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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:organic heterobicyclic ring
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Accession:CHEBI:73541 term browser browse the term
Definition:A bicyclic organic group that contains both carbon and hetero atoms.
Synonyms:related_synonym: organic heterobicyclic rings

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2-methylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein] CTD PMID:15802305 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A multiple interactions ISO 2-methyl-5-HT binds to and results in increased activity of HTR3A protein CTD PMID:15802305 NCBI chr 9:48,899,213...48,911,152
Ensembl chr 9:48,899,213...48,911,099 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15802305 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:15802305 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
5-methoxy-N,N-diisopropyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
decreases activity		 ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion CTD PMID:26599973 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
decreases activity		 ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole CTD PMID:26599973 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075 		JBrowse link
G Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 increases metabolic processing ISO CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr15:82,402,845...82,407,253
Ensembl chr15:82,402,846...82,407,195 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases activity		 ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone CTD PMID:26599973 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
6-hydroxymelatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 multiple interactions ISO Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin] CTD PMID:11181495 NCBI chr 7:126,672,865...126,690,443
Ensembl chr 7:126,672,865...126,676,432 		JBrowse link
G Sult1d1 sulfotransferase family 1D, member 1 multiple interactions EXP Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin] CTD PMID:11181495 NCBI chr 5:87,554,650...87,569,006
Ensembl chr 5:87,554,645...87,569,027 		JBrowse link
9-hydroxycanthin-6-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP3 protein CTD PMID:29225138 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein CTD PMID:29225138 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP9 protein CTD PMID:29225138 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL2 mRNA CTD PMID:29225138 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL5 mRNA CTD PMID:29225138 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518 		JBrowse link
ajmalicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity
multiple interactions		 ISO raubasine results in decreased activity of CYP2D6 protein
raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]		 CTD PMID:15930738 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions ISO raubasine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:29782822 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
ajmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions ISO Ajmaline inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:29782822 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Ajmaline results in decreased activity of KCNH2 protein CTD PMID:15599706 PMID:24052561 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha decreases activity
affects response to substance		 EXP
ISO		 Ajmaline results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Ajmaline		 CTD PMID:10662748 PMID:15520322 PMID:20174578 NCBI chr 9:119,483,404...119,579,030
Ensembl chr 9:119,483,408...119,579,016 		JBrowse link
alcuronium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding		 ISO WIN 62577 inhibits the reaction [Alcuronium binds to CHRM4 protein] CTD PMID:16709648 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688 		JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions ISO Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546 		JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) multiple interactions ISO Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632 		JBrowse link
alpha-ergocryptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergocryptine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
bromocriptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases expression
multiple interactions		 ISO Bromocriptine results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]		 CTD PMID:9111066 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B increases activity
increases expression
multiple interactions		 ISO Bromocriptine results in increased activity of ABCB1B promoter
Bromocriptine results in increased expression of ABCB1B mRNA
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]		 CTD PMID:9111066 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression
multiple interactions		 ISO Bromocriptine results in increased expression of AKR1C3 mRNA
methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA]		 CTD PMID:21427058 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bromocriptine results in increased expression of ATF3 mRNA; Bromocriptine results in increased expression of ATF3 protein CTD PMID:21867702 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO Bromocriptine results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein		 CTD PMID:15046398 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bdnf brain derived neurotrophic factor decreases secretion EXP Bromocriptine results in decreased secretion of BDNF protein CTD PMID:12770616 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007 		JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions EXP [Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein CTD PMID:11786374 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]
Bromocriptine results in decreased expression of CYP11A1 protein		 CTD PMID:12742521 PMID:21427058 NCBI chr 9:57,998,024...58,027,031
Ensembl chr 9:58,006,411...58,027,023 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 affects metabolic processing
multiple interactions
affects binding		 ISO CYP3A4 protein affects the metabolism of Bromocriptine
Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
Bromocriptine binds to CYP3A4 protein		 CTD PMID:15286053 PMID:17198380 PMID:19299527 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Dbh dopamine beta hydroxylase decreases activity ISO Bromocriptine results in decreased activity of DBH protein CTD PMID:501350 NCBI chr 2:27,165,507...27,183,204
Ensembl chr 2:27,165,233...27,183,200 		JBrowse link
G Drd2 dopamine receptor D2 affects expression
affects response to substance
multiple interactions
decreases expression
increases expression
increases response to substance		 ISO
EXP		 Bromocriptine affects the expression of DRD2 mRNA
DRD2 protein affects the susceptibility to Bromocriptine
Bromocriptine binds to and results in increased activity of DRD2 mRNA; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]
Bromocriptine results in decreased expression of DRD2 mRNA
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Bromocriptine results in increased expression of DRD2 mRNA
DRD2 polymorphism results in increased susceptibility to Bromocriptine		 CTD PMID:1534540 PMID:8103596 PMID:15781964 PMID:16901644 PMID:20063113 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions
decreases expression		 ISO [1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA
Bromocriptine results in decreased expression of DRD3 mRNA		 CTD PMID:17000468 NCBI chr16:43,754,015...43,825,982
Ensembl chr16:43,754,026...43,822,932 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions EXP [Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein CTD PMID:11786374 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G Fshb follicle stimulating hormone beta increases expression ISO Bromocriptine results in increased expression of FSHB protein CTD PMID:86031 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor decreases expression
decreases secretion		 EXP Bromocriptine results in decreased expression of GDNF mRNA
Bromocriptine results in decreased secretion of GDNF protein		 CTD PMID:12770616 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575 		JBrowse link
G Gh growth hormone increases expression
decreases expression		 ISO Bromocriptine results in increased expression of GH1 protein
Bromocriptine results in decreased expression of GH1 protein		 CTD PMID:772175 PMID:3226523 PMID:3745407 PMID:7293648 PMID:19420816 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bromocriptine results in increased expression of HMOX1 mRNA; Bromocriptine results in increased expression of HMOX1 protein CTD PMID:21867702 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Bromocriptine binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 NCBI chr19:35,958,415...36,058,133
Ensembl chr19:35,958,734...36,057,507 		JBrowse link
G Ins2 insulin II decreases expression ISO Bromocriptine results in decreased expression of INS protein CTD PMID:16803851 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381 		JBrowse link
G Lhb luteinizing hormone beta increases expression ISO Bromocriptine results in increased expression of LHB protein CTD PMID:86031 NCBI chr 7:45,417,608...45,421,855
Ensembl chr 7:45,420,820...45,421,897
Ensembl chr 7:45,420,820...45,421,897 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK1 protein] CTD PMID:19595700 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK3 protein] CTD PMID:19595700 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases localization ISO Bromocriptine results in increased localization of NFE2L2 protein CTD PMID:21867702 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Ngf nerve growth factor increases secretion EXP Bromocriptine results in increased secretion of NGF protein CTD PMID:12770616 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein] CTD PMID:21867702 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA] CTD PMID:21427058 NCBI chr 1:136,842,562...136,960,448
Ensembl chr 1:136,842,571...136,960,448 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein] CTD PMID:15677882 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314 		JBrowse link
G Pomc pro-opiomelanocortin-alpha decreases expression
increases expression
multiple interactions		 ISO Bromocriptine results in decreased expression of POMC protein alternative form
Bromocriptine results in increased expression of POMC mRNA; Bromocriptine results in increased expression of POMC protein modified form
Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]		 CTD PMID:1325994 PMID:6274577 PMID:12742521 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects localization		 ISO Bromocriptine promotes the reaction [Estrogens results in increased expression of and results in increased cleavage of PRKCD protein]
Bromocriptine affects the localization of PRKCD protein		 CTD PMID:19595700 NCBI chr14:30,595,353...30,626,414
Ensembl chr14:30,595,354...30,626,210 		JBrowse link
G Prl prolactin multiple interactions
decreases secretion
decreases expression		 ISO
EXP		 Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
Bromocriptine results in decreased secretion of PRL protein
Bromocriptine results in decreased expression of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]		 CTD PMID:86031 PMID:86795 PMID:90217 PMID:1407345 PMID:1874184 PMID:2042694 PMID:2887062 PMID:3019639 PMID:3208992 PMID:3625096 PMID:3660204 PMID:3745407 PMID:3776530 PMID:4072572 PMID:6441721 PMID:6477585 PMID:6507109 PMID:6669217 PMID:6693536 PMID:6986893 PMID:7106173 PMID:7168914 PMID:7243090 PMID:7670571 PMID:8914150 PMID:11685661 PMID:11786374 PMID:12106810 PMID:12161478 PMID:12742521 PMID:12824819 PMID:15046398 PMID:15677882 PMID:21427058 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA] CTD PMID:21427058 NCBI chr 5:125,277,087...125,341,094
Ensembl chr 5:125,277,087...125,341,094 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein] CTD PMID:21867702 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Bromocriptine results in decreased expression of STAR protein CTD PMID:12742521 NCBI chr 8:25,808,474...25,815,982
Ensembl chr 8:25,806,555...25,815,982 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A affects localization EXP Bromocriptine affects the localization of STAT5A protein CTD PMID:17884938 NCBI chr11:100,859,351...100,885,169
Ensembl chr11:100,859,351...100,885,169 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Bromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA] CTD PMID:1534540 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein] CTD PMID:15677882 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]
Bromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:11752888 PMID:21867702 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VEGFA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of VEGFA protein] CTD PMID:15677882 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
G Vip vasoactive intestinal polypeptide multiple interactions ISO Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]		 CTD PMID:6441721 PMID:15677882 NCBI chr10:5,639,193...5,647,617
Ensembl chr10:5,639,218...5,647,617 		JBrowse link
brucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha fetoprotein multiple interactions ISO brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:24060683 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907 		JBrowse link
G Bax BCL2-associated X protein increases expression EXP
ISO		 brucine results in increased expression of BAX protein CTD PMID:16443926 PMID:21684292 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO brucine results in decreased expression of BCL2 protein CTD PMID:16443926 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions		 ISO
EXP		 [brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP3 protein
brucine results in increased expression of CASP3 protein
