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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nafenopin
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Accession:CHEBI:7449 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-nafenopin. It is a peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an hypolipidemic agent.
Synonyms:exact_synonym: rac-2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid
 related_synonym: 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   C 13437 SU;   CH 13-437;   CH 13437;   Ciba 13437 SU;   D,L-nafenopin;   DL-nafenopin;   Melipan;   SU-13437;   alpha-methyl-alpha-(p-1,2,3,4-tetrahydronaphth-1-ylphenoxy)propionic acid;   nafenopina;   nafenopine;   nafenopinum
 xref: CAS:3771-19-5;   KEGG:C11371;   KEGG:D05102
 xref_mesh: MESH:D009255
 xref: PMID:10383891;   PMID:10573520;   PMID:10726969;   PMID:10869456;   PMID:10903494;   PMID:10964109;   PMID:11133804;   PMID:18079279;   PMID:3053229;   PMID:7009388;   PMID:9950074;   Patent:DE2018135;   Reaxys:2005820;   Wikipedia:Nafenopin


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nafenopin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 protein CTD PMID:15071170 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein CTD PMID:15071170 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects expression EXP Nafenopin affects the expression of ATP5F1B protein CTD PMID:10903494 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Cat catalase increases expression
multiple interactions		 EXP Nafenopin results in increased expression of CAT protein
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of CAT protein		 CTD PMID:6845354 PMID:15071170 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Nafenopin results in increased expression of CHRM3 protein CTD PMID:10903494 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP Nafenopin results in increased expression of CYP4A1 mRNA
Okadaic Acid inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]; tautomycin inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]		 CTD PMID:18079279 PMID:19647067 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Nafenopin results in decreased expression of ECH1 protein CTD PMID:10903494 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Nafenopin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA CTD PMID:15071170 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Nafenopin results in decreased expression of ERP29 protein CTD PMID:10903494 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Nafenopin results in increased expression of GSTA3 protein CTD PMID:8914623 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Nafenopin results in decreased expression of GSTM2 protein CTD PMID:8914623 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression EXP Nafenopin results in increased expression of HIBADH protein CTD PMID:10903494 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Nafenopin results in increased expression of HMOX1 protein CTD PMID:25690736 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Nafenopin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression EXP Nafenopin results in increased expression of P4HB protein CTD PMID:10903494 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases phosphorylation
increases activity
decreases expression
increases expression		 ISO
EXP		 [Nafenopin results in increased activity of PPARA protein] which results in increased expression of CYP4A6 mRNA; aroclor 1260 inhibits the reaction [Nafenopin results in increased activity of PPARA protein]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein]
Nafenopin results in decreased phosphorylation of PPARA protein
Nafenopin results in increased activity of PPARA protein; Nafenopin results in increased activity of PPARA protein mutant form
Nafenopin results in decreased expression of PPARA mRNA
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of CAT protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA; Okadaic Acid inhibits the reaction [Nafenopin results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein mutant form]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein]
Nafenopin results in increased expression of PPARA protein		 CTD PMID:7684926 PMID:15071170 PMID:18079279 PMID:24812009 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Vim vimentin increases expression EXP Nafenopin results in increased expression of VIM protein CTD PMID:10903494 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        aetiopathogenetic role 19267
          carcinogenic agent 18554
            nafenopin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      monocarboxylic acid 18028
                                        2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid 18
                                          (R)-nafenopin 18
                                            nafenopin 18
paths to the root