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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-DAMP(1+)
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Accession:CHEBI:73467 term browser browse the term
Definition:A quaternary ammonium salt obtained by formal methylation of the tertiary amino function of 4-diphenylacetoxy-N-methylpiperidine.
Synonyms:exact_synonym: 4-(2,2-diphenylacetoxy)-1,1-dimethylpiperidinium
 related_synonym: 4-DAMP;   4-Diphenylacetoxy-1,1-dimethylpiperidinium;   Formula=C21H26NO2;   InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1;   InChIKey=HYJRTXSYDAFGJK-UHFFFAOYSA-N;   N,N-dimethyl-4-(diphenylacetoxy)piperidinium;   SMILES=C[N+]1(C)CCC(CC1)OC(=O)C(c1ccccc1)c1ccccc1
 xref: CAS:81405-11-0
 xref_mesh: MESH:C042375
 xref: Reaxys:3686582


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4-DAMP(1+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:11306684 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein] CTD PMID:11306684 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein] CTD PMID:9846649 PMID:11306684 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Cs citrate synthase decreases activity EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased activity of CS protein CTD PMID:27491814 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Dnm1l dynamin 1-like increases phosphorylation EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased phosphorylation of DNM1L protein CTD PMID:27491814 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased expression of FIS1 protein CTD PMID:27491814 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [oxotremorine M results in increased expression of FOS mRNA] CTD PMID:11128034 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Mfn1 mitofusin 1 decreases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN1 protein CTD PMID:27491814 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mfn2 mitofusin 2 decreases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN2 protein CTD PMID:27491814 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression EXP 4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of OPA1 protein CTD PMID:27491814 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      molecular entity 19770
        ion 15945
          organic ion 8455
            organic cation 7309
              quaternary ammonium ion 5098
                4-DAMP(1+) 12
                  4-DAMP methiodide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      s-block molecular entity 19423
                        hydrogen molecular entity 19416
                          hydrides 18755
                            inorganic hydride 17460
                              pnictogen hydride 17435
                                nitrogen hydride 17281
                                  ammonium 8216
                                    ammonium ion derivative 8212
                                      quaternary ammonium ion 5098
                                        4-DAMP(1+) 12
                                          4-DAMP methiodide 0
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