,944...51,527,508
JBrowse link
G Klf4 Kruppel like factor 4 increases expression
multiple interactions
ISO Rimonabant results in increased expression of KLF4 mRNA
MIR466J mRNA affects the reaction [Rimonabant results in increased expression of KLF4 mRNA]; Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of KLF4 mRNA]
CTD PMID:30910812 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KLF6 mRNA] CTD PMID:19030233 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Klhl9 kelch-like family member 9 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KLHL9 mRNA] CTD PMID:19030233 NCBI chr 5:103,333,747...103,337,931 JBrowse link
G Kpna3 karyopherin subunit alpha 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KPNA3 mRNA] CTD PMID:19030233 NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
JBrowse link
G Kpnb1 karyopherin subunit beta 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of KPNB1 mRNA] CTD PMID:19030233 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LAMP2 mRNA] CTD PMID:19030233 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LARGE1 mRNA]
Rimonabant affects the expression of LARGE1 mRNA
CTD PMID:19030233 NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930
JBrowse link
G Lep leptin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of BCL2 protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of CCND2 protein]; Rimonabant inhibits the reaction [LEP gene mutant form results in decreased expression of INS1 protein] CTD PMID:19030233 PMID:26967640 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Rimonabant inhibits the reaction [Dronabinol results in decreased expression of LHB protein] CTD PMID:9825732 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,898,267...95,901,963
Ensembl chr 1:95,898,267...95,901,963
JBrowse link
G Lipc lipase C, hepatic type increases expression ISO Rimonabant results in increased expression of LIPC mRNA CTD PMID:20110567 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lipe lipase E, hormone sensitive type affects expression ISO Rimonabant affects the expression of LIPE mRNA CTD PMID:20110567 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Lmo1 LIM domain only 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LMO1 mRNA] CTD PMID:19030233 NCBI chr 1:163,132,338...163,168,521
Ensembl chr 1:163,132,339...163,168,522
JBrowse link
G Lpgat1 lysophosphatidylglycerol acyltransferase 1 affects expression ISO Rimonabant affects the expression of LPGAT1 mRNA CTD PMID:19030233 NCBI chr13:103,294,622...103,365,372
Ensembl chr13:103,294,528...103,362,333
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of LRRFIP1 mRNA] CTD PMID:19030233 NCBI chr 9:91,592,032...91,720,250
Ensembl chr 9:91,643,197...91,720,250
JBrowse link
G Mag myelin-associated glycoprotein multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of MAG protein] CTD PMID:32956517 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Rimonabant results in increased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:31570772 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects localization
decreases activity
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]
Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in decreased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in decreased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Rimonabant affects the localization of MAPK1 protein
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]
Rimonabant results in decreased activity of MAPK1 protein
CTD PMID:8526880 PMID:11553284 PMID:12657697 PMID:12834810 PMID:16282221 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
affects localization
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]
Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in decreased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in decreased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Rimonabant results in decreased activity of MAPK3 protein
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [delta(9)-tetrahydrocannabinolic acid results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; Rimonabant inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]
Rimonabant affects the localization of MAPK3 protein
CTD PMID:8526880 PMID:11553284 PMID:12657697 PMID:12834810 PMID:16282221 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein] CTD PMID:18950629 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MARCHF6 mRNA] CTD PMID:19030233 NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MBNL1 mRNA] CTD PMID:19030233 NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MBNL2 mRNA] CTD PMID:19030233 NCBI chr15:97,385,238...97,542,924
Ensembl chr15:97,385,244...97,542,937
JBrowse link
G Mest mesoderm specific transcript affects expression
multiple interactions
ISO Rimonabant affects the expression of MEST mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
CTD PMID:19030233 NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
JBrowse link
