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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:masoprocol
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Accession:CHEBI:73468 term browser browse the term
Definition:The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.
Synonyms:exact_synonym: 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
 related_synonym: Actinex;   CHX-100;   Formula=C18H22O4;   InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+;   InChIKey=HCZKYJDFEPMADG-TXEJJXNPSA-N;   SMILES=C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1;   erythro-nordihydroguaiaretic acid;   masoprocolum;   meso-1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane;   meso-2,3-bis(3,4-dihydroxyphenylmethyl)butane;   meso-4,4'-(2,3-dimethyl-1,4-butanediyl)bis(pyrocatechol);   meso-4,4'-(2,3-dimethyltetramethylene)dipyrocatechol;   meso-4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol;   meso-NDGA;   meso-beta,gamma-dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butan;   meso-nordihydroguaiaretic acid
 xref: CAS:27686-84-6;   CAS:500-38-9;   DrugBank:DB00179;   Drug_Central:1637;   HMDB:HMDB0014325;   KEGG:C10719;   KEGG:D04862;   KNApSAcK:C00000693
 xref_mesh: MESH:D009637
 xref: PMID:10027587;   PMID:10206430;   PMID:10411373;   PMID:10950827;   PMID:11016888;   PMID:15814253;   PMID:18672930;   PMID:1869646;   PMID:8040425;   PMID:8412980;   PMID:9169274;   PMID:9617755;   Reaxys:2056826;   Reaxys:9874298;   Wikipedia:Masoprocol


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masoprocol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Masoprocol binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Masoprocol results in decreased phosphorylation of AKT1 protein CTD PMID:19503098 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions
decreases activity
ISO Masoprocol affects the phosphorylation of and affects the activity of ALK protein mutant form
Masoprocol results in decreased activity of ALK protein
CTD PMID:19503098 NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type multiple interactions
decreases activity
ISO
EXP
Masoprocol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
Masoprocol results in decreased activity of ALOX12 protein
CTD PMID:3928952, PMID:6240459, PMID:9258337, PMID:17027136, PMID:23238474 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
decreases activity
EXP
ISO
Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]
Masoprocol results in decreased activity of ALOX15 protein
[Masoprocol results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid
CTD PMID:15574791, PMID:18984061 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects response to substance
decreases activity
multiple interactions
ISO
EXP
ALOX5 protein affects the susceptibility to Masoprocol
Masoprocol results in decreased activity of ALOX5 protein
Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]
[Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; Masoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]
CTD PMID:2724698, PMID:2849922, PMID:3928952, PMID:6240459, PMID:10698703, PMID:18083043, PMID:19503098 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Ar androgen receptor affects binding EXP Masoprocol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Masoprocol results in increased expression of BAX protein
MYC affects the reaction [Masoprocol results in increased expression of BAX protein]
CTD PMID:15034932 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein CTD PMID:17645780 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO
EXP
Masoprocol results in increased cleavage of CASP3 protein
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased cleavage of and results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Masoprocol results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]
[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:10203695, PMID:10653524, PMID:11470254, PMID:15034932, PMID:17645780, PMID:17651887, PMID:18645000, PMID:19503098 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein
Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]
Masoprocol results in increased expression of CASP8 protein
CTD PMID:10203695, PMID:17645780 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Masoprocol results in increased activity of CASP9 protein CTD PMID:15034932 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] CTD PMID:18083043 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Masoprocol results in decreased expression of CCND1 protein CTD PMID:11953870 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 decreases methylation
increases expression
ISO Masoprocol results in decreased methylation of CDH1 promoter
Masoprocol results in increased expression of CDH1 mRNA; Masoprocol results in increased expression of CDH1 protein
CTD PMID:18418215 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases methylation
increases expression
ISO Masoprocol results in decreased methylation of CDKN2A promoter
Masoprocol results in increased expression of CDKN2A mRNA; Masoprocol results in increased expression of CDKN2A protein
CTD PMID:18164318 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form] CTD PMID:17395008 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB mRNA]; Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB protein] CTD PMID:8591993 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Masoprocol results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO Masoprocol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO Masoprocol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein] CTD PMID:18645000 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Masoprocol binds to and results in increased activity of ESR1 protein CTD PMID:19063592 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Masoprocol results in increased expression of FAS protein CTD PMID:17645780 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO
EXP
Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of FASLG protein]
CTD PMID:10203695, PMID:17651887 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein] CTD PMID:17395008 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]] CTD PMID:10692565 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fpr1 formyl peptide receptor 1 decreases activity ISO Masoprocol results in decreased activity of FPR1 protein CTD PMID:17520823 NCBI chr 1:59,759,025...59,767,258
