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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lachrymator
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Accession:CHEBI:74136 term browser browse the term
Definition:Any substance that stimulates the corneal nerves in the eves to cause tears.
Synonyms:related_synonym: lachrymators
 xref: PMID:4919431


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allyl isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO allyl isothiocyanate results in decreased expression of ACTA2 mRNA CTD PMID:24036144 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression ISO allyl isothiocyanate results in decreased expression of AGER mRNA CTD PMID:24036144 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of AIF1 protein] CTD PMID:27241356 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:17571167 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
EXP safranal inhibits the reaction [allyl isothiocyanate results in increased secretion of CALCA protein] CTD PMID:30636360 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases cleavage
ISO AG 1879 inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] CTD PMID:23219522 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:25744308, PMID:27241356 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO allyl isothiocyanate results in increased expression of CDKN1A mRNA CTD PMID:17937621 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO allyl isothiocyanate results in decreased expression of COL1A1 mRNA CTD PMID:24036144 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA] CTD PMID:25069801 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 protein]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]] CTD PMID:25069801 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
decreases activity
EXP allyl isothiocyanate results in decreased expression of CYP3A2 mRNA
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
allyl isothiocyanate results in decreased activity of CYP3A2 protein
CTD PMID:22664424, PMID:25069801 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO allyl isothiocyanate results in increased expression of GADD45A mRNA CTD PMID:17937621 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
multiple interactions
ISO allyl isothiocyanate results in increased activity of GCLC protein
allyl isothiocyanate results in increased expression of GCLC mRNA
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]
CTD PMID:24036144 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]] CTD PMID:27241356, PMID:30927557 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase increases activity
multiple interactions
decreases activity
EXP
ISO
allyl isothiocyanate results in increased activity of GSR protein
allyl isothiocyanate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein]
allyl isothiocyanate results in decreased activity of GSR protein
CTD PMID:17937621, PMID:22664424, PMID:25744308 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases activity ISO allyl isothiocyanate results in increased activity of GSTA3 promoter CTD PMID:19232536 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing ISO GSTP1 protein affects the metabolism of allyl isothiocyanate CTD PMID:7826396 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
EXP
ISO
allyl isothiocyanate results in increased activity of HMOX1 protein
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]
allyl isothiocyanate results in increased expression of HMOX1 protein
allyl isothiocyanate results in increased expression of HMOX1 mRNA; allyl isothiocyanate results in increased expression of HMOX1 protein
CTD PMID:22664424, PMID:23942037, PMID:27241356 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein] CTD PMID:23219522, PMID:23994502 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO allyl isothiocyanate results in increased phosphorylation of MAPK3 protein
[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]
CTD PMID:23219522, PMID:23994502 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO allyl isothiocyanate results in increased expression of MUC5AC mRNA CTD PMID:31944254 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO allyl isothiocyanate results in increased expression of NDRG1 mRNA CTD PMID:17937621 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
increases activity
EXP
ISO
allyl isothiocyanate results in increased expression of NFE2L2 protein
allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]
allyl isothiocyanate results in increased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to allyl isothiocyanate]
CTD PMID:20932822, PMID:22664424, PMID:24036144, PMID:30927557 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
EXP allyl isothiocyanate results in increased activity of NQO1 protein
allyl isothiocyanate results in increased expression of NQO1 mRNA
CTD PMID:22664424 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP
allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [SR 12813 results in increased expression of CYP3A4 mRNA]]
allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]
CTD PMID:25069801 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO allyl isothiocyanate inhibits the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]
allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]]
CTD PMID:25069801 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO allyl isothiocyanate results in decreased expression of PDGFRB mRNA CTD PMID:24036144 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP allyl isothiocyanate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG protein]; allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of PPARG protein] CTD PMID:30927557 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP allyl isothiocyanate inhibits the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in decreased expression of SLC2A2 protein]] CTD PMID:30927557 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]] CTD PMID:25069801 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP allyl isothiocyanate results in increased secretion of TAC1 protein CTD PMID:16725114 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:27241356, PMID:28483571 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
affects response to substance
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein; [allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein; [allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium; Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]; BDKRB2 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased uptake of Calcium]
