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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:promegestone
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Accession:CHEBI:73390 term browser browse the term
Definition:A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
Synonyms:exact_synonym: (17beta)-17-methyl-17-propionylestra-4,9-dien-3-one
 related_synonym: 17,21-dimethyl-19-norpregna-4,9(10)-diene-3,20-dione;   17alpha-methyl-17-propionylestra-4,9-dien-3-one;   Formula=C22H30O2;   InChI=1S/C22H30O2/c1-4-20(24)22(3)12-10-19-18-7-5-14-13-15(23)6-8-16(14)17(18)9-11-21(19,22)2/h13,18-19H,4-12H2,1-3H3/t18-,19+,21+,22-/m1/s1;   InChIKey=QFFCYTLOTYIJMR-XMGTWHOFSA-N;   R 5020;   RU5020;   SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1CC[C@@]1(C)[C@@]2([H])CC[C@]1(C)C(=O)CC;   promegestona;   promegestonum
 alt_id: CHEBI:34933
 xref: CAS:34184-77-5;   Drug_Central:2285;   KEGG:C14208;   KEGG:D08431
 xref_mesh: MESH:D011397
 xref: PMID:1563574;   PMID:18979300;   PMID:19250196;   PMID:19429233;   PMID:19962254;   PMID:21228216;   PMID:23466250;   PMID:23597562;   PMID:3386236;   PMID:3748873;   PMID:570871;   PMID:6169181;   PMID:7647331;   PMID:7979190;   PMID:885117;   PMID:9749835;   Reaxys:5104746;   Wikipedia:Promegestone

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promegestone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions
increases expression		 ISO methoxyacetic acid promotes the reaction [Promegestone results in increased expression of ACSL1 mRNA] CTD PMID:15103026 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP Promegestone results in increased phosphorylation of AKT1 protein
fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of AKT1 protein]; Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of AKT1 protein]		 CTD PMID:16020483 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 multiple interactions ISO [Promegestone co-treated with methoxyacetic acid] results in increased expression of AP1G1 mRNA CTD PMID:15103026 NCBI chr19:41,805,252...41,860,076 JBrowse link
G Ar androgen receptor affects binding EXP Promegestone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Areg amphiregulin multiple interactions ISO [Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein; [Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:21258428 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Arid1a AT-rich interaction domain 1A multiple interactions ISO Promegestone promotes the reaction [ARID1A protein binds to PGR protein] CTD PMID:19609353 NCBI chr 5:151,904,687...151,977,973
Ensembl chr 5:151,904,684...151,977,636 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Promegestone results in increased expression of CCND1 mRNA CTD PMID:19609353 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Promegestone results in increased expression of CYP26A1 mRNA
[Promegestone co-treated with Estradiol] results in increased expression of CYP26A1 mRNA		 CTD PMID:16955405 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 multiple interactions
increases expression		 ISO methoxyacetic acid promotes the reaction [Promegestone results in increased expression of DLG5 mRNA] CTD PMID:15103026 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977 		JBrowse link
G Elf5 E74 like ETS transcription factor 5 increases expression ISO Promegestone results in increased expression of ELF5 protein CTD PMID:20519331 NCBI chr 3:93,333,514...93,374,454
Ensembl chr 3:93,351,619...93,371,656 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Promegestone results in increased expression of FOS mRNA
SMARCA2 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]; SMARCA4 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]		 CTD PMID:19609353 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases expression		 ISO PGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA] CTD PMID:16675544 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Glul glutamate-ammonia ligase increases expression
multiple interactions		 ISO Promegestone results in increased expression of GLUL mRNA
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of GLUL mRNA]		 CTD PMID:15103026 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Gpsm2 G-protein signaling modulator 2 increases expression
multiple interactions		 ISO Promegestone results in increased expression of GPSM2 mRNA
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of GPSM2 mRNA]		 CTD PMID:15103026 NCBI chr 2:211,480,120...211,528,096
Ensembl chr 2:211,480,400...211,527,919 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]; mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]; Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]; Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter] CTD PMID:16807381 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO Promegestone results in decreased expression of LHB mRNA CTD PMID:16675544 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]; Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]
[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]; Gefitinib inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16020483 PMID:21258428 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 Fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein]; Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein]
[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein; gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein]; gefitinib inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16020483 PMID:21258428 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mt2A metallothionein 2A increases expression
multiple interactions		 ISO Promegestone results in increased expression of MT2A mRNA
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT2A mRNA]		 CTD PMID:15103026 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 ISO SMARCA2 protein affects the reaction [Promegestone results in increased expression of MYC mRNA]; SMARCA4 protein affects the reaction [Promegestone results in increased expression of MYC mRNA] CTD PMID:19609353 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myo10 myosin X multiple interactions