G Mgll monoglyceride lipase affects response to substance ISO MGLL protein affects the susceptibility to Rimonabant CTD PMID:21911610 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mir16 microRNA 16 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of MIR16 mRNA] CTD PMID:19030233 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO Rimonabant inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein] CTD PMID:31220554 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression EXP Rimonabant results in decreased expression of MMP13 mRNA CTD PMID:21863215 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mog myelin oligodendrocyte glycoprotein multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased expression of MOG protein] CTD PMID:32956517 NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
JBrowse link
G Mospd1 motile sperm domain containing 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MOSPD1 mRNA] CTD PMID:19030233 NCBI chr  X:133,100,200...133,127,960
Ensembl chr  X:133,100,422...133,127,908
JBrowse link
G Mycbp2 MYC binding protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of MYCBP2 mRNA] CTD PMID:19030233 NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NAP1L1 mRNA] CTD PMID:19030233 NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions EXP [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Rimonabant] affects the expression of NAPEPLD mRNA CTD PMID:32833042 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Ncl nucleolin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NCL mRNA] CTD PMID:19030233 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Ndc1 NDC1 transmembrane nucleoporin affects expression ISO Rimonabant affects the expression of NDC1 mRNA CTD PMID:19030233 NCBI chr 5:122,155,992...122,202,295
Ensembl chr 5:122,155,967...122,202,291
JBrowse link
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFB11 mRNA] CTD PMID:19030233 NCBI chr  X:1,572,805...1,575,063
Ensembl chr  X:1,572,785...1,575,062
JBrowse link
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFB9 mRNA]
Rimonabant affects the expression of NDUFB9 mRNA
CTD PMID:19030233 NCBI chr 7:90,481,013...90,487,360
Ensembl chr 7:90,436,621...90,488,009
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of NDUFS8 mRNA] CTD PMID:19030233 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NEDD4 mRNA] CTD PMID:19030233 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Nek7 NIMA-related kinase 7 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NEK7 mRNA]
Rimonabant affects the expression of NEK7 mRNA
CTD PMID:19030233 NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NFATC3 mRNA] CTD PMID:19030233 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Rimonabant results in increased expression of NFE2L2 mRNA CTD PMID:30365523 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nid1 nidogen 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NID1 mRNA]
Rimonabant affects the expression of NID1 mRNA
CTD PMID:19030233 NCBI chr17:86,085,046...86,158,277
Ensembl chr17:86,085,077...86,158,267
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of NLRP3]
Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of NLRP3 protein]
CTD PMID:27932991 PMID:32832534 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[Rimonabant co-treated with SR 144528] inhibits the reaction [OMDM-1 cpd inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NOS2]; Rimonabant promotes the reaction [PF 3845 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Rimonabant inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in decreased expression of NOS2 mRNA]
CTD PMID:11520904 PMID:15748152 PMID:30910812 PMID:31121907 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npr3 natriuretic peptide receptor 3 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NPR3 mRNA]
Rimonabant affects the expression of NPR3 mRNA
CTD PMID:19030233 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Rimonabant results in increased expression of NQO1 mRNA; Rimonabant results in increased expression of NQO1 protein CTD PMID:30365523 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NR3C1 mRNA] CTD PMID:19030233 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Ntn1 netrin 1 multiple interactions
decreases expression
ISO Rimonabant affects the reaction [Dietary Fats affects the expression of NTN1 protein]; Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NTN1 mRNA]; Rimonabant inhibits the reaction [MIR762 mRNA results in increased expression of NTN1 mRNA]
Rimonabant results in decreased expression of NTN1 mRNA
CTD PMID:30910812 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of OPA1 mRNA] CTD PMID:19030233 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 affects expression
multiple interactions
ISO Rimonabant affects the expression of OSBPL8 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of OSBPL8 mRNA]
CTD PMID:19030233 NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Rimonabant results in decreased expression of PARP1 protein CTD PMID:19479993 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PCX mRNA] CTD PMID:19030233 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Rimonabant results in increased expression of PCK1 mRNA CTD PMID:20110567 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PCYOX1 mRNA]
