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Accession:CHEBI:7443 term browser browse the term
Definition:A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Synonyms:related_synonym: 4-(6-Methoxy-2-naphthalenyl)-2-butanone;   4-(6-Methoxy-2-naphthyl)-2-butanone;   Formula=C15H16O2;   InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3;   InChIKey=BLXXJMDCKKHMKV-UHFFFAOYSA-N;   Relafen;   SMILES=COc1ccc2cc(CCC(C)=O)ccc2c1;   nabumetona;   nabumetonum
 xref: Beilstein:2103472 "ChemIDplus";   CAS:42924-53-8 "ChemIDplus";   CAS:42924-53-8 "KEGG DRUG";   CAS:42924-53-8 "NIST Chemistry WebBook";   DrugBank:DB00461;   Drug_Central:1863 "DrugCentral";   HMDB:HMDB0014604;   KEGG:D00425;   LINCS:LSM-3453
 xref_mesh: MESH:C035605
 xref: PDBeChem:NBO;   PMID:21532165 "Europe PMC";   PMID:21650014 "Europe PMC";   PMID:21674107 "Europe PMC";   PMID:21898684 "Europe PMC";   PMID:22028826 "Europe PMC";   PMID:22298755 "Europe PMC";   PMID:22381180 "Europe PMC";   PMID:22605805 "Europe PMC";   PMID:22977877 "Europe PMC";   PMID:23020786 "Europe PMC";   PMID:23129452 "Europe PMC";   PMID:23132511 "Europe PMC";   PMID:23225308 "Europe PMC";   PMID:23584048 "Europe PMC";   PMID:23781467 "Europe PMC";   PMID:23781476 "Europe PMC";   PMID:23806470 "Europe PMC";   PMID:24074034 "Europe PMC";   PMID:24083957 "Europe PMC";   Reaxys:2103472 "Reaxys";   Wikipedia:Nabumetone

show annotations for term's descendants       view all columns           Sort by:
nabumetone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Sell selectin L JBrowse link 13 82,369,820 82,387,774 RGD:6480464
G Utrn utrophin JBrowse link 1 6,451,809 6,970,040 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pro-agent 8766
          prodrug 8563
            nabumetone 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                carbocyclic compound 17501
                                  carbopolycyclic compound 14743
                                    carbobicyclic compound 4527
                                      naphthalenes 3721
                                        alkyloxynaphthalene 109
                                          methoxynaphthalene 109
                                            nabumetone 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.