brucine results in increased expression of and results in increased activity of CASP3 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]		 CTD PMID:16442763 PMID:16443926 PMID:17449162 PMID:21684292 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO brucine results in increased activity of and results in increased cleavage of CASP9 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [brucine results in increased activity of and results in increased cleavage of CASP9 protein]
[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP9 protein		 CTD PMID:16443926 PMID:21684292 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions ISO brucine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] CTD PMID:24060683 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions ISO brucine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM1 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; brucine promotes the reaction [Bethanechol binds to CHRM1 protein]; brucine promotes the reaction [Carbachol binds to CHRM1 protein]; brucine promotes the reaction [furtrethonium binds to CHRM1 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM1 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]] CTD PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:15294002 PMID:16439611 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions
affects binding		 ISO brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM2 protein]; brucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
brucine binds to CHRM2 protein		 CTD PMID:9495826 PMID:10069518 PMID:15647330 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions
affects binding		 ISO brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM3 protein]; brucine binds to and results in increased activity of CHRM3 protein mutant form; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM3 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Arecoline binds to CHRM3 protein]; brucine promotes the reaction [Bethanechol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; brucine promotes the reaction [furtrethonium binds to CHRM3 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM3 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
brucine binds to CHRM3 protein		 CTD PMID:9224827 PMID:10069518 PMID:15647330 PMID:20466821 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding		 ISO brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM4 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM4 protein]; brucine promotes the reaction [Bethanechol binds to CHRM4 protein]; brucine promotes the reaction [Carbachol binds to CHRM4 protein]; brucine promotes the reaction [furtrethonium binds to CHRM4 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM4 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; WIN 62577 inhibits the reaction [brucine binds to CHRM4 protein] CTD PMID:9224827 PMID:10069518 PMID:16709648 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688 		JBrowse link
G Ctsd cathepsin D decreases expression ISO
EXP		 brucine results in decreased expression of CTSD mRNA
brucine results in decreased expression of CTSD mRNA; brucine results in decreased expression of CTSD protein		 CTD PMID:23933019 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein CTD PMID:21800547 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO brucine results in increased expression of CYP2B1 protein CTD PMID:7906730 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO brucine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197 		JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 increases expression ISO brucine results in increased expression of CYP2B3 protein CTD PMID:8850324 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity		 ISO [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein; [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein
brucine results in increased activity of CYP2E1 protein		 CTD PMID:21800547 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases metabolic processing EXP CYP3A11 protein results in increased metabolism of brucine CTD PMID:31284022 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO
EXP		 brucine results in decreased expression of FN1 mRNA
brucine results in decreased expression of FN1 mRNA; brucine results in decreased expression of FN1 protein		 CTD PMID:23933019 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200 		JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO brucine analog binds to and results in decreased activity of GLRA1 protein; brucine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 PMID:16687139 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP brucine results in increased expression of GPT protein CTD PMID:31284022 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686 		JBrowse link
G Lox lysyl oxidase decreases expression ISO
EXP		 brucine results in decreased expression of LOX mRNA
brucine results in decreased expression of LOX mRNA; brucine results in decreased expression of LOX protein		 CTD PMID:23933019 NCBI chr18:52,516,060...52,529,867
Ensembl chr18:52,516,067...52,529,867 		JBrowse link
G Mbp myelin basic protein affects expression ISO brucine affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:82,475,091...82,585,637
Ensembl chr18:82,475,146...82,585,637 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO
EXP		 brucine results in decreased expression of MMP2 mRNA
brucine results in decreased expression of MMP2 mRNA; brucine results in decreased expression of MMP2 protein		 CTD PMID:23933019 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420 		JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions EXP NPAS2 protein affects the metabolism of and affects the susceptibility to brucine CTD PMID:31284022 NCBI chr 1:39,193,702...39,363,240
Ensembl chr 1:39,193,731...39,363,236 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO brucine inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:24060683 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO brucine results in decreased expression of PTGS2 protein CTD PMID:16442763 PMID:17449162 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Tnf tumor necrosis factor decreases secretion EXP
ISO		 brucine results in decreased secretion of TNF protein CTD PMID:21684292 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
caracurine VII term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2, cardiac affects binding ISO caracurine binds to CHRM2 protein CTD PMID:15647330 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac affects binding ISO caracurine binds to CHRM3 protein CTD PMID:15647330 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847 		JBrowse link
cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186 		JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:127,800,197...127,831,859
Ensembl chr 2:127,801,122...127,831,865 		JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 2:118,598,202...118,641,592
Ensembl chr 2:118,598,211...118,641,591 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533 		JBrowse link
G Cdc34 cell division cycle 34 decreases expression ISO cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr10:79,682,193...79,688,398
Ensembl chr10:79,682,195...79,688,398 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr16:18,780,447...18,811,972
Ensembl chr16:18,780,447...18,811,987 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:46,760,461...46,771,530
Ensembl chr14:46,760,541...46,771,669 		JBrowse link
G Cenpf centromere protein F decreases expression ISO cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:189,640,606...189,688,107
Ensembl chr 1:189,640,606...189,688,086 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 5:138,164,583...138,172,111
Ensembl chr 5:138,164,583...138,172,422 		JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 2:132,816,137...132,844,197
Ensembl chr 2:132,816,141...132,844,197 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758 		JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 2:181,763,332...181,827,775
Ensembl chr 2:181,763,332...181,827,797 		JBrowse link
G Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 decreases expression ISO cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:191,821,449...191,833,049
Ensembl chr 1:191,821,444...191,833,050 		JBrowse link
G Trp53 transformation related protein 53 increases expression
increases activity		 ISO cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein		 CTD PMID:16120219 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Ttk Ttk protein kinase decreases expression ISO cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 9:83,834,651...83,872,390
Ensembl chr 9:83,834,689...83,872,389 		JBrowse link
demethoxyfumitremorgin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of AKT1 protein CTD PMID:28359723 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO demethoxyfumitremorgin C results in increased expression of BAX protein CTD PMID:28359723 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2 protein CTD PMID:28359723 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO demethoxyfumitremorgin C results in decreased expression of BCL2L1 protein CTD PMID:28359723 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728 		JBrowse link
G Casp3 caspase 3 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP3 protein CTD PMID:28359723 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP8 protein CTD PMID:28359723 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 increases activity ISO demethoxyfumitremorgin C results in increased activity of CASP9 protein CTD PMID:28359723 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO demethoxyfumitremorgin C results in increased cleavage of PARP1 protein CTD PMID:28359723 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
dihydro-beta-erythroidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:12511591 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 6:64,729,125...64,731,245
Ensembl chr 6:64,729,125...64,731,245 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA] CTD PMID:23056257 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 multiple interactions ISO Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:9687574 NCBI chr 9:55,010,117...55,026,562
Ensembl chr 9:55,010,111...55,026,562 		JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions
affects binding		 ISO
EXP		 Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine		 CTD PMID:9687574 PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 PMID:16915382 PMID:18385335 PMID:19047205 PMID:20100906 PMID:28555334 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546 		JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 increases activity
multiple interactions
affects response to substance		 ISO Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form
Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein		 CTD PMID:10082212 PMID:19448648 NCBI chr 7:63,098,692...63,212,526
Ensembl chr 7:63,098,692...63,212,569 		JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) multiple interactions ISO
EXP		 Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]		 CTD PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 PMID:16915382 PMID:18385335 PMID:19047205 PMID:20100906 PMID:21715663 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632 		JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 affects binding
multiple interactions		 ISO [CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]		 CTD PMID:9687574 NCBI chr 9:55,028,154...55,048,953
Ensembl chr 9:55,028,154...55,048,779 		JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 multiple interactions ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein] CTD PMID:20457658 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293 		JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions ISO Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA] CTD PMID:28555334 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA] CTD PMID:28555334 NCBI chr 2:70,561,303...70,602,014
Ensembl chr 2:70,553,072...70,602,014 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions ISO Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein] CTD PMID:23999947 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA] CTD PMID:29981921 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA] CTD PMID:29981921 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043 		JBrowse link
dihydroergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity ISO Dihydroergotamine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 decreases activity ISO Dihydroergotamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity		 ISO
EXP		 Dihydroergotamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Dihydroergotamine results in decreased activity of CYP1A1 protein
Dihydroergotamine results in increased activity of CYP1A1 protein		 CTD PMID:18420780 PMID:18493746 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity EXP Dihydroergotamine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061 		JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity EXP Dihydroergotamine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity EXP
ISO		 Dihydroergotamine results in decreased activity of CYP2D22 protein
Dihydroergotamine results in decreased activity of CYP2D6 protein		 CTD PMID:18420780 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity EXP
ISO		 Dihydroergotamine results in decreased activity of CYP3A11 protein
Dihydroergotamine results in decreased activity of CYP3A4 protein		 CTD PMID:18420780 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dihydroergotamine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824 		JBrowse link
ellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]] CTD PMID:11577022 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO ellipticine results in increased expression of BAX protein CTD PMID:16027529 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO ellipticine results in decreased expression of BCL2 protein CTD PMID:16027529 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO ellipticine results in decreased expression of and results in increased cleavage of BID protein CTD PMID:21843585 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]