increases expression		 ISO methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MYO10 mRNA] CTD PMID:15103026 NCBI chr 2:77,868,398...78,072,443
Ensembl chr 2:77,868,412...78,071,309 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases phosphorylation ISO Promegestone results in increased phosphorylation of NR3C1 protein CTD PMID:18483179 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
increases uptake
affects localization
increases activity		 ISO
EXP		 1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Promegestone results in increased activity of PGR protein]; Bortezomib inhibits the reaction [Promegestone results in increased activity of PGR protein]; carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein]; Decitabine inhibits the reaction [Promegestone results in increased activity of PGR protein]; fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein]; fluoxastrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; kresoxim-methyl inhibits the reaction [Promegestone results in increased activity of PGR protein]; methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]; metoprine inhibits the reaction [Promegestone results in increased activity of PGR protein]; Mifepristone inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; picoxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein]; Promegestone promotes the reaction [ARID1A protein binds to PGR protein]; Promegestone promotes the reaction [SMARCE1 protein binds to PGR protein]; pyrachlostrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein]; Rotenone inhibits the reaction [Promegestone results in increased activity of PGR protein]; ST 1481 inhibits the reaction [Promegestone results in increased activity of PGR protein]; trifloxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; Vorinostat inhibits the reaction [Promegestone results in increased activity of PGR protein]; ZNF366 protein inhibits the reaction [Promegestone results in increased activity of PGR protein]
Promegestone binds to PGR protein
PGR protein results in increased uptake of Promegestone
PGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA]
Promegestone affects the localization of PGR protein		 CTD PMID:15103026 PMID:16020483 PMID:16675544 PMID:18486176 PMID:19609353 PMID:20008677 PMID:21795739 PMID:23765520 PMID:30818834 PMID:30951782 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 increases expression
multiple interactions		 ISO Promegestone results in increased expression of QSOX1 mRNA
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of QSOX1 mRNA]		 CTD PMID:15103026 NCBI chr13:73,423,396...73,460,890
Ensembl chr13:73,423,397...73,460,935 		JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor multiple interactions
increases expression		 ISO methoxyacetic acid promotes the reaction [Promegestone results in increased expression of RBBP7 mRNA] CTD PMID:15103026 NCBI chr  X:33,648,682...33,665,821
Ensembl chr  X:33,648,682...33,665,821 		JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 multiple interactions ISO SMARCA2 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]; SMARCA2 protein affects the reaction [Promegestone results in increased expression of MYC mRNA] CTD PMID:19609353 NCBI chr 1:244,615,811...244,783,736
Ensembl chr 1:244,615,821...244,782,706 		JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 multiple interactions ISO SMARCA4 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]; SMARCA4 protein affects the reaction [Promegestone results in increased expression of MYC mRNA] CTD PMID:19609353 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468 		JBrowse link
G Smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 multiple interactions ISO Promegestone promotes the reaction [SMARCE1 protein binds to PGR protein] CTD PMID:19609353 NCBI chr10:87,116,827...87,138,890
Ensembl chr10:87,116,827...87,137,965 		JBrowse link
G Sp1 Sp1 transcription factor increases expression
multiple interactions		 ISO Promegestone results in increased expression of SP1 mRNA; Promegestone results in increased expression of SP1 protein
mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]; Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]		 CTD PMID:16807381 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases expression		 ISO mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]; Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]
Promegestone results in increased expression of SP3 mRNA; Promegestone results in increased expression of SP3 protein		 CTD PMID:16807381 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase multiple interactions ISO [Promegestone co-treated with methoxyacetic acid] results in increased expression of TIGAR mRNA CTD PMID:15103026 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063 		JBrowse link
G Vdr vitamin D receptor increases expression ISO Promegestone results in increased expression of VDR protein CTD PMID:7662588 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Zfp366 zinc finger protein 366 multiple interactions ISO ZNF366 protein inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:20008677 NCBI chr 2:29,410,169...29,498,661
Ensembl chr 2:29,410,579...29,498,664 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 multiple interactions ISO [Promegestone co-treated with Estradiol] results in increased expression of ZFP36L1 mRNA CTD PMID:19146866 NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pharmaceutical 19338
          drug 19338
            antineoplastic agent 17009
              promegestone 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16189
                                        oxo steroid 9287
                                          3-oxo steroid 8816
                                            3-oxo-Delta(4) steroid 7945
                                              promegestone 34
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