2-pyridylethylamine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2-pyridylethylamine	go back to main search page
Accession:	CHEBI:74024	browse the term
Definition:	An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2.
Synonyms:	exact_synonym:	2-(pyridin-2-yl)ethanamine
	related_synonym:	2-Pyridineethanamine; Formula=C7H10N2; InChI=1S/C7H10N2/c8-5-4-7-3-1-2-6-9-7/h1-3,6H,4-5,8H2; InChIKey=XPQIPUZPSLAZDV-UHFFFAOYSA-N; Lilly 04432; SMILES=NCCc1ccccn1; alpha-Pyridylethylamine
	xref:	CAS:2706-56-1; LINCS:LSM-15486
	xref_mesh:	MESH:C006183
	xref:	PMID:23006827; PMID:23157658; PMID:23466693; PMID:23808378; Reaxys:111208; Wikipedia:2-Pyridylethylamine

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Rat (8) Mouse (8) Human (8) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (8)

2-pyridylethylamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cytochrome c, somatic

multiple interactions

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054

G

histamine receptor H 1

multiple interactions

2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]

PMID:9657254 PMID:16143415

NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

interleukin 6

increases expression
multiple interactions

2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA
HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

superoxide dismutase 1

multiple interactions

SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

tumor protein p53

multiple interactions

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19812
role	19784
chemical role	19418
environmental contaminant	18820
pyridine	51
2-pyridylethylamine	8
Path 2
Term	Annotations
CHEBI ontology	19812
subatomic particle	19810
composite particle	19810
hadron	19810
baryon	19810
nucleon	19810
atomic nucleus	19810
atom	19810
main group element atom	19755
main group molecular entity	19755
s-block molecular entity	19605
hydrogen molecular entity	19595
hydrides	19072
inorganic hydride	17983
pnictogen hydride	17970
nitrogen hydride	17867
azane	17653
ammonia	17652
organic amino compound	17652
primary amino compound	9036
primary amine	5909
2-pyridylethylamine	8

paths to the root