Rimonabant affects the expression of PCYOX1 mRNA
CTD PMID:19030233 NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
JBrowse link
G Phip pleckstrin homology domain interacting protein multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PHIP mRNA] CTD PMID:19030233 NCBI chr 8:83,776,802...83,891,192
Ensembl chr 8:83,781,465...83,894,283
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha affects expression
multiple interactions
ISO Rimonabant affects the expression of PIK3CA mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PIK3CA mRNA]
CTD PMID:19030233 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Plac8 placenta associated 8 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PLAC8 mRNA] CTD PMID:19030233 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PLEKHA1 mRNA] CTD PMID:19030233 NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156
JBrowse link
G Plin2 perilipin 2 decreases expression
multiple interactions
ISO Rimonabant results in decreased expression of PLIN2 protein
Rimonabant inhibits the reaction [Oleic Acid results in increased expression of PLIN2 protein]
CTD PMID:31570772 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Pmm1 phosphomannomutase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PMM1 mRNA] CTD PMID:19030233 NCBI chr 7:113,466,632...113,477,004
Ensembl chr 7:113,466,632...113,477,022
JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of POLD2 mRNA] CTD PMID:19030233 NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160
JBrowse link
G Polr2j RNA polymerase II subunit J multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of POLR2J mRNA] CTD PMID:19030233 NCBI chr12:20,543,038...20,548,590
Ensembl chr12:20,543,038...20,548,594
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Rimonabant results in increased expression of PPARA mRNA CTD PMID:30365523 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Rimonabant affects the expression of PPARG mRNA CTD PMID:20110567 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppfibp1 PPFIA binding protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PPFIBP1 mRNA] CTD PMID:19030233 NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PPP1CB mRNA] CTD PMID:19030233 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PPP3CA mRNA] CTD PMID:19030233 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prkd3 protein kinase D3 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRKD3 mRNA]
Rimonabant affects the expression of PRKD3 mRNA
CTD PMID:19030233 NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance
multiple interactions
ISO
EXP
PRKN results in decreased susceptibility to Rimonabant
Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein]
CTD PMID:15882845 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO
EXP
Rimonabant inhibits the reaction [Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]]
Dronabinol affects the reaction [Rimonabant results in increased expression of PRL protein]; Rimonabant inhibits the reaction [Dronabinol results in decreased expression of PRL protein]
CTD PMID:9825732 PMID:15099659 PMID:31154070 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prpf40a pre-mRNA processing factor 40 homolog A multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRPF40A mRNA] CTD PMID:19030233 NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 affects expression
multiple interactions
ISO Rimonabant affects the expression of PRPS1 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRPS1 mRNA]
CTD PMID:19030233 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PTBP3 mRNA] CTD PMID:19030233 NCBI chr 5:74,313,536...74,399,439
Ensembl chr 5:74,315,101...74,399,791
JBrowse link
G Pten phosphatase and tensin homolog affects expression
multiple interactions
EXP Rimonabant affects the expression of PTEN mRNA
[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Rimonabant] affects the expression of PTEN mRNA
CTD PMID:32833042 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of PTGES2 mRNA] CTD PMID:19030233 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PTGS2 protein]]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; Rimonabant inhibits the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]] CTD PMID:26209559 PMID:30769029 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PTP4A1 mRNA] CTD PMID:19030233 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Pyy peptide YY multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PYY mRNA] CTD PMID:19030233 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Rimonabant inhibits the reaction [Ethanol promotes the reaction [EHMT2 protein binds to RAC1 promoter]]; Rimonabant inhibits the reaction [Ethanol results in decreased expression of RAC1 protein] CTD PMID:30143782 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Rimonabant inhibits the reaction [Dronabinol results in increased localization of RAF1 protein]; Rimonabant inhibits the reaction [methanandamide results in increased localization of RAF1 protein] CTD PMID:12834810 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ramp2 receptor activity modifying protein 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of RAMP2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RAMP2 mRNA]
