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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylmalonic acid
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Accession:CHEBI:741548 term browser browse the term
Definition:A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group.
Synonyms:exact_synonym: ethylpropanedioic acid
 related_synonym: 1,1-propanedicarboxylic acid;   2-ethylmalonic acid;   Formula=C5H8O4;   InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9);   InChIKey=UKFXDFUAPNAMPJ-UHFFFAOYSA-N;   SMILES=CCC(C(O)=O)C(O)=O;   alpha-carboxybutyric acid
 xref: CAS:516-05-2;   CAS:601-75-2;   HMDB:HMDB0000622
 xref_mesh: MESH:D008764
 xref: PMID:20187168;   PMID:22133302;   PMID:23161776;   PMID:6860317;   Reaxys:774334
 cyclic_relationship: is_conjugate_acid_of CHEBI:132938;   is_conjugate_acid_of CHEBI:132939


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ethylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of AIF1 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]
CTD PMID:28223158 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of IL1B protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]
CTD PMID:28223158 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein] CTD PMID:28223158 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:28223158 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      group 19678
        inorganic group 19163
          oxo group 18499
            organic oxo compound 18499
              carbonyl compound 18499
                dicarboxylic acids and O-substituted derivatives 10287
                  dicarboxylic acid 10279
                    ethylmalonic acid 6
                      (R)-ethylmalonyl-CoA 0
                      (S)-ethylmalonyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      dicarboxylic acids and O-substituted derivatives 10287
                                        dicarboxylic acid 10279
                                          alpha,omega-dicarboxylic acid 2786
                                            malonic acid 60
                                              ethylmalonic acid 6
                                                (R)-ethylmalonyl-CoA 0
                                                (S)-ethylmalonyl-CoA 0
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