ellipticine results in increased activity of CASP3 protein		 CTD PMID:16027529 PMID:21843585 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; ellipticine results in increased cleavage of and results in increased activity of CASP7 protein; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] CTD PMID:21843585 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO ellipticine results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:21843585 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO ellipticine results in increased activity of CASP9 protein
ellipticine results in increased cleavage of and results in increased activity of CASP9 protein		 CTD PMID:16027529 PMID:21843585 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression		 ISO ellipticine results in decreased expression of CCNB1 protein
ellipticine results in increased expression of CCNB1 protein		 CTD PMID:16027529 PMID:21843585 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ellipticine results in decreased expression of CCND1 protein CTD PMID:21843585 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO ellipticine results in decreased expression of CDC25C protein CTD PMID:16027529 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO ellipticine results in decreased expression of and results in increased phosphorylation of CDK1 protein CTD PMID:16027529 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression
multiple interactions		 ISO ellipticine results in increased expression of CDKN1A protein
[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]		 CTD PMID:29471073 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO ellipticine results in decreased expression of CDKN1B protein CTD PMID:21843585 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
increases activity
multiple interactions		 ISO
EXP		 CYP1A1 protein results in increased metabolism of ellipticine
ellipticine results in increased expression of CYP1A1 protein
ellipticine results in increased activity of CYP1A1 protein
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
[ellipticine results in decreased activity of CYP1A1 protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; ellipticine inhibits the reaction [troglitazone results in increased activity of CYP1A1 protein]
ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]		 CTD PMID:17973980 PMID:18308446 PMID:18493746 PMID:21932800 PMID:22917556 PMID:29471073 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO CYP1A2 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]		 CTD PMID:18493746 PMID:22917556 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions		 ISO
EXP		 CYP1B1 protein results in increased metabolism of ellipticine
ellipticine inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]		 CTD PMID:11577022 PMID:22917556 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing ISO CYP2C9 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing ISO CYP2C9 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases metabolic processing ISO CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of ellipticine CTD PMID:22917556 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases metabolic processing
multiple interactions		 ISO CYP3A4 protein results in increased metabolism of ellipticine
[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 12-hydroxyellipticine; [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 13-hydroxyellipticine; [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine; [CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine; [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 12-hydroxyellipticine]; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 13-hydroxyellipticine]; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine]; Protons inhibits the reaction [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine]		 CTD PMID:22390216 PMID:22917556 PMID:30914192 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions ISO [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form; FTL protein binds to and results in decreased uptake of ellipticine CTD PMID:30914192 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form
ellipticine results in increased expression of H2AX protein modified form		 CTD PMID:30914192 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein] CTD PMID:21843585 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein]; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein] CTD PMID:21843585 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO ellipticine results in increased cleavage of PARP1 protein CTD PMID:21843585 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Por P450 (cytochrome) oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine CTD PMID:22390216 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326 		JBrowse link
G Top2b topoisomerase (DNA) II beta decreases response to substance
increases response to substance		 ISO TOP2B protein mutant form results in decreased susceptibility to ellipticine
TOP2B protein mutant form results in increased susceptibility to ellipticine		 CTD PMID:15322234 PMID:16239602 NCBI chr14:16,365,206...16,430,787
Ensembl chr14:16,365,179...16,435,462 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
increases response to substance		 ISO TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [ellipticine results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [ellipticine results in increased expression of CYP1A1 protein]
ellipticine results in increased expression of TP53 protein
TP53 protein results in increased susceptibility to ellipticine		 CTD PMID:29471073 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO ellipticine results in decreased expression of XIAP protein CTD PMID:16027529 PMID:21843585 NCBI chr  X:42,059,613...42,109,664
Ensembl chr  X:42,059,679...42,109,656 		JBrowse link
ergocristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity		 ISO ergocristine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ergocristine results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616 		JBrowse link
G Casp3 caspase 3 increases activity ISO ergocristine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
ergosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
ergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] CTD PMID:19121572 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357 		JBrowse link
G Casp3 caspase 3 increases activity ISO Ergotamine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] CTD PMID:19121572 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Ergotamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985 		JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B multiple interactions ISO Ergotamine binds to and results in increased activity of HTR2B protein CTD PMID:11104741 NCBI chr 1:86,097,546...86,116,231
Ensembl chr 1:86,099,026...86,111,970 		JBrowse link
fumigaclavine C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression EXP fumigaclavine C results in decreased expression of IFNG mRNA; fumigaclavine C results in decreased expression of IFNG protein CTD PMID:16023606 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892 		JBrowse link
G Il12a interleukin 12a decreases expression EXP fumigaclavine C results in decreased expression of IL12A mRNA CTD PMID:16023606 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP fumigaclavine C results in decreased expression of IL1B mRNA CTD PMID:16023606 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il2 interleukin 2 decreases expression EXP fumigaclavine C results in decreased expression of IL2 mRNA; fumigaclavine C results in decreased expression of IL2 protein CTD PMID:16023606 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 EXP fumigaclavine C results in decreased activity of MMP9 protein
fumigaclavine C results in decreased expression of MMP9 mRNA		 CTD PMID:16023606 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP fumigaclavine C results in decreased expression of TNF mRNA CTD PMID:16023606 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein		 CTD PMID:22037238 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Harmaline results in decreased activity of MAOA protein CTD PMID:15178694 PMID:24373881 PMID:28302559 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity
increases expression		 ISO harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA		 CTD PMID:27590872 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity		 ISO [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein		 CTD PMID:22037238 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein		 CTD PMID:20732341 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions
decreases activity		 ISO harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein		 CTD PMID:30189235 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions
decreases activity		 ISO harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A2 protein		 CTD PMID:30189235 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488 		JBrowse link
G Taar1 trace amine-associated receptor 1 increases activity
multiple interactions		 EXP harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr10:23,920,406...23,921,404
Ensembl chr10:23,920,356...23,921,469 		JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Axin2 axin 2 multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr11:108,917,828...108,950,783
Ensembl chr11:108,920,349...108,950,783 		JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr 3:55,045,469...55,057,634
Ensembl chr 3:55,045,469...55,055,501 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 9:109,875,518...109,893,895
Ensembl chr 9:109,875,579...109,893,895 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation ISO Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) decreases expression ISO Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr 7:143,458,339...143,461,059
Ensembl chr 7:143,458,339...143,461,050 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A decreases expression ISO Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B decreases expression ISO Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 4:89,306,289...89,311,032
Ensembl chr 4:89,306,299...89,311,039 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 increases phosphorylation
multiple interactions		 EXP Harmine results in increased phosphorylation of CHD4 protein
AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]		 CTD PMID:27805061 NCBI chr 6:125,095,980...125,130,591
Ensembl chr 6:125,095,981...125,130,591 		JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A multiple interactions
increases expression		 EXP Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein		 CTD PMID:27805061 NCBI chr18:67,343,564...67,367,794
Ensembl chr18:67,343,604...67,367,785 		JBrowse link
G Cox8b cytochrome c oxidase subunit 8B increases expression EXP Harmine results in increased expression of COX8B protein CTD PMID:27805061 NCBI chr 7:140,898,942...140,900,446
Ensembl chr 7:140,898,945...140,900,446 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO
EXP		 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein		 CTD PMID:22001777 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases expression EXP Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438 		JBrowse link
G Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a multiple interactions
affects binding
decreases activity		 ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein		 CTD PMID:21573099 PMID:25751815 NCBI chr16:94,569,947...94,695,519
Ensembl chr16:94,570,010...94,695,517 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892 		JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 4:136,172,274...136,196,057
Ensembl chr 4:136,172,394...136,196,057 		JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr10:110,745,439...110,787,384
Ensembl chr10:110,745,439...110,787,384 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr 7:48,866,429...48,882,073
Ensembl chr 7:48,866,429...48,881,596 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions EXP [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576 		JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr 6:128,362,994...128,375,886
Ensembl chr 6:128,362,967...128,376,146 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr12:25,093,799...25,096,092
Ensembl chr12:25,093,799...25,097,140 		JBrowse link
G Ins1 insulin I multiple interactions EXP Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476 		JBrowse link
G Ins2 insulin II increases expression ISO Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381 		JBrowse link
G Lepr leptin receptor multiple interactions EXP Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352 		JBrowse link
G Mafa v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) increases expression ISO Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr15:75,745,501...75,748,321
Ensembl chr15:75,745,490...75,748,228 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Harmine results in decreased activity of MAOA protein CTD PMID:24373881 PMID:28302559 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090 		JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 affects localization ISO Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:80,606,205...80,713,071
Ensembl chr18:80,606,205...80,713,071 		JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 affects localization ISO Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr 2:168,476,410...168,601,657
Ensembl chr 2:168,476,410...168,601,657 		JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 affects localization ISO Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr 8:106,058,818...106,130,537
Ensembl chr 8:106,058,840...106,130,537 		JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 affects localization ISO Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr14:55,824,795...55,833,943
Ensembl chr14:55,823,144...55,833,943 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr 5:147,270,097...147,275,848
