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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazoloquinoline
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Accession:CHEBI:74147 term browser browse the term
Definition:Any organic heterotricyclic compound that consists of a pyrazole ring ortho-fused to a quinoline.
Synonyms:related_synonym: pyrazoloquinolines


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quinpirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Quinpirole results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
CTD PMID:9111066 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
increases expression
increases activity
EXP Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]
Quinpirole results in increased expression of ABCB1B mRNA
CTD PMID:9111066 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adcy5 adenylate cyclase 5 multiple interactions ISO ADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein] CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Cfl1 cofilin 1 multiple interactions
increases phosphorylation
ISO DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein] CTD PMID:27717053 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases activity
increases response to substance
affects response to substance
ISO
EXP
[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; [Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein; DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]; Quinpirole binds to and results in increased activity of DRD2 protein; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
Quinpirole results in increased activity of DRD2 protein
DRD2 protein results in increased susceptibility to Quinpirole
[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine; cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]; estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]; Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]; Quinpirole binds to and results in increased activity of DRD2 protein; tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]
DRD2 protein affects the susceptibility to Quinpirole
DRD2 results in increased susceptibility to Quinpirole
DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]; DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]
CTD PMID:1724532, PMID:8032591, PMID:9547254, PMID:10936494, PMID:11124974, PMID:11790512, PMID:12071432, PMID:12523492, PMID:17958328, PMID:20580787, PMID:27717053, PMID:27920206 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO
EXP
Quinpirole binds to and results in increased activity of DRD3 protein
mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]
CTD PMID:10683862, PMID:12523492 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA] CTD PMID:9729266 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
increases expression
EXP Quinpirole results in decreased expression of FOS mRNA; Quinpirole results in decreased expression of FOS protein
8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein; [SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein]; Quinpirole inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]
CTD PMID:7845612, PMID:7914358, PMID:8102797, PMID:8577368, PMID:8864302, PMID:9751140, PMID:12122080 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein] CTD PMID:12122080 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Quinpirole results in increased phosphorylation of MAPK1 protein CTD PMID:27717053 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Quinpirole results in increased phosphorylation of MAPK3 protein CTD PMID:27717053 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO Quinpirole results in decreased secretion of MMP9 protein CTD PMID:27920206 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] CTD PMID:12183048 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO Quinpirole results in increased activity of ODC1 protein CTD PMID:10354516 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
ISO Quinpirole results in decreased expression of POU5F1 mRNA
DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]
CTD PMID:27920206 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance ISO RGS9 affects the susceptibility to Quinpirole CTD PMID:15728856 NCBI chr10:97,509,971...97,582,188
Ensembl chr10:97,509,971...97,582,188
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein CTD PMID:27717053 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects response to substance ISO SLC18A2 protein affects the susceptibility to Quinpirole CTD PMID:12716422 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression
affects localization
EXP
ISO
Quinpirole results in increased expression of SLC6A3 mRNA
Quinpirole affects the localization of SLC6A3 protein
CTD PMID:20875051 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA CTD PMID:9751140 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression EXP Quinpirole results in increased expression of TREX1 mRNA CTD PMID:20298760 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein] CTD PMID:12223546 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          nitrogen atom 18542
            nitrogen molecular entity 18542
              organonitrogen compound 18312
                organonitrogen heterocyclic compound 17461
                  pyrazoloquinoline 23
                    2-(5-butylthiophen-2-yl)-2,5-dihydropyrazolo[4,3-c]quinolin-3-one 0
                    SCH51344 0
                    quinpirole 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotricyclic compound 14571
                                      pyrazoloquinoline 23
                                        2-(5-butylthiophen-2-yl)-2,5-dihydropyrazolo[4,3-c]quinolin-3-one 0
                                        SCH51344 0
                                        quinpirole 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.