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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-chloro-7-iodoquinolin-8-ol
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Accession:CHEBI:74460 term browser browse the term
Definition:A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Synonyms:related_synonym: 5-Chlor-7-jod-8-hydroxy-chinolin;   5-chloro-7-iodo-8-hydroxyquinoline;   5-chloro-7-iodo-8-quinolinol;   5-chloro-8-hydroxy-7-iodoquinoline;   7-iodo-5-chloroxine;   Formula=C9H5ClINO;   InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H;   InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N;   SMILES=Oc1c(I)cc(Cl)c2cccnc12;   chloroiodoquin;   clioquinol;   clioquinolum;   iodochlorhydroxyquinoline;   iodochlorohydroxyquin;   iodochloroxyquinoline
 xref: CAS:130-26-7;   DrugBank:DB04815;   Drug_Central:681;   KEGG:D03538;   LINCS:LSM-2186
 xref_mesh: MESH:D007464
 xref: PDBeChem:CQL;   PMID:15074181;   PMID:15651505;   PMID:16087879;   PMID:185949;   PMID:20651355;   PMID:21080020;   PMID:21199452;   PMID:21247386;   PMID:21426304;   PMID:21899946;   PMID:22248233;   PMID:22269164;   PMID:22627294;   PMID:226725;   PMID:23044228;   PMID:23360710;   PMID:23627708;   Patent:DE117767;   Patent:US641491;   Reaxys:153637;   Wikipedia:Clioquinol


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5-chloro-7-iodoquinolin-8-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein] CTD PMID:25856695 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ago2 argonaute RISC catalytic component 2 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein CTD PMID:22415087 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Clioquinol results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:15,912,431...15,923,045 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; [Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein CTD PMID:16648635 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; [Clioquinol binds to Copper] which results in increased degradation of APP protein modified form; [Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form; Clioquinol inhibits the reaction [Copper results in increased secretion of APP protein alternative form]; Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form] CTD PMID:16648635 PMID:18346929 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO [Clioquinol binds to Copper] which results in decreased expression of AR protein CTD PMID:17308104 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Clioquinol results in increased expression of ATF3 mRNA CTD PMID:32661532 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Clioquinol results in increased phosphorylation of ATM protein CTD PMID:22627294 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atox1 antioxidant 1 copper chaperone increases oxidation ISO Clioquinol results in increased oxidation of ATOX1 protein CTD PMID:33034664 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO Clioquinol results in decreased expression of BNIP3L mRNA CTD PMID:19502547 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17287498 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Clioquinol results in increased expression of CDKN1A mRNA CTD PMID:22627294 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Commd1 copper metabolism domain containing 1 affects response to substance ISO COMMD1 gene SNP affects the susceptibility to Clioquinol CTD PMID:25622337 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
JBrowse link
G Dbh dopamine beta-hydroxylase increases expression
decreases secretion
ISO Clioquinol results in increased expression of DBH mRNA
Clioquinol results in decreased secretion of DBH protein
CTD PMID:33034664 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Dcp1b decapping mRNA 1B multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA CTD PMID:22415087 NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145
JBrowse link
G Dicer1 dicer 1 ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein CTD PMID:22415087 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein CTD PMID:22415087 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of EGFR protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein; [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of EGFR protein]; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Clioquinol results in decreased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO Clioquinol results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751
JBrowse link
G Egr1 early growth response 1 increases expression ISO Clioquinol results in increased expression of EGR1 mRNA CTD PMID:19502547 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein CTD PMID:22415087 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Epo erythropoietin increases expression
decreases expression
ISO Clioquinol results in increased expression of EPO mRNA
Clioquinol results in decreased expression of EPO mRNA
CTD PMID:16973622 PMID:19502547 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clioquinol promotes the reaction [FOS protein binds to CXCL8 promoter] CTD PMID:29966605 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Clioquinol results in increased expression of GADD45A mRNA CTD PMID:22627294 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions
ISO Clioquinol results in decreased expression of GATA2 protein
GATA2 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA2 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD PMID:29966605 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata3 GATA binding protein 3 decreases expression
multiple interactions
ISO Clioquinol results in decreased expression of GATA3 protein
Clioquinol inhibits the reaction [GATA3 protein binds to CXCL8 promoter]; GATA3 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA3 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD PMID:29966605 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Clioquinol results in increased phosphorylation of H2AX protein CTD PMID:22627294 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
decreases hydroxylation
decreases ubiquitination
increases activity
ISO [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
[Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
Clioquinol results in decreased hydroxylation of HIF1A protein
Clioquinol results in decreased ubiquitination of HIF1A protein
Clioquinol results in increased activity of HIF1A protein
CTD PMID:16973622 PMID:19502547 PMID:19679656 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor multiple interactions
decreases activity
ISO Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
Clioquinol results in decreased activity of HIF1AN protein
CTD PMID:16973622 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO Clioquinol results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clioquinol results in increased expression of HMOX1 mRNA CTD PMID:32661532 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clioquinol promotes the reaction [JUN protein binds to CXCL8 promoter] CTD PMID:29966605 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lox lysyl oxidase increases expression
decreases secretion
ISO Clioquinol results in increased expression of LOX mRNA
Clioquinol results in decreased secretion of LOX protein
CTD PMID:33034664 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:16648635 PMID:18346929 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:16648635 PMID:18346929 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein] CTD PMID:16648635 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO Clioquinol results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mir130a microRNA 130a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA CTD PMID:22415087 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir223 microRNA 223 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA CTD PMID:22415087 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir29a microRNA 29a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA CTD PMID:22415087 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP2 protein CTD PMID:16648635 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein CTD PMID:16648635 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein] CTD PMID:23360710 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mog myelin oligodendrocyte glycoprotein multiple interactions ISO Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein] CTD PMID:23360710 NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]] CTD PMID:25758465 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]] CTD PMID:25758465 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression ISO Clioquinol results in decreased expression of P4HA2 mRNA CTD PMID:19502547 NCBI chr10:38,243,047...38,271,989
Ensembl chr10:38,243,139...38,287,314
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Clioquinol results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:18346929 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Clioquinol results in increased phosphorylation of TP53 protein] CTD PMID:22627294 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression
multiple interactions
ISO Clioquinol results in increased expression of VEGFA mRNA; Clioquinol results in increased expression of VEGFA protein
Clioquinol results in decreased expression of VEGFA mRNA
HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
CTD PMID:16973622 PMID:19502547 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vopp1 VOPP1 WW domain binding protein decreases expression ISO Clioquinol results in decreased expression of ECOP mRNA CTD PMID:19502547 NCBI chr 4:87,363,678...87,432,747
Ensembl chr 4:87,363,477...87,450,375
JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          5-chloro-7-iodoquinolin-8-ol 56
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organonitrogen heterocyclic compound 17639
                                    quinolines 2595
                                      hydroxyquinoline 308
                                        monohydroxyquinoline 308
                                          5-chloro-7-iodoquinolin-8-ol 56
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