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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nisoxetine
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Accession:CHEBI:73410 term browser browse the term
Definition:A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Synonyms:exact_synonym: 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
 related_synonym: 3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamine;   3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamine;   DL-N-Methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine;   Formula=C17H21NO2;   InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3;   InChIKey=ITJNARMNRKSWTA-UHFFFAOYSA-N;   N-Methyl-gamma-(2-methylphenoxy)phenylpropanolamine;   SMILES=CNCCC(Oc1ccccc1OC)c1ccccc1;   nisoxetina;   nisoxetinum
 xref: CAS:53179-07-0;   CAS:57226-61-6;   KEGG:D05173;   LINCS:LSM-1934
 xref_mesh: MESH:C011386
 xref: PMID:21933682;   PMID:22166377;   PMID:22781838;   PMID:22874414;   PMID:22889000;   PMID:23431425;   PMID:23597562;   Reaxys:2946689;   Wikipedia:Nisoxetine


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nisoxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Amphetamine inhibits the reaction [nisoxetine binds to SLC6A2 protein]; Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein] CTD PMID:11082428 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO nisoxetine binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        pharmacological role 19120
          neurotransmitter agent 16808
            adrenergic agent 9179
              adrenergic uptake inhibitor 4822
                nisoxetine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            inorganic hydride 18191
                              pnictogen hydride 18181
                                nitrogen hydride 18092
                                  azane 17895
                                    ammonia 17894
                                      organic amino compound 17894
                                        secondary amino compound 6958
                                          nisoxetine 2
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