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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:7451 term browser browse the term
Definition:A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.
Synonyms:exact_synonym: (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
 related_synonym: (E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine;   Formula=C21H21N;   InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+;   InChIKey=OZGNYLLQHRPOBR-DHZHZOJOSA-N;   SMILES=CN(C\\C=C\\c1ccccc1)Cc1cccc2ccccc12;   naftifin;   naftifina;   naftifinum;   trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine
 xref: CAS:65472-88-0;   DrugBank:DB00735;   Drug_Central:1872;   HMDB:HMDB0014873;   KEGG:C08071;   KEGG:D08245
 xref_mesh: MESH:C029178
 xref: PMID:18212112;   PMID:24196340;   PMID:25294700;   PMID:6388170;   Patent:BE853976;   Patent:US4282251;   Reaxys:2983617;   Wikipedia:Naftifine

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naftifine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO naftifine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        inhibitor 18304
          sterol biosynthesis inhibitor 2914
            naftifine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    main group molecular entity 19763
                      s-block molecular entity 19511
                        hydrogen molecular entity 19503
                          hydrides 18775
                            inorganic hydride 17505
                              pnictogen hydride 17478
                                nitrogen hydride 17323
                                  azane 17040
                                    ammonia 17039
                                      organic amino compound 17038
                                        tertiary amino compound 8652
                                          tertiary amine 610
                                            naftifine 1
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