CTD PMID:19030233 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Rbms1 RNA binding motif, single stranded interacting protein 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RBMS1 mRNA] CTD PMID:19030233 NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RBPJ mRNA] CTD PMID:19030233 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO Rimonabant inhibits the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]
Rimonabant results in decreased expression of RELA protein
CTD PMID:21373835 PMID:26209559 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RFNG mRNA]
Rimonabant affects the expression of RFNG mRNA
CTD PMID:19030233 NCBI chr10:106,047,221...106,050,331
Ensembl chr10:106,047,221...106,050,345
JBrowse link
G Rgs11 regulator of G-protein signaling 11 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RGS11 mRNA] CTD PMID:19030233 NCBI chr10:15,222,803...15,231,060
Ensembl chr10:15,222,803...15,231,060
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein] CTD PMID:31220554 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK3 protein] CTD PMID:31220554 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G rnf141 ring finger protein 141 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF141 mRNA] CTD PMID:19030233 NCBI chr 1:164,933,972...164,957,081
Ensembl chr 1:164,931,077...164,957,118
JBrowse link
G Rnf185 ring finger protein 185 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RNF185 mRNA] CTD PMID:19030233 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864
JBrowse link
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF19A mRNA] CTD PMID:19030233 NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222
JBrowse link
G Rnf2 ring finger protein 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF2 mRNA] CTD PMID:19030233 NCBI chr13:63,553,964...63,584,047
Ensembl chr13:63,554,862...63,583,099
JBrowse link
G Rnf6 ring finger protein 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RNF6 mRNA] CTD PMID:19030233 NCBI chr12:8,816,777...8,826,870
Ensembl chr12:8,816,833...8,826,847
JBrowse link
G Rp9 RP9, pre-mRNA splicing factor multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RP9 mRNA] CTD PMID:19030233 NCBI chr 8:20,955,447...21,005,225
Ensembl chr 8:20,941,362...21,005,175
JBrowse link
G Rpf2 ribosome production factor 2 homolog multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPF2 mRNA] CTD PMID:19030233 NCBI chr20:43,630,003...43,651,477
Ensembl chr20:43,629,951...43,651,509
JBrowse link
G Rpl18 ribosomal protein L18 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPL18 mRNA] CTD PMID:19030233 NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452
JBrowse link
G Rpl28 ribosomal protein L28 affects expression
multiple interactions
ISO Rimonabant affects the expression of RPL28 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPL28 mRNA]
CTD PMID:19030233 NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
JBrowse link
G Rpl41 ribosomal protein L41 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPL41 mRNA] CTD PMID:19030233 NCBI chr 7:977,885...978,965 JBrowse link
G Rps10 ribosomal protein S10 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPS10 mRNA] CTD PMID:19030233 NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
JBrowse link
G Rps15 ribosomal protein S15 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPS15 mRNA] CTD PMID:19030233 NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
JBrowse link
G Rps28 ribosomal protein S28 affects expression ISO Rimonabant affects the expression of RPS28 mRNA CTD PMID:19030233 NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Rimonabant results in decreased phosphorylation of RPS6 protein CTD PMID:30687088 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps8 ribosomal protein S8 affects expression
multiple interactions
ISO Rimonabant affects the expression of RPS8 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RPS8 mRNA]
CTD PMID:19030233 NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268
JBrowse link
G Rras2 RAS related 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RRAS2 mRNA] CTD PMID:19030233 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G Rxrb retinoid X receptor beta multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RXRB mRNA] CTD PMID:19030233 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
G Ryk receptor-like tyrosine kinase affects expression
multiple interactions
ISO Rimonabant affects the expression of RYK mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of RYK mRNA]
CTD PMID:19030233 NCBI chr 8:103,419,348...103,492,083
Ensembl chr 8:103,419,275...103,491,698
