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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naftifine
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Accession:CHEBI:7451 term browser browse the term
Definition:A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.
Synonyms:exact_synonym: (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
 related_synonym: (E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine;   Formula=C21H21N;   InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+;   InChIKey=OZGNYLLQHRPOBR-DHZHZOJOSA-N;   SMILES=CN(C\\C=C\\c1ccccc1)Cc1cccc2ccccc12;   naftifin;   naftifina;   naftifinum;   trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine
 xref: CAS:65472-88-0;   DrugBank:DB00735;   Drug_Central:1872;   HMDB:HMDB0014873;   KEGG:C08071;   KEGG:D08245
 xref_mesh: MESH:C029178
 xref: PMID:18212112;   PMID:24196340;   PMID:25294700;   PMID:6388170;   Patent:BE853976;   Patent:US4282251;   Reaxys:2983617;   Wikipedia:Naftifine


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naftifine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO naftifine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        inhibitor 18924
          sterol biosynthesis inhibitor 6562
            naftifine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        tertiary amino compound 10153
                                          tertiary amine 645
                                            naftifine 1
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