Ensembl chr 5:147,269,959...147,275,848 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 EXP [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein		 CTD PMID:20519739 PMID:27805061 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression		 EXP Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]
Harmine results in increased expression of PPARGC1A protein		 CTD PMID:27805061 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Prdm16 PR domain containing 16 increases expression
multiple interactions		 EXP Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]		 CTD PMID:27805061 NCBI chr 4:154,316,122...154,637,360
Ensembl chr 4:154,316,125...154,636,873 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions
increases expression		 EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]
Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein		 CTD PMID:27805061 NCBI chr 8:83,290,348...83,298,456
Ensembl chr 8:83,290,352...83,298,452 		JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions EXP Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr11:59,248,036...59,290,751
Ensembl chr11:59,248,033...59,290,752 		JBrowse link
ibogaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Ibogaine results in decreased activity of KCNH2 protein CTD PMID:23707769 PMID:24307198 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha decreases activity ISO Ibogaine results in decreased activity of SCN5A protein CTD PMID:23707769 NCBI chr 9:119,483,404...119,579,030
Ensembl chr 9:119,483,408...119,579,016 		JBrowse link
G Sec24d Sec24 related gene family, member D (S. cerevisiae) increases response to substance ISO SEC24D protein results in increased susceptibility to Ibogaine CTD PMID:27555326 NCBI chr 3:123,264,801...123,365,641
Ensembl chr 3:123,267,455...123,365,641 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions
increases expression		 ISO Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein		 CTD PMID:27555326 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672 		JBrowse link
icajine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium channel, voltage-gated, type V, alpha multiple interactions ISO icajine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 9:119,483,404...119,579,030
Ensembl chr 9:119,483,408...119,579,016 		JBrowse link
lisuride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO Lisuride binds to and results in decreased activity of ADRA1A protein; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr14:66,635,251...66,771,240
Ensembl chr14:66,635,251...66,771,168 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Lisuride binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 NCBI chr19:35,958,415...36,058,133
Ensembl chr19:35,958,734...36,057,507 		JBrowse link
G Ifng interferon gamma increases expression ISO Lisuride results in increased expression of IFNG CTD PMID:7948314 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892 		JBrowse link
G Prl prolactin multiple interactions
decreases secretion		 ISO Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Lisuride results in decreased expression of and results in decreased secretion of PRL protein
Lisuride analog results in decreased secretion of PRL protein; Lisuride results in decreased secretion of PRL protein		 CTD PMID:386688 PMID:6492995 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Lisuride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488 		JBrowse link
luzindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein] CTD PMID:23554006 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Gast gastrin multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 NCBI chr11:100,334,407...100,336,997
Ensembl chr11:100,334,407...100,336,996 		JBrowse link
G Gsr glutathione reductase multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein] CTD PMID:23554006 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163 		JBrowse link
G Mtnr1a melatonin receptor 1A multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein] CTD PMID:28238930 NCBI chr 8:45,069,107...45,089,233
Ensembl chr 8:45,069,137...45,088,506 		JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions EXP
ISO		 [luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin; luzindole binds to and results in decreased activity of MTNR1B protein
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]		 CTD PMID:11270484 PMID:21473625 PMID:28238930 NCBI chr 9:15,862,614...15,874,556
Ensembl chr 9:15,824,528...15,874,556 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]] CTD PMID:26283214 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PPARG protein] CTD PMID:29734669 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]] CTD PMID:25159133 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Prnp prion protein multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 NCBI chr 2:131,909,928...131,938,436
Ensembl chr 2:131,909,928...131,938,429 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]] CTD PMID:26283214 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] CTD PMID:25159133 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein] CTD PMID:23554006 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein] CTD PMID:23554006 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]] CTD PMID:26283214 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
lysergic acid diethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos FBJ osteosarcoma oncogene increases expression ISO Lysergic Acid Diethylamide results in increased expression of FOS mRNA CTD PMID:10521585 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273 		JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B multiple interactions
affects binding		 ISO 2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein] CTD PMID:14659797 PMID:29458138 NCBI chr 1:86,097,546...86,116,231
Ensembl chr 1:86,099,026...86,111,970 		JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 affects binding ISO Lysergic Acid Diethylamide binds to HTR6 protein CTD PMID:21866910 NCBI chr 4:139,059,706...139,075,570
Ensembl chr 4:139,061,108...139,075,570 		JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in decreased expression of ABCB1 protein] CTD PMID:28223141 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Abcb6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 multiple interactions
decreases metabolic processing		 EXP [ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
ABCB6 gene mutant form results in decreased metabolism of Melatonin		 CTD PMID:25623066 NCBI chr 1:75,171,640...75,180,392
Ensembl chr 1:75,171,717...75,180,392 		JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr 5:115,110,299...115,119,346
Ensembl chr 5:115,110,299...115,119,346 		JBrowse link
G Acan aggrecan increases expression ISO Melatonin results in increased expression of ACAN mRNA CTD PMID:20738756 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of ACHE]; Melatonin inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Melatonin inhibits the reaction [Dexamethasone results in increased activity of ACHE protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:19705549 PMID:21986892 PMID:22013727 PMID:30372842 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466 		JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:26882442 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Melatonin results in decreased expression of ADIPOQ mRNA CTD PMID:20738756 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028 		JBrowse link
G Adora2b adenosine A2b receptor multiple interactions
decreases expression		 EXP [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]
Melatonin results in decreased expression of ADORA2B mRNA		 CTD PMID:21461237 NCBI chr11:62,248,984...62,266,452
Ensembl chr11:62,248,984...62,266,453 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of AGER protein] CTD PMID:29763682 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936 		JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) decreases expression ISO Melatonin results in decreased expression of AGT protein CTD PMID:19018803 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions		 ISO
EXP		 Melatonin results in increased phosphorylation of AKT1 protein
Melatonin inhibits the reaction [cyfluthrin results in increased expression of AKT1 mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]		 CTD PMID:18078454 PMID:21138475 PMID:22225513 PMID:23374533 PMID:23963992 PMID:31330490 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Alas1 aminolevulinic acid synthase 1 multiple interactions EXP Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein] CTD PMID:24523661 NCBI chr 9:106,233,455...106,247,954
Ensembl chr 9:106,233,455...106,248,654 		JBrowse link
G Alb albumin multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in decreased expression of ALB protein] CTD PMID:16652224 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602 		JBrowse link
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA] CTD PMID:23963992 NCBI chr13:24,907,579...24,937,661
Ensembl chr13:24,907,579...24,937,661 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney increases expression ISO Melatonin results in increased expression of ALPL mRNA CTD PMID:20738756 NCBI chr 4:137,741,731...137,796,384
Ensembl chr 4:137,741,733...137,796,384 		JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of AOX1 mRNA] CTD PMID:31330490 NCBI chr 1:58,029,809...58,106,410
Ensembl chr 1:58,029,931...58,106,413 		JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions
decreases expression		 ISO
EXP		 Melatonin affects the reaction [APP protein binds to APP protein]; Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form]
Melatonin analog results in decreased expression of APP protein; Melatonin results in decreased expression of APP protein		 CTD PMID:10617124 PMID:18231852 PMID:18537544 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766 		JBrowse link
G Ar androgen receptor multiple interactions
increases expression		 ISO [Melatonin co-treated with Ethanol] results in increased expression of AR protein; Ethanol inhibits the reaction [Melatonin results in increased expression of AR protein] CTD PMID:23591044 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like multiple interactions ISO Melatonin affects the reaction [Rotenone affects the expression of ARNTL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of ARNTL] CTD PMID:23085516 PMID:25430725 NCBI chr 7:113,178,471...113,314,126
Ensembl chr 7:113,207,465...113,314,126 		JBrowse link
G Astl astacin-like metalloendopeptidase (M12 family) multiple interactions EXP Melatonin inhibits the reaction [bisphenol A results in decreased expression of and affects the localization of ASTL protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of and affects the localization of ASTL protein] CTD PMID:28178360 PMID:31931096 NCBI chr 2:127,338,639...127,357,655
Ensembl chr 2:127,338,639...127,357,651 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein] CTD PMID:23591579 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein] CTD PMID:17645694 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein] CTD PMID:18715270 PMID:28070110 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771 		JBrowse link
G Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr15:38,661,904...38,692,444
Ensembl chr15:38,661,933...38,692,446 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation		 ISO
EXP		 Melatonin promotes the reaction [YWHAB protein binds to BAD protein]
Melatonin results in increased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased phosphorylation of BAD protein]		 CTD PMID:18078454 PMID:21138475 PMID:29763682 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO
EXP		 [Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]		 CTD PMID:10965999 PMID:19220725 PMID:23963992 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009 		JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
multiple interactions		 ISO
EXP		 Melatonin results in decreased expression of BAX protein
Melatonin results in increased expression of BAX mRNA
Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Indomethacin affects the localization of BAX protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Methionine results in increased expression of BAX protein]
Melatonin results in increased expression of BAX protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]
[Doxorubicin co-treated with Melatonin] results in increased expression of BAX protein; [Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; Melatonin inhibits the reaction [BAX protein binds to BAX protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BAX protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]; Melatonin results in increased activity of and results in increased expression of BAX protein		 CTD PMID:9649124 PMID:10965999 PMID:14690559 PMID:15683462 PMID:15964511 PMID:16213988 PMID:16499559 PMID:18078454 PMID:18339127 PMID:19012662 PMID:19220725 PMID:19552762 PMID:20041988 PMID:20333787 PMID:20964710 PMID:21138475 PMID:22526374 PMID:23963992 PMID:24799992 PMID:31330490 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
increases expression
affects localization		 ISO
EXP		 [Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Melatonin co-treated with Tretinoin] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Melatonin] results in decreased expression of BCL2 protein; Melatonin inhibits the reaction [Cisplatin affects the expression of BCL2 protein]; Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]
Melatonin results in decreased expression of BCL2 mRNA
[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein; Melatonin inhibits the reaction [decamethrin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Methionine results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]
Melatonin results in decreased expression of BCL2 protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]
Melatonin results in increased expression of BCL2 protein