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Rimonabant results in increased expression of SCARB1 mRNA CTD PMID:20110567 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Rimonabant results in decreased expression of SCD1 mRNA CTD PMID:20110567 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SCD2 mRNA] CTD PMID:19030233 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
JBrowse link
G Scoc short coiled-coil protein multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SCOC mRNA] CTD PMID:19030233 NCBI chr19:24,659,651...24,689,236
Ensembl chr19:24,659,651...24,693,217
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEC62 mRNA] CTD PMID:19030233 NCBI chr 2:112,570,810...112,607,576
Ensembl chr 2:112,570,819...112,601,814
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEC63 mRNA] CTD PMID:19030233 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
JBrowse link
G Sema3c semaphorin 3C multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEMA3C mRNA] CTD PMID:19030233 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
JBrowse link
G Sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase affects expression ISO Rimonabant affects the expression of SEPSECS mRNA CTD PMID:19030233 NCBI chr14:58,311,484...58,341,745
Ensembl chr14:58,311,499...58,341,740
JBrowse link
G Septin2 septin 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SEPTIN2 mRNA] CTD PMID:19030233 NCBI chr 9:94,018,141...94,051,386
Ensembl chr 9:94,018,208...94,051,386
JBrowse link
G Septin6 septin 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SEPTIN6 mRNA] CTD PMID:19030233 NCBI chr  X:116,153,255...116,230,334
Ensembl chr  X:116,153,255...116,230,115
JBrowse link
G Serpinb6a serpin family B member 6A multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SERPINB6A mRNA]
Rimonabant affects the expression of SERPINB6A mRNA
CTD PMID:19030233 NCBI chr17:30,871,428...30,989,703
Ensembl chr17:30,871,468...31,014,427
JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Rimonabant results in decreased expression of SERPINE1 protein CTD PMID:17882151 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sestd1 SEC14 and spectrin domain containing 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SESTD1 mRNA]
Rimonabant affects the expression of SESTD1 mRNA
CTD PMID:19030233 NCBI chr 3:62,123,590...62,220,759
Ensembl chr 3:62,129,887...62,220,546
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SGTA mRNA] CTD PMID:19030233 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458
JBrowse link
G Sh3bgrl SH3 domain binding glutamate-rich protein like multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SH3BGRL mRNA] CTD PMID:19030233 NCBI chr  X:74,167,029...74,263,783
Ensembl chr  X:74,166,871...74,263,783
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SIPA1L1 mRNA]
Rimonabant affects the expression of SIPA1L1 mRNA
CTD PMID:19030233 NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SLC2A4 mRNA] CTD PMID:19030233 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SLC39A10 mRNA] CTD PMID:19030233 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SLC39A8 mRNA] CTD PMID:19030233 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SMARCA2 mRNA] CTD PMID:19030233 NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression EXP Rimonabant results in decreased expression of SOCS1 mRNA CTD PMID:30365523 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression EXP Rimonabant results in decreased expression of SOCS3 mRNA CTD PMID:30365523 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 affects expression ISO Rimonabant affects the expression of SORBS2 mRNA CTD PMID:19030233 NCBI chr16:46,435,220...46,748,743
Ensembl chr16:46,435,237...46,626,514
JBrowse link
G Sparc secreted protein acidic and cysteine rich multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SPARC mRNA]
Rimonabant affects the expression of SPARC mRNA
CTD PMID:19030233 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SPTBN1 mRNA]
Rimonabant affects the expression of SPTBN1 mRNA
CTD PMID:19030233 NCBI chr14:103,842,684...104,008,507
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of SRC protein] CTD PMID:16046413 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srp72 signal recognition particle 72 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SRP72 mRNA] CTD PMID:19030233 NCBI chr14:31,168,175...31,195,717
Ensembl chr14:31,168,293...31,195,729
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ST3GAL6 mRNA] CTD PMID:19030233 NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Rimonabant inhibits the reaction [HU 211 results in increased phosphorylation of STAT3 protein] CTD PMID:16046413 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO [MIR466J mRNA co-treated with Rimonabant] affects the expression of STAT6 mRNA; Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of STAT6 mRNA] CTD PMID:30910812 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Stim2 stromal interaction molecule 2 multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of STIM2 mRNA]
Rimonabant affects the expression of STIM2 mRNA
CTD PMID:19030233 NCBI chr14:56,878,428...57,004,405
