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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions increases expression |
ISO |
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of ACSL1 mRNA] |
CTD |
PMID:15103026 |
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
EXP |
Promegestone results in increased phosphorylation of AKT1 protein fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of AKT1 protein]; Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:16020483 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Ap1g1 |
adaptor related protein complex 1 subunit gamma 1 |
multiple interactions |
ISO |
[Promegestone co-treated with methoxyacetic acid] results in increased expression of AP1G1 mRNA |
CTD |
PMID:15103026 |
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NCBI chr19:37,744,633...37,831,134
Ensembl chr19:37,744,633...37,829,167
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Ar |
androgen receptor |
affects binding |
EXP |
Promegestone binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Areg |
amphiregulin |
multiple interactions |
ISO |
[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein; [Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21258428 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Arid1a |
AT-rich interaction domain 1A |
multiple interactions |
ISO |
Promegestone promotes the reaction [ARID1A protein binds to PGR protein] |
CTD |
PMID:19609353 |
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NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
Promegestone results in increased expression of CCND1 mRNA |
CTD |
PMID:19609353 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of CYP26A1 mRNA [Promegestone co-treated with Estradiol] results in increased expression of CYP26A1 mRNA |
CTD |
PMID:16955405 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Dlg5 |
discs large MAGUK scaffold protein 5 |
multiple interactions increases expression |
ISO |
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of DLG5 mRNA] |
CTD |
PMID:15103026 |
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NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837
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G |
Elf5 |
E74 like ETS transcription factor 5 |
increases expression |
ISO |
Promegestone results in increased expression of ELF5 protein |
CTD |
PMID:20519331 |
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NCBI chr 3:89,808,837...89,836,977
Ensembl chr 3:89,797,880...89,836,973
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of FOS mRNA SMARCA2 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]; SMARCA4 protein affects the reaction [Promegestone results in increased expression of FOS mRNA] |
CTD |
PMID:19609353 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions increases expression |
ISO |
PGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA] |
CTD |
PMID:16675544 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Glul |
glutamate-ammonia ligase |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of GLUL mRNA methoxyacetic acid promotes the reaction [Promegestone results in increased expression of GLUL mRNA] |
CTD |
PMID:15103026 |
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NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gpsm2 |
G-protein signaling modulator 2 |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of GPSM2 mRNA methoxyacetic acid promotes the reaction [Promegestone results in increased expression of GPSM2 mRNA] |
CTD |
PMID:15103026 |
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NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
multiple interactions |
ISO |
mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]; mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]; Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]; Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter] |
CTD |
PMID:16807381 |
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NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Promegestone results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
ISO |
Promegestone results in decreased expression of LHB mRNA |
CTD |
PMID:16675544 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]; Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein] [Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein; Gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]; Gefitinib inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:16020483 PMID:21258428 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP ISO |
Fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein]; Mifepristone inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein] [Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein; gefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein]; gefitinib inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:16020483 PMID:21258428 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mt2A |
metallothionein 2A |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of MT2A mRNA methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT2A mRNA] |
CTD |
PMID:15103026 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases expression |
ISO |
SMARCA2 protein affects the reaction [Promegestone results in increased expression of MYC mRNA]; SMARCA4 protein affects the reaction [Promegestone results in increased expression of MYC mRNA] |
CTD |
PMID:19609353 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myo10 |
myosin X |
multiple interactions increases expression |
ISO |
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MYO10 mRNA] |
CTD |
PMID:15103026 |
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NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases phosphorylation |
ISO |
Promegestone results in increased phosphorylation of NR3C1 protein |
CTD |
PMID:18483179 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Pgr |
progesterone receptor |
multiple interactions increases activity affects localization increases uptake affects binding |
ISO EXP |
1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Promegestone results in increased activity of PGR protein]; Bortezomib inhibits the reaction [Promegestone results in increased activity of PGR protein]; carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein]; Decitabine inhibits the reaction [Promegestone results in increased activity of PGR protein]; fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein]; fluoxastrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; kresoxim-methyl inhibits the reaction [Promegestone results in increased activity of PGR protein]; methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]; metoprine inhibits the reaction [Promegestone results in increased activity of PGR protein]; Mifepristone inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; picoxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein]; Promegestone promotes the reaction [ARID1A protein binds to PGR protein]; Promegestone promotes the reaction [SMARCE1 protein binds to PGR protein]; pyrachlostrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein]; Rotenone inhibits the reaction [Promegestone results in increased activity of PGR protein]; ST 1481 inhibits the reaction [Promegestone results in increased activity of PGR protein]; trifloxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; Vorinostat inhibits the reaction [Promegestone results in increased activity of PGR protein]; ZNF366 protein inhibits the reaction [Promegestone results in increased activity of PGR protein] Promegestone affects the localization of PGR protein PGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA] PGR protein results in increased uptake of Promegestone Promegestone binds to PGR protein |
CTD |
PMID:15103026 PMID:16020483 PMID:16675544 PMID:18486176 PMID:19609353 PMID:20008677 PMID:21795739 PMID:23765520 PMID:30818834 PMID:30951782 More...
