Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nabumetone
go back to main search page
Accession:CHEBI:7443 term browser browse the term
Definition:A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Synonyms:related_synonym: 4-(6-Methoxy-2-naphthalenyl)-2-butanone;   4-(6-Methoxy-2-naphthyl)-2-butanone;   Formula=C15H16O2;   InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3;   InChIKey=BLXXJMDCKKHMKV-UHFFFAOYSA-N;   Relafen;   SMILES=COc1ccc2cc(CCC(C)=O)ccc2c1;   nabumetona;   nabumetonum
 xref: Beilstein:2103472;   CAS:42924-53-8;   DrugBank:DB00461;   Drug_Central:1863;   HMDB:HMDB0014604;   KEGG:D00425;   LINCS:LSM-3453
 xref_mesh: MESH:C035605
 xref: PDBeChem:NBO;   PMID:21532165;   PMID:21650014;   PMID:21674107;   PMID:21898684;   PMID:22028826;   PMID:22298755;   PMID:22381180;   PMID:22605805;   PMID:22977877;   PMID:23020786;   PMID:23129452;   PMID:23132511;   PMID:23225308;   PMID:23584048;   PMID:23781467;   PMID:23781476;   PMID:23806470;   PMID:24074034;   PMID:24083957;   Reaxys:2103472;   Wikipedia:Nabumetone


show annotations for term's descendants           Sort by:
nabumetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nabumetone results in decreased expression of BCL2 protein CTD PMID:16019514 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO nabumetone results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO nabumetone results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP nabumetone metabolite results in decreased activity of PTGS1 protein CTD PMID:9258749 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity EXP nabumetone metabolite results in decreased activity of PTGS2 protein CTD PMID:9258749 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sell selectin L affects expression ISO nabumetone affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Utrn utrophin increases expression ISO nabumetone results in increased expression of UTRN mRNA; nabumetone results in increased expression of UTRN protein CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        pro-agent 11523
          prodrug 11284
            nabumetone 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                carbocyclic compound 18563
                                  carbopolycyclic compound 17167
                                    carbobicyclic compound 5871
                                      naphthalenes 3847
                                        alkyloxynaphthalene 112
                                          methoxynaphthalene 113
                                            nabumetone 7
paths to the root