Ensembl chr14:56,878,645...57,004,179
JBrowse link
G Strn4 striatin 4 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of STRN4 mRNA] CTD PMID:19030233 NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858
JBrowse link
G Tcea1 transcription elongation factor A1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TCEA1 mRNA] CTD PMID:19030233 NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
JBrowse link
G Tcea1l1 transcription elongation factor A1-like 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TCEA1 mRNA] CTD PMID:19030233 NCBI chr15:10,401,012...10,403,460
Ensembl chr15:10,400,829...10,402,942
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Rimonabant results in decreased expression of TGFB1 mRNA CTD PMID:30365523 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TGIF2 mRNA] CTD PMID:19030233 NCBI chr 3:145,333,152...145,348,599
Ensembl chr 3:145,333,418...145,348,596
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity
EXP Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein]; Rimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein]
Rimonabant results in increased activity of TH protein
CTD PMID:9188039 PMID:10700552 PMID:15882845 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions EXP Rimonabant inhibits the reaction [methanandamide affects the expression of THY1 mRNA] CTD PMID:17591864 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Rimonabant results in decreased expression of TIMP1 mRNA CTD PMID:21863215 PMID:30365523 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmed7 transmembrane p24 trafficking protein 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TMED7 mRNA] CTD PMID:19030233 NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TNF]; Rimonabant inhibits the reaction [forsythiaside inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of TNF protein]]
Rimonabant results in decreased expression of TNF mRNA
CTD PMID:20110567 PMID:30365523 PMID:30769029 PMID:32832534 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TOMM20 mRNA] CTD PMID:19030233 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198
JBrowse link
G Tpm4 tropomyosin 4 affects expression
multiple interactions
ISO Rimonabant affects the expression of TPM4 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of TPM4 mRNA]
CTD PMID:19030233 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Rimonabant inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Rimonabant inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; Rimonabant inhibits the reaction [N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of TRPV1 protein] CTD PMID:11278420 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of TSEN2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TSEN2 mRNA]
CTD PMID:19030233 NCBI chr 4:148,602,805...148,638,219
Ensembl chr 4:148,602,863...148,638,215
JBrowse link
G Tspan5 tetraspanin 5 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TSPAN5 mRNA] CTD PMID:19030233 NCBI chr 2:227,294,180...227,469,361
Ensembl chr 2:227,294,217...227,465,664
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP Rimonabant results in increased expression of TXNRD1 mRNA CTD PMID:30365523 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Unc5b unc-5 netrin receptor B multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of UNC5B mRNA] CTD PMID:30910812 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537
JBrowse link
G Usp46 ubiquitin specific peptidase 46 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of USP46 mRNA] CTD PMID:19030233 NCBI chr14:34,150,055...34,219,227
Ensembl chr14:34,150,004...34,219,227
JBrowse link
G Usp48 ubiquitin specific peptidase 48 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of USP48 mRNA] CTD PMID:19030233 NCBI chr 5:149,800,189...149,867,838
Ensembl chr 5:149,800,179...149,867,719
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO Rimonabant inhibits the reaction [Glucose results in increased expression of VCAM1 protein]
Rimonabant results in decreased expression of VCAM1 protein
CTD PMID:21373835 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcl vinculin multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of VCL mRNA] CTD PMID:19030233 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of and results in decreased secretion of VEGFA protein] CTD PMID:15313899 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions
affects expression
ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of VIM mRNA]
Rimonabant affects the expression of VIM mRNA
CTD PMID:19030233 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of VLDLR mRNA] CTD PMID:19030233 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Wdr26 WD repeat domain 26 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WDR26 mRNA] CTD PMID:19030233 NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295
JBrowse link
G Wdr7 WD repeat domain 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of WDR7 mRNA] CTD PMID:19030233 NCBI chr18:57,165,482...57,448,568
Ensembl chr18:57,165,488...57,448,540