Melatonin affects the localization of BCL2 protein		 CTD PMID:9649124 PMID:10965999 PMID:12220328 PMID:14690559 PMID:14993511 PMID:16213988 PMID:16499559 PMID:17645694 PMID:18078454 PMID:18339127 PMID:18715270 PMID:18724894 PMID:19220725 PMID:20041988 PMID:20333787 PMID:21138475 PMID:21244482 PMID:23963992 PMID:24799992 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2L1 mRNA]
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein]		 CTD PMID:19220725 PMID:21244482 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP
ISO		 Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Dietary Fats results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Ethanol results in decreased expression of BDNF mRNA]		 CTD PMID:29476728 PMID:30372842 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression		 ISO Cisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein] CTD PMID:24799992 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286 		JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression ISO Melatonin results in increased expression of BGLAP mRNA CTD PMID:20738756 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression		 ISO Melatonin promotes the reaction [BID protein binds to BAX protein]
Melatonin results in increased expression of BID protein		 CTD PMID:19552762 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of BNIP3 mRNA] CTD PMID:31330490 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Ethanol results in increased expression of BTG2 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA] CTD PMID:28095641 NCBI chr 1:134,074,865...134,079,155
Ensembl chr 1:134,075,170...134,079,120 		JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr12:100,199,435...100,209,824
Ensembl chr12:100,199,435...100,209,814 		JBrowse link
G Capn1 calpain 1 multiple interactions ISO Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CAPN1 mRNA] CTD PMID:30372842 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO		 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP1 protein		 CTD PMID:23963992 PMID:25903262 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased expression of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP12 protein]
Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP12 protein]		 CTD PMID:17645694 PMID:18715270 PMID:28070110 PMID:30910607 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity
decreases expression		 ISO
EXP		 [Doxorubicin co-treated with Melatonin] results in increased expression of CASP3 protein; [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP3 protein; Melatonin inhibits the reaction [cyfluthrin results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin promotes the reaction [flavone results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein]
Melatonin results in decreased activity of CASP3 protein
Melatonin results in increased activity of CASP3 protein
Melatonin results in decreased expression of CASP3 protein
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]
Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]		 CTD PMID:12220328 PMID:12880480 PMID:15683462 PMID:15800915 PMID:15964511 PMID:16879318 PMID:17602819 PMID:17645694 PMID:17910606 PMID:18571630 PMID:18715270 PMID:19012662 PMID:19220725 PMID:19552762 PMID:20130848 PMID:20333787 PMID:21244482 PMID:21431366 PMID:22526374 PMID:25454643 PMID:25903262 PMID:29763682 PMID:29966675 PMID:30372842 PMID:30404999 PMID:31330490 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]
Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]
Melatonin results in increased activity of CASP8 protein		 CTD PMID:19012662 PMID:21431366 PMID:25454643 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO
EXP		 Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]
Melatonin results in increased activity of CASP9 protein
Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]		 CTD PMID:19012662 PMID:19220725 PMID:19552762 PMID:20130848 PMID:20964710 PMID:21431366 PMID:23963992 PMID:29763682 PMID:30404999 PMID:30910607 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
decreases activity		 EXP
ISO		 [aluminum lactate co-treated with Melatonin] results in increased expression of CAT mRNA; [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CAT mRNA]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Urethane results in increased expression of CAT protein]
Melatonin results in increased expression of CAT mRNA
[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
Melatonin results in decreased activity of CAT protein
[aluminum lactate co-treated with Melatonin] results in increased activity of CAT mRNA; [aluminum lactate co-treated with Melatonin] results in increased activity of CAT protein; [Melatonin co-treated with aluminum lactate] results in increased expression of CAT mRNA; [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]		 CTD PMID:9194422 PMID:12500499 PMID:12823611 PMID:15589378 PMID:16098089 PMID:16703270 PMID:16931443 PMID:17195641 PMID:19405147 PMID:19539013 PMID:19680607 PMID:19961921 PMID:20556922 PMID:22013727 PMID:22526374 PMID:23374533 PMID:23554006 PMID:24318767 PMID:24733834 PMID:26286521 PMID:28803342 PMID:29763682 PMID:31931096 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Cck cholecystokinin increases secretion ISO Melatonin results in increased secretion of CCK protein CTD PMID:15009505 NCBI chr 9:121,489,824...121,495,694
Ensembl chr 9:121,489,824...121,495,694 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22225513 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP
ISO		 Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CCL5 mRNA]		 CTD PMID:22225513 PMID:31330490 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518 		JBrowse link
G Ccl9 chemokine (C-C motif) ligand 9 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL9 mRNA] CTD PMID:22225513 NCBI chr11:83,572,917...83,578,636
Ensembl chr11:83,572,919...83,578,636 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Melatonin results in decreased expression of CCNB1 mRNA; Melatonin results in decreased expression of CCNB1 protein CTD PMID:21108658 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Melatonin results in decreased expression of CCND1 mRNA; Melatonin results in decreased expression of CCND1 protein CTD PMID:21108658 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Cd14 CD14 antigen multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of CD14 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798 		JBrowse link
G Cd200 CD200 antigen decreases expression EXP Melatonin results in decreased expression of CD200 protein CTD PMID:27503577 NCBI chr16:45,382,111...45,409,060
Ensembl chr16:45,382,135...45,409,053 		JBrowse link
G Cd36 CD36 molecule multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CD36 mRNA] CTD PMID:21689150 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Melatonin results in decreased expression of CDK1 mRNA; Melatonin results in decreased expression of CDK1 protein CTD PMID:21108658 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938 		JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Melatonin results in decreased expression of CDK4 mRNA; Melatonin results in decreased expression of CDK4 protein CTD PMID:21108658 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression
multiple interactions		 ISO Melatonin results in increased expression of CDKN1A protein
Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]		 CTD PMID:12071473 PMID:18384530 PMID:29330934 PMID:29734669 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions
decreases expression		 EXP [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]
Melatonin results in decreased expression of CISH mRNA		 CTD PMID:21461237 NCBI chr 9:107,296,659...107,302,784
Ensembl chr 9:107,296,026...107,302,784 		JBrowse link
G Ckb creatine kinase, brain multiple interactions ISO Melatonin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CKB protein] CTD PMID:19389042 NCBI chr12:111,669,355...111,672,338
Ensembl chr12:111,669,361...111,672,338 		JBrowse link
G Clec4a3 C-type lectin domain family 4, member a3 multiple interactions
increases expression		 EXP Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC4A3 mRNA]
Melatonin results in increased expression of CLEC4A3 mRNA		 CTD PMID:21461237 NCBI chr 6:122,952,515...122,969,878
Ensembl chr 6:122,952,515...122,969,875 		JBrowse link
G Clec4n C-type lectin domain family 4, member n multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC4N mRNA]
Melatonin results in decreased expression of CLEC4N mRNA		 CTD PMID:21461237 NCBI chr 6:123,229,843...123,247,024
Ensembl chr 6:123,229,843...123,247,021 		JBrowse link
G Clock circadian locomotor output cycles kaput multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 NCBI chr 5:76,209,868...76,305,603
Ensembl chr 5:76,209,868...76,304,792 		JBrowse link
G Colec12 collectin sub-family member 12 multiple interactions EXP [Lipopolysaccharides co-treated with Melatonin] results in increased expression of COLEC12 mRNA CTD PMID:21461237 NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions EXP Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of COX4I1 protein] CTD PMID:30910607 NCBI chr 8:120,668,225...120,674,209
Ensembl chr 8:120,668,222...120,674,207 		JBrowse link
G Cox6b1 cytochrome c oxidase, subunit 6B1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 7:30,616,971...30,626,114
Ensembl chr 7:30,616,861...30,626,151 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA] CTD PMID:23963992 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548 		JBrowse link
G Cry1 cryptochrome 1 (photolyase-like) multiple interactions ISO Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]; Melatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA] CTD PMID:23085516 PMID:25430725 NCBI chr10:85,131,700...85,185,054
Ensembl chr10:85,131,700...85,185,064 		JBrowse link
G Cry2 cryptochrome 2 (photolyase-like) affects expression
multiple interactions		 ISO Melatonin affects the expression of CRY2 mRNA
Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]; Melatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]		 CTD PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr 2:92,403,646...92,434,085
Ensembl chr 2:92,403,646...92,434,043 		JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]] CTD PMID:26990689 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO Melatonin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein] CTD PMID:21392095 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038 		JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions
decreases expression		 EXP [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CXCL10 mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
Melatonin results in decreased expression of CXCL10 mRNA		 CTD PMID:21461237 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of CYBB mRNA] CTD PMID:31330490 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
decreases activity		 ISO Melatonin results in decreased expression of CYP19A1
Melatonin results in decreased activity of CYP19A1 protein		 CTD PMID:16080194 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation		 ISO Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA]
Melatonin results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of Melatonin		 CTD PMID:15616152 PMID:19919601 PMID:20033131 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation
multiple interactions
increases metabolic processing
increases hydroxylation
affects metabolic processing
decreases activity		 ISO
EXP		 CYP1A2 protein results in decreased methylation of Melatonin
[ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
CYP1A2 protein results in increased hydroxylation of Melatonin
CYP1A2 protein affects the metabolism of Melatonin
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA
Melatonin results in decreased activity of CYP1A2 protein
Melatonin inhibits the reaction [CYP1A2 protein results in increased hydrolysis of Benzo(a)pyrene]		 CTD PMID:15616152 PMID:15626586 PMID:15824912 PMID:17565714 PMID:19919601 PMID:20033131 PMID:22634058 PMID:25623066 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation		 ISO 2,4,3',5'-tetramethoxystilbene inhibits the reaction [CYP1B1 protein results in increased hydroxylation of Melatonin]
Melatonin results in decreased activity of CYP1B1 protein		 CTD PMID:15616152 PMID:19919601 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions EXP Melatonin inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:28095641 NCBI chr 1:74,713,148...74,737,897
Ensembl chr 1:74,713,574...74,737,892 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions ISO Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases methylation
increases hydroxylation		 ISO CYP2C19 protein results in decreased methylation of Melatonin
CYP2C19 protein results in increased hydroxylation of Melatonin		 CTD PMID:15616152 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]		 CTD PMID:20338863 PMID:20964710 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]]; Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of CYP3A11 mRNA] CTD PMID:15617534 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP Melatonin results in decreased expression of CYP7A1 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]		 CTD PMID:28095641 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 multiple interactions EXP Melatonin inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:28095641 NCBI chr 9:121,914,356...121,916,305
Ensembl chr 9:121,914,356...121,916,305 		JBrowse link
G Dap3 death associated protein 3 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 3:88,920,803...88,951,213
Ensembl chr 3:88,920,803...88,951,181 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of DDIT3 protein] CTD PMID:18715270 PMID:28070110 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of DNM1L protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]
Melatonin inhibits the reaction [Rotenone results in increased expression of DNM1L protein]		 CTD PMID:26882442 PMID:29183837 PMID:29966675 NCBI chr16:16,312,228...16,359,038
Ensembl chr16:16,312,230...16,358,959 		JBrowse link
