Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:5-chloro-7-iodoquinolin-8-ol
go back to main search page
Accession:CHEBI:74460 term browser browse the term
Definition:A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Synonyms:related_synonym: 5-Chlor-7-jod-8-hydroxy-chinolin;   5-chloro-7-iodo-8-hydroxyquinoline;   5-chloro-7-iodo-8-quinolinol;   5-chloro-8-hydroxy-7-iodoquinoline;   7-iodo-5-chloroxine;   Formula=C9H5ClINO;   InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H;   InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N;   SMILES=Oc1c(I)cc(Cl)c2cccnc12;   chloroiodoquin;   clioquinol;   clioquinolum;   iodochlorhydroxyquinoline;   iodochlorohydroxyquin;   iodochloroxyquinoline
 xref: CAS:130-26-7 "ChemIDplus";   CAS:130-26-7 "NIST Chemistry WebBook";   DrugBank:DB04815;   Drug_Central:681 "DrugCentral";   KEGG:D03538;   LINCS:LSM-2186
 xref_mesh: MESH:D007464
 xref: PDBeChem:CQL;   PMID:15074181 "Europe PMC";   PMID:15651505 "Europe PMC";   PMID:16087879 "Europe PMC";   PMID:185949 "Europe PMC";   PMID:20651355 "Europe PMC";   PMID:21080020 "Europe PMC";   PMID:21199452 "Europe PMC";   PMID:21247386 "Europe PMC";   PMID:21426304 "Europe PMC";   PMID:21899946 "Europe PMC";   PMID:22248233 "Europe PMC";   PMID:22269164 "Europe PMC";   PMID:22627294 "Europe PMC";   PMID:226725 "Europe PMC";   PMID:23044228 "Europe PMC";   PMID:23360710 "Europe PMC";   PMID:23627708 "Europe PMC";   Patent:DE117767;   Patent:US641491;   Reaxys:153637 "Reaxys";   Wikipedia:Clioquinol


show annotations for term's descendants       view all columns           Sort by:
 
5-chloro-7-iodoquinolin-8-ol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:6480464
G Ak1 adenylate kinase 1 JBrowse link 3 11,652,143 11,659,135 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Commd1 copper metabolism domain containing 1 JBrowse link 14 107,664,321 107,759,974 RGD:6480464
G Dcp1b decapping mRNA 1B JBrowse link 4 151,249,654 151,287,018 RGD:6480464
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:6480464
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:6480464
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:6480464
G Hif3a hypoxia inducible factor 3 subunit alpha JBrowse link 1 78,976,318 78,997,869 RGD:6480464
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:6480464
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:6480464
G Mir130a microRNA 130a JBrowse link 3 72,141,037 72,141,124 RGD:6480464
G Mir223 microRNA 223 JBrowse link X 65,367,812 65,367,921 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mog myelin oligodendrocyte glycoprotein JBrowse link 20 2,003,871 2,014,284 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:6480464
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 JBrowse link 10 39,435,227 39,464,134 RGD:6480464
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6480464
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Vopp1 VOPP1 WW domain binding protein JBrowse link 4 88,441,067 88,515,141 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          5-chloro-7-iodoquinolin-8-ol 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organonitrogen heterocyclic compound 16961
                                    quinolines 2400
                                      hydroxyquinoline 296
                                        monohydroxyquinoline 296
                                          5-chloro-7-iodoquinolin-8-ol 50
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.