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ONTOLOGY REPORT - ANNOTATIONS


Term:nafenopin
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Accession:CHEBI:7449 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-nafenopin. It is a peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an hypolipidemic agent.
Synonyms:exact_synonym: rac-2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid
 related_synonym: 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   C 13437 SU;   CH 13-437;   CH 13437;   Ciba 13437 SU;   D,L-nafenopin;   DL-nafenopin;   Melipan;   SU-13437;   alpha-methyl-alpha-(p-1,2,3,4-tetrahydronaphth-1-ylphenoxy)propionic acid;   nafenopina;   nafenopine;   nafenopinum
 xref: CAS:3771-19-5 "ChemIDplus";   CAS:3771-19-5 "KEGG COMPOUND";   KEGG:C11371;   KEGG:D05102
 xref_mesh: MESH:D009255
 xref: PMID:10383891 "Europe PMC";   PMID:10573520 "Europe PMC";   PMID:10726969 "Europe PMC";   PMID:10869456 "Europe PMC";   PMID:10903494 "Europe PMC";   PMID:10964109 "Europe PMC";   PMID:11133804 "Europe PMC";   PMID:18079279 "Europe PMC";   PMID:3053229 "Europe PMC";   PMID:7009388 "Europe PMC";   PMID:9950074 "Europe PMC";   Patent:DE2018135;   Reaxys:2005820 "Reaxys";   Wikipedia:Nafenopin


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nafenopin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa1a acetyl-CoA acyltransferase 1A JBrowse link 8 128,027,880 128,036,471 RGD:6480464
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6480464
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Ech1 enoyl-CoA hydratase 1 JBrowse link 1 87,009,798 87,015,996 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6480464
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Hibadh 3-hydroxyisobutyrate dehydrogenase JBrowse link 4 82,604,369 82,702,429 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link 10 109,736,459 109,748,070 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          carcinogenic agent 17766
            nafenopin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid 18
                                            (R)-nafenopin 18
                                              nafenopin 18
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.