Ensembl chr 1:59,765,835...59,767,042
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
Masoprocol results in increased expression of HMOX1 mRNA; Masoprocol results in increased expression of HMOX1 protein CTD PMID:18852027, PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases expression
increases activity
ISO 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased expression of HSD11B2 mRNA]; [Masoprocol co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; Masoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]; Masoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein] CTD PMID:10377029, PMID:18032417 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18491370, PMID:18645000 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases activity
ISO Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]; Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]; Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]
Masoprocol results in decreased activity of IGF1R protein
CTD PMID:18491370, PMID:18645000 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Masoprocol results in decreased susceptibility to IL1B protein
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:8186192, PMID:12573452, PMID:21211511 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:8186192 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Masoprocol results in decreased expression of JUN mRNA
Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]
CTD PMID:10692565, PMID:15034932 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] CTD PMID:18984061 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Krt1 keratin 1 multiple interactions ISO Masoprocol inhibits the reaction [Calcium results in increased expression of KRT1 mRNA] CTD PMID:12069687 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Masoprocol inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:6430271 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]
Masoprocol results in decreased phosphorylation of MAPK1 protein
CTD PMID:17395008, PMID:19503098 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Masoprocol results in decreased phosphorylation of MAPK3 protein
Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein]
CTD PMID:17395008, PMID:19503098 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form] CTD PMID:17395008 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form] CTD PMID:17395008 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:17395008, PMID:21211511 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
ISO Masoprocol results in increased expression of MYC protein
MYC affects the reaction [Masoprocol results in increased expression of BAX protein]; MYC affects the reaction [Masoprocol results in increased expression of MYC protein]; MYC affects the reaction [Masoprocol results in increased expression of TP53 protein]
CTD PMID:15034932 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Masoprocol affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:18852027 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form] CTD PMID:17395008 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein] CTD PMID:17651887 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions EXP Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] CTD PMID:17651887 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA] CTD PMID:22037733 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Masoprocol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:2105358 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Otc ornithine carbamoyltransferase multiple interactions EXP Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Masoprocol affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein] CTD PMID:25770929 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] CTD PMID:28111842 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prl prolactin multiple interactions EXP Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:7575673, PMID:12573452 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Masoprocol results in decreased phosphorylation of RB1 protein CTD PMID:18164318 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form] CTD PMID:17395008 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Masoprocol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions EXP Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] CTD PMID:17962351 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:8760145, PMID:12031898 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Masoprocol results in decreased phosphorylation of STAT3 protein CTD PMID:19503098 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA] CTD PMID:19194550 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
Masoprocol results in decreased susceptibility to TNF protein
CTD PMID:8186192, PMID:8760145, PMID:21211511 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP10 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17645780 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO MYC affects the reaction [Masoprocol results in increased expression of TP53 protein] CTD PMID:15034932 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Masoprocol inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium] CTD PMID:21453681 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] CTD PMID:17962351 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Masoprocol CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Masoprocol CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Masoprocol CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein] CTD PMID:17520823 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            masoprocol 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic aromatic compound 19116
                                  phenols 18109
                                    benzenediols 6019
                                      catechols 3157
                                        nordihydroguaiaretic acid 71
                                          masoprocol 71
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.