G Dnm2 dynamin 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 9:21,424,908...21,507,759
Ensembl chr 9:21,424,908...21,507,759 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein] CTD PMID:24969583 NCBI chr13:54,051,183...54,055,658
Ensembl chr13:54,051,183...54,055,705 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]
Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]		 CTD PMID:18289173 PMID:24969583 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892 		JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr19:8,967,041...8,978,180
Ensembl chr19:8,967,041...8,978,479 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] CTD PMID:28070110 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:28070110 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:19054297 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 7:111,067,985...111,083,030
Ensembl chr 7:111,067,750...111,083,030 		JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:20,933,395...20,950,608
Ensembl chr  X:20,933,395...20,950,608 		JBrowse link
G Eno2 enolase 2, gamma neuronal multiple interactions EXP Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein] CTD PMID:24969583 NCBI chr 6:124,760,053...124,769,673
Ensembl chr 6:124,760,053...124,769,673 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 increases expression ISO Melatonin results in increased expression of ERCC1 protein CTD PMID:24799992 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524 		JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]; Melatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein] CTD PMID:20136702 PMID:28070110 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
decreases expression		 ISO
EXP		 Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]
Melatonin results in decreased expression of ESR1 mRNA
Melatonin results in decreased expression of ESR1 mRNA; Melatonin results in decreased expression of ESR1 protein
[Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 protein; Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA]		 CTD PMID:15813899 PMID:16030176 PMID:16051031 PMID:16635015 PMID:23591044 PMID:26990689 PMID:27551335 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
decreases expression		 ISO [Melatonin co-treated with Ethanol] results in increased expression of ESR2 protein; Ethanol inhibits the reaction [Melatonin results in decreased expression of ESR2 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of ESR2 protein] CTD PMID:23591044 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression ISO Melatonin results in decreased expression of FABP4 mRNA CTD PMID:20738756 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576 		JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
decreases expression		 ISO
EXP		 Melatonin inhibits the reaction [bisphenol A results in increased expression of FAS protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]
Melatonin results in decreased expression of FAS mRNA; Melatonin results in decreased expression of FAS protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]		 CTD PMID:14993511 PMID:20181888 PMID:23963992 PMID:25454643 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772 		JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein] CTD PMID:14993511 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FASN mRNA] CTD PMID:21689150 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA]
Melatonin results in decreased expression of FCGR2B mRNA		 CTD PMID:21461237 NCBI chr 1:170,960,558...170,976,071
Ensembl chr 1:170,958,617...170,976,547 		JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]; Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein] CTD PMID:19476551 NCBI chr14:58,070,671...58,112,854
Ensembl chr14:58,070,547...58,112,720 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased expression of FIS1 protein] CTD PMID:29966675 NCBI chr 5:136,953,275...136,966,234
Ensembl chr 5:136,953,275...136,966,234 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] CTD PMID:19524604 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Melatonin inhibits the reaction [Capsaicin results in increased expression of FOS protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of FOS protein] CTD PMID:19172228 PMID:28238930 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Melatonin inhibits the reaction [Ethanol results in decreased expression of FSHB protein] CTD PMID:23591044 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
multiple interactions		 ISO
EXP		 Melatonin results in increased activity of G6PD protein
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of G6PD protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein		 CTD PMID:16224550 PMID:25903262 PMID:29763682 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein] CTD PMID:19409439 NCBI chr16:42,248,552...42,340,651
Ensembl chr16:42,248,442...42,340,651 		JBrowse link
G Gast gastrin multiple interactions
increases expression		 ISO luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 PMID:16207293 NCBI chr11:100,334,407...100,336,997
Ensembl chr11:100,334,407...100,336,996 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]] CTD PMID:25550330 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]
Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein]		 CTD PMID:17572393 PMID:25288107 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] CTD PMID:15700767 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:15700767 PMID:26882442 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression		 ISO
EXP		 [aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA
Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]
Melatonin results in increased expression of GPX1 mRNA		 CTD PMID:15589378 PMID:25288107 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA CTD PMID:20033131 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr11:115,644,045...115,708,597
Ensembl chr11:115,644,045...115,708,597 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form] CTD PMID:15842767 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084 		JBrowse link
G Gsr glutathione reductase multiple interactions
increases activity
decreases expression		 ISO
EXP		 [Cadmium Chloride co-treated with Melatonin] results in decreased expression of GSR mRNA; aluminum lactate affects the reaction [Melatonin results in increased activity of GSR protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased activity of GSR protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of GSR protein
Melatonin results in decreased expression of GSR protein
[aluminum lactate co-treated with Melatonin] results in increased expression of GSR mRNA; aluminum lactate promotes the reaction [Melatonin results in decreased expression of GSR protein]; luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased expression of GSR protein]
Melatonin results in decreased expression of GSR mRNA		 CTD PMID:12823611 PMID:16098089 PMID:16224550 PMID:16931443 PMID:19405147 PMID:19680607 PMID:21442002 PMID:21840368 PMID:22526374 PMID:23554006 PMID:24969583 PMID:25288107 PMID:25903262 PMID:29763682 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163 		JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions ISO [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:20033131 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA CTD PMID:20033131 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions EXP
ISO		 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]
Melatonin affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA]		 CTD PMID:21986892 PMID:23963992 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of HAVCR1 protein] CTD PMID:29763682 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein] CTD PMID:27413111 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]
Melatonin results in increased expression of HMOX1 protein
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
Melatonin results in decreased expression of HMOX1 mRNA		 CTD PMID:10942521 PMID:12420312 PMID:16948784 PMID:17645694 PMID:18715270 PMID:20197452 PMID:20433640 PMID:21442002 PMID:21986892 PMID:25288107 PMID:27871981 PMID:30372842 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
decreases expression		 ISO [Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA; Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]
Melatonin results in decreased expression of HMOX2 mRNA		 CTD PMID:21442002 PMID:21986892 NCBI chr16:4,726,361...4,766,742
Ensembl chr16:4,726,361...4,766,742 		JBrowse link
G Hsf1 heat shock factor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:23963992 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728 		JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of HSPA1A mRNA] CTD PMID:31330490 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:20136702 PMID:28070110 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547 		JBrowse link
G Hspa9 heat shock protein 9 multiple interactions ISO Melatonin affects the reaction [Mercuric Chloride results in increased expression of HSPA9 protein] CTD PMID:16801527 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357 		JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO		 Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IFNG protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG mRNA]		 CTD PMID:16373423 PMID:23374533 PMID:23963992 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL10 protein] CTD PMID:16373423 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]
Melatonin results in decreased expression of IL1A mRNA		 CTD PMID:21461237 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression		 EXP
ISO		 Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
Melatonin results in decreased secretion of IL1B protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]
Melatonin results in decreased expression of IL1B mRNA		 CTD PMID:15714805 PMID:16373423 PMID:19028472 PMID:20374443 PMID:21461237 PMID:23963992 PMID:27413111 PMID:28238930 PMID:29763682 PMID:30372842 PMID:30595364 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il2 interleukin 2 increases activity
multiple interactions		 ISO
EXP		 Melatonin results in increased activity of IL2 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL2 protein]		 CTD PMID:9730580 PMID:16373423 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion		 ISO
EXP		 Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 protein]
Melatonin results in decreased secretion of IL6 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL6 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]		 CTD PMID:16373423 PMID:20374443 PMID:21158907 PMID:27413111 PMID:28238930 PMID:29763682 PMID:30595364 PMID:32554039 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Insr insulin receptor multiple interactions ISO Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein] CTD PMID:19705549 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:29763682 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 6:108,213,083...108,551,116
Ensembl chr 6:108,213,096...108,551,109 		JBrowse link
G Izumo1r IZUMO1 receptor, JUNO multiple interactions EXP Melatonin inhibits the reaction [bisphenol A affects the expression of and affects the localization of IZUMO1R protein]; Melatonin inhibits the reaction [Ethinyl Estradiol affects the localization of IZUMO1R protein] CTD PMID:28178360 PMID:31931096 NCBI chr 9:14,885,814...14,903,951
Ensembl chr 9:14,885,814...14,903,949 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of JUN protein] CTD PMID:28238930 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases expression
multiple interactions		 EXP Melatonin results in decreased expression of KEAP1 protein
Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]		 CTD PMID:25288107 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361 		JBrowse link
G Kl klotho multiple interactions EXP 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]] CTD PMID:25550330 NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of LAMP2 protein] CTD PMID:26882442 NCBI chr  X:38,399,647...38,456,460
Ensembl chr  X:38,401,357...38,456,454 		JBrowse link
G Lep leptin decreases expression ISO Melatonin results in decreased expression of LEP mRNA
Melatonin results in decreased expression of LEP protein		 CTD PMID:19028472 PMID:20738756 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO [Melatonin co-treated with LHB protein] results in increased chemical synthesis of Testosterone; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of LHB] CTD PMID:16054318 PMID:23085516 NCBI chr 7:45,417,608...45,421,855
Ensembl chr 7:45,420,820...45,421,897
Ensembl chr 7:45,420,820...45,421,897 		JBrowse link
G Lpl lipoprotein lipase decreases expression ISO Melatonin results in decreased expression of LPL mRNA CTD PMID:20738756 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448 		JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:27413111 PMID:28238930 NCBI chr 1:16,688,456...16,709,605
Ensembl chr 1:16,688,051...16,709,611 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr11:110,399,102...110,525,522
Ensembl chr11:110,399,122...110,525,522 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK1 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]		 CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 increases expression ISO Melatonin results in increased expression of MAPK10 protein CTD PMID:19012662 NCBI chr 5:102,908,547...103,212,604
Ensembl chr 5:102,907,948...103,211,334 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK3 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]		 CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Melatonin results in increased expression of MAPK8 protein CTD PMID:19012662 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Melatonin results in increased expression of MAPK9 protein CTD PMID:19012662 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP
ISO		 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Melatonin inhibits the reaction [Wortmannin results in increased phosphorylation of MAPT protein]
Melatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]
Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]		 CTD PMID:10617124 PMID:15842767 PMID:23963992 PMID:31833155 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] CTD PMID:29476728 NCBI chr18:82,475,091...82,585,637
Ensembl chr18:82,475,146...82,585,637 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions ISO Melatonin inhibits the reaction [oxaliplatin results in decreased expression of MCL1 protein] CTD PMID:20626587 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176 		JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic multiple interactions ISO Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:20033131 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO [Doxorubicin results in increased susceptibility to Melatonin] which results in increased expression of MFN1 protein; [Melatonin results in increased susceptibility to Doxorubicin] which results in increased expression of MFN1 protein CTD PMID:29966675 NCBI chr 3:32,529,443...32,579,225
Ensembl chr 3:32,529,465...32,579,239 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of MFN2 protein] CTD PMID:26882442 PMID:29966675 NCBI chr 4:147,873,586...147,904,909
Ensembl chr 4:147,873,599...147,904,704 		JBrowse link
G Mir497 microRNA 497 increases expression
multiple interactions		 EXP Melatonin results in increased expression of MIR497 mRNA
MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]		 CTD PMID:28095641 NCBI chr11:70,234,717...70,234,800
Ensembl chr11:70,234,717...70,234,800 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions
decreases expression		 ISO Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MKI67 protein]
Melatonin results in decreased expression of MKI67 mRNA; Melatonin results in decreased expression of MKI67 protein		 CTD PMID:19028472 PMID:21062352 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein]
Melatonin inhibits the reaction [sodium arsenite results in increased expression of MMP2 protein]		 CTD PMID:16150113 PMID:16934674 PMID:29763682 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in increased expression of and results in increased secretion of MMP9 protein] CTD PMID:16150113 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Melatonin promotes the reaction [lead acetate results in increased expression of MT1A mRNA] CTD PMID:25601058 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327 		JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA] CTD PMID:25601058 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568 		JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
increases expression
multiple interactions		 ISO Melatonin analog binds to MTNR1A protein; Melatonin binds to MTNR1A protein
Melatonin results in increased expression of MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]
[Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein; luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]		 CTD PMID:11063602 PMID:17645693 PMID:20399199 PMID:23591044 PMID:28027439 PMID:28238930 PMID:29330934 NCBI chr 8:45,069,107...45,089,233
Ensembl chr 8:45,069,137...45,088,506 		JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions
increases expression
affects binding		 EXP
ISO		 [luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
Melatonin analog binds to MTNR1B protein; Melatonin binds to MTNR1B protein		 CTD PMID:11063602 PMID:11270484 PMID:16030176 PMID:17645693 PMID:20399199 PMID:26283214 PMID:28027439 PMID:28238930 NCBI chr 9:15,862,614...15,874,556
Ensembl chr 9:15,824,528...15,874,556 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
increases activity		 ISO Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Melatonin results in increased activity of MTOR protein		 CTD PMID:19054297 PMID:24799992 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA1 protein] CTD PMID:29330934 NCBI chr12:4,247,362...4,477,206
Ensembl chr12:4,247,362...4,477,182 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein] CTD PMID:29330934 NCBI chr 2:165,992,637...166,073,242
Ensembl chr 2:165,992,636...166,073,242 		JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 multiple interactions
decreases expression
affects response to substance		 EXP Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of NEDD4 protein]; Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]; Melatonin promotes the reaction [Cycloheximide results in decreased expression of NEDD4 protein]; Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein]
Melatonin results in decreased expression of NEDD4 protein
[NEDD4 protein affects the susceptibility to Oxygen deficiency] which affects the susceptibility to Melatonin		 CTD PMID:31325559 NCBI chr 9:72,662,331...72,749,851
Ensembl chr 9:72,662,346...72,749,852 		JBrowse link
G Nefh neurofilament, heavy polypeptide decreases phosphorylation EXP Melatonin analog results in decreased phosphorylation of NEFH protein; Melatonin results in decreased phosphorylation of NEFH protein CTD PMID:18231852 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064 		JBrowse link
G Nes nestin decreases expression
multiple interactions		 ISO Melatonin results in decreased expression of NES protein
Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]		 CTD PMID:16369854 PMID:17572393 PMID:21269327 NCBI chr 3:87,971,093...87,980,451
Ensembl chr 3:87,971,078...87,980,451 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression		 ISO
EXP		 Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NFE2L2 mRNA]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]
Melatonin results in increased expression of NFE2L2 protein		 CTD PMID:20433640 PMID:25288107 PMID:25550330 PMID:27871981 PMID:30372842 PMID:31330490 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NFKB1 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NFKB1 mRNA]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]		 CTD PMID:19028472 PMID:21158907 PMID:23963992 PMID:30372842 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]]; Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein] CTD PMID:26283214 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
decreases expression		 ISO Melatonin affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA]
Melatonin results in decreased expression of NOS1 mRNA		 CTD PMID:16948784 PMID:21442002 PMID:21986892 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
decreases expression		 EXP
ISO		 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NOS2 mRNA]
Melatonin results in increased expression of NOS2 mRNA
Melatonin results in decreased expression of NOS2 mRNA
Melatonin affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA]; Melatonin affects the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Amphetamine results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]		 CTD PMID:12074098 PMID:16801527 PMID:16948784 PMID:18524487 PMID:21442002 PMID:21986892 PMID:22526374 PMID:23963992 PMID:29763682 PMID:30372842 PMID:31330490 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]] CTD PMID:21585521 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474 		JBrowse link
G Npm1 nucleophosmin 1 multiple interactions EXP Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr11:33,152,498...33,164,142
Ensembl chr11:33,152,287...33,163,206 		JBrowse link
G Nppb natriuretic peptide type B multiple interactions ISO Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA] CTD PMID:17198541 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression		 ISO
EXP		 [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Melatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA]
Melatonin affects the reaction [manganese chloride affects the expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]
Melatonin results in increased expression of NQO1 protein		 CTD PMID:20033131 PMID:20433640 PMID:24969583 PMID:25288107 PMID:27871981 PMID:31330490 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions
affects activity		 ISO Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]
Melatonin affects the activity of NQO2 protein		 CTD PMID:20399199 PMID:22289031 NCBI chr13:33,964,655...33,988,465
Ensembl chr13:33,964,687...33,988,443 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein] CTD PMID:21689150 NCBI chr 2:91,184,061...91,202,829
Ensembl chr 2:91,184,061...91,202,834 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA] CTD PMID:15617534 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects localization		 ISO
EXP		 Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Melatonin promotes the reaction [Dexamethasone results in decreased expression of NR3C1 mRNA]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]]
Melatonin inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Melatonin affects the localization of NR3C1 protein		 CTD PMID:10463946 PMID:15813899 PMID:18395440 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NRF1 protein] CTD PMID:26882442 NCBI chr 6:30,047,985...30,153,458
Ensembl chr 6:30,047,988...30,153,458 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein] CTD PMID:23963992 PMID:29476728 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970 		JBrowse link
G P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:100,588,358...100,594,927
Ensembl chr  X:100,590,154...100,594,869 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Melatonin inhibits the reaction [Doxorubicin results in increased expression of PARP1 protein modified form] CTD PMID:29966675 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator decreases expression ISO Melatonin results in decreased expression of PAWR protein CTD PMID:15964511 NCBI chr10:108,332,189...108,414,391
Ensembl chr10:108,332,121...108,414,240 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression		 ISO Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein]
Melatonin results in decreased expression of PCNA mRNA		 CTD PMID:19028472 PMID:21062352 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314 		JBrowse link
G Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr15:103,503,034...103,530,056
Ensembl chr15:103,503,034...103,530,052 		JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr 5:75,151,322...75,198,206
Ensembl chr 5:75,152,292...75,198,215 		JBrowse link
G Per1 period circadian clock 1 multiple interactions ISO Melatonin affects the reaction [Cadmium Chloride affects the expression of PER1]; Melatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA] CTD PMID:17590544 PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr11:69,095,108...69,109,965
Ensembl chr11:69,095,217...69,109,960 		JBrowse link
G Per2 period circadian clock 2 multiple interactions
affects expression		 ISO Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA]
Melatonin affects the expression of PER2 mRNA		 CTD PMID:17590544 PMID:21442002 PMID:25430725 NCBI chr 1:91,415,977...91,459,351
Ensembl chr 1:91,415,982...91,459,324 		JBrowse link
G Pf4 platelet factor 4 multiple interactions EXP [Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA CTD PMID:21461237 NCBI chr 5:90,772,435...90,773,383
Ensembl chr 5:90,772,435...90,773,383 		JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression		 ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR]
Melatonin results in decreased expression of PGR protein alternative form
[Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form; [Ethanol co-treated with Melatonin] results in increased expression of PGR protein alternative form; Ethanol inhibits the reaction [Melatonin results in decreased expression of PGR protein alternative form]; Melatonin inhibits the reaction [Ethanol results in decreased expression of PGR protein alternative form]		 CTD PMID:22041583 PMID:23591044 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein] CTD PMID:26882442 PMID:29966675 NCBI chr 4:138,313,409...138,326,296
Ensembl chr 4:138,313,409...138,326,307 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions
decreases response to substance		 ISO [Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein
Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]; Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]
Melatonin results in decreased susceptibility to POMC protein		 CTD PMID:11478929 PMID:19301769 PMID:21332028 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression
multiple interactions		 ISO Melatonin results in decreased expression of POU5F1 mRNA; Melatonin results in decreased expression of POU5F1 protein
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein]		 CTD PMID:27551335 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression
multiple interactions
increases expression		 ISO Melatonin results in decreased expression of PPARG mRNA
GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PPARG protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PPARG protein]		 CTD PMID:20738756 PMID:29734669 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]; Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]		 CTD PMID:25159133 PMID:26882442 PMID:29966675 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein] CTD PMID:26882442 NCBI chr17:10,840,359...12,063,370
Ensembl chr17:10,840,384...12,063,361 		JBrowse link
G Prl prolactin multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL] CTD PMID:23085516 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205 		JBrowse link
G Prnp prion protein multiple interactions
increases expression		 ISO GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PRNP protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PRNP protein]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]] CTD PMID:29734669 NCBI chr 2:131,909,928...131,938,436
Ensembl chr 2:131,909,928...131,938,429 		JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions		 ISO Melatonin results in decreased expression of PROM1 mRNA; Melatonin results in decreased expression of PROM1 protein
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; N-caproylsphingosine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; N-caproylsphingosine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein]		 CTD PMID:30421542 NCBI chr 5:43,993,621...44,102,047
