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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor
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Accession:CHEBI:74234 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the activity of sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), EC 1.1.1.153, which plays an important part in the biosynthesis of tetrahydrobiopterin.
Synonyms:related_synonym: 7,8-dihydrobiopterin:NADP(+) oxidoreductase;   7,8-dihydrobiopterin:NADP(+) oxidoreductases;   L-erythro-7,8-dihydrobiopterin:NADP(+) oxidoreductase inhibitor;   L-erythro-7,8-dihydrobiopterin:NADP(+) oxidoreductase inhibitors;   sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) (EC 1.1.1.153) inhibitors;   sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) inhibitor;   sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) inhibitors;   sepiapterin reductase inhibitor;   sepiapterin reductase inhibitors
 xref: Wikipedia:Sepiapterin_reductase


show annotations for term's descendants           Sort by:
co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases secretion EXP Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
nitrososulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G HMGB1 high mobility group box 1 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G IFNG interferon gamma increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IFNG protein CTD PMID:22331489 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL13 interleukin 13 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL1A interleukin 1 alpha increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL1B protein CTD PMID:28444390 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL5 interleukin 5 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL5 protein CTD PMID:22331489 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL6 protein CTD PMID:28444390 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MPO myeloperoxidase affects binding
multiple interactions		 EXP 4-nitrososulfamethoxazole binds to MPO protein
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole		 CTD PMID:25531135 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200 		JBrowse link
G TNF tumor necrosis factor increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of TNF protein CTD PMID:28444390 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases hydroxylation EXP CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases hydroxylation EXP CYP2C9 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G HMBS hydroxymethylbilane synthase decreases activity ISO Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LPO lactoperoxidase decreases expression EXP Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr17:58,238,584...58,268,518
Ensembl chr17:58,218,548...58,268,518 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases expression EXP Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NAT2 N-acetyltransferase 2 increases acetylation EXP NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 decreases expression EXP Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr21:33,025,935...33,029,185
Ensembl chr21:33,025,935...33,029,196 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 decreases expression EXP Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 decreases expression EXP Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
sulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP Sulfamethoxazole results in decreased activity of ABCB11 protein
Sulfamethoxazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ACAN aggrecan decreases expression ISO Sulfamethoxazole results in decreased expression of ACAN mRNA CTD PMID:26107568 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,353 		JBrowse link
G ALB albumin multiple interactions EXP Sulfamethoxazole metabolite binds to and results in increased metabolism of ALB protein CTD PMID:19358516 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression ISO Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP Sulfamethoxazole results in increased secretion of CXCL8 protein CTD PMID:22609641 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions ISO [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Sulfamethoxazole metabolite binds to and results in increased metabolism of GSTP1 protein CTD PMID:19358516 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HLA-G major histocompatibility complex, class I, G affects expression EXP Sulfamethoxazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G IFNG interferon gamma increases secretion ISO Sulfamethoxazole analog results in increased secretion of IFNG protein CTD PMID:15588915 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL5 interleukin 5 increases secretion ISO Sulfamethoxazole analog results in increased secretion of IL5 protein CTD PMID:15588915 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G MIR155 microRNA 155 increases expression EXP Sulfamethoxazole results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR18A microRNA 18a increases expression EXP Sulfamethoxazole results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821 		JBrowse link
G MIR21 microRNA 21 increases expression EXP Sulfamethoxazole results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MPO myeloperoxidase multiple interactions EXP [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole CTD PMID:25531135 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NAT2 N-acetyltransferase 2 increases metabolic processing EXP NAT2 protein results in increased metabolism of Sulfamethoxazole CTD PMID:16847467 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase decreases expression EXP Sulfamethoxazole results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412 		JBrowse link
G PIR pirin increases expression EXP Sulfamethoxazole results in increased expression of PIR mRNA CTD PMID:22609641 NCBI chr  X:15,384,799...15,493,333
Ensembl chr  X:15,384,799...15,493,564 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression ISO Sulfamethoxazole results in decreased expression of SOX9 mRNA CTD PMID:26107568 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416 		JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB5B cytochrome b5 type B multiple interactions EXP [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr16:69,424,619...69,466,264
Ensembl chr16:69,398,402...69,466,264 		JBrowse link
G CYB5R3 cytochrome b5 reductase 3 multiple interactions EXP [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr22:42,617,840...42,649,392
Ensembl chr22:42,615,730...42,720,870 		JBrowse link
G MTARC1 mitochondrial amidoxime reducing component 1 multiple interactions EXP [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 1:220,786,913...220,819,659
Ensembl chr 1:220,786,352...220,819,659 		JBrowse link
G MTARC2 mitochondrial amidoxime reducing component 2 multiple interactions EXP [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 1:220,748,322...220,784,815
Ensembl chr 1:220,748,225...220,784,815 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25922
    role 25837
      biological role 25815
        biochemical role 25063
          enzyme inhibitor 22141
            EC 1.* (oxidoreductase) inhibitor 19028
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 6226
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 4391
                  EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor 43
                    sulfadiazine 11
                    sulfamethoxazole + 34
paths to the root