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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mesulergine
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Accession:CHEBI:73378 term browser browse the term
Definition:A member of the class of ergot alkaloids that is known to act on serotonin and dopamine receptors.
Synonyms:exact_synonym: N'-[(8alpha)-1,6-dimethylergolin-8-yl]-N,N-dimethylsulfuric diamide
 related_synonym: Formula=C18H26N4O2S;   InChI=1S/C18H26N4O2S/c1-20(2)25(23,24)19-13-9-15-14-6-5-7-16-18(14)12(10-21(16)3)8-17(15)22(4)11-13/h5-7,10,13,15,17,19H,8-9,11H2,1-4H3/t13-,15+,17+/m0/s1;   InChIKey=JLVHTNZNKOSCNB-YSVLISHTSA-N;   N'-(1,6-Dimethylergolin-8alpha-yl)-N,N-dimethylsulfamide;   SMILES=C1=C2C3=C(C=CC=C3[C@@]4([C@@](C2)(N(C[C@H](C4)NS(N(C)C)(=O)=O)C)[H])[H])N1C;   mesulergina;   mesulerginum
 xref: CAS:64795-35-3;   LINCS:LSM-4045
 xref_mesh: MESH:C031649
 xref: PMID:21190911;   PMID:22313641;   PMID:23597562;   PMID:2895480;   PMID:3428838;   PMID:3708600;   PMID:3881692;   PMID:3895033;   PMID:4067602;   PMID:6230246;   PMID:6386276;   PMID:6488683;   PMID:6527137;   Patent:US4515950;   Reaxys:714438;   Wikipedia:Mesulergine



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mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2b 5-hydroxytryptamine receptor 2B affects binding
multiple interactions
ISO mesulergine binds to HTR2B protein
Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]
CTD PMID:11930908 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
ISO
EXP
mesulergine binds to HTR2C protein
Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]
N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD PMID:18083778 PMID:19439326 PMID:19700373 PMID:29458138 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO mesulergine binds to HTR7 protein
[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Prl prolactin multiple interactions EXP mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein] CTD PMID:1421203 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        pharmacological role 19105
          neurotransmitter agent 16542
            serotonergic drug 4260
              serotonergic antagonist 2647
                mesulergine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    main group molecular entity 19971
                      s-block molecular entity 19765
                        hydrogen molecular entity 19756
                          hydrides 19120
                            inorganic hydride 17878
                              pnictogen hydride 17861
                                nitrogen hydride 17747
                                  azane 17494
                                    ammonia 17493
                                      organic amino compound 17493
                                        polyamine 8326
                                          diamine 8255
                                            ergoline 19
                                              mesulergine 4
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