Term: | asukamycin |
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Accession: | CHEBI:73481
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Definition: | A polyketide that is a member of the manumycin family of antibiotics and exhibits strong antibacterial, antifungal, and antineoplastic activities. Isolated from from the actinomycete bacterium Streptomyces nodosus subsp. asukaensis. |
Synonyms: | exact_synonym: | (2E,4E,6E)-7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-{(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)amino]-7-oxohepta-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]hepta-2,4,6-trienamide |
| related_synonym: | AM 1042; Formula=C31H34N2O7; InChI=1S/C31H34N2O7/c34-23-17-18-24(35)27(23)33-26(37)16-10-3-4-11-19-31(39)20-22(28(38)29-30(31)40-29)32-25(36)15-9-2-1-6-12-21-13-7-5-8-14-21/h1-4,6,9-12,15-16,19-21,29-30,34,39H,5,7-8,13-14,17-18H2,(H,32,36)(H,33,37)/b2-1+,4-3+,12-6+,15-9+,16-10+,19-11+/t29-,30-,31+/m1/s1; InChIKey=SSHVAUUEPNULMP-JHWDTTIQSA-N; SMILES=OC1=C(NC(=O)\\C=C\\C=C\\C=C\\[C@]2(O)C=C(NC(=O)\\C=C\\C=C\\C=C\\C3CCCCC3)C(=O)[C@H]3O[C@@H]23)C(=O)CC1; asukamycin A1 |
| alt_id: | CHEBI:29521 |
| xref: | Beilstein:3639742; CAS:61116-33-4; KEGG:C12099; KNApSAcK:C00018105; PMCID:PMC3513075; PMID:15038738; PMID:16816183; PMID:19787206; PMID:20522559; PMID:21854515; PMID:22555913; PMID:3553432; PMID:993129; Patent:US4226879; Reaxys:6674537 |
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