ONTOLOGY REPORT - ANNOTATIONS
Term: nabumetone
Accession: CHEBI:7443
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Definition: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Synonyms: related_synonym: 4-(6-Methoxy-2-naphthalenyl)-2-butanone; 4-(6-Methoxy-2-naphthyl)-2-butanone; Formula=C15H16O2; InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3; InChIKey=BLXXJMDCKKHMKV-UHFFFAOYSA-N; Relafen; SMILES=COc1ccc2cc(CCC(C)=O)ccc2c1; nabumetona; nabumetonum
xref: Beilstein:2103472 "ChemIDplus"; CAS:42924-53-8 "ChemIDplus"; CAS:42924-53-8 "KEGG DRUG"; CAS:42924-53-8 "NIST Chemistry WebBook"; DrugBank:DB00461; Drug_Central:1863 "DrugCentral"; HMDB:HMDB0014604; KEGG:D00425; LINCS:LSM-3453
xref_mesh: MESH:C035605
xref: PDBeChem:NBO; PMID:21532165 "Europe PMC"; PMID:21650014 "Europe PMC"; PMID:21674107 "Europe PMC"; PMID:21898684 "Europe PMC"; PMID:22028826 "Europe PMC"; PMID:22298755 "Europe PMC"; PMID:22381180 "Europe PMC"; PMID:22605805 "Europe PMC"; PMID:22977877 "Europe PMC"; PMID:23020786 "Europe PMC"; PMID:23129452 "Europe PMC"; PMID:23132511 "Europe PMC"; PMID:23225308 "Europe PMC"; PMID:23584048 "Europe PMC"; PMID:23781467 "Europe PMC"; PMID:23781476 "Europe PMC"; PMID:23806470 "Europe PMC"; PMID:24074034 "Europe PMC"; PMID:24083957 "Europe PMC"; Reaxys:2103472 "Reaxys"; Wikipedia:Nabumetone
G
Bcl2
BCL2, apoptosis regulator
13
26,605,426
26,769,374
RGD:6480464
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
6
109,300,433
109,303,299
RGD:6480464
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
11
65,022,100
65,058,546
RGD:6480464
G
Ptgs1
prostaglandin-endoperoxide synthase 1
3
15,560,685
15,582,339
RGD:6480464
G
Ptgs2
prostaglandin-endoperoxide synthase 2
13
67,351,230
67,356,920
RGD:6480464
G
Sell
selectin L
13
82,369,820
82,387,774
RGD:6480464
G
Utrn
utrophin
1
6,451,809
6,970,040
RGD:6480464
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