Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylmalonic acid
go back to main search page
Accession:CHEBI:741548 term browser browse the term
Definition:A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group.
Synonyms:exact_synonym: ethylpropanedioic acid
 related_synonym: 1,1-propanedicarboxylic acid;   2-ethylmalonic acid;   Formula=C5H8O4;   InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9);   InChIKey=UKFXDFUAPNAMPJ-UHFFFAOYSA-N;   SMILES=CCC(C(O)=O)C(O)=O;   alpha-carboxybutyric acid
 xref: CAS:516-05-2;   CAS:601-75-2;   HMDB:HMDB0000622
 xref_mesh: MESH:D008764
 xref: PMID:20187168;   PMID:22133302;   PMID:23161776;   PMID:6860317;   Reaxys:774334
 cyclic_relationship: is_conjugate_acid_of CHEBI:132938;   is_conjugate_acid_of CHEBI:132939


show annotations for term's descendants           Sort by:
ethylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions		 EXP Methylmalonic Acid results in increased expression of AIF1 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]		 CTD PMID:28223158 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Methylmalonic Acid results in increased expression of IL1B protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]		 CTD PMID:28223158 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein] CTD PMID:28223158 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]		 CTD PMID:28223158 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      atom 19930
        nonmetal atom 19859
          carbon atom 19812
            organic molecular entity 19812
              lipid 18000
                fatty acid derivative 8984
                  dicarboxylic fatty acid 2652
                    ethylmalonic acid 6
                      (R)-ethylmalonyl-CoA 0
                      (S)-ethylmalonyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      monocarboxylic acid 18025
                                        fatty acid 16852
                                          fatty acid derivative 8984
                                            dicarboxylic fatty acid 2652
                                              ethylmalonic acid 6
                                                (R)-ethylmalonyl-CoA 0
                                                (S)-ethylmalonyl-CoA 0
paths to the root