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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:organic heterobicyclic ring
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Accession:CHEBI:73541 term browser browse the term
Definition:A bicyclic organic group that contains both carbon and hetero atoms.
Synonyms:related_synonym: organic heterobicyclic rings

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brucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP brucine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:12757728 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,150...12,600,249 		JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions		 EXP Melatonin results in increased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]		 CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CASP3 caspase 3 decreases expression EXP Melatonin results in decreased expression of CASP3 mRNA CTD PMID:31535366 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G CAT catalase multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA] CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Melatonin results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886 		JBrowse link
G PLIN2 perilipin 2 multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein] CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,274 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein] CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Melatonin results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723 		JBrowse link
G TP53 tumor protein p53 multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Melatonin results in decreased expression of TP53 mRNA		 CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819 		JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2C 5-hydroxytryptamine receptor 2C affects binding
multiple interactions		 EXP mesulergine binds to HTR2C protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]		 CTD PMID:11927170 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356 		JBrowse link
physostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity
multiple interactions		 EXP Physostigmine results in decreased activity of ACHE protein
Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]		 CTD PMID:21414391 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149 		JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Serotonin results in increased expression of FOS mRNA; Serotonin results in increased expression of FOS protein
sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein]		 CTD PMID:11426759 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein]
Serotonin results in increased expression of JUN mRNA; Serotonin results in increased expression of JUN protein		 CTD PMID:11426759 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP Serotonin results in increased phosphorylation of MAPK1 protein
sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11426759 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein] CTD PMID:11426759 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
strychnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP Strychnine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:12757728 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,150...12,600,249 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 875
    chemical entity 875
      group 838
        organic group 391
          cyclic organic group 15
            organic heterobicyclic ring 15
              indole skeleton + 15
              indolizidine skeleton 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 875
    subatomic particle 860
      composite particle 860
        hadron 860
          baryon 860
            nucleon 860
              atomic nucleus 860
                atom 860
                  main group element atom 850
                    p-block element atom 847
                      carbon group element atom 823
                        carbon group molecular entity 823
                          organic molecular entity 822
                            organic group 391
                              cyclic organic group 15
                                organic heterobicyclic ring 15
                                  indole skeleton + 15
                                  indolizidine skeleton 0
paths to the root