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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nafenopin
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Accession:CHEBI:7449 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-nafenopin. It is a peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an hypolipidemic agent.
Synonyms:exact_synonym: rac-2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid
 related_synonym: 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   C 13437 SU;   CH 13-437;   CH 13437;   Ciba 13437 SU;   D,L-nafenopin;   DL-nafenopin;   Melipan;   SU-13437;   alpha-methyl-alpha-(p-1,2,3,4-tetrahydronaphth-1-ylphenoxy)propionic acid;   nafenopina;   nafenopine;   nafenopinum
 xref: CAS:3771-19-5;   KEGG:C11371;   KEGG:D05102
 xref_mesh: MESH:D009255
 xref: PMID:10383891;   PMID:10573520;   PMID:10726969;   PMID:10869456;   PMID:10903494;   PMID:10964109;   PMID:11133804;   PMID:18079279;   PMID:3053229;   PMID:7009388;   PMID:9950074;   Patent:DE2018135;   Reaxys:2005820;   Wikipedia:Nafenopin



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nafenopin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 protein CTD PMID:15071170 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein CTD PMID:15071170 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects expression EXP Nafenopin affects the expression of ATP5F1B protein CTD PMID:10903494 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP Nafenopin results in increased expression of CAT protein
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of CAT protein
CTD PMID:6845354 PMID:15071170 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Nafenopin results in increased expression of CHRM3 protein CTD PMID:10903494 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP Nafenopin results in increased expression of CYP4A1 mRNA
Okadaic Acid inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]; tautomycin inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]
CTD PMID:18079279 PMID:19647067 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Nafenopin results in decreased expression of ECH1 protein CTD PMID:10903494 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Nafenopin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA CTD PMID:15071170 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Nafenopin results in decreased expression of ERP29 protein CTD PMID:10903494 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP Nafenopin results in increased expression of GSTA3 protein CTD PMID:8914623 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Nafenopin results in decreased expression of GSTM2 protein CTD PMID:8914623 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression EXP Nafenopin results in increased expression of HIBADH protein CTD PMID:10903494 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Nafenopin results in increased expression of HMOX1 protein CTD PMID:25690736 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Nafenopin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression EXP Nafenopin results in increased expression of P4HB protein CTD PMID:10903494 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
increases expression
decreases expression
decreases phosphorylation
ISO
EXP
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of CYP4A6 mRNA; aroclor 1260 inhibits the reaction [Nafenopin results in increased activity of PPARA protein]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein]
Nafenopin results in increased expression of PPARA protein
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of CAT protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA; Okadaic Acid inhibits the reaction [Nafenopin results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein mutant form]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein]
Nafenopin results in decreased expression of PPARA mRNA
Nafenopin results in increased activity of PPARA protein; Nafenopin results in increased activity of PPARA protein mutant form
CTD PMID:7684926 PMID:15071170 PMID:18079279 PMID:24812009 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Vim vimentin increases expression EXP Nafenopin results in increased expression of VIM protein CTD PMID:10903494 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        aetiopathogenetic role 19050
          carcinogenic agent 18381
            nafenopin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        monocarboxylic acid 17639
                                          2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid 18
                                            (R)-nafenopin 18
                                              nafenopin 18
paths to the root