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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-allylcysteine
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Accession:CHEBI:74077 term browser browse the term
Definition:An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.
Synonyms:exact_synonym: S-prop-2-en-1-yl-L-cysteine
 related_synonym: Formula=C6H11NO2S;   InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1;   InChIKey=ZFAHNWWNDFHPOH-YFKPBYRVSA-N;   L-DeoxyallIIn;   S-2-Propenyl-L-Cysteine;   S-allyl-L-cysteine;   SMILES=N[C@@H](CSCC=C)C(O)=O
 xref: CAS:21593-77-1;   HMDB:HMDB0034323;   KEGG:C16759
 xref_mesh: MESH:C065299
 xref: PMID:21166677;   PMID:21560330;   PMID:22052207;   PMID:22981633;   Reaxys:1722895;   Wikipedia:S-Allyl_cysteine
 cyclic_relationship: is_tautomer_of CHEBI:133648


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S-allylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation		 ISO dorsomorphin inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]; S-allylcysteine promotes the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of ACACA protein]; sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]; STO 609 inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]
S-allylcysteine results in decreased expression of BCL2 protein		 CTD PMID:16030430 PMID:17155983 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] CTD PMID:16030430 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases phosphorylation ISO S-allylcysteine results in increased phosphorylation of CAMK2A protein CTD PMID:23465592 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP1 protein] CTD PMID:32453893 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO
EXP		 S-allylcysteine results in increased cleavage of CASP3 protein
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP3 protein]
[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]		 CTD PMID:16030430 PMID:17155983 PMID:22033380 PMID:32453893 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 EXP
ISO		 [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]
S-allylcysteine results in increased activity of CASP8 protein
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine results in decreased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]		 CTD PMID:16030430 PMID:22033380 PMID:31067004 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [lead acetate results in decreased activity of CAT protein]		 CTD PMID:18548744 PMID:19391111 PMID:20951120 PMID:22033380 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO S-allylcysteine results in increased expression of CDH1 protein CTD PMID:17155983 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP S-allylcysteine results in increased expression of CYP3A2 protein CTD PMID:16000231 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fadd Fas associated via death domain increases expression
multiple interactions		 ISO S-allylcysteine results in increased expression of FADD protein
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]		 CTD PMID:31067004 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine inhibits the reaction [FAS protein binds to FAS protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; S-allylcysteine promotes the reaction [FAS protein binds to FAS protein]; S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]		 CTD PMID:22033380 PMID:31067004 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]
S-allylcysteine results in increased expression of FASLG protein		 CTD PMID:31067004 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of FASN mRNA] CTD PMID:23465592 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GAL mRNA] CTD PMID:17182065 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein] CTD PMID:22033380 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP		 [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]
S-allylcysteine inhibits the reaction [Cyclosporine results in increased activity of GPT protein]		 CTD PMID:19391111 PMID:22033380 PMID:32453893 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of GSR protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] CTD PMID:16757080 PMID:19391111 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GUSB mRNA] CTD PMID:17182065 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein] CTD PMID:32453893 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:32453893 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jup junction plakoglobin increases expression ISO S-allylcysteine results in increased expression of JUP protein CTD PMID:17155983 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of KCNN4 protein] CTD PMID:22033380 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Klk1 kallikrein 1 decreases expression ISO S-allylcysteine results in decreased expression of KLK3 protein CTD PMID:17155983 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of MMP2 protein] CTD PMID:19391111 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of MPO protein] CTD PMID:32453893 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP S-allylcysteine promotes the reaction [Potassium Dichromate results in increased expression of NFE2L2 protein] CTD PMID:18548744 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NLRP3 protein] CTD PMID:32453893 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2]; S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of NOS2 protein] CTD PMID:16614485 PMID:19391111 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in decreased expression of OGDH mRNA] CTD PMID:17182065 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; S-allylcysteine inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]] CTD PMID:22033380 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PTGS2 protein] CTD PMID:32453893 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of RELA protein] CTD PMID:19391111 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of SMPD1 protein] CTD PMID:22033380 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]; S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein]; S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]; sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]; STO 609 inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:16614485 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TLR4 protein] CTD PMID:32453893 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:32453893 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation		 ISO SB 203580 inhibits the reaction [S-allylcysteine results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with S-allylcysteine] results in increased phosphorylation of TRP53 protein		 CTD PMID:31067004 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Upk2 uroplakin 2 multiple interactions ISO S-allylcysteine inhibits the reaction [Cyclophosphamide results in decreased expression of UPK2 mRNA]; S-allylcysteine inhibits the reaction [Cyclophosphamide results in decreased expression of UPK2 protein] CTD PMID:27234646 NCBI chr 8:44,779,198...44,781,190
Ensembl chr 8:44,779,198...44,781,190 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            S-allylcysteine 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        amino acid 14872
                                          alpha-amino acid 12865
                                            L-alpha-amino acid 11583
                                              serine family amino acid 2556
                                                L-cysteine 1332
                                                  L-cysteine derivative 1322
                                                    S-substituted L-cysteine 353
                                                      L-cysteine thioether 276
                                                        S-organyl-L-cysteine 43
                                                          S-hydrocarbyl-L-cysteine 43
                                                            S-allylcysteine 41
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