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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GW 501516
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Accession:CHEBI:73726 term browser browse the term
Definition:An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.
Synonyms:exact_synonym: {2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
 related_synonym: Endurobol;   Formula=C21H18F3NO3S2;   GSK-516;   GW 1516;   GW 501,516;   GW-516;   GW1516;   GW501,516;   GW501516;   InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27);   InChIKey=YDBLKRPLXZNVNB-UHFFFAOYSA-N;   SMILES=Cc1cc(SCc2sc(nc2C)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O;   UNII-7I2HA1NU22
 xref: CAS:317318-70-0;   LINCS:LSM-5330
 xref_mesh: MESH:C425931
 xref: PMID:14604391;   PMID:14758356;   PMID:16242326;   PMID:16625823;   PMID:18047848;   PMID:19946680;   PMID:21511987;   PMID:22466297;   PMID:22814748;   PMID:22982594;   PMID:23046570;   PMID:23100242;   PMID:23607100;   Reaxys:9440826;   Wikipedia:GW_501516


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GW 501516 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP
ISO		 GW 501516 results in increased expression of ABCA1 mRNA; GW 501516 results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABHD3 abhydrolase domain containing 3, phospholipase multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA CTD PMID:16197558 NCBI chr18:21,650,901...21,704,774
Ensembl chr18:21,650,901...21,704,780 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA CTD PMID:16197558 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA CTD PMID:16197558 NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression ISO GW 501516 results in increased expression of ACOX1 mRNA CTD PMID:16574099 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ANGPTL4 angiopoietin like 4 multiple interactions
increases expression		 EXP [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA
GW 501516 results in increased expression of ANGPTL4 mRNA		 CTD PMID:16197558 PMID:34627044 NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370 		JBrowse link
G APOA1 apolipoprotein A1 multiple interactions EXP
ISO		 GW 501516 promotes the reaction [APOA1 protein results in increased secretion of Lipids] CTD PMID:19201410 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein]; GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine]; GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein]; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G BCL6 BCL6 transcription repressor multiple interactions EXP BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:23737761 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP
ISO		 BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
GW 501516 results in decreased expression of CCL2 mRNA
GW 501516 inhibits the reaction [Palmitates results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]		 CTD PMID:16574099 PMID:21966476 PMID:23737761 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA CTD PMID:16197558 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions
increases expression		 EXP
ISO		 [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA
GW 501516 results in increased expression of CPT1A mRNA		 CTD PMID:16197558 PMID:16574099 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CPT1B carnitine palmitoyltransferase 1B multiple interactions
increases expression		 ISO RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 decreases expression EXP GW 501516 results in decreased expression of CX3CR1 mRNA CTD PMID:19850645 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions EXP GW 501516 inhibits the reaction [APP gene mutant form results in increased expression of CYBB protein] CTD PMID:22886847 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 multiple interactions EXP GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA CTD PMID:16197558 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G ECH1 enoyl-CoA hydratase 1 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA CTD PMID:16197558 NCBI chr19:38,815,422...38,831,794
Ensembl chr19:38,815,422...38,831,841 		JBrowse link
G FABP1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO
EXP		 GW 501516 results in increased expression of FABP1 mRNA
[GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA		 CTD PMID:16197558 PMID:16574099 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062 		JBrowse link
G GCH1 GTP cyclohydrolase 1 multiple interactions EXP GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein] CTD PMID:22886847 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826 		JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA CTD PMID:16197558 NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672 		JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA CTD PMID:16197558 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905 		JBrowse link
G HSDL2 hydroxysteroid dehydrogenase like 2 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA CTD PMID:16197558 NCBI chr 9:112,380,108...112,472,405
Ensembl chr 9:112,380,080...112,472,405 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:23737761 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression		 EXP
ISO		 BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
GW 501516 results in decreased expression of IL1B mRNA		 CTD PMID:16574099 PMID:23737761 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 decreases expression ISO GW 501516 results in decreased expression of IL6 mRNA CTD PMID:16574099 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KIZ kizuna centrosomal protein multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA CTD PMID:16197558 NCBI chr20:21,125,975...21,246,622
Ensembl chr20:21,125,983...21,246,622 		JBrowse link
G LIPC lipase C, hepatic type multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA CTD PMID:16197558 NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844 		JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions ISO MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] CTD PMID:23737761 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA CTD PMID:16197558 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases activity ISO GW 501516 results in increased activity of NFE2L2 protein CTD PMID:30114225 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression ISO GW 501516 results in decreased expression of NFKB1 mRNA CTD PMID:16574099 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP GW 501516 inhibits the reaction [APP gene mutant form results in decreased phosphorylation of NOS3 protein] CTD PMID:22886847 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18701451 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18701451 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 increases expression EXP GW 501516 results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression
affects response to substance
multiple interactions		 EXP
ISO		 GW 501516 results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to GW 501516
NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]		 CTD PMID:19201410 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP GW 501516 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] CTD PMID:21400612 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA CTD PMID:16197558 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 increases expression EXP GW 501516 results in increased expression of PDK4 mRNA CTD PMID:34627044 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
G PDZK1 PDZ domain containing 1 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA CTD PMID:16197558 NCBI chr 1:145,670,852...145,707,400
Ensembl chr 1:145,670,852...145,708,148 		JBrowse link
G PLIN2 perilipin 2 multiple interactions
increases expression		 EXP [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA] CTD PMID:16197558 PMID:23737761 NCBI chr 9:19,108,388...19,127,492
Ensembl chr 9:19,108,375...19,149,290 		JBrowse link
G PLTP phospholipid transfer protein multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA CTD PMID:16197558 NCBI chr20:45,898,620...45,912,155
Ensembl chr20:45,898,621...45,912,155 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
affects response to substance
increases expression
affects binding		 EXP
ISO		 [Calcitriol co-treated with GW 501516] results in increased expression of PPARA mRNA; NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]
PPARA protein affects the susceptibility to GW 501516
GW 501516 binds to PPARA protein		 CTD PMID:19201410 PMID:19667161 PMID:23843199 PMID:25689681 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta affects binding
multiple interactions
increases expression
increases activity		 EXP
ISO		 GW 501516 binds to PPARB protein; GW 501516 binds to PPARD protein
4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 501516 results in increased expression of PPARD mRNA]; [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA; GW 501516 binds to and results in increased activity of PPARD protein
GW 501516 results in increased activity of PPARD protein
[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein]
[Calcitriol co-treated with GW 501516] results in increased expression of PPARD mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ABHD3 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADM mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ACADVL mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CEBPA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of CPT1A mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of DDIT4 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of ECH1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of FABP1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HADHA mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of KIZ mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of LIPC mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of NEDD9 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PCK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PDZK1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of PLTP mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of RNU7-65P mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA; [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA; GW 501516 binds to and results in increased activity of PPARD protein; GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA]		 CTD PMID:16197558 PMID:17275789 PMID:18292206 PMID:18701451 PMID:19103650 More... NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
increases activity		 EXP
ISO		 GW 501516 results in increased expression of PPARG mRNA
GW 501516 results in increased activity of PPARG protein		 CTD PMID:16386710 PMID:19201410 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
increases expression		 ISO
EXP		 [GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA
GW 501516 results in increased expression of PPARGC1A mRNA		 CTD PMID:17275789 PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA] CTD PMID:32238697 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; RELA protein inhibits the reaction [GW 501516 results in increased expression of CPT1B mRNA] CTD PMID:18701451 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RNU7-65P RNA, U7 small nuclear 65 pseudogene multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of RNU7-65P mRNA CTD PMID:16197558 NCBI chr 6:49,344,802...49,344,861
Ensembl chr 6:49,344,800...49,344,861 		JBrowse link
G SELE selectin E multiple interactions EXP BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:23737761 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA CTD PMID:16197558 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of SLC22A7 mRNA CTD PMID:16197558 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SLC30A10 solute carrier family 30 member 10 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA CTD PMID:16197558 NCBI chr 1:219,910,445...219,959,098
Ensembl chr 1:219,685,427...219,959,018 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD1 protein] CTD PMID:22886847 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD3 superoxide dismutase 3 multiple interactions EXP GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of SOD3 protein] CTD PMID:22886847 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B decreases activity ISO GW 501516 results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of SULT2A1 mRNA CTD PMID:16197558 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression ISO GW 501516 results in decreased expression of TGFB1 mRNA CTD PMID:16574099 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; PPARD mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]
GW 501516 results in decreased expression of TNF mRNA		 CTD PMID:16574099 PMID:21966476 PMID:23737761 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TRIB2 tribbles pseudokinase 2 multiple interactions EXP [GW 501516 binds to PPARD protein] which results in increased expression of TRIB2 mRNA CTD PMID:16197558 NCBI chr 2:12,716,936...12,742,734
Ensembl chr 2:12,716,910...12,742,734 		JBrowse link
G UCP2 uncoupling protein 2 increases expression ISO GW 501516 results in increased expression of UCP2 mRNA CTD PMID:16239165 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:23737761 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VDR vitamin D receptor increases expression
multiple interactions		 EXP GW 501516 results in increased expression of VDR mRNA
[Calcitriol co-treated with GW 501516] results in increased expression of VDR mRNA		 CTD PMID:19667161 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        aetiopathogenetic role 24592
          carcinogenic agent 22899
            GW 501516 66
              GW 501516 sulfone 0
              GW 501516 sulfoxide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  heteroarene 18772
                                    monocyclic heteroarene 16133
                                      azole 15691
                                        thiazoles 2093
                                          1,3-thiazoles 1272
                                            GW 501516 66
                                              GW 501516 sulfone 0
                                              GW 501516 sulfoxide + 0
paths to the root