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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-allylcysteine
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Accession:CHEBI:74077 term browser browse the term
Definition:An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.
Synonyms:exact_synonym: S-prop-2-en-1-yl-L-cysteine
 related_synonym: Formula=C6H11NO2S;   InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1;   InChIKey=ZFAHNWWNDFHPOH-YFKPBYRVSA-N;   L-DeoxyallIIn;   S-2-Propenyl-L-Cysteine;   S-allyl-L-cysteine;   SMILES=N[C@@H](CSCC=C)C(O)=O
 xref: CAS:21593-77-1;   HMDB:HMDB0034323;   KEGG:C16759
 xref_mesh: MESH:C065299
 xref: PMID:21166677;   PMID:21560330;   PMID:22052207;   PMID:22981633;   Reaxys:1722895;   Wikipedia:S-Allyl_cysteine
 cyclic_relationship: is_tautomer_of CHEBI:133648


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S-allylcysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation
ISO dorsomorphin inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]; S-allylcysteine promotes the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of ACACA protein]; sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]; STO 609 inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]
S-allylcysteine results in decreased expression of BCL2 protein
CTD PMID:16030430 PMID:17155983 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] CTD PMID:16030430 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases phosphorylation ISO S-allylcysteine results in increased phosphorylation of CAMK2A protein CTD PMID:23465592 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp1 caspase 1 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP1 protein] CTD PMID:32453893 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO
EXP
S-allylcysteine results in increased cleavage of CASP3 protein
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP3 protein]
[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]
CTD PMID:16030430 PMID:17155983 PMID:22033380 PMID:32453893 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
EXP
ISO
[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]
S-allylcysteine results in increased activity of CASP8 protein
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine results in decreased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]
CTD PMID:16030430 PMID:22033380 PMID:31067004 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions EXP
ISO
S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; S-allylcysteine inhibits the reaction [lead acetate results in decreased activity of CAT protein]
CTD PMID:18548744 PMID:19391111 PMID:20951120 PMID:22033380 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdh1 cadherin 1 increases expression ISO S-allylcysteine results in increased expression of CDH1 protein CTD PMID:17155983 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ctsd cathepsin D multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP S-allylcysteine results in increased expression of CYP3A2 protein CTD PMID:16000231 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Fadd Fas associated via death domain increases expression
multiple interactions
ISO S-allylcysteine results in increased expression of FADD protein
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]
CTD PMID:31067004 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine inhibits the reaction [FAS protein binds to FAS protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; S-allylcysteine promotes the reaction [FAS protein binds to FAS protein]; S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]
CTD PMID:22033380 PMID:31067004 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]
S-allylcysteine results in increased expression of FASLG protein
CTD PMID:31067004 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of FASN mRNA] CTD PMID:23465592 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GAL mRNA] CTD PMID:17182065 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein] CTD PMID:22033380 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]
S-allylcysteine inhibits the reaction [Cyclosporine results in increased activity of GPT protein]
CTD PMID:19391111 PMID:22033380 PMID:32453893 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in decreased activity of GSR protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] CTD PMID:16757080 PMID:19391111 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GUSB mRNA] CTD PMID:17182065 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein] CTD PMID:32453893 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:32453893 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jup junction plakoglobin increases expression ISO S-allylcysteine results in increased expression of JUP protein CTD PMID:17155983 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of KCNN4 protein] CTD PMID:22033380 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Klk1 kallikrein 1 decreases expression ISO S-allylcysteine results in decreased expression of KLK3 protein CTD PMID:17155983 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of MMP2 protein] CTD PMID:19391111 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of MPO protein] CTD PMID:32453893 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP S-allylcysteine promotes the reaction [Potassium Dichromate results in increased expression of NFE2L2 protein] CTD PMID:18548744 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NLRP3 protein] CTD PMID:32453893 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2]; S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of NOS2 protein] CTD PMID:16614485 PMID:19391111 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP S-allylcysteine inhibits the reaction [Isoproterenol results in decreased expression of OGDH mRNA] CTD PMID:17182065 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; S-allylcysteine inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]] CTD PMID:22033380 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PTGS2 protein] CTD PMID:32453893 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of RELA protein] CTD PMID:19391111 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of SMPD1 protein] CTD PMID:22033380 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO dorsomorphin inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]; S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein]; S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]; sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]; STO 609 inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP S-allylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:16614485 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TLR4 protein] CTD PMID:32453893 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:32453893 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO SB 203580 inhibits the reaction [S-allylcysteine results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with S-allylcysteine] results in increased phosphorylation of TRP53 protein
CTD PMID:31067004 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Upk2 uroplakin 2 multiple interactions ISO S-allylcysteine inhibits the reaction [Cyclophosphamide results in decreased expression of UPK2 mRNA]; S-allylcysteine inhibits the reaction [Cyclophosphamide results in decreased expression of UPK2 protein] CTD PMID:27234646 NCBI chr 8:48,772,906...48,774,898
Ensembl chr 8:48,772,906...48,774,898
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19790
      biological role 19790
        biochemical role 19328
          metabolite 19309
            S-allylcysteine 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        amino acid 14111
                                          alpha-amino acid 11593
                                            L-alpha-amino acid 11430
                                              serine family amino acid 2057
                                                L-cysteine 1139
                                                  L-cysteine derivative 1128
                                                    S-substituted L-cysteine 148
                                                      L-cysteine thioether 66
                                                        S-organyl-L-cysteine 43
                                                          S-hydrocarbyl-L-cysteine 43
                                                            S-allylcysteine 41
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