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ONTOLOGY REPORT - ANNOTATIONS


Term:6-aminonicotinamide
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Accession:CHEBI:74514 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.
Synonyms:related_synonym: 2-amino-5-carbamoylpyridine;   6-AN;   6-ANA;   6-Aminonikotinsaeureamid;   6-amino-3-pyridinecarboxamide;   6-aminonicotinic acid amide;   Formula=C6H7N3O;   InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10);   InChIKey=ZLWYEPMDOUQDBW-UHFFFAOYSA-N;   SMILES=NC(=O)c1ccc(N)nc1;   SR 4388
 xref: CAS:329-89-5 "ChemIDplus";   CAS:329-89-5 "NIST Chemistry WebBook"
 xref_mesh: MESH:D015120
 xref: MetaCyc:CPD-9571;   PMID:125068 "Europe PMC";   PMID:145497 "Europe PMC";   PMID:152349 "Europe PMC";   PMID:155198 "Europe PMC";   PMID:2948367 "Europe PMC";   PMID:3156443 "Europe PMC";   PMID:6236288 "Europe PMC";   PMID:6445393 "Europe PMC";   PMID:9516960 "Europe PMC";   Reaxys:116042 "Reaxys"


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6-aminonicotinamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6480464
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:6480464
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        biochemical role 19130
          antimetabolite 8465
            6-aminonicotinamide 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  6-aminonicotinamide 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.