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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylmalonic acid
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Accession:CHEBI:741548 term browser browse the term
Definition:A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group.
Synonyms:exact_synonym: ethylpropanedioic acid
 related_synonym: 1,1-propanedicarboxylic acid;   2-ethylmalonic acid;   Formula=C5H8O4;   InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9);   InChIKey=UKFXDFUAPNAMPJ-UHFFFAOYSA-N;   SMILES=CCC(C(O)=O)C(O)=O;   alpha-carboxybutyric acid
 xref: CAS:516-05-2;   CAS:601-75-2;   HMDB:HMDB0000622
 xref_mesh: MESH:D008764
 xref: PMID:20187168;   PMID:22133302;   PMID:23161776;   PMID:6860317;   Reaxys:774334
 cyclic_relationship: is_conjugate_acid_of CHEBI:132938;   is_conjugate_acid_of CHEBI:132939



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ethylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of AIF1 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]
CTD PMID:28223158 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of IL1B protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]
CTD PMID:28223158 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein] CTD PMID:28223158 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:28223158 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              lipid 17493
                ethylmalonic acid 6
                  (R)-ethylmalonyl-CoA 0
                  (S)-ethylmalonyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      dicarboxylic acids and O-substituted derivatives 10371
                                        dicarboxylic acid 10364
                                          alpha,omega-dicarboxylic acid 2804
                                            malonic acid 61
                                              ethylmalonic acid 6
                                                (R)-ethylmalonyl-CoA 0
                                                (S)-ethylmalonyl-CoA 0
paths to the root