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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GR 113808
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Accession:CHEBI:73380 term browser browse the term
Definition:An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.
Synonyms:exact_synonym: (1-{2-[(methylsulfonyl)amino]ethyl}piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate
 related_synonym: Formula=C19H27N3O4S;   GR113808;   InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3;   InChIKey=MOZPSIXKYJUTKI-UHFFFAOYSA-N;   SMILES=Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
 xref: CAS:144625-51-4;   LINCS:LSM-3098
 xref_mesh: MESH:C082871
 xref: PMID:23597562;   Patent:EP501322;   Reaxys:7778599;   Wikipedia:GR-113\,808


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GR 113808 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
affects binding		 ISO
EXP		 GR 113808 binds to and results in decreased activity of HTR4 protein
GR 113808 binds to HTR4 protein		 CTD PMID:11020291 PMID:12736770 PMID:15236628 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]] CTD PMID:30611738 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]] CTD PMID:30611738 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:30611738 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]] CTD PMID:30611738 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:13,361,006...13,398,748 		JBrowse link
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  CHEBI ontology 19904
    role 19875
      biological role 19873
        pharmacological role 19109
          neurotransmitter agent 16818
            serotonergic drug 4390
              serotonergic antagonist 2691
                GR 113808 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      carbon group element atom 19779
                        carbon atom 19776
                          organic molecular entity 19776
                            organic molecule 19730
                              organic cyclic compound 19522
                                organic heterocyclic compound 18896
                                  organic heteropolycyclic compound 18320
                                    organic heterobicyclic compound 17261
                                      benzopyrrole 9759
                                        indoles 9447
                                          indolyl carboxylate ester 35
                                            GR 113808 5
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