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Qsox1 |
quiescin sulfhydryl oxidase 1 |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of QSOX1 mRNA methoxyacetic acid promotes the reaction [Promegestone results in increased expression of QSOX1 mRNA] |
CTD |
PMID:15103026 |
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NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459
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G |
Rbbp7 |
RB binding protein 7, chromatin remodeling factor |
multiple interactions increases expression |
ISO |
methoxyacetic acid promotes the reaction [Promegestone results in increased expression of RBBP7 mRNA] |
CTD |
PMID:15103026 |
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NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226
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G |
Smarca2 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
multiple interactions |
ISO |
SMARCA2 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]; SMARCA2 protein affects the reaction [Promegestone results in increased expression of MYC mRNA] |
CTD |
PMID:19609353 |
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NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
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G |
Smarca4 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
multiple interactions |
ISO |
SMARCA4 protein affects the reaction [Promegestone results in increased expression of FOS mRNA]; SMARCA4 protein affects the reaction [Promegestone results in increased expression of MYC mRNA] |
CTD |
PMID:19609353 |
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NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975
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G |
Smarce1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
multiple interactions |
ISO |
Promegestone promotes the reaction [SMARCE1 protein binds to PGR protein] |
CTD |
PMID:19609353 |
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NCBI chr10:84,159,270...84,180,547
Ensembl chr10:84,159,275...84,179,989
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G |
Sp1 |
Sp1 transcription factor |
increases expression multiple interactions |
ISO |
Promegestone results in increased expression of SP1 mRNA; Promegestone results in increased expression of SP1 protein mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]; Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter] |
CTD |
PMID:16807381 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sp3 |
Sp3 transcription factor |
multiple interactions increases expression |
ISO |
mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]; Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter] Promegestone results in increased expression of SP3 mRNA; Promegestone results in increased expression of SP3 protein |
CTD |
PMID:16807381 |
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NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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G |
Tigar |
TP53 induced glycolysis regulatory phosphatase |
multiple interactions |
ISO |
[Promegestone co-treated with methoxyacetic acid] results in increased expression of TIGAR mRNA |
CTD |
PMID:15103026 |
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NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
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G |
Vdr |
vitamin D receptor |
increases expression |
ISO |
Promegestone results in increased expression of VDR protein |
CTD |
PMID:7662588 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Zfp366 |
zinc finger protein 366 |
multiple interactions |
ISO |
ZNF366 protein inhibits the reaction [Promegestone results in increased activity of PGR protein] |
CTD |
PMID:20008677 |
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NCBI chr 2:30,578,552...30,640,546
Ensembl chr 2:30,578,715...30,642,182
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G |
Zfp36l1 |
zinc finger protein 36, C3H type-like 1 |
multiple interactions |
ISO |
[Promegestone co-treated with Estradiol] results in increased expression of ZFP36L1 mRNA |
CTD |
PMID:19146866 |
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NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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