Ensembl chr 5:43,993,620...44,102,032 		JBrowse link
G Psen1 presenilin 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199 		JBrowse link
G Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA] CTD PMID:23963992 NCBI chr 7:28,041,702...28,050,092
Ensembl chr 7:28,041,707...28,050,101 		JBrowse link
G Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 multiple interactions EXP [Oxygen deficiency co-treated with Melatonin] results in decreased expression of PSMD3 protein CTD PMID:31325559 NCBI chr11:98,682,554...98,695,978
Ensembl chr11:98,682,554...98,695,979 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA] CTD PMID:18588940 PMID:23376440 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Rab7 RAB7, member RAS oncogene family multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of RAB7A protein] CTD PMID:26882442 NCBI chr 6:87,999,106...88,045,270
Ensembl chr 6:87,999,106...88,045,270 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 6:115,618,569...115,676,635
Ensembl chr 6:115,618,067...115,676,635 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein] CTD PMID:10965999 PMID:15813899 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]]; Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]
Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]		 CTD PMID:20433640 PMID:22225513 PMID:22526374 PMID:26283214 PMID:27871981 PMID:27899301 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G Renbp renin binding protein multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of RENBP protein] CTD PMID:29763682 NCBI chr  X:73,922,121...73,930,850
Ensembl chr  X:73,922,121...73,930,850 		JBrowse link
G Rgn regucalcin multiple interactions ISO Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]] CTD PMID:29734669 NCBI chr  X:20,549,766...20,562,089
Ensembl chr  X:20,549,787...20,562,089 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein] CTD PMID:29763682 NCBI chr13:34,002,225...34,035,170
Ensembl chr13:34,002,363...34,037,147 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK3 protein] CTD PMID:29763682 NCBI chr14:55,784,995...55,788,857
Ensembl chr14:55,784,995...55,788,865 		JBrowse link
G Rora RAR-related orphan receptor alpha affects binding EXP Melatonin binds to RORA protein CTD PMID:16030176 NCBI chr 9:68,653,404...69,388,246
Ensembl chr 9:68,653,786...69,388,246 		JBrowse link
G Rpl19 ribosomal protein L19 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr11:98,022,003...98,030,493
Ensembl chr11:98,026,710...98,030,492 		JBrowse link
G Rpl23 ribosomal protein L23 multiple interactions EXP Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr11:97,777,526...97,782,439
Ensembl chr11:97,777,527...97,782,437 		JBrowse link
G Rpl3 ribosomal protein L3 multiple interactions EXP Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of RPL3 protein] CTD PMID:31325559 NCBI chr15:80,077,781...80,083,406
Ensembl chr15:80,077,791...80,091,868 		JBrowse link
G Rps19 ribosomal protein S19 multiple interactions EXP Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr 7:24,884,592...24,889,811
Ensembl chr 7:24,884,371...24,889,806 		JBrowse link
G Rps7 ribosomal protein S7 multiple interactions EXP Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr12:28,630,847...28,635,953
Ensembl chr12:28,630,854...28,635,953 		JBrowse link
G Runx2 runt related transcription factor 2 increases expression ISO Melatonin results in increased expression of RUNX2 mRNA CTD PMID:20738756 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797 		JBrowse link
G S100g S100 calcium binding protein G increases expression
multiple interactions		 ISO Melatonin results in increased expression of S100G mRNA; Melatonin results in increased expression of S100G protein
Hydrogen Peroxide promotes the reaction [Melatonin results in increased expression of S100G protein]		 CTD PMID:20041988 NCBI chr  X:162,961,992...162,964,599
Ensembl chr  X:162,961,992...162,964,599 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 ISO
EXP		 Melatonin results in decreased expression of SIRT1 protein
Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]		 CTD PMID:21062352 PMID:25159133 PMID:29966675 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions EXP Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:20964710 NCBI chr19:59,260,878...59,296,012
Ensembl chr19:59,260,896...59,296,012 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions EXP
ISO		 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA]
Melatonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]		 CTD PMID:21599003 PMID:23963992 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]		 CTD PMID:17198541 PMID:29763682 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]
Melatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]		 CTD PMID:18289173 PMID:24969583 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672 		JBrowse link
G Snca synuclein, alpha multiple interactions ISO Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Melatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]] CTD PMID:17645694 PMID:18289173 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
increases activity
increases expression		 ISO
EXP		 [aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; [Cadmium Chloride co-treated with Melatonin] results in increased expression of SOD1 mRNA; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD1 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]
Melatonin results in increased activity of SOD1 protein
Melatonin results in increased expression of SOD1 mRNA
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]		 CTD PMID:11523592 PMID:15589378 PMID:17198541 PMID:19405147 PMID:19680607 PMID:20210856 PMID:21442002 PMID:23554006 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases activity
increases expression		 ISO
EXP		 Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD2 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD2 protein]
luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of SOD2 protein]
Melatonin results in increased expression of SOD2 mRNA
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]		 CTD PMID:10942521 PMID:11523592 PMID:15589378 PMID:16098089 PMID:20210856 PMID:21442002 PMID:23554006 PMID:25288107 PMID:26882442 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of SQSTM1 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]		 CTD PMID:26882442 PMID:31330490 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein] CTD PMID:21689150 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Melatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:21158907 PMID:22225513 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases response to substance
increases phosphorylation		 EXP
ISO		 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
STAT3 protein results in increased susceptibility to Melatonin
Melatonin results in increased phosphorylation of STAT3 protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of STAT3 protein]		 CTD PMID:19028472 PMID:21342247 PMID:22225513 PMID:23963992 PMID:27871981 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 1:51,987,106...52,107,189
Ensembl chr 1:51,987,148...52,107,189 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr11:100,859,351...100,885,169
Ensembl chr11:100,859,351...100,885,169 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] CTD PMID:27871981 NCBI chr10:127,642,955...127,660,987
Ensembl chr10:127,642,986...127,660,957 		JBrowse link
G Syp synaptophysin multiple interactions ISO Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]; Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein] CTD PMID:17572393 PMID:19409439 NCBI chr  X:7,638,580...7,653,256
Ensembl chr  X:7,638,471...7,653,256 		JBrowse link
G Syt5 synaptotagmin V multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr 7:4,539,765...4,547,541
Ensembl chr 7:4,539,765...4,547,541 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin CTD PMID:16952380 NCBI chr 3:81,958,412...81,975,728
Ensembl chr 3:81,957,090...81,976,202 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP
ISO		 Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein]
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]		 CTD PMID:21797922 PMID:26882442 NCBI chr10:71,225,468...71,238,328
Ensembl chr10:71,225,464...71,238,280 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]] CTD PMID:27551335 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277 		JBrowse link
G Tfrc transferrin receptor decreases expression ISO Melatonin results in decreased expression of TFRC mRNA; Melatonin results in decreased expression of TFRC protein CTD PMID:17091493 PMID:18571630 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 [Tretinoin co-treated with Melatonin] results in increased expression of TGFB1 mRNA
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]		 CTD PMID:9649124 PMID:17572393 PMID:23963992 PMID:26882442 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO
EXP		 Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]		 CTD PMID:18289173 PMID:19409439 PMID:20964710 PMID:24969583 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions ISO Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] CTD PMID:16934674 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of TLR4 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:27413111 PMID:28238930 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion		 EXP
ISO		 Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of TNF protein]; Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
melatonin inhibits the reaction [liver reperfusion increases secretion of Tnf protein in plasma]
Melatonin results in decreased secretion of TNF protein
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Melatonin inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF protein]		 CTD PMID:15714805 PMID:16373423 PMID:17602819 PMID:19028472 PMID:19080501 PMID:20374443 PMID:23374533 PMID:23963992 PMID:26283214 PMID:27413111 PMID:28238930 PMID:29763682 PMID:30595364 PMID:32554039, PMID:11592783 RGD:2325259 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b increases response to substance EXP TNFRSF1B protein results in increased susceptibility to Melatonin CTD PMID:21342247 NCBI chr 4:145,212,368...145,246,870
Ensembl chr 4:145,213,463...145,246,870 		JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of TRADD protein] CTD PMID:29763682 NCBI chr 8:105,258,575...105,264,594
Ensembl chr 8:105,258,286...105,264,609 		JBrowse link
G Trappc6a trafficking protein particle complex 6A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in decreased expression of TRAPPC6A mRNA] CTD PMID:31330490 NCBI chr 7:19,508,665...19,516,145
Ensembl chr 7:19,508,395...19,516,145 		JBrowse link
G Trf transferrin increases expression
multiple interactions		 ISO Melatonin results in increased expression of TF protein
[Melatonin results in increased expression of TF protein] which affects the abundance of Iron		 CTD PMID:18571630 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO
EXP		 Melatonin results in increased expression of TP53 protein
Melatonin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TP53 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]
Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]		 CTD PMID:12071473 PMID:14993511 PMID:19012662 PMID:20041988 PMID:20964710 PMID:23963992 PMID:24799992 PMID:25454643 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]; Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA] CTD PMID:16948784 PMID:23085516 NCBI chr 3:102,777,398...102,789,082
Ensembl chr 3:102,775,465...102,782,718 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions EXP Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]] CTD PMID:27871981 NCBI chr18:32,815,383...32,819,799
Ensembl chr18:32,815,383...32,819,797 		JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr17:35,833,920...35,838,301
Ensembl chr17:35,833,921...35,838,306 		JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 multiple interactions ISO TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein] CTD PMID:30421542 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829 		JBrowse link
G Ubb ubiquitin B multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr11:62,551,171...62,553,213
Ensembl chr11:62,551,171...62,553,213 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions ISO Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]; Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA] CTD PMID:22846377 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003 		JBrowse link
G Vamp5 vesicle-associated membrane protein 5 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 6:72,368,049...72,380,468
Ensembl chr 6:72,368,794...72,380,468 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Melatonin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:32554039 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
G Vps45 vacuolar protein sorting 45 multiple interactions EXP Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 3:95,999,832...96,059,661
Ensembl chr 3:95,999,832...96,058,466 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Melatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein] CTD PMID:17645694 PMID:28070110 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide multiple interactions ISO Melatonin promotes the reaction [YWHAB protein binds to BAD protein] CTD PMID:18078454 NCBI chr 2:163,995,197...164,018,588
Ensembl chr 2:163,994,960...164,018,588 		JBrowse link
G Yy1 YY1 transcription factor multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA] CTD PMID:28095641 NCBI chr12:108,792,945...108,820,148
Ensembl chr12:108,792,973...108,820,148 		JBrowse link
G Zp2 zona pellucida glycoprotein 2 multiple interactions EXP Melatonin inhibits the reaction [bisphenol A results in increased cleavage of ZP2 protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in increased cleavage of ZP2 protein] CTD PMID:28178360 PMID:31931096 NCBI chr 7:120,126,762...120,145,291
Ensembl chr 7:120,126,772...120,145,291 		JBrowse link
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