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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-DAMP(1+)
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Accession:CHEBI:73467 term browser browse the term
Definition:A quaternary ammonium salt obtained by formal methylation of the tertiary amino function of 4-diphenylacetoxy-N-methylpiperidine.
Synonyms:exact_synonym: 4-(2,2-diphenylacetoxy)-1,1-dimethylpiperidinium
 related_synonym: 4-DAMP;   4-Diphenylacetoxy-1,1-dimethylpiperidinium;   Formula=C21H26NO2;   InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1;   InChIKey=HYJRTXSYDAFGJK-UHFFFAOYSA-N;   N,N-dimethyl-4-(diphenylacetoxy)piperidinium;   SMILES=C[N+]1(C)CCC(CC1)OC(=O)C(c1ccccc1)c1ccccc1
 xref: CAS:81405-11-0
 xref_mesh: MESH:C042375
 xref: Reaxys:3686582


show annotations for term's descendants           Sort by:
4-DAMP(1+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:11306684 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein] CTD PMID:11306684 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein] CTD PMID:9846649 PMID:11306684 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Cs citrate synthase decreases activity EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased activity of CS protein CTD PMID:27491814 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Dnm1l dynamin 1-like increases phosphorylation EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased phosphorylation of DNM1L protein CTD PMID:27491814 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased expression of FIS1 protein CTD PMID:27491814 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [oxotremorine M results in increased expression of FOS mRNA] CTD PMID:11128034 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mfn1 mitofusin 1 decreases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN1 protein CTD PMID:27491814 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mfn2 mitofusin 2 decreases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN2 protein CTD PMID:27491814 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of OPA1 protein CTD PMID:27491814 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
4-DAMP methiodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 affects binding IDA 4-DAMP methiodide inhibits response to acetylcholine in rat aortic rings RGD PMID:8075871 RGD:2303390 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      molecular entity 19880
        ion 17095
          organic ion 11438
            organic cation 8948
              quaternary ammonium ion 5302
                4-DAMP(1+) 12
                  4-DAMP methiodide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  ammonium 8307
                                    ammonium ion derivative 8322
                                      quaternary ammonium ion 5302
                                        4-DAMP(1+) 12
                                          4-DAMP methiodide 1
paths to the root