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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nisoxetine
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Accession:CHEBI:73410 term browser browse the term
Definition:A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Synonyms:exact_synonym: 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
 related_synonym: 3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamine;   3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamine;   DL-N-Methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine;   Formula=C17H21NO2;   InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3;   InChIKey=ITJNARMNRKSWTA-UHFFFAOYSA-N;   N-Methyl-gamma-(2-methylphenoxy)phenylpropanolamine;   SMILES=CNCCC(Oc1ccccc1OC)c1ccccc1;   nisoxetina;   nisoxetinum
 xref: CAS:53179-07-0;   CAS:57226-61-6;   KEGG:D05173;   LINCS:LSM-1934
 xref_mesh: MESH:C011386
 xref: PMID:21933682;   PMID:22166377;   PMID:22781838;   PMID:22874414;   PMID:22889000;   PMID:23431425;   PMID:23597562;   Reaxys:2946689;   Wikipedia:Nisoxetine


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nisoxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Amphetamine inhibits the reaction [nisoxetine binds to SLC6A2 protein]; Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein] CTD PMID:11082428 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
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G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO nisoxetine binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
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Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        pharmacological role 18837
          neurotransmitter agent 16455
            adrenergic agent 8970
              adrenergic uptake inhibitor 4717
                nisoxetine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    subatomic particle 19774
      composite particle 19774
        hadron 19774
          baryon 19774
            nucleon 19774
              atomic nucleus 19774
                atom 19774
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19432
                        hydrogen molecular entity 19427
                          hydrides 18757
                            inorganic hydride 17485
                              pnictogen hydride 17462
                                nitrogen hydride 17316
                                  azane 17025
                                    ammonia 17024
                                      organic amino compound 17023
                                        secondary amino compound 6590
                                          nisoxetine 2
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