TRPA1 affects the susceptibility to allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [allyl isothiocyanate binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein
TRPA1 mRNA affects the susceptibility to allyl isothiocyanate; TRPA1 protein polymorphism affects the susceptibility to allyl isothiocyanate
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; [TRPA1 protein results in increased susceptibility to sodium persulfate] which affects the susceptibility to allyl isothiocyanate; allyl isothiocyanate binds to and results in increased activity of TRPA1 protein; Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Gentamicins inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Indomethacin inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]
CTD PMID:15046718, PMID:15843607, PMID:17314320, PMID:17571167, PMID:17825279, PMID:19507004, PMID:20086034, PMID:20442136, PMID:20720158, PMID:21689654, PMID:22935519, PMID:23994502, PMID:26039217, PMID:27735854, PMID:27738742, PMID:29054683, PMID:30636360, PMID:30738091 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases activity ISO allyl isothiocyanate results in increased activity of TRPM8 protein CTD PMID:29054683 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity
ISO TRPV1 affects the susceptibility to allyl isothiocyanate
allyl isothiocyanate results in increased activity of TRPV1 protein
CTD PMID:21430076, PMID:29054683 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity ISO allyl isothiocyanate results in decreased activity of TXNRD1 protein CTD PMID:17937621 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; allyl isothiocyanate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
benzyl bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO benzyl bromide results in increased expression of CXCR4 mRNA CTD PMID:20713136 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO benzyl bromide results in increased expression of HMOX1 mRNA CTD PMID:20713136 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta increases expression ISO benzyl bromide results in increased expression of IL1B mRNA CTD PMID:20713136 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO benzyl bromide results in increased expression of IL1R2 mRNA CTD PMID:20713136 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO benzyl bromide results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO benzyl bromide results in increased expression of TNFAIP6 mRNA CTD PMID:20713136 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
methyl isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta3 glutathione S-transferase alpha 3 increases activity ISO methyl isothiocyanate results in increased activity of GSTA3 promoter CTD PMID:19232536 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Il10 interleukin 10 multiple interactions ISO methyl isothiocyanate promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; methyl isothiocyanate promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:15933225 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO methyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA] CTD PMID:15933225 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO methyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:15933225 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
nonivamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression
multiple interactions
ISO nonivamide results in increased expression of ATF3 mRNA
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of ATF3 mRNA
CTD PMID:17332266 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [nonivamide binds to and results in increased activity of CCND1 protein] which results in decreased expression of CCND1 mRNA
nonivamide results in decreased expression of CCND1 mRNA
CTD PMID:17332266 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 multiple interactions
increases expression
ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of CCNG2 mRNA
nonivamide results in increased expression of CCNG2 mRNA
CTD PMID:17332266 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO nonivamide results in increased expression of CXCL2 mRNA CTD PMID:22155782 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO nonivamide results in increased expression of CXCL1 mRNA CTD PMID:22155782 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases response to substance
multiple interactions
affects expression
increases expression
ISO DDIT3 protein results in decreased susceptibility to nonivamide
[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA
nonivamide affects the expression of DDIT3 mRNA
nonivamide results in increased expression of DDIT3 mRNA; nonivamide results in increased expression of DDIT3 protein
CTD PMID:17332266, PMID:21343315, PMID:21949157 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
decreases response to substance
increases phosphorylation
ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein; salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide]
nonivamide results in increased phosphorylation of EIF2A protein
CTD PMID:17332266 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA
nonivamide results in increased expression of GADD45A mRNA
CTD PMID:17332266 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA
nonivamide results in increased expression of HSPA5 mRNA
CTD PMID:17332266 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO nonivamide results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 increases expression ISO nonivamide results in increased expression of IL6 mRNA CTD PMID:22155782 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases response to substance
increases activity
ISO [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of ATF3 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of CCNG2 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA; [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein; nonivamide binds to and results in increased activity of TRPV1 protein
TRPV1 protein results in increased susceptibility to nonivamide
nonivamide results in increased activity of TRPV1 protein
CTD PMID:17332266, PMID:21343315, PMID:22155782 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biophysical role 12642
          lachrymator 61
            allyl isothiocyanate 43
            benzyl bromide 6
            bromoacetone 0
            methyl isothiocyanate 4
            nonivamide 12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.