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WSB1 mRNA] CTD PMID:19030233 NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WWP1 mRNA] CTD PMID:19030233 NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of WWTR1 mRNA] CTD PMID:19030233 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
ISO Rimonabant results in increased expression of XBP1 mRNA
[Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of XBP1 mRNA alternative form]; gemcitabine promotes the reaction [Rimonabant results in increased expression of XBP1 mRNA]
CTD PMID:21525939 PMID:31054322 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 affects expression
multiple interactions
ISO Rimonabant affects the expression of ZDHHC2 mRNA
Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ZDHHC2 mRNA]
CTD PMID:19030233 NCBI chr16:51,808,465...51,878,060
Ensembl chr16:51,808,468...51,878,060
JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of ZDHHC7 mRNA] CTD PMID:19030233 NCBI chr19:48,139,309...48,156,673
Ensembl chr19:48,139,527...48,156,673
JBrowse link
G Zhx1 zinc fingers and homeoboxes 1 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ZHX1 mRNA] CTD PMID:19030233 NCBI chr 7:89,582,363...89,611,337
Ensembl chr 7:89,582,243...89,611,264
JBrowse link
G Znrf2 zinc and ring finger 2 multiple interactions ISO Rimonabant inhibits the reaction [Dietary Fats results in increased expression of ZNRF2 mRNA] CTD PMID:19030233 NCBI chr 4:83,950,406...84,032,676
Ensembl chr 4:83,949,309...84,027,818
JBrowse link
G Zwilch zwilch kinetochore protein affects expression ISO Rimonabant affects the expression of ZWILCH mRNA CTD PMID:19030233 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
JBrowse link
sibutramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sibutramine results in increased expression of BAX protein CTD PMID:27838152 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sibutramine results in decreased expression of BCL2 protein CTD PMID:27838152 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity ISO sibutramine results in increased activity of CASP3 protein CTD PMID:27838152 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO sibutramine results in decreased activity of CYP2B6 protein
sibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:23777987 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO sibutramine results in decreased activity of CYP2C19 protein CTD PMID:23777987 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects response to substance
affects metabolic processing
ISO CYP3A4 protein affects the susceptibility to sibutramine
CYP3A4 protein affects the metabolism of sibutramine
CTD PMID:27838152 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO sibutramine results in increased expression of DDIT3 mRNA; sibutramine results in increased expression of DDIT3 protein CTD PMID:27838152 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO sibutramine results in decreased expression of and affects the phosphorylation of NOS3 protein CTD PMID:27838152 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression ISO sibutramine results in decreased expression of PSMB5 protein CTD PMID:27838152 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO sibutramine results in decreased expression of PSMB8 protein CTD PMID:27838152 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
JBrowse link
tris(picolinato)chromium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Avp arginine vasopressin multiple interactions EXP chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]; chromium tripicolinate affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; INS1 protein affects the reaction [chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] CTD PMID:9446840 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased expression of BAX protein] CTD PMID:19376147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO chromium tripicolinate results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased activity of CASP3 protein]
CTD PMID:19376147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
chromium tripicolinate results in decreased activity of CAT protein
CTD PMID:19693677 PMID:23122718 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of GSR protein] CTD PMID:23122718 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form CTD PMID:17684468 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP chromium tripicolinate results in decreased expression of and results in decreased activity of PTPN1 protein CTD PMID:16424121 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        pharmacological role 19070
          anti-obesity agent 463
            (S)-nandinine + 0
            AS1842856 0
            UAB126 0
            desiccated thyroid extract 0
            duvoglustat + 26
            ginsenoside Rb1 22
            indirubin-3'-monoxime 48
            lorcaserin 4
            orlistat 103
            resolvin D2 14
            rimonabant 324
            semaglutide 0
            sibiskoside 0
            sibutramine 11
            sigmoidin A 0
            tris(picolinato)chromium 9
paths to the root