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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-pyridylethylamine
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Accession:CHEBI:74024 term browser browse the term
Definition:An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2.
Synonyms:exact_synonym: 2-(pyridin-2-yl)ethanamine
 related_synonym: 2-Pyridineethanamine;   Formula=C7H10N2;   InChI=1S/C7H10N2/c8-5-4-7-3-1-2-6-9-7/h1-3,6H,4-5,8H2;   InChIKey=XPQIPUZPSLAZDV-UHFFFAOYSA-N;   Lilly 04432;   SMILES=NCCc1ccccn1;   alpha-Pyridylethylamine
 xref: CAS:2706-56-1;   LINCS:LSM-15486
 xref_mesh: MESH:C006183
 xref: PMID:23006827;   PMID:23157658;   PMID:23466693;   PMID:23808378;   Reaxys:111208;   Wikipedia:2-Pyridylethylamine



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2-pyridylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO
EXP
2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] CTD PMID:9657254 PMID:16143415 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA
HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]
CTD PMID:9657254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      chemical role 19544
        environmental contaminant 18826
          pyridine 51
            2-pyridylethylamine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        primary amino compound 8282
                                          primary amine 5860
                                            2-pyridylethylamine 8
paths to the root