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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naftifine
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Accession:CHEBI:7451 term browser browse the term
Definition:A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.
Synonyms:exact_synonym: (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
 related_synonym: (E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine;   Formula=C21H21N;   InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+;   InChIKey=OZGNYLLQHRPOBR-DHZHZOJOSA-N;   SMILES=CN(C\\C=C\\c1ccccc1)Cc1cccc2ccccc12;   naftifin;   naftifina;   naftifinum;   trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine
 xref: CAS:65472-88-0;   DrugBank:DB00735;   Drug_Central:1872;   HMDB:HMDB0014873;   KEGG:C08071;   KEGG:D08245
 xref_mesh: MESH:C029178
 xref: PMID:18212112;   PMID:24196340;   PMID:25294700;   PMID:6388170;   Patent:BE853976;   Patent:US4282251;   Reaxys:2983617;   Wikipedia:Naftifine


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naftifine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO naftifine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        inhibitor 18924
          sterol biosynthesis inhibitor 6573
            naftifine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    main group molecular entity 19853
                      s-block molecular entity 19684
                        hydrogen molecular entity 19673
                          hydrides 19150
                            inorganic hydride 18129
                              pnictogen hydride 18118
                                nitrogen hydride 18024
                                  azane 17823
                                    ammonia 17822
                                      organic amino compound 17822
                                        tertiary amino compound 10136
                                          tertiary amine 634
                                            naftifine 1
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