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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GR 113808
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Accession:CHEBI:73380 term browser browse the term
Definition:An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.
Synonyms:exact_synonym: (1-{2-[(methylsulfonyl)amino]ethyl}piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate
 related_synonym: Formula=C19H27N3O4S;   GR113808;   InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3;   InChIKey=MOZPSIXKYJUTKI-UHFFFAOYSA-N;   SMILES=Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
 xref: CAS:144625-51-4;   LINCS:LSM-3098
 xref_mesh: MESH:C082871
 xref: PMID:23597562;   Patent:EP501322;   Reaxys:7778599;   Wikipedia:GR-113\,808



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GR 113808 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
affects binding
ISO
EXP
GR 113808 binds to and results in decreased activity of HTR4 protein
GR 113808 binds to HTR4 protein
CTD PMID:11020291 PMID:12736770 PMID:15236628 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]] CTD PMID:30611738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]] CTD PMID:30611738 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:30611738 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]] CTD PMID:30611738 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link

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  CHEBI ontology 19800
    role 19751
      biological role 19751
        pharmacological role 18837
          neurotransmitter agent 16451
            serotonergic drug 4008
              serotonergic antagonist 2332
                GR 113808 5
Path 2
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterobicyclic compound 16859
                                      benzopyrrole 9562
                                        indoles 9236
                                          indolyl carboxylate ester 24
